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Funktionen
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Universitätsprofessor/in, Institut für Physiologische Chemie
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Stellvertreter/in, Institut für Physiologische Chemie
Aktuelle Veranstaltungen
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WiSe 2025
- Biochemie 2 für Medizintechniker (PV)
- Biochemie I für Chemiker (WA)
- Spezialisierung in Medizinisch-Biologischer Chemie
- Spezialisierung in Medizinisch-Biologischer Chemie (PV)
- Seminar der Physiologischen Chemie (Biochemie/Molekularbiologie) Teil II (Drittsemester) (PV)
- Vorlesung Biochemie/Molekularbiologie Teil II (WA)
- Integriertes Seminar Notfallmedizin (PV)
- Vertiefungspraktikum Biochemie für Chemiker (PV)
- BIOME Seminar „Basic Science in Transplantation"
- Vertiefungsseminar für Medizinische Biologen
- Seminar Biochemie 2 für Medizintechniker (PV)
- Kolloquium über neuere Arbeiten auf dem Gebiet der Biochemie (*)
- Seminar für Diplomanden und Doktoranden (*) (Naturwissenschaftler und Mediziner)
- Anleitung zu wissenschaftlichem Arbeiten (*)
Vergangene Veranstaltungen (max. 10)
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SoSe 2025
- Praktikum der Physiologischen Chemie (Biochemie/Molekularbiologie) f. Med. Biologen (PV)
- Physiologische Chemie (Biochemie/Molekularbiologie) Teil I (WA)
- Praktikum der Physiologischen Chemie (Biochemie/Molekularbiologie) (PV)
- Physiologische Chemie (Biochemie/Molekularbiologie) Repetitorien (WA)
- Praktikum der Biochemie für Chemiker (WP)
- Seminar Gestörte Organfunktionen (PV)
- Physiologische Chemie (Biochemie/Molekularbiologie) f. Med. Biologen Repetitorien (PV)
- Wahlfach Pathobiologie (WP)
- Kolloquium über neuere Arbeiten auf dem Gebiet der Biochemie (*)
- Vertiefungspraktikum Biochemie für Chemiker (PV)
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Cold storage of human precision-cut lung slices in TiProtec preserves cellular composition and transcriptional responses and enables on-demand mechanistic studiesIn: Respiratory Research, Jg. 26, 2025, Nr. 1, 57DOI (Open Access)
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Treatment of Staphylococcus aureus infection with sphingosine in ex vivo perfused and ventilated lungsIn: The Journal of Heart and Lung Transplantation, Jg. 43, 2024, Nr. 1, S. 100 – 110DOI (Open Access)
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Composition of ex vivo perfusion solutions and kinetics define differential cytokine/chemokine secretion in a porcine cardiac arrest model of lung preservationIn: Frontiers in Cardiovascular Medicine, Jg. 10, 2023, 1245618DOI (Open Access)
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Human HepaRG liver spheroids : cold storage protocol and study on pyridinium oxime-induced hepatotoxicity in vitroIn: Chemico-Biological Interactions, Jg. 369, 2023, 110285DOI (Open Access)
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Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungsIn: PLoS ONE, Jg. 17, 2022, e0271620DOI (Open Access)
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Characterisation of cold-induced mitochondrial fission in porcine aortic endothelial cellsIn: Molecular Medicine, Jg. 28, 2022, Nr. 1, 13DOI (Open Access)
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Custodiol-MP for ex vivo lung perfusion : A comparison in a porcine model of donation after circulatory determination of deathIn: The International Journal of Artificial Organs (IJAO), Jg. 45, 2022, Nr. 2, S. 162 – 173DOI (Open Access)
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HTK-N as a new preservation solution for human kidney preservation : Results of a pilot randomized controlled clinical phase II trial in living donor transplantationIn: Clinical Transplantation, Jg. 36, 2022, Nr. 3, e14543DOI (Open Access)
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Recovery from cold-induced mitochondrial fission in endothelial cells requires reconditioning temperatures of ≥ 25◦CIn: Frontiers in Transplantation, Jg. 1, 2022, 1044551DOI, Online Volltext (Open Access)
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Cold- and Low Chloride-Induced Alterations In Mitochondrial Morphology and Ultrastructure : A Study In Endothelial CellsIn: Cryobiology, Jg. 103, 2021, S. 172 – 173
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Inhaled sphingosine has no adverse side effects in isolated ventilated and perfused pig lungsIn: Scientific Reports, Jg. 11, 2021, Nr. 1, 18607DOI, Online Volltext (Open Access)
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Optimization of long-term cold storage of rat precision-cut lung slices with a tissue preservation solutionIn: American Journal of Physiology: Lung Cellular and Molecular Physiology, Jg. 321, 2021, Nr. 6, S. L1023 – L1035DOI (Open Access)
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Use of the new preservation solution Custodiol-MP for ex vivo reconditioning of kidney graftsIn: Artificial Organs, Jg. 45, 2021, Nr. 9, S. 1117 – 1123DOI (Open Access)
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A novel histidine–tryptophan–ketoglutarate formulation ameliorates intestinal injury in a cold storage and ex vivo warm oxygenated reperfusion model in ratsIn: Bioscience Reports, Jg. 40, 2020, Nr. 5, S. BSR20191989DOI (Open Access)
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Effects of immediate versus delayed ex-vivo lung perfusion in a porcine cardiac arrest donation modelIn: The International Journal of Artificial Organs (IJAO), Jg. 42, 2019, Nr. 7, S. 362 – 369
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Cold storage injury to rat small-bowel transplants - beneficial effect of a modified HTK solutionIn: Transplantation, Jg. 102, 2018, Nr. 10, S. 1666 – 1673
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Methylene Blue Treatment of Grafts During Cold Ischemia Time Reduces the Risk of Hepatitis C Virus TransmissionIn: The Journal of Infectious Diseases (JID), Jg. 218, 2018, Nr. 11, S. 1711 – 1721DOI (Open Access)
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Preservation of Cell Structure, Metabolism, and Biotransformation Activity of Liver-On-Chip Organ Models by Hypothermic StorageIn: Advanced Healthcare Materials, Jg. 7, 2018, Nr. 2, S. 1700616
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Serum- and albumin-free cryopreservation of endothelial monolayers with a new solutionIn: Organogenesis, Jg. 14, 2018, Nr. 2, S. 107 – 121DOI (Open Access)
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Serum-Free Cryopreservation of Primary Rat Hepatocytes in a Modified Cold Storage Solution: Improvement of Cell Attachment and FunctionIn: Biopreservation and Biobanking, Jg. 16, 2018, Nr. 4, S. 285 – 295
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Characterization of injury in isolated rat proximal tubules during cold incubation and rewarmingIn: PLoS ONE, Jg. 12, 2017, Nr. 7, S. e0180553DOI (Open Access)
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Mitochondrial Impairment as a Key Factor for the Lack of Attachment after Cold Storage of Hepatocyte SuspensionsIn: Cell Transplantation, Jg. 26, 2017, Nr. 12, S. 1855 – 1867DOI (Open Access)
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Resveratrol Does Not Protect from Ischemia-Induced Acute Kidney Injury in an in Vivo Rat ModelIn: Kidney & Blood Pressure Research, Jg. 42, 2017, Nr. 6, S. 1090 – 1103DOI, Online Volltext (Open Access)
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Controlled Oxygenated Rewarming of Cold Stored Livers Prior to Transplantation : First Clinical Application of a New ConceptIn: Transplantation, Jg. 100, 2016, Nr. 1, S. 147 – 152DOI (Open Access)
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Kidney transplantation after oxygenated machine perfusion preservation with Custodiol-N solutionIn: Transplant International, Jg. 28, 2015, Nr. 9, S. 1102 – 1108DOI (Open Access)
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Influence of oxygen concentration during hypothermic machine perfusion on porcine kidneys from donation after circulatory deathIn: Transplantation, Jg. 98, 2014, Nr. 9, S. 944 – 950
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Subnormothermic machine perfusion for preservation of porcine kidneys in a donation after circulatory death modelIn: Transplant International, Jg. 27, 2014, Nr. 10, S. 1097 – 1106
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Hepatic and Pancreatic Systems : Steatosis does not impair liver regeneration after partial hepatectomyIn: Laboratory Investigation, Jg. 93, 2013, Nr. 1, S. 20 – 30
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Use of the new preservation solution Custodiol-N supplemented with dextran for hypothermic machine perfusion of the kidneyIn: Cryobiology, Jg. 66, 2013, Nr. 2, S. 131 – 135
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„Transportschäden“ von Transplantaten : Zellulärer Energiemangel, „ranzige“ Membranen und zerstörte Zellkraftwerke – und was man dagegen tun kann…In: Unikate: Berichte aus Forschung und Lehre, 2013, Nr. 44: Medizin : 50 Jahre Universitätsklinikum Essen, S. 92 – 105DOI, Online Volltext (Open Access)
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A new preservation solution for lung transplantation : Evaluation in a porcine transplantation modelIn: The Journal of Heart and Lung Transplantation, Jg. 31, 2012, Nr. 3, S. 310 – 317
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Aggravation of cold-induced injury in Vero-B4 cells by RPMI 1640 medium – Identification of the responsible medium componentsIn: BMC Biotechnology, Jg. 12, 2012, 73DOI, Online Volltext (Open Access)
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Cold storage of rat hepatocyte suspensions for one week in a customized cold storage solution - preservation of cell attachment and metabolismIn: PLoS ONE, Jg. 7, 2012, Nr. 7, S. e40444DOI (Open Access)
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FNOCT as a fluorescent probe for in vivo localization of nitric oxide distribution in tobacco rootsIn: Plant Physiology and Biochemistry, Jg. 59, 2012, S. 80 – 89
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HTK-N, a modified HTK solution, decreases preservation injury in a model of microsteatotic rat liver transplantationIn: Langenbeck's Archives of Surgery, Jg. 397, 2012, Nr. 8, S. 1323 – 1331
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Improved Kidney Isograft Survival with a New Histidine-Tryptophan-Ketoglutarate (HTK)-Based Cold Preservation SolutionIn: Transplantation, Jg. 94, 2012, Nr. Suppl.10, S. 1139
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Improved kidney isograft survival with a new Histidine-Tryptophane-Ketoglutarate (HTK)-based cold preservation solutionIn: Nephrology Dialysis Transplantation (NDT), Jg. 27, 2012, Nr. Suppl. 2, S. 519
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Improvement of the Cold Storage of Isolated Human HepatocytesIn: Cell Transplantation, Jg. 21, 2012, Nr. 1, S. 23 – 37DOI (Open Access)
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Reduction of chronic graft injury with a new HTK-based preservation solution in a murine heart transplantation modelIn: Cryobiology, Jg. 64, 2012, Nr. 3, S. 273 – 278
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Assessment of a chloride-poor versus a chloride-containing version of a modified histidine-tryptophan-ketoglutarate solution in a rat liver transplantation modelIn: Liver Transplantation, Jg. 17, 2011, Nr. 6, S. 650 – 660
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Cold-induced injury to lung epithelial cells can be inhibited by iron chelators - implications for lung preservationIn: European Journal of Cardio-Thoracic Surgery, Jg. 40, 2011, Nr. 4, S. 948 – 955
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Evaluation of Functional and Structural Alterations in Muscle Tissue after Short-Term Cold Storage in a New Tissue Preservation SolutionIn: Cells Tissues Organs, Jg. 194, 2011, Nr. 6, S. 501 – 509
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Preservation of human artery function following prolonged cold storage with a new solutionIn: Journal of Vascular Surgery, Jg. 53, 2011, Nr. 4, S. 1063 – 1070DOI (Open Access)
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Prolonged cold storage using a new histidine-tryptophan-ketoglutarate-based preservation solution in isogeneic cardiac mouse graftsIn: European Heart Journal, Jg. 32, 2011, Nr. 4, S. 509 – 516
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Eine neue Lösung zur kalten Lagerung von BlutgefäßenIn: Gefäßchirurgie, Jg. 15, 2010, Nr. 6, S. 442 – 447
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Eine neue Lösung zur kalten Lagerung von BlutgefäßenIn: Zeitschrift für Herz-, Thorax- und Gefäßchirurgie (ZHTG), Jg. 24, 2010, Nr. 6, S. 341 – 346
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Glycine pretreatment ameliorates liver injury after partial hepatectomy in the ratIn: Journal of Investigative Surgery, Jg. 23, 2010, Nr. 1, S. 12 – 20
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Pyrene-based fluorescent nitric oxide cheletropic traps (FNOCTs) for the detection of nitric oxide in cell cultures and tissuesIn: Chemistry - A European Journal, Jg. 16, 2010, Nr. 36, S. 11121 – 11132
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Use of a New Modified HTK Solution for Machine Preservation of Marginal Liver GraftsIn: Journal of Surgical Research, Jg. 160, 2010, Nr. 1, S. 155 – 162
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Evaluation of a modified HTK solution containing the new iron chelator LK 614 in an isolated rat liver perfusion modelIn: Journal of Investigative Surgery, Jg. 22, 2009, Nr. 5, S. 340 – 347
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Erythropoietin treatment improves liver regeneration and survival in rat models of extended liver resection and living donor liver transplantationIn: Transplantation, Jg. 86, 2008, Nr. 11, S. 1578 – 1585
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Preservation of pig liver allografts after warm ischemia : Normothermic perfusion versus cold storageIn: Langenbecks Archiv für Chirurgie, Jg. 382, 1997, Nr. 4, S. 175 – 184
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Cold Storage of Human Precision-cut Lung Slices Preserves Cellular and Transcriptional Identity Enabling Optimized On-demand Translational Lung ResearchIn: American Journal of Respiratory and Critical Care Medicine (AJRCCM). New York: American Thoracic Society, Jg. 211, 2025, A7646
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Composition of Ex Vivo Lung Perfusion Solutions and Kinetics Define Differential Cytokine and Chemokine Secretion in a Porcine Cardiac Arrest Model of Lung PreservationIn: The Journal of Heart and Lung Transplantation. Amsterdam: Elsevier, Jg. 40, 2021, Nr. 4, S. S346
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Composition of ex lung perfusion solutions and kinetics define differential cytokine/chemokine secretion in a porcine cardiac arrest model of lung preservationIn: Transplant International. Lausanne: Frontiers Media, Jg. 33, 2020, Nr. S2, Special Issue: Abstracts of the 29th Annual Meeting of the German Transplantation Society, Cologne, Germany, 15–17 October 2020, S. 14 – 15DOI (Open Access)
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Inflammatory Response after Immediate versus Delayed Ex-Vivo Lung Perfusion in a Porcine Cardiac Arrest Donation Model
ISHLT 40th Annual Meeting, April 22-25, Montreal, Canada,In: The Journal of Heart and Lung Transplantation. Amsterdam: Elsevier, Jg. 39, 2020, Nr. 4, Supplement, S. S200 -
Use of the new preservation solution Custodiol-MP for ex vivo reconditioning of kidney graftsIn: Transplant International. Lausanne: Frontiers Media, Jg. 33, 2020, Nr. S2, Special Issue: Abstracts of the 29th Annual Meeting of the German Transplantation Society, Cologne, Germany, 15–17 October 2020, S. 34 – 35DOI (Open Access)
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Charakterisierung der Zellschädigung von Lungenepithelzellen durch Kaltlagerung/Wiedererwärmung
Herbsttagung der Sektion Zellbiologie in der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V., Essen, 09.–10.11.2018,In: Pneumologie. Stuttgart: Thieme, Jg. 73, 2019, Nr. 02, S. 114 – 115 -
A Novel Histidine‐Tryptophan‐Ketoglutarate (HTK‐N) Formulation Ameliorates Ischemia‐reperfusion Injury in Intestinal Grafts
27th Annual Meeting of the German Transplantation Society, Berlin, Germany, 7–10 November 2018,In: Transplant International. Lausanne: Frontiers Media, Jg. 31, 2018, Nr. S5, S. 42 -
Effects of Short and Long Term Cold Static Preservation Followed by Normothermic Ex Vivo Lung Perfusion in a Porcine Model
ISHLT 38th Annual Meeting and Scientific Sessions, 11-14 April 2018, Nice, France,In: The Journal of Heart and Lung Transplantation. Amsterdam: Elsevier, Jg. 37, 2018, Nr. 4, Supplement, S. S224 -
Use of Modified Custodiol‐N as Perfusion Solution in ex vivo Lung Perfusion (EVLP)
27th Annual Meeting of the German Transplantation Society, Berlin, Germany, 7–10 November 2018,In: Transplant International. Lausanne: Frontiers Media, Jg. 31, 2018, Nr. S5, S. 39DOI (Open Access) -
Controlled Oxygenated Rewarming and Subnormothermic Machine Perfusion of Steatotic Livers : First Clinical ResultsIn: American Journal of Transplantation. Amsterdam: Elsevier, Jg. 16, 2016, Nr. Suppl. 3, S. 377
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Custodial-N attenuates the cold storage-induced development of graft vasculopathy in a rat aortic transplantation modelIn: Transplant International. Lausanne: Frontiers Media, Jg. 29, 2016, Nr. Suppl. 3, S. 45DOI (Open Access)
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Hepatic steatosis induced by Western diet modulates expression of HGF and ERK signalling and improves liver regeneration in mice after 70% partial hepatectomyIn: Journal of Hepatology. Amsterdam; Copenhagen; Oxford: Elsevier, Jg. 56, 2012, Nr. Supplement 2, S. S499
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Liver Transplantation in Swine Using Modified Histidine-Tryptophan-Ketoglutarate Solution - Safety and Feasability StudyIn: Transplantation. Philadelphia: Lippincott Williams & Wilkins, Jg. 94, 2012, Nr. 10S, S. 512
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Safety study of modified HTK solution-first results after liver transplantation in swine
19th Annual Congress of the German Transplantation Society, Hamburg, Germany, 7‐9 October 2010,In: Transplant International. Lausanne: Frontiers Media, Jg. 23, 2010, Nr. Suppl. 2, S. 25 -
Morphological alterations in primary hepatocytes upon nanomaterial incubation assessed by digital holographic microscopy and holotomographyIn: Quantitative Phase Imaging VIII / Quantitative Phase Imaging VIII, 22-27 January 2022, San Francisco, California, United States & 20-24 February 2022, online; Quantitative Phase Imaging ; San Francisco, Calif. ; 2022.01.22-27 / Liu, Yang; Popescu, Gabriel; Park, YongKeun; Liu, Yang; Popescu, Gabriel; Park, Yong Keun (Hrsg.). Bellingham: SPIE, 2022, 119700H
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Novel ex-vivo perfusion system : functional characteristics of human noncirrhotic and cirrhotic liver sections mirror patients' clinical parameters
The International Liver Congress™ 2012, 47th Annual Meeting of the European Association for the Study of the Liver, 18-22 April 2012, Barcelona, Spain,In: Journal of Hepatology. Amsterdam; Copenhagen; Oxford: Elsevier, Jg. 56, 2012, Nr. Supplement 2, S. S74