GRK 2762 - Publications
2026
Quantifying Treatment Resistance in Mixtures of Gastrointestinal Stromal Tumor Cells with BARMIX. Systems Biology
Darbalaei M, Mühlenberg T, Zummack J, Dujardin P, Grunewald S, Baginska A, Munteanu P, Martinez Cruz M, Dorsch M, Schramm A, Bauer S, Hoffmann D, Grüner BM. Quantifying Treatment Resistance in Mixtures of Gastrointestinal Stromal Tumor Cells with BARMIX. Systems Biology. Preprint posted online March 25, 2026. doi:10.64898/2026.03.23.713602
Berzosertib enhances the sensitivity of pediatric diffuse midline glioma H3K27-altered cells to radiotherapy
Gorainow N, Sander F, Picard D, Frolich MC, Eul K, Etemadi Afshar S, Asche J, Monje M, Raabe E, Bartl J, Borkhardt A, Reifenberger G, Dunker N, Busch M, Pauck D, Qin N, Matschke J, Remke M, Jendrossek V. Berzosertib enhances the sensitivity of pediatric diffuse midline glioma H3K27-altered cells to radiotherapy. Cell Death Dis. Mar 20 2026;doi:10.1038/s41419-026-08567-7
The role of KDM5B in creating synthetic vulnerabilities in combination with radiotherapy in melanoma cells
Larafa S, Schaffrin M, Brass P, Varaljai R, Scharfenberg S, Kravchenko-Balasha N, Polinovski G, Herlyn M, Tarade N, Wiemann S, Roesch A, Schadendorf D, Jendrossek V, Matschke J, Shannan B. The role of KDM5B in creating synthetic vulnerabilities in combination with radiotherapy in melanoma cells. Cell Commun Signal. Mar 5 2026;doi:10.1186/s12964-026-02714-5
Homologous Recombination and Alternative End-Joining Repair Pathways are Important Determinants of Radiosensitivity to Proton Radiotherapy
Hessenow R, Matschke J, Mladenov E, Lin X, Heinzelmann F, Esser JN, Afshar SE, Li F, Soni A, Mollers C, Busch M, Dunker N, Pantelias G, Baumer C, Stuschke M, Iliakis G, Timmermann B, Jendrossek V. Homologous Recombination and Alternative End-Joining Repair Pathways are Important Determinants of Radiosensitivity to Proton Radiotherapy. Int J Radiat Oncol Biol Phys. Feb 25 2026;doi:10.1016/j.ijrobp.2026.02.234
Radiation Dose-Dependent and -Independent Pulmonary Infiltrates in Patients with High-Grade Pneumonitis After Radiochemotherapy and Durvalumab Consolidation for Stage III NSCLC
Herz A, Khouya A, Guberina M, Metzenmacher M, Opitz M, Pöttgen C, Fischedick G, Hautzel H, Gauler T, Herrmann K, Büscher E, Bölükbas S, Doerr F, Baldes N, Klüner LV, Schaarschmidt BM, Karpf-Wissel R, Winantea J, Bos D, Jendrossek V, Mladenov E, Gockeln L, Hetzel MA, Wirsdörfer F, Schuler M, Stuschke M, Guberina N. Radiation Dose-Dependent and -Independent Pulmonary Infiltrates in Patients with High-Grade Pneumonitis After Radiochemotherapy and Durvalumab Consolidation for Stage III NSCLC. Diagnostics. 2026;16(6):827. Doi: 10.3390/diagnostics16060827
The future of mathematical oncology in the age of AI
Rockne RC, Andersen M, Anderson ARA, Basanta D, Bentivegna A, Benzekry S, Branciamore S, Bruningk SC, Conte M, Farahpour F, Karolak A, Kohn-Luque A, Lorenzo G, Manookian B, Rodin AS, Schmalenstroer L, Soler J, Tomasetti C, Urbaniak K. The future of mathematical oncology in the age of AI. NPJ Syst Biol Appl. Jan 26 2026;12(1):22. doi:10.1038/s41540-026-00656-9
Biological Effects in Clinical Proton Beams That Suppress c-NHEJ and Enhance HR and Alt-EJ
Mladenov E, Pressler M, Mladenova V, Soni A, Li F, Heinzelmann F, Esser JN, Hessenow R, Gkika E, Jendrossek V, Timmermann B, Stuschke M, Iliakis G. Evidence for Quasi-High-LET Biological Effects in Clinical Proton Beams That Suppress c-NHEJ and Enhance HR and Alt-EJ. Cells. Jan 4 2026;15(1)doi:10.3390/cells15010086
CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer
Patel UA, Shi MY, Kazan JM, Nixon KCJ, Ran X, Nair SN, Huang O, Song L, Aparnathi MK, He MY, Bakhtiari M, Krishnan R, Hessenow RK, Philip V, Ketela T, Jendrossek V, Hakem R, He HH, Kridel R, Lok BH. CRISPR Screen Identifies HDAC3 as a Novel Radiosensitizing Target in Small Cell Lung Cancer. Mol Cancer Ther. Jan 2 2026;25(1):183–195. doi:10.1158/1535-7163.MCT-24-0861
2025
Senescent fibroblasts modulate the radiation response of neighboring epithelial cells
Buchholzki M, Stasch LM, Budeus B, Ketheeswaranathan V, Sevindik ZF, Jendrossek V, Klein D. Senescent fibroblasts modulate the radiation response of neighboring epithelial cells. Cell Death Discov. Oct 20 2025;11(1):468. doi:10.1038/s41420-025-02796-z
Development of a leucine-rich repeat-containing protein 15-targeted radio-immunotheranostic approach to deplete pro-tumorigenic mechanisms and immunotherapy resistance
Storey CM, Altai M, Luckerath K, Zedan W, Zhu H, Breuer L, Trajkovic-Arsic M, Park J, Hasson A, Siveke J, Abou D, Marks H, Ulmert E, Ridley A, Safi M, Lamminmaki U, Yuen C, Geres S, Mao L, Cheng M, Subudhi SK, Siddiqui BA, Federman N, Czernin J, Herrmann K, Bentolila L, Yang X, Graeber TG, Damoiseaux R, Thorek D, Ulmert D. Development of a leucine-rich repeat-containing protein 15-targeted radio-immunotheranostic approach to deplete pro-tumorigenic mechanisms and immunotherapy resistance. Signal Transduct Target Ther. Sep 30 2025;10(1):319. doi: 10.1038/s41392-025-02410-9
Generating Free-floating Normal Human Epithelial-Fibroblast Spheroid Co-Cultures
Stasch LM, Buchholzki M, Ketheeswaranathan V, Sevindik Z, Jendrossek V, Budeus B, Klein D. Generating Free-floating Normal Human Epithelial-Fibroblast Spheroid Co-Cultures.J Vis Exp. Jul 3 2025;(221)doi:10.3791/68440
The effect of Durvalumab consolidation after definitive radiochemotherapy for non-operable stage III NSCLC on the dose effect relation for therapy related pulmonary infiltrates as a risk factor for pneumonitis
Herz A, Guberina, M, Pöttgen C, Gauler T, Ton TTM, Fischedick G, Kiwitt L, Khouya A, Lübcke W, Hoffmann C, Schuler M, Metzenmacher M, Schaarschmidt B, Bos D, Opitz M, Hautzel H, Darwiche K, Bölükbas S, Grapatsas K, Gockeln L, Hetzel M , Mladenov E, Wirsdörfer F , Jendrossek V, Stuschke, M, Guberina N. The effect of Durvalumab consolidation after definitive radiochemotherapy for non-operable stage III NSCLC on the dose effect relation for therapy related pulmonary infiltrates as a risk factor for pneumonitis. Transl Lung Cancer. 2025. doi: 10.21037/tlcr-2024-1284.
MetaboDynamics: Bayesian analysis of longitudinal metabolomics data
Danielzik K, Kitanovski S, Matschke J, Hoffmann D. MetaboDynamics: Bayesian analysis of longitudinal metabolomics data. Bioconductor. 2025. doi: 10.18129/B9.bioc.MetaboDynamics.
Matrix-Free Normal Human Epithelial-Fibroblast 3D Spheroid Cultures for In Vitro Lung Modeling
Stasch LM, Buchholzki M, Kitanovski S, Budeus B, Klein D. Matrix-Free Normal Human Epithelial-Fibroblast 3D Spheroid Cultures for In Vitro Lung Modeling. Methods Mol Biol. 2025. doi: 10.1007/7651_2025_622.
ClustIRR: Clustering of immune receptor repertoires
Kitanovski S, Wollek K. ClustIRR: Clustering of immune receptor repertoires. Bioconductor. 2025. doi: 10.18129/B9.bioc.ClustIRR,R package version 1.6.0, doi: 10.18129/B9.bioc.ClustIRR.
Quantitative Visualisierung von HTseq-Daten
Kitanovski S, Wollek K, Hoffmann D. Quantitative Visualisierung von HTseq-Daten. Biospektrum 31, 49–51. 2025. doi: 10.1007/s12268-025-2369-0.
2024
Metabolic pathway-based subtypes associate glycan biosynthesis and treatment response in head and neck cancer
Dankó B, Hess J, Unger K, Samaga D, Walz C, Walch A, Sun N, Baumeister P, Zeng PYF, Walter F, Marschner S, Späth R, Gires O, Herkommer T, Dazeh R, Matos T, Kreutzer L, Matschke J, Eul K, Klauschen F, Pflugradt U, Canis M, Ganswindt U, Mymryk JS, Wollenberg B, Nichols AC, Belka C, Zitzelsberger H, Lauber K, Selmansberger M. Metabolic pathway-based subtypes associate glycan biosynthesis and treatment response in head and neck cancer. NPJ Precis Oncol. 2024 May 23;8(1):116. doi: 10.1038/s41698-024-00602-0.
2023
The Multifaceted Roles of Lamins in Lung Cancer and DNA Damage Response
Janetzko J, Oeck S, Schramm A. The Multifaceted Roles of Lamins in Lung Cancer and DNA Damage Response. Cancers (Basel). Nov 21 2023;15(23);doi:10.3390/cancers15235501