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Universitätsklinikum Essen, Medizinisches Forschungszentrum, Raum 3.016
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Hufelandstr. 55
45147 Essen
45147 Essen
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Wiss. Mitarbeiter/in und Wiss. Assistent/in, Institut für Physiologie
Universitätsklinikum Essen, Medizinisches Forschungszentrum, Raum 3.016
AnschriftHufelandstr. 55
45147 EssenTelefon
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Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Calcium Electroporation versus Electrochemotherapy with Bleomycin in an In Vivo CAM-Based Uveal Melanoma Xenograft ModelIn: International Journal of Molecular Sciences (IJMS) , Jg. 25 2024, Nr. 2, 938DOI, Online Volltext (Open Access)
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Electroporation with Calcium or Bleomycin : First Application in an In Vivo Uveal Melanoma Patient-Derived Xenograft ModelIn: Pharmaceuticals , Jg. 17 2024, Nr. 7, 905DOI, Online Volltext (Open Access)
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The Chick Chorioallantoic Membrane as a Xenograft Model for the Quantitative Analysis of Uveal Melanoma Metastasis in Multiple OrgansIn: Cells , Jg. 13 2024, Nr. 14, 1169DOI, Online Volltext (Open Access)
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Wolfram-silicone implants as effective radiation shielding for ocular brachytherapy : dosimetric features and in vivo animal study on biocompatibilityIn: Canadian Journal of Ophthalmology , Jg. 59 2024, Nr. 5, S. e515 – e524DOI (Open Access)
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Blockade of ß-Adrenergic Receptors by Nebivolol Enables Tumor Control Potential for Uveal Melanoma in 3D Tumor Spheroids and 2D CulturesIn: International Journal of Molecular Sciences (IJMS) , Jg. 24 2023, Nr. 6DOI (Open Access)
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Chick Chorioallantoic Membrane as a Patient-Derived Xenograft Model for Uveal Melanoma : Imaging Modalities for Growth and Vascular EvaluationIn: Cancers , Jg. 2023 2023, Nr. 15, 1436DOI, Online Volltext (Open Access)
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Macrophage-Orbital Fibroblast Interaction and Hypoxia Promote Inflammation and Adipogenesis in Graves' OrbitopathyIn: Endocrinology , Jg. 164 2023, Nr. 2, bqac203DOI (Open Access)
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An Early Wave of Macrophage Infiltration Intertwined with Antigen-Specific Proinflammatory T Cells and Browning of Adipose Tissue Characterizes the Onset of Orbital Inflammation in a Mouse Model of Graves' OrbitopathyIn: Thyroid , Jg. 32 2022, Nr. 3, S. 283 – 293
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Calcium Electroporation Reduces Viability and Proliferation Capacity of Four Uveal Melanoma Cell Lines in 2D and 3D CulturesIn: Cancers , Jg. 14 2022, Nr. 12, 2889DOI, Online Volltext (Open Access)
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Optimisation of the Chicken Chorioallantoic Membrane Assay in Uveal Melanoma ResearchIn: Pharmaceutics , Jg. 14 2022, Nr. 1, 13DOI, Online Volltext (Open Access)
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The Adrenergic Receptor Antagonist Carvedilol Elicits Anti-Tumor Responses in Uveal Melanoma 3D Tumor Spheroids and May Serve as Co-Adjuvant Therapy with RadiationIn: Cancers , Jg. 14 2022, Nr. 13, 3097DOI, Online Volltext (Open Access)
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Electrochemotherapy with bleomycin enhances radiosensitivity of uveal melanomas : First in vitro results in 3d cultures of primary uveal melanoma cell linesIn: Cancers , Jg. 13 2021, Nr. 12, 3086DOI (Open Access)
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Modulating gut microbiota in a mouse model of Graves’ orbitopathy and its impact on induced diseaseIn: Microbiome , Jg. 9 2021, Nr. 1, 45DOI (Open Access)
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Predicting the Course of Graves’ Orbitopathy Using Serially Measured TSH-Receptor Autoantibodies by Automated Binding Immunoassays and the Functional BioassayIn: Hormone and Metabolic Research , Jg. 53 2021, Nr. 07, S. 435 – 443DOI (Open Access)
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Predicting the Relapse of Hyperthyroidism in Treated Graves’ Disease with Orbitopathy by Serial Measurements of TSH-Receptor AutoantibodiesIn: Hormone and Metabolic Research , Jg. 53 2021, Nr. 4, S. 235 – 244DOI (Open Access)
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Lessons from mouse models of Graves’ diseaseIn: Endocrine , Jg. 68 2020, Nr. 2, S. 265 – 270DOI (Open Access)
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Search of reference biomarkers reflecting orbital tissue remodeling in the course of Graves' orbitopathyIn: Folia Histochemica et Cytobiologica , Jg. 1 2020, Nr. 1, S. 37 – 45DOI (Open Access)
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A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' OrbitopathyIn: Thyroid , Jg. 29 2019, Nr. 1, S. 111 – 123
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Fingolimod Improves the Outcome of Experimental Graves' Disease and Associated Orbitopathy by Modulating the Autoimmune Response to the Thyroid-Stimulating Hormone ReceptorIn: Thyroid , Jg. 29 2019, Nr. 9, S. 1286 – 1301
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Immunotherapy with fingolimod improves outcome of experimental Graves disease and associated orbitopathy by modulating autoimmune response to thyroid stimulating hormone receptorIn: Investigative Ophthalmology & Visual Science, IOVS , Jg. 60 2019, Nr. 9
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CD40 Enhances Sphingolipids in Orbital Fibroblasts : Potential Role of Sphingosine-1-Phosphate in Inflammatory T-Cell Migration in Graves' OrbitopathyIn: Investigative Ophthalmology & Visual Science, IOVS , Jg. 59 2018, Nr. 13, S. 5391 – 5397DOI (Open Access)
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Genetic immunization with mouse thyrotrophin hormone receptor plasmid breaks self-tolerance for a murine model of autoimmune thyroid disease and Graves' orbitopathyIn: Clinical and Experimental Immunology , Jg. 191 2018, Nr. 3, S. 255 – 267DOI (Open Access)
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Graves’ orbitopathy occurs sex-independently in an autoimmune hyperthyroid mouse modelIn: Scientific Reports , Jg. 8 2018, S. 13096DOI, Online Volltext (Open Access)
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Gut Microbiome in BALB/c and C57BL/6J Mice Undergoing Experimental Thyroid Autoimmunity Associate with Differences in Immunological Responses and Thyroid FunctionIn: Hormone and Metabolic Research , Jg. 50 2018, Nr. 12, S. 932 – 941DOI (Open Access)
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Gut microbiota in experimental murine model of Graves' orbitopathy established in different environments may modulate clinical presentation of diseaseIn: Microbiome , Jg. 6 2018, Nr. 1, 97DOI (Open Access)
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Multimodal assessment of orbital immune cell infiltration and tissue remodeling during development of graves disease by ¹H¹⁹F MRIIn: Magnetic Resonance in Medicine , Jg. 80 2018, Nr. 2, S. 711 – 718
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Noninflammatory diffuse follicular hypertrophy/hyperplasia of graves disease : Morphometric evaluation in an experimental mouse modelIn: European Thyroid Journal , Jg. 7 2018, Nr. 3, S. 111 – 119DOI (Open Access)
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Molecular tweezers inhibit PARP-1 by a new mechanismIn: European Journal of Organic Chemistry 2017, Nr. 16, S. 2223 – 2229
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Comparative assessment of female mouse model of Graves' orbitopathy under different environments, accompanied by proinflammatory cytokine and T-cell responses to thyrotropin hormone receptor antigenIn: Endocrinology , Jg. 157 2016, Nr. 4, S. 1673 – 1682DOI (Open Access)
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Endokrine OrbitopathieIn: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft , Jg. 113 2016, Nr. 4, S. 349 – 366
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Endokrine OrbitopathieIn: Klinische Monatsblätter für Augenheilkunde , Jg. 233 2016, Nr. 12, S. 1385 – 1407
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Hypoxia-Dependent HIF-1 Activation Impacts on Tissue Remodeling in Graves' Ophthalmopathy-Implications for SmokingIn: The Journal of Clinical Endocrinology & Metabolism (JCEM) , Jg. 101 2016, Nr. 12, S. 4834 – 4842
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Pathogenic Phenotype of Adipogenesis and Hyaluronan in Orbital Fibroblasts From Female Graves' Orbitopathy Mouse ModelIn: Endocrinology , Jg. 157 2016, Nr. 10, S. 3771 – 3778
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Erratum: Modeling Graves' Orbitopathy in Experimental Graves' DiseaseIn: Hormone and Metabolic Research , Jg. 47 2015, Nr. 10, S. e4
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Modeling Graves' Orbitopathy in Experimental Graves' DiseaseIn: Hormone and Metabolic Research , Jg. 47 2015, Nr. 10, S. 797 – 803
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Orbital fibroblasts from graves' orbitopathy patients share functional and immunophenotypic properties with mesenchymal stem/stromal cellsIn: Investigative Ophthalmology & Visual Science, IOVS , Jg. 56 2015, Nr. 11, S. 6549 – 6557DOI (Open Access)
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Type I cell ROS kinetics under hypoxia in the intact mouse carotid body ex vivo : a FRET-based studyIn: American Journal of Physiology: Lung Cellular and Molecular Physiology , Jg. 308 2015, Nr. 1, S. C61 – C67
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Current Insights into Animal Models of Graves’ Disease and OrbitopathyIn: Hormone and Metabolic Research , Jg. 45 2013, Nr. 8, S. 549 – 555
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Examination of orbital tissues in murine models of graves' disease reveals expression of UCP-1 and the TSHR in retrobulbar adipose tissuesIn: Hormone and Metabolic Research , Jg. 45 2013, Nr. 6, S. 401 – 407
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Rocket fuel for the quantification of S-nitrosothiols : highly specific reduction of S-nitrosothiols to thiols by methylhydrazineIn: Free Radical Research , Jg. 47 2013, Nr. 2, S. 104 – 115
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Update endokrine OrbitopathieIn: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft , Jg. 110 2013, Nr. 11, S. 1079 – 1096
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Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signallingIn: Journal of Cell Science , Jg. 125 2012, Nr. 21, S. 5168 – 5176
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Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxiaIn: Free Radical Research , Jg. 46 2012, Nr. 6, S. 705 – 717
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Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signalingIn: Nucleic Acids Research , Jg. 40 2012, Nr. 5, S. 1928 – 1943DOI (Open Access)
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A Novel Mechanism Involved in the Pathogenesis of Graves Ophthalmopathy (GO) : Clathrin Is a Possible Targeting Molecule for Inhibiting Local Immune Response in the OrbitIn: The Journal of Clinical Endocrinology & Metabolism (JCEM) , Jg. 96 2011, Nr. 11, S. E1727 – 1736
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Multifocal animated imaging of changes in cellular oxygen and calcium concentrations and membrane potential within the intact adult mouse carotid body ex vivoIn: American Journal of Physiology: Cell Physiology , Jg. 301 2011, Nr. 2, S. C266 – 71
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Complex Regulation of the Transactivation Function of Hypoxia-inducible Factor-1α by Direct Interaction with Two Distinct Domains of the CREB-binding Protein/p300In: The Journal of Biological Chemistry (JBC) , Jg. 285 2010, Nr. 4, S. 2601 – 2609
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Oxygen-sensing under the influence of nitric oxideIn: Cellular Signalling , Jg. 22 2010, Nr. 3, S. 349 – 356
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Role of N-acetyl-N-nitroso-tryptophan as nitric oxide donor in the modulation of HIF-1-dependent signalingIn: Biological Chemistry , Jg. 391 2010, Nr. 5, S. 533 – 540
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Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cellsIn: Blood , Jg. 100 2002, Nr. 7, S. 2623 – 2628
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Measurement of ROS levels and membrane potential dynamics in the intact carotid body ex vivoIn: Arterial Chemoreceptors in Physiology and Pathophysiology / XVIIIth Meeting of the International Society for Arterial Chemoreception ; Leeds, June 30 - July 3, 2014 / Peers, Chris; Kumar, Prem; Wyatt, Christopher; Gauda, Estelle; Nurse, Colin A.; Prabhakar, Nanduri (Hrsg.) 2015, S. 55 – 59
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Die Regulation der Hypoxie-abhängigen GenexpressionUniversität Duisburg-Essen 2010