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Aktuelle Veranstaltungen
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WiSe 2025
- Anleitung zu selbständigem wissenschaftlichen Arbeiten (*)
- Seminar für Molekularbiologie / Zellbiologie u. experimentelle Krebsforschung (mit Gastsprechern) (*)
- Prinzipien der zellulären Signaltransduktion (*)
- Molekulare Mechanismen bakterieller Infektionen (*)
- Seminar für Studierende im Praktischen Jahr
- Molekulare Immunologie (*)
Vergangene Veranstaltungen (max. 10)
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SoSe 2025
- Prinzipien der zellulären Signaltransduktion (*)
- Seminar für Molekularbiologie / Zellbiologie u. experimentelle Krebsforschung (mit Gastsprechern) (*)
- Anleitung zu selbständigem wissenschaftlichen Arbeiten (*)
- Molekulare Immunologie (*)
- Molekulare Mechanismen bakterieller Infektionen (*)
- Seminar für Studierende im Praktischen Jahr
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WiSe 2024
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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A mouse model of cardiac immunoglobulin light chain amyloidosis reveals insights into tissue accumulation and toxicity of amyloid fibrilsIn: Nature Communications, Jg. 16, 2025, Nr. 1, 2992DOI (Open Access)
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Delays in diagnosis and treatment of ATTR cardiac amyloidosis : A real-world data analysisIn: ESC Heart Failure, Jg. 12, 2025, Nr. 4, S. 2969 – 2975DOI (Open Access)
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Gain or amplification of 1q21 in systemic light chain amyloidosis is associated with advanced Mayo stage, plasma cell disease and worse overall survivalIn: Annals of Hematology, Jg. 104, 2025, Nr. 3, S. 1777 – 1788DOI (Open Access)
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Global patterns of amyloid typing : results of a survey by the International Society of Amyloidosis (ISA)In: Amyloid, Jg. 32, 2025, Nr. 2, S. 139 – 144
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Influence of amitriptyline therapy on T cell phenotype in chronic pain patientsIn: Biomedicine & Pharmacotherapy, Jg. 191, 2025, 118529DOI (Open Access)
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(Non)-Exertional Variables of Cardiopulmonary Exercise Testing in Heart Failure with and Without Cardiac AmyloidosisIn: Current Heart Failure Reports, Jg. 21, 2024, Nr. 3, S. 224 – 237DOI (Open Access)
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Current Therapies and Future Horizons in Cardiac Amyloidosis TreatmentIn: Current Heart Failure Reports, Jg. 21, 2024, Nr. 4, S. 305 – 321DOI (Open Access)
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Daratumumab in first-line treatment of patients with light chain amyloidosis and Mayo stage IIIb improves treatment response and overall survivalIn: Haematologica / The Hematology Journal, Jg. 109, 2024, Nr. 1, S. 220 – 230DOI (Open Access)
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Real-world analysis of teclistamab in 123 RRMM patients from GermanyIn: Leukemia, Jg. 38, 2024, Nr. 2, S. 365 – 371DOI (Open Access)
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Screening for Occult Transthyretin Amyloidosis in Patients with Severe Aortic Stenosis and Amyloid Red FlagsIn: Journal of Clinical Medicine (JCM), Jg. 13, 2024, Nr. 3, 671DOI (Open Access)
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Teclistamab in relapsed or refractory AL amyloidosis : a multinational retrospective case seriesIn: Blood, Jg. 143, 2024, Nr. 8, S. 734 – 737
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Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinomaIn: Journal of Molecular Medicine, Jg. 101, 2023, Nr. 7, S. 891 – 903DOI (Open Access)
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Corneal confocal microscopy identifies corneal nerve loss and increased Langerhans cells in presymptomatic carriers and patients with hereditary transthyretin amyloidosisIn: Journal of Neurology, Jg. 270, 2023, Nr. 7, S. 3483 – 3491DOI (Open Access)
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Medications Modulating the Acid Sphingomyelinase/Ceramide System and 28-Day Mortality among Patients with SARS-CoV-2: An Observational StudyIn: Pharmaceuticals, Jg. 16, 2023, Nr. 8, 1107DOI (Open Access)
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Quantitative ⁹⁹mTc-DPD-SPECT/CT assessment of cardiac amyloidosisIn: Journal of Nuclear Cardiology, Jg. 30, 2023, Nr. 1, S. 101 – 111DOI (Open Access)
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Regression of Myocardial ⁹⁹mTc-DPD Uptake After Tafamidis Treatment of Cardiac Transthyretin AmyloidosisIn: Journal of Nuclear Medicine (JNM), Jg. 64, 2023, Nr. 7, S. 1083 – 1086DOI (Open Access)
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Risk of Death in Individuals Hospitalized for COVID-19 With and Without Psychiatric Disorders : An Observational Multicenter Study in FranceIn: Biological Psychiatry Global Open Science, Jg. 3, 2023, Nr. 1, S. 56 – 67DOI (Open Access)
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Simultaneous targeting of mitochondrial Kv1.3 and lysosomal acid sphingomyelinase amplifies killing of pancreatic ductal adenocarcinoma cells in vitro and in vivoIn: Journal of Molecular Medicine, Jg. 101, 2023, Nr. 3, S. 295 – 310DOI (Open Access)
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A novel TTR mutation (p.Ala65Val) underlying late-onset hereditary transthyretin (ATTRv) amyloidosis with mixed cardiac and neuropathic phenotype : a case reportIn: BMC Neurology, Jg. 22, 2022, Nr. 1, 469DOI, Online Volltext (Open Access)
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Acquired Hemophilia A : A Permanent Challenge for All PhysiciansIn: Medicines, Jg. 9, 2022, Nr. 3, 21DOI, Online Volltext (Open Access)
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Antidepressant Use and Its Association with 28-Day Mortality in Inpatients with SARS-CoV-2 : Support for the FIASMA Model against COVID-19In: Journal of Clinical Medicine (JCM), Jg. 11, 2022, Nr. 19, 5882DOI (Open Access)
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Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse ModelIn: International Journal of Molecular Sciences (IJMS), Jg. 23, 2022, Nr. 21, S. 13623DOI (Open Access)
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Association between FIASMA psychotropic medications and reduced risk of intubation or death in individuals with psychiatric disorders hospitalized for severe COVID-19 : an observational multicenter studyIn: Translational Psychiatry, Jg. 12, 2022, 90DOI (Open Access)
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Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in miceIn: The Journal of Biological Chemistry (JBC), Jg. 298, 2022, Nr. 8, 102185DOI (Open Access)
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Clinical features and predictors of atrial fibrillation in patients with light-chain or transthyretin cardiac amyloidosisIn: ESC Heart Failure, Jg. 9, 2022, Nr. 3, S. 1740 – 1748DOI, Online Volltext (Open Access)
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Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality : Results from 49,089 COVID-19 inpatientsIn: Molecular Psychiatry, Jg. 27, 2022, Nr. 3, S. 1278 – 1280DOI (Open Access)
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Corneal confocal microscopy to detect early immune-mediated small nerve fibre loss in AL amyloidosisIn: Annals of Clinical and Translational Neurology, Jg. 9, 2022, Nr. 6, S. 853 – 863DOI, Online Volltext (Open Access)
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Luspatercept, a two‐edged sword in beta‐thalassemia‐associated paravertebral extramedullary hematopoietic masses (EHMs)In: European Journal of Haematology, Jg. 109, 2022, Nr. 6, S. 664 – 671DOI (Open Access)
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Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple MyelomaIn: Cancers, Jg. 14, 2022, Nr. 8, 1955DOI, Online Volltext (Open Access)
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Prevalence and predictors of neurological manifestations in systemic AL amyloidosisIn: Journal of the Neurological Sciences, Jg. 440, 2022, 120341
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Sphingosine as a new antifungal agent against Candida and Aspergillus spp.In: International Journal of Molecular Sciences (IJMS), Jg. 23, 2022, Nr. 24, 15510DOI, Online Volltext (Open Access)
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Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasmaIn: Journal of Molecular Medicine, Jg. 100, 2022, Nr. 10, S. 1493 – 1508DOI (Open Access)
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¹⁸F-flutemetamol positron emission tomography in cardiac amyloidosisIn: Journal of Nuclear Cardiology, Jg. 29, 2022, Nr. 2, S. 779 – 789DOI (Open Access)
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Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter StudyIn: Clinical Pharmacology & Therapeutics, Jg. 110, 2021, Nr. 6, S. 1498 – 1511DOI (Open Access)
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Daratumumab, lenalidomide, and dexamethasone in systemic light-chain amyloidosis: High efficacy, relevant toxicity and main adverse effect of gain 1q21In: American Journal of Hematology, Jg. 96, 2021, Nr. 7, S. E253 – E257DOI (Open Access)
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Ex vivo assay to evaluate the efficacy of drugs targeting sphingolipids in preventing SARS-CoV-2 infection of nasal epithelial cellsIn: STAR Protocols, Jg. 2, 2021, Nr. 1, 100356DOI (Open Access)
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Impact of time to diagnosis on Mayo stages, treatment outcome, and survival in patients with AL amyloidosis and cardiac involvementIn: European Journal of Haematology, Jg. 107, 2021, Nr. 4, S. 449 – 457DOI (Open Access)
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Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cellsIn: The Journal of Biological Chemistry (JBC), Jg. 296, 2021, 100701DOI (Open Access)
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Integrative genomic analyses of patient-matched intracranial and extracranial metastases reveal a novel brain-specific landscape of genetic variants in driver genes of malignant melanomaIn: Cancers, Jg. 13, 2021, Nr. 4, S. 731DOI, Online Volltext (Open Access)
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Pregnancies and neonatal outcomes in patients with sickle cell disease (SCD) : Still a (high-)risk constellation?In: Journal of Personalized Medicine, Jg. 11, 2021, Nr. 9, 870DOI, Online Volltext (Open Access)
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Rare variant (p.Ser43Asn) of familial transthyretin amyloidosis associated with isolated cardiac phenotype : A case series with literature reviewIn: Molecular Genetics & Genomic Medicine, Jg. 9, 2021, Nr. 12, e1581DOI, Online Volltext (Open Access)
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Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19 : Current evidence and potential mechanismsIn: Molecular Psychiatry, Jg. 26, 2021, Nr. 12, S. 7098 – 7099DOI (Open Access)
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A Novel Visible Range FRET Probe for Monitoring Acid Sphingomyelinase Activity in Living CellsIn: Chemistry - A European Journal, Jg. 26, 2020, Nr. 26, S. 5780 – 5783DOI (Open Access)
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Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitroIn: Journal of Lipid Research, Jg. 61, 2020, Nr. 6, S. 896 – 910DOI (Open Access)
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Daratumumab for systemic AL amyloidosis : prognostic factors and adverse outcome with nephrotic-range albuminuriaIn: Blood, Jg. 135, 2020, Nr. 18, S. 1517 – 1530DOI (Open Access)
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Diagnosing cardiac amyloidosis in every-day practice : A practical guide for the cardiologistIn: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 28, 2020, S. 100519DOI (Open Access)
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Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial CellsIn: Cell Reports Medicine, Jg. 1, 2020, Nr. 8, 100142DOI (Open Access)
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Publisher Correction to: 18F-florbetaben positron emission tomography detects cardiac involvement in systemic AA amyloidosisIn: European Journal of Nuclear Medicine and Molecular Imaging, Jg. 47, 2020, Nr. 13, S. 3196DOI (Open Access)
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Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2In: The Journal of Biological Chemistry (JBC), Jg. 295, 2020, Nr. 45, S. 15174 – 15182DOI (Open Access)
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Veno-Venous Extracorporeal Membrane Oxygenation in Adult Patients with Sickle Cell Disease and Acute Chest Syndrome : a Single-Center ExperienceIn: Hemoglobin, Jg. 44, 2020, Nr. 2, S. 71 – 77
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¹⁸F-florbetaben positron computed tomography detects cardiac involvement in systemic AA amyloidosisIn: European Journal of Nuclear Medicine and Molecular Imaging, Jg. 47, 2020, Nr. 13, S. 3186 – 3187DOI (Open Access)
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Acid sphingomyelinase deficiency ameliorates farber diseaseIn: International Journal of Molecular Sciences (IJMS), Jg. 20, 2019, Nr. 24, S. 6253DOI (Open Access)
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Clinical development of sphingosine as anti-bacterial drug : Inhalation of sphingosine in mini pigs has no adverse side effectsIn: Cellular Physiology and Biochemistry, Jg. 53, 2019, Nr. 6, S. 1015 – 1028DOI (Open Access)
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Inhibition of PI-3-K and AKT Amplifies Kv1.3 Inhibitor-Induced Death of Human T Leukemia CellsIn: Cellular Physiology and Biochemistry, Jg. 53, 2019, Nr. S1, S. 1 – 10DOI (Open Access)
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Signalling Effects Induced by Acid Ceramidase in Human Epithelial Or Leukemic Cell LinesIn: Cellular Physiology and Biochemistry, Jg. 52, 2019, Nr. 5, S. 1092 – 1102DOI (Open Access)
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Highlight : Sphingolipids in infectious biology and immunologyIn: Biological Chemistry, Jg. 399, 2018, Nr. 10, S. 1113 – 1113
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Pathological manifestations of Farber disease in a new mouse modelIn: Biological Chemistry, Jg. 399, 2018, Nr. 10, S. 1183 – 1202DOI, Online Volltext (Open Access)
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Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosisIn: Molecular Metabolism, Jg. 6, 2017, Nr. 5, S. 416 – 427DOI (Open Access)
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Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in plateletsIn: Clinical and Experimental Metastasis, Jg. 34, 2017, Nr. 1, S. 25 – 35
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Regulation of Arthritis Severity by the Acid SphingomyelinaseIn: Cellular Physiology and Biochemistry, Jg. 43, 2017, Nr. 4, S. 1460 – 1471DOI (Open Access)
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High Frequencies of Anti-Host Reactive CD8+ T Cells Ignore Non-Hematopoietic Antigen after Bone Marrow Transplantation in a Murine ModelIn: Cellular Physiology and Biochemistry, Jg. 38, 2016, Nr. 4, S. 1343 – 1353DOI (Open Access)
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Role of Acid Sphingomyelinase-Induced Signaling in Melanoma Cells for Hematogenous Tumor MetastasisIn: Cellular Physiology and Biochemistry, Jg. 38, 2016, Nr. 1, S. 1 – 14DOI (Open Access)
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Pseudomonas aeruginosa Pyocyanin Induces Neutrophil Death via Mitochondrial Reactive Oxygen Species and Mitochondrial Acid SphingomyelinaseIn: Antioxidants and Redox Signaling, Jg. 22, 2015, Nr. 13, S. 1097 – 1110DOI (Open Access)
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Regulation of hematogenous tumor metastasis by acid sphingomyelinaseIn: EMBO Molecular Medicine, Jg. 7, 2015, Nr. 6, S. 714 – 734DOI (Open Access)
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Targeting a mitochondrial potassium channel to fight cancerIn: Cell Calcium, Jg. 58, 2015, Nr. 1, S. 131 – 138
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Regulation of the inflammasome by ceramide in cystic fibrosis lungsIn: Cellular Physiology and Biochemistry, Jg. 34, 2014, Nr. 1, S. 45 – 55DOI (Open Access)
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Connexin 31 (GJB3) deficiency in mouse trophoblast stem cells alters giant cell differentiation and leads to loss of oxygen sensingIn: Biology of Reproduction, Jg. 87, 2012, Nr. 2, S. 37
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p53 protein expression in chronic lymphocytic leukemiaIn: Leukemia and Lymphoma, Jg. 53, 2012, Nr. 7, S. 1282 – 1288
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Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infectionsIn: Nature Medicine, Jg. 17, 2011, Nr. 3, S. 341 – 346
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Gene dosage effects in chronic lymphocytic leukemiaIn: Cancer Genetics and Cytogenetics, Jg. 203, 2010, Nr. 2, S. 149 – 160
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The zinc finger protein and transcriptional repressor Gfi1 as a regulator of the innate immune responseIn: Immunobiology, Jg. 213, 2008, Nr. 3-4, S. 341 – 352
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Ceramide : physiological and pathophysiological aspectsIn: Archives of Biochemistry and Biophysics (ABB), Jg. 462, 2007, Nr. 2, S. 171 – 175
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Gründung einer Arbeitsgruppe „Lymphknotenmetastasierung“ am Westdeutschen Tumorzentrum (WTZE), Universitätsklinikum EssenIn: Der Urologe, Jg. 46, 2007, Nr. 9, S. 1257 – 1260
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Proapoptotische Antikörper als neue TumortherapeutikaIn: Der Urologe, Jg. 46, 2007, Nr. 9, S. 1262 – 1265
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Biomarkers for monitoring patients with cardiac amyloidosis during transthyretin-stabilizer therapy
European Society of Cardiology Congress (ESC) 2024, 30 August – 02 September 2024, London, UK,In: European Heart Journal. Oxford: Oxford University Press (OUP), Jg. 45, 2024, Nr. Supplement 1, ehae666775 -
Delays in diagnosis and treatment initiation of ATTR cardiac amyloidosis : a real-world data analysis
European Society of Cardiology Congress (ESC) 2024, 30 August – 02 September 2024, London, UK,In: European Heart Journal. Oxford: Oxford University Press (OUP), Jg. 45, 2024, Nr. Supplement 1, ehae666774 -
Gain or Amplification of 1q21 in Systemic Light Chain Amyloidosis Is Associated with Advanced Mayo Stage, Plasma Cell Disease and Worse Overall SurvivalIn: Blood. The 66th ASH Annual Meeting, December 7-10, 2024, San Diego, USA: American Society of Hematology, Jg. 144, 2024, Nr. Supplement 1, S. 3309DOI (Open Access)
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Antidepressant Use and Its Association with 28-Day Mortality in Inpatients with SARS-CoV-2 : Support for the FIASMA Model against COVID-19
31st European Congress of Psychiatry, EPA 2023, 25-28 March 2023, Paris, France,In: European Psychiatry. Cambridge: Cambridge University Press, Jg. 66, 2023, Nr. S1, S. S118 – S119DOI (Open Access) -
Real-World Analysis of Teclistamab in 115 RRMM Patients from GermanyIn: Blood. Washington; New York, NY [u.a.]; Philadelphia, Pa.: American Society of Hematology, Jg. 142, 2023, Nr. Supplement 1: Annual Meeting Abstracts (65th ASH Annual Meeting and Exposition, 9-12 Dezember 2023, San Diego), S. 3329 – 3329DOI (Open Access)
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Screening for occult transthyretin amyloidosis in patients with degenerative aortic stenosis and amyloid red-flagsIn: European Journal of Heart Failure. Oxford: Wiley, Jg. 25, 2023, Nr. Suppl. 2, S. 359 – 359
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Glomerular Fitration Rate and Lactate Dehydrogenase Predicts Survival in Mayo Iiib Stage Light-Chain Amyloidosis
64th ASH Annual Meeting, December 10-13, 2022, New Orleans, LA, USA,In: Blood. Washington; New York, NY [u.a.]; Philadelphia, Pa.: American Society of Hematology, Jg. 140, 2022, Nr. Supplement 1: 64th Annual Meeting, S. 12571 – 12572DOI (Open Access) -
Think twice : Anemia of chronic disease (ACD) due to angiomatoid fibrous histiocytoma (AFH)
Virtuelle Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 09.–11. Oktober 2020,In: Oncology Research and Treatment. Basel: Karger, Jg. 43, 2020, Nr. Suppl. 4, S. 181DOI (Open Access) -
Effects of nitric oxide on hematogenous metastasis
9th International Luebeck Conference Pathophysiology and Pharmacology of Erythropoietin and other Hemopoietic Grow Factors, 13 - 15 July 2012, Lübeck, Germany,In: American Journal of Hematology. Hoboken: Wiley-Blackwell - STM, Jg. 87, 2012, Nr. 10, S. E112 – E112 -
Role of the acid sphingomyelinase in hematogenous tumor metastasis in a mouse model
Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie. Basel, 30.09.–04.10. 2011,In: Onkologie. Basel: Karger, Jg. 34, 2011, Nr. Suppl. 6, S. 46 -
Role of the antigenic stimulation in the pathogenesis of chronic lymphocytic leukemia
Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie. Berlin, 1.–5. Oktober 2010,In: Onkologie. Basel: Karger, Jg. 33, 2010, Nr. Suppl. 6, S. 39 -
Analysis of lipids in ceramide-enriched membrane domainsIn: Lipid Rafts: Methods and Protocols / Bieberich, Erhard (Hrsg.): Springer, 2021, S. 207 – 213
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Hemmung der sauren Sphingomyelinase als neuer therapeutischer AngriffspunktDuisburg ; Essen, 2020