GRK 2762 - Research Projects

Research Projects GRK 2762Heterogeneity, plasticity and dynamic in cancer cell, tumor and normal tissue responses to cancer radiotherapy

 

Principal Investigators

Titles of research projects

L

Role of molecular heterogeneity of NSCLC in RT outcome

L1

Grüner

Role of molecular heterogeneity for radiation resistance and metastatic ability in NSCLC

L2

Matschke

Subtype-specific vulnerabilities of KRAS-driven NSCLC cells with intrinsic or adaptive radiation resistance

L3

Schramm

Impact of somatic Lamin mutations on radiation response in lung cancer

L4

Stuschke

Interplay of exosomal miRNAs and genomic alteration in radiation response modulation and use as prognostic factors in NSCLC

P

Role of spatial heterogeneity of PDAC in RT outcome

P1

Siveke/Matschke/Timmermann

Effect of KRAS gene dosage and molecular subtype on radiosensitivity in PDAC

P2

Siveke

Radiotherapy-induced tumor and stromal cell state regulation in PDAC

P3

Lückerath

Exploring radioimmunotherapy (RIT) as an immunomodulatory therapy in quasi-mesenchymal (QM) versus classic PDAC

T

Role of host-specific immune repertoires in RT-induced toxicity

T1

Guberina/Jendrossek

Biomarkers of pneumonitis and lung fibrosis upon thoracic RT/RCTx with or without concomitant anti-PD-L1 antibody therapy

T2

Jendrossek/Westendorf

Role of the host microbiota for radiation-induced lung toxicity

T3

Rassaf

Modulation of stroma-immune interaction to prevent RT-induced cardiac injury

M

Computational Modeling

M1

Hoffmann

Development of modular computational modeling pipelines for reproducible radiation oncology research

M2

Farahpour

Mathematical modeling of radiotherapy-induced immune responses