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Prof. Dr. rer. nat. Stefanie Flohe

Funktionen

  • Leitende/r Oberarzt/-ärztin, Zentrum für Orthopädie und Unfallchirurgie

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Rajcsanyi, Luisa; Oral, Simge; Borgardt, Julia; Vondran, Florian; Beetz, Oliver; Sambou, Joanne; Ugurel, Selma; Peters, Triinu; Flohe, Stefanie; Kindler-Röhrborn, Andrea; Budeus, Bettina; Oezcelik, Arzu; Hinney, Anke
    Distinct liver sections exhibit sex-specific gene expression patterns in Lewis rats
    In: Scientific Reports, Jg. 15, 2025, Nr. 1, 32143
    DOI (Open Access)
  • Fu, Zuyi; Rumpret, Matevž; Kube-Golovin, Irina; Lyndin, Mykola; Solntceva, Vera; Zhao, Yuxi; Konieva, Anastasia; Liu, Na; Press, Adrian T.; Flohe, Stefanie; Bauer, Michael; Wennemuth, Gunther; Singer, Bernhard B.; McCarthy, Alex J.
    LILRA5 Functions to Induce ROS Production on Innate Immune Cells
    In: European Journal of Immunology, Jg. 55, 2025, Nr. 10, e70079
    DOI (Open Access)
  • Deinhardt-Emmer, Stefanie; Chousterman, Benjamin G; Schefold, Joerg C; Flohé, Stefanie B.; Skirecki, Tomasz; Kox, Matthijs; Winkler, Martin S; Cossarizza, Andrea; Wiersinga, W Joost; van der Poll, Tom; Weigand, Markus A; Cajander, Sara; Giamarellos-Bourboulis, Evangelos J; Lachmann, Gunnar; Girardis, Massimo; Scicluna, Brendon P; Ferrer, Ricard; Payen, Didier; Weis, Sebastian; Torres, Antoni; Bermejo-Martín, Jesús F; Osuchowski, Marcin F; Rubio, Ignacio; Bouma, Hjalmar R
    Sepsis in patients who are immunocompromised : Diagnostic challenges and future therapies
    In: The Lancet Respiratory Medicine, Jg. 13, 2025, Nr. 7, S. 623 – 637
    DOI, Online Volltext (Open Access)
  • Flohe, Stefanie
    Shock Synopsis October 2025
    In: Shock, Jg. 64, 2025, Nr. 4, S. 371 – 372
    DOI
  • Cajander, Sara; Kox, Matthijs; Scicluna, Brendon P.; Weigand, Markus A.; Almansa Mora, Raquel; Flohé, Stefanie B.; Martin-Loeches, Ignacio; Lachmann, Gunnar; Girardis, Massimo; Garcia-Salido, Alberto; Brunkhorst, Frank M.; Bauer, Michael; Torres, Antoni; Cossarizza, Andrea; Monneret, Guillaume; Cavaillon, Jean-Marc; Shankar-Hari, Manu; Giamarellos-Bourboulis, Evangelos J.; Winkler, Martin Sebastian; Skirecki, Tomasz; Osuchowski, Marcin; Rubio, Ignacio; Bermejo-Martin, Jesus F.; Schefold, Joerg C.; Venet, Fabienne
    Profiling the dysregulated immune response in sepsis : Overcoming challenges to achieve the goal of precision medicine
    In: The Lancet Respiratory Medicine, Jg. 12, 2024, Nr. 4, S. 305 – 322
    DOI, Online Volltext (Open Access)
  • Giamarellos-Bourboulis, Evangelos J.; Dimopoulos, George; Flohé, Stefanie; Kotsaki, Antigoni; van der Poll, Tom; Skirecki, Tomasz; Torres, Antoni; Netea, Mihai G.
    The European Shock Society meets the Immunosep Consortium for personalized sepsis treatment
    In: Shock, Jg. 59, 2023, Nr. 3S, S. 21 – 25
    DOI
  • Müller-Heck, Roman M.; Bösken, Björn; Michiels, Ivo; Dudda, Marcel; Jäger, Marcus; Flohé, Stefanie B.
    Major Surgical Trauma Impairs the Function of Natural Killer Cells but Does Not Affect Monocyte Cytokine Synthesis
    In: Life, Jg. 12, 2022, Nr. 1, 13
    DOI, Online Volltext (Open Access)
  • Antoni, Anne-Charlotte; Pylaeva, Ekaterina; Budeus, Bettina; Jablonska, Jadwiga; Klein-Hitpaß, Ludger; Dudda, Marcel; Flohé, Stefanie B.
    TLR2-induced CD8⁺ T-cell deactivation shapes dendritic cell differentiation in the bone marrow during sepsis
    In: Frontiers in Immunology, Jg. 13, 2022, 945409
    DOI (Open Access)
  • Winkler, Martin S.; Skirecki, Tomasz; Brunkhorst, Frank M.; Cajander, Sara; Cavaillon, Jean-Marc; Ferrer, Ricard; Flohe, Stefanie; García-Salido, Alberto; Giamarellos-Bourboulis, Evangelos J.; Girardis, Massimo; Kox, Matthijs; Lachmann, Gunnar; Martin-Loeches, Ignacio; Netea, Mihai G.; Spinetti, Thibaud; Schefold, Joerg C.; Torres, Antoni; Uhle, Florian; Venet, Fabienne; Weis, Sebastian; Scherag, Andre; Rubio, Ignacio; Osuchowski, Marcin F.
    Bridging animal and clinical research during SARS-CoV-2 pandemic : A new-old challenge
    In: eBioMedicine, Jg. 66, 2021, S. 103291
    DOI (Open Access)
  • Wienhöfer, Lisa; Marker, Max; Antoni, Anne-Charlotte; Sutter, Kathrin; Sander, André; Dudda, Marcel; Flohe, Stefanie
    TLR4 Transactivates CD8⁺ T Lymphocytes upon Acute Sterile Tissue Injury
    In: ImmunoHorizons, Jg. 5, 2021, Nr. 5, S. 298 – 306
    DOI, Online Volltext (Open Access)
  • Osuchowski, Marcin F; Winkler, Martin S; Skirecki, Tomasz; Cajander, Sara; Shankar-Hari, Manu; Lachmann, Gunnar; Monneret, Guillaume; Venet, Fabienne; Bauer, Michael; Brunkhorst, Frank M; Weis, Sebastian; Garcia-Salido, Alberto; Kox, Matthijs; Cavaillon, Jean-Marc; Uhle, Florian; Weigand, Markus A; Flohe, Stefanie; Wiersinga, W Joost; Almansa, Raquel; de la Fuente, Amanda; Martin-Loeches, Ignacio; Meisel, Christian; Spinetti, Thibaud; Schefold, Joerg C; Cilloniz, Catia; Torres, Antoni; Giamarellos-Bourboulis, Evangelos J; Ferrer, Ricard; Girardis, Massimo; Cossarizza, Andrea; Netea, Mihai G; van der Poll, Tom; Bermejo-Martín, Jesús F; Rubio, Ignacio
    The COVID-19 puzzle : deciphering pathophysiology and phenotypes of a new disease entity
    In: The Lancet Respiratory Medicine, Jg. 9, 2021, Nr. 6, S. 622 – 642
    DOI (Open Access)
  • Bösken, Björn; Hepner-Schefczyk, Monika; Vonderhagen, Sonja; Dudda, Marcel; Flohe, Stefanie
    An Inverse Relationship Between c-Kit/CD117 and mTOR Confers NK Cell Dysregulation Late After Severe Injury
    In: Frontiers in Immunology, Jg. 11, 2020, S. 1200
    DOI, Online Volltext (Open Access)
  • Osuchowski, Marcin F.; Aletti, Federico; Cavaillon, Jean-Marc; Flohé, Stefanie B.; Giamarellos-Bourboulis, Evangelos J.; Huber-Lang, Markus; Relja, Borna; Skirecki, Tomasz; Szabó, Andrea; Maegele, Marc
    SARS-CoV-2/COVID-19 : Evolving Reality, Global Response, Knowledge Gaps, and Opportunities
    In: Shock, Jg. 54, 2020, Nr. 4, S. 416 – 437
    DOI, Online Volltext (Open Access)
  • Kleinertz, Holger; Hepner-Schefczyk, Monika; Ehnert, Sabrina; Claus, Maren; Halbgebauer, Rebecca; Boller, Lea; Huber-Lang, Markus; Cinelli, Paolo; Kirschning, Carsten Jürgen; Flohé, Sascha; Sander, André; Waydhas, Christian; Vonderhagen, Sonja; Jäger, Marcus; Dudda, Marcel; Watzl, Carsten; Flohe, Stefanie
    Circulating growth/differentiation factor 15 is associated with human CD56(bright) natural killer cell dysfunction and nosocomial infection in severe systemic inflammation
    In: eBioMedicine, Jg. 43, 2019, S. 380 – 391
    DOI (Open Access)
  • Rubio, Ignacio; Osuchowski, Marcin F; Shankar-Hari, Manu; Skirecki, Tomasz; Winkler, Martin Sebastian; Lachmann, Gunnar; La Rosée, Paul; Monneret, Guillaume; Venet, Fabienne; Bauer, Michael; Brunkhorst, Frank M; Kox, Matthijs; Cavaillon, Jean-Marc; Uhle, Florian; Weigand, Markus A; Flohe, Stefanie; Wiersinga, W Joost; Martin-Fernandez, Marta; Almansa, Raquel; Martin-Loeches, Ignacio; Torres, Antoni; Giamarellos-Bourboulis, Evangelos J; Girardis, Massimo; Cossarizza, Andrea; Netea, Mihai G; van der Poll, Tom; Scherag, Andre; Meisel, Christian; Schefold, Joerg C; Bermejo-Martín, Jesús F
    Current gaps in sepsis immunology: new opportunities for translational research
    In: The Lancet Infectious Diseases, Jg. 19, 2019, Nr. 12, S. e422 – e436
    DOI (Open Access)
  • Henze, Katharina; Herten, Monika; Haversath, Marcel; Busch, André; Brandau, Sven; Hackel, Alexander; Flohe, Stefanie; Jäger, Marcus
    Surgical vacuum filter-derived stromal cells are superior in proliferation to human bone marrow aspirate
    In: Stem Cell Research & Therapy, Jg. 10, 2019, S. 338
    DOI (Open Access)
  • Petri, Robert Michael; Hackel, Alexander; Hahnel, Katrin; Dumitru, Claudia Alexandra; Bruderek, Kirsten; Flohe, Stefanie; Paschen, Annette; Lang, Stephan; Brandau, Sven
    Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function
    In: Stem Cell Reports, Jg. 9, 2017, Nr. 3, S. 985 – 998
    DOI (Open Access)
  • Hackel, A. M.; Petri, Maximilian; Hahnel, K.; Dumitru, C. A.; Bruderek, K.; Flohe, Stefanie; Paschen, Annette; Lang, Stephan; Brandau, Sven
    Activated tissue-resident mesenchymal stromal cells regulate natural killer cell immune and tissue regenerative function
    In: European Journal of Immunology, Jg. 47, 2017, Nr. S2, Special Issue:47th Annual Meeting of the German Society for Immunology, 12–15 September, 2017, Erlangen, Germany, S. 62
    DOI
  • Schweigkofler, U; Flohe, Stefanie; Hoffmann, R; Matthes, G; Paffrath, T; Wölfl, C; Fischer, M; Kehrberger, E; Marung, H; Moecke, H; Prückner, S; Urban, B; Trentzsch, H; Fachexperten der Eckpunktepapier-Konsensusgruppe
    Erratum zu: Tracerdiagnose Schwerverletzte/Polytrauma im Eckpunktepapier 2016
    In: Der Unfallchirurg, Jg. 120, 2017, Nr. 3, S. 272
    DOI
  • Smirnov, Anna; Pohlmann, Stephanie; Nehring, Melanie; Ali, Shafaqat; Mann-Nüttel, Ritu; Scheu, Stefanie; Antoni, Anne-Charlotte; Hansen, Wiebke; Büettner, Manuela; Gardiasch, Miriam J.; Westendorf, Astrid; Wirsdörfer, Florian; Pastille, Eva; Dudda, Marcel; Flohe, Stefanie
    Sphingosine 1-Phosphate- and C-C Chemokine Receptor 2-Dependent Activation of CD4+ Plasmacytoid Dendritic Cells in the Bone Marrow Contributes to Signs of Sepsis-Induced Immunosuppression
    In: Frontiers in Immunology, Jg. 8, 2017, 1622
    DOI (Open Access)
  • Wirsdörfer, Florian; Bangen, Jörg-Martin; Pastille, Eva; Schmitz, Daniel; Flohé, Sascha; Schumak, Beatrix; Flohe, Stefanie
    Dendritic Cell-Like Cells Accumulate in Regenerating Murine Skeletal Muscle after Injury and Boost Adaptive Immune Responses Only upon a Microbial Challenge
    In: PLoS ONE, Jg. 11, 2016, Nr. 5, S. e0155870
    DOI (Open Access)
  • Cui, Rongtao; Rekasi, Heike; Hepner-Schefczyk, Monika; Fessmann, Kai; Petri, Robert M; Bruderek, Kirsten; Brandau, Sven; Jäger, Marcus; Flohe, Stefanie
    Human mesenchymal stromal/stem cells acquire immunostimulatory capacity upon cross-talk with natural killer cells and might improve the NK cell function of immunocompromised patients
    In: Stem Cell Research & Therapy, Jg. 7, 2016, Nr. 1, S. 88
    DOI (Open Access)
  • Hildebrand, Frank; Pape, Hans-Christoph; Marzi, Ingo; Andruszkow, Hagen; Flohe, Stefanie; Huber-Lang, Markus; van Griensven, Martijn
    Is There an Impact of Concomitant Injuries and Timing of Fixation of Major Fractures on Fracture Healing? : A Focused Review of Clinical and Experimental Evidence
    In: Journal of Orthopaedic Trauma (JOT), Jg. 30, 2016, Nr. 3, S. 104 – 112
    DOI
  • Pastille, Eva; Pohlmann, Stephanie; Wirsdörfer, Florian; Reib, Anna; Flohe, Stefanie
    A disturbed interaction with accessory cells upon opportunistic infection with Pseudomonas aeruginosa contributes to an impaired IFN-γ production of NK cells in the lung during sepsis-induced immunosuppression
    In: Innate Immunity, Jg. 21, 2015, Nr. 2, S. 115 – 126
    DOI
  • Wirsdörfer, Florian; Bangen, Jörg-Martin; Pastille, Eva; Hansen, Wiebke; Flohe, Stefanie
    Breaking the co-operation between bystander T-cells and natural killer cells prevents the development of immunosuppression after traumatic skeletal muscle injury in mice
    In: Clinical Science, Jg. 128, 2015, Nr. 11, S. 825 – 838
    DOI (Open Access)
  • Austermann, Judith; Friesenhagen, Judith; Fassl, Selina Kathleen; Petersen, Beatrix; Ortkras, Theresa; Burgmann, Johanna; Barczyk-Kahlert, Katarzyna; Faist, Eugen; Zedler, Siegfried; Pirr, Sabine; Rohde, Christian; Müller-Tidow, Carsten; vonKöckritz-Blickwede, Maren; vonKaisenberg, Constantin S.; Flohe, Stefanie; Ulas, Thomas; Schultze, Joachim L.; Roth, Johannes; Vogl, Thomas; Viemann, Dorothee; Fassl, Selina Kathleen; von Köckritz-Blickwede, Maren; von Kaisenberg, Constantin S.; Flohé, Stefanie B.; Schultze, Joachim L.
    Erratum: Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions
    In: Cell Reports, Jg. 11, 2015, Nr. 5, S. 849
    DOI
  • Reinhardt, Renate; Pohlmann, Stephanie; Kleinertz, Holger; Hepner-Schefczyk, Monika; Paul, Andreas; Flohe, Stefanie
    Invasive Surgery Impairs the Regulatory Function of Human CD56bright Natural Killer Cells in Response to Staphylococcus aureus : Suppression of Interferon-γ Synthesis
    In: PLoS ONE, Jg. 10, 2015, Nr. 6, S. e0130155
    DOI (Open Access)
  • Wafaisade, S.; Wyen, H.; Mutschler, M.; Lendemans, Sven; Bouillon, B.; Flohe, Stefanie; Paffrath, T.; Maegele, M.; Tjardes, T.; Probst, C.
    Stand der Gerinnungs- und Transfusionstherapie beim Schwerverletzten : Eine deutschlandweite Online-Umfrage
    In: Der Unfallchirurg, Jg. 118, 2015, Nr. 12, S. 1033 – 1040
    DOI
  • Austermann, Judith; Friesenhagen, Judith; Fassl, Selina Kathleen; Ortkras, Theresa; Burgmann, Johanna; Barczyk-Kahlert, Katarzyna; Faist, Eugen; Zedler, Siegfried; Pirr, Sabine; Rohde, Christian; Müller-Tidow, Carsten; von Köckritz-Blickwede, Maren; von Kaisenberg, Constantin S; Flohe, Stefanie; Ulas, Thomas; Schultze, Joachim L; Roth, Johannes; Vogl, Thomas; Viemann, Dorothee
    Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions
    In: Cell Reports, Jg. 9, 2014, Nr. 6, S. 2112 – 2123
    DOI (Open Access)
  • Brandau, Sven; Jakob, Mark; Bruderek, Kirsten; Bootz, Friedrich; Giebel, Bernd; Radtke, Stefan; Mauel, Katharina; Jäger, Marcus; Flohe, Stefanie; Lang, Stephan
    Correction : Mesenchymal stem cells augment the anti-bacterial activity of neutrophil granulocytes
    In: PLoS ONE, Jg. 9, 2014, Nr. 9, S. e106903
    DOI (Open Access)
  • Thomas, Heike; Jäger, Marcus; Mauel, Katharina; Brandau, Sven; Lask, Sara; Flohe, Stefanie
    Interaction with Mesenchymal Stem Cells Provokes Natural Killer Cells for Enhanced IL-12/IL-18-Induced Interferon-Gamma Secretion
    In: Mediators of Inflammation, 2014, 143463
    DOI (Open Access)
  • De Haan, Jacco Juri; Pastille, Eva; Wirsdörfer, Florian; Lubbers, Tim; Greve, Jan Willem M; Zhang, Yang; Buurman, Wim A.; Flohe, Stefanie
    Lipid-rich enteral nutrition improves the defense against an opportunistic infection during polymicrobial sepsis
    In: Shock, Jg. 41, 2014, Nr. 2, S. 109 – 114
    DOI
  • Dehne, Nathalie; Kerkweg, Uta; Flohe, Stefanie; Brüne, Bernhard; Fandrey, Joachim
    Activation of hypoxia-inducible factor 1 in skeletal muscle cells after exposure to damaged muscle cell debris
    In: Shock, Jg. 35, 2011, Nr. 6, S. 632 – 638
    DOI (Open Access)
  • Friedrichs, Melanie; Wirsdöerfer, Florian; Flohe, Stefanie; Schneider, Sabine; Wülling, Manuela; Vortkamp, Andrea
    BMP signaling balances proliferation and differentiation of muscle satellite cell descendants.
    In: BMC Cell Biology, Jg. 12, 2011, 26
    DOI, Online Volltext (Open Access)
  • Pastille, Eva; Didovic, Sonja; Brauckmann, Daniela; Rani, Meenakshi; Agrawal, Hemant; Schade, Fritz Ulrich; Zhang, Yang; Flohe, Stefanie
    Modulation of Dendritic Cell Differentiation in the Bone Marrow Mediates Sustained Immunosuppression after Polymicrobial Sepsis
    In: The Journal of Immunology (JI), Jg. 186, 2011, Nr. 2, S. 977 – 986
    DOI
  • Huber-Lang, Markus; Flohé, Stefanie B.; Marzi, I.
    Netzwerk Traumaforschung der Deutschen Gesellschaft für Orthopädie und Unfallchirurgie
    In: Der Unfallchirurg, Jg. 114, 2011, Nr. 9, S. 825 – 828
    DOI
  • Schmitz, Daniel; Bangen, Jörg-Martin; Herborn, Christoph U.; Husain, Baher; Lendemans, Sven; Flohe, Stefanie; Metz, Klaus; Schade, Fritz Ulrich; Täger, Georg; Oberbeck, Rainer; Kobbe, Philipp; Waydhas, Christian; Flohé, Sascha
    Isolated closed minor-muscle injury of the lower leg did not cause an obvious systemic immune response
    In: Inflammation Research, Jg. 59, 2010, Nr. 2, S. 141 – 149
    DOI

    • Abstracts

  • Wirsdörfer, Florian; Bangen, Jörg-Martin; Schmitz, Daniel; Schade, Fritz Ulrich; Flohe, Stefanie
    Dendritic cells that infiltrate damaged skeletal muscle tissue reverse impaired Th-cell responses after trauma
    In: Inflammation Research. Cham; Basel; Boston; Berlin; Heidelberg [u.a.]: Springer, Jg. 59, 2010, Nr. Suppl. 1, S. S42
    DOI
  • Pastille, Eva; Zhang, Yang; Kroell, Nadine; Bak, Michaela; Schade, Fritz Ulrich; Flohe, Stefanie
    Systemic infection alters differentiation of dendritic cells in the bone marrow and mediates chronic dendritic cell dysfunction
    8th World Congress on Trauma, Shock, Inflammation and Sepsis – TSIS 2010 – March 9th-13th, 2010, Munich, Germany,
    In: Inflammation Research. Cham; Basel; Boston; Berlin; Heidelberg [u.a.]: Springer, Jg. 59 Suppl., 2010, S. S20 – S21
    DOI

    • Bücher/Sammelwerke/Tagungsbände

  • Flohe, Stefanie
    Modulation des angeborenen Immunsystems nach Trauma und bei Sepsis
    Duisburg, Essen, 2008