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Institut für Zellbiologie (Tumorforschung) am Universitätsklinikum Essen
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Virchowstraße 173
45122 Essen
45122 Essen
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Universitätsprofessor/in, Institut für Zellbiologie (Tumorforschung)
Aktuelle Veranstaltungen
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SoSe 2025
- Mitarbeiterseminar in englischer Sprache (Exp. Onkologie)
- Neue Literatur (Zellbiologie, experimentelle Krebsforschung) (*)
- Praktikum Zell- und Molekularbiologie für med. Biologen (Bachelor) (PV)
- Neue Literatur der Zell- und Molekularbiologie für Med. Biologen
- Seminar Neue Literatur der Zell- und Molekularbiologie für med. Biologen (Bachelor) Gruppe II
- Seminar Neue Literatur der Zell- und Molekularbiologie für med. Biologen (Bachelor) Gruppe I
- Vorlesung des GRK 1739 (mit Gastsprechern)
- Mitarbeiterseminar zur Besprechung aktueller Arbeiten
- Mitarbeiterseminar in englischer Sprache (Molecular Cell Biology and Exp. Radiation Oncology)
- Anleitung zu selbständigen wissenschaftlichen Arbeiten (*)
- Seminar für Zellbiologie und experimentelle Krebsforschung (mit Gastsprechern) (*)
Vergangene Veranstaltungen (max. 10)
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WiSe 2024
- Biologie für Mediziner
- Biologie für Mediziner
- Laborpraktikum III für Masterstudenten der medizinischen Biologie (WP)
- Begleitvorlesung zum Praktikum Biologie für Mediziner (1. FS)
- Molekular- und Zellbiologie für Biomediziner (PV)
- Laborpraktikum I für Masterstudenten der medizinischen Biologie (WP)
- Biologie für Mediziner (1. FS)
- Laborpraktikum II für Masterstudenten der medizinischen Biologie (WP)
- Mitarbeiterseminar in englischer Sprache (Exp. Onkologie)
- Anleitung zu selbständigen wissenschaftlichen Arbeiten (*)
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Diagnosis and treatment of radiation induced pneumonitis in patients with lung cancer : An ESTRO clinical practice guidelineIn: Radiotherapy and Oncology (The Green Journal) , Jg. 207 2025, 110837DOI (Open Access)
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CD73/adenosine dynamics in treatment-induced pneumonitis : balancing efficacy with risks of adverse events in combined radio-immunotherapiesIn: Frontiers in Cell and Developmental Biology , Jg. 12 2024, 1471072DOI (Open Access)
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GRB2 is a BECN1 interacting protein that regulates autophagyIn: Cell Death and Disease , Jg. 15 2024, Nr. 1, 14DOI, Online Volltext (Open Access)
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Long-Term Survival in Patients with Oligometastatic Non-Small Cell Lung Cancer by a Multimodality Treatment : Comparison with Stage III DiseaseIn: Cancers , Jg. 16 2024, Nr. 6, 1174DOI (Open Access)
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α-Ketoglutarate supplementation and NAD+ modulation enhance metabolic rewiring and radiosensitization in SLC25A1 inhibited cancer cellsIn: Cell Death Discovery , Jg. 10 2024, Nr. 1, 27DOI, Online Volltext (Open Access)
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A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in GlioblastomaIn: Clinical Cancer Research , Jg. 29 2023, Nr. 2, S. 488 – 500DOI (Open Access)
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Combined radiation- and immune checkpoint-inhibitor-induced pneumonitis : The challenge to predict and detect overlapping immune-related adverse effects from evolving laboratory biomarkers and clinical imagingIn: Neoplasia: An International Journal for Oncology Research , Jg. 39 2023, 100892DOI (Open Access)
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Comparative transcriptomic and proteomic signature of lung alveolar macrophages reveals the integrin CD11b as a regulatory hub during pneumococcal pneumonia infectionIn: Frontiers in Immunology , Jg. 14 2023, 1227191DOI, Online Volltext (Open Access)
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Accumulation of oncometabolite D-2-Hydroxyglutarate by SLC25A1 inhibition: A metabolic strategy for induction of HR-ness and radiosensitivityIn: Cell Death and Disease , Jg. 13 2022, Nr. 7, 641DOI, Online Volltext (Open Access)
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CD47 restricts antiviral function of alveolar macrophages during influenza virus infectionIn: iScience , Jg. 25 2022, Nr. 12, 105540
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CD9- and CD81-positive extracellular vesicles provide a marker to monitor glioblastoma cell response to photon-based and proton-based radiotherapyIn: Frontiers in Oncology , Jg. 12 2022, 947439DOI, Online Volltext (Open Access)
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Correction to : Bcl-2/Bcl-xL inhibitor ABT-263 overcomes hypoxia-driven radioresistence and improves radiotherapyIn: Cell Death and Disease , Jg. 13 2022, Nr. 4, 367DOI (Open Access)
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Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM CellsIn: Frontiers in Cell and Developmental Biology , Jg. 10 2022, 852812DOI, Online Volltext (Open Access)
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Stromal Fibroblasts Counteract the Caveolin-1-Dependent Radiation Response of LNCaP Prostate Carcinoma CellsIn: Frontiers in Oncology , Jg. 12 2022, 802482DOI, Online Volltext (Open Access)
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Targeting AKT-Dependent Regulation of Antioxidant Defense Sensitizes AKT-E17K Expressing Cancer Cells to Ionizing RadiationIn: Frontiers in Oncology , Jg. 12 2022, 920017DOI, Online Volltext (Open Access)
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A BAP1 synonymous mutation results in exon skipping, loss of function and worse patient prognosisIn: iScience , Jg. 24 2021, Nr. 3, 102173DOI (Open Access)
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Activation of anti-oxidant Keap1/Nrf2 pathway modulates efficacy of dihydroartemisinin-based monotherapy and combinatory therapy with ionizing radiationIn: Free Radical Biology and Medicine , Jg. 168 2021, S. 44 – 54
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Adaptation to chronic-cycling hypoxia renders cancer cells resistant to mth1-inhibitor treatment which can be counteracted by glutathione depletionIn: Cells , Jg. 10 2021, Nr. 11, 3040DOI, Online Volltext (Open Access)
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Bcl-2/Bcl-xL inhibitor ABT-263 overcomes hypoxia-driven radioresistence and improves radiotherapyIn: Cell Death and Disease , Jg. 12 2021, Nr. 7, 694DOI, Online Volltext (Open Access)
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Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinomaIn: Cell Death and Disease , Jg. 12 2021, Nr. 12, 1162DOI (Open Access)
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Loss of pro-apoptotic Bax and Bak increases resistance to dihydroartemisinin-mediated cytotoxicity in normoxia but not in hypoxia in HCT116 colorectal cancer cellsIn: Free Radical Biology and Medicine , Jg. 174 2021, S. 157 – 170
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Metabolic reprograming of antioxidant defense : A precision medicine perspective for radiotherapy of lung cancer?In: Biochemical Society Transactions , Jg. 49 2021, Nr. 3, S. 1265 – 1277
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Metabolism of cancer cells commonly responds to irradiation by a transient early mitochondrial shutdownIn: iScience , Jg. 24 2021, Nr. 11, 103366DOI (Open Access)
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Metformin protects against radiation-induced acute effects by limiting senescence of bronchial-epithelial cellsIn: International Journal of Molecular Sciences (IJMS) , Jg. 22 2021, Nr. 13, 7064DOI, Online Volltext (Open Access)
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The Biomarker Potential of Caveolin-1 in Penile CancerIn: Frontiers in Oncology , Jg. 11 2021, S. 606122DOI, Online Volltext (Open Access)
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The vascular nature of lung-resident mesenchymal stem cellsIn: Stem Cells Translational Medicine , Jg. 10 2021, Nr. 1, S. 128 – 143DOI, Online Volltext (Open Access)
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A new twist in protein kinase b/akt signaling : Role of altered cancer cell metabolism in akt-mediated therapy resistanceIn: International Journal of Molecular Sciences (IJMS) , Jg. 21 2020, Nr. 22, S. 8563DOI, Online Volltext (Open Access)
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Caveolin-1 regulates the ASMase/ceramide-mediated radiation response of endothelial cells in the context of tumor–stroma interactionsIn: Cell Death and Disease , Jg. 11 2020, Nr. 4, 228DOI (Open Access)
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Cellular Senescence in the Lung : The Central Role of Senescent Epithelial CellsIn: International Journal of Molecular Sciences (IJMS) , Jg. 21 2020, Nr. 9, S. 3279DOI, Online Volltext (Open Access)
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Combined radiotherapy and concurrent tumor treating fields (TTFields) for glioblastoma : Dosimetric consequences on non-coplanar IMRT as initial results from a phase i trialIn: Radiation Oncology , Jg. 15 2020, Nr. 1, S. 83DOI, Online Volltext (Open Access)
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Host CD39 Deficiency Affects Radiation-Induced Tumor Growth Delay and Aggravates Radiation-Induced Normal Tissue ToxicityIn: Frontiers in Oncology , Jg. 10 2020, S. 554883DOI, Online Volltext (Open Access)
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Oncometabolites and the response to radiotherapyIn: Radiation Oncology , Jg. 15 2020, S. 197DOI, Online Volltext (Open Access)
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Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End JoiningIn: Cells , Jg. 9 2020, Nr. 4, S. 889DOI, Online Volltext (Open Access)
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Addendum: de Leve, S.; et al. The CD73/Ado System—A New Player in RT Induced Adverse Late Effects. Cancers 2019, 11, 1578In: Cancers , Jg. 11 2019, Nr. 12, S. 1898DOI (Open Access)
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Effects of Irradiation with Protons and Photons on the Survival of Glioblastoma Cell Lines and the Secretion of Exosomes in vitroIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 195 2019, Nr. Suppl. 1, S. 173
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High-throughput Evaluation of Protein Migration and Localization after Laser Micro-IrradiationIn: Scientific Reports , Jg. 9 2019, Nr. 1, S. 3148DOI (Open Access)
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Impact of Cancer-Associated Fibroblast on the Radiation-Response of Solid Xenograft TumorsIn: Frontiers in Molecular Biosciences , Jg. 6 2019, 70DOI, Online Volltext (Open Access)
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Implementation of the chick chorioallantoic membrane (CAM) model in radiation biology and experimental radiation oncology researchIn: Cancers , Jg. 11 2019, Nr. 10, S. 1499DOI, Online Volltext (Open Access)
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Inhibition of Radiation-Induced Ccl2 Signaling Protects Lungs from Vascular Dysfunction and Endothelial Cell LossIn: Antioxidants and Redox Signaling , Jg. 30 2019, Nr. 2, S. 213 – 231
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Linking radiation-induced damage to systemic effects : what can we learn from preclinical models of normal tissue complicationsIn: Radiotherapy and Oncology (The Green Journal) , Jg. 133 2019, Nr. Suppl. 1, S. 6DOI (Open Access)
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Progression-Related Loss of Stromal Caveolin 1 Levels Mediates Radiation Resistance in Prostate Carcinoma via the Apoptosis Inhibitor TRIAP1In: Journal of Clinical Medicine (JCM) , Jg. 8 2019, Nr. 3, 348DOI, Online Volltext (Open Access)
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Sequence-dependent cross-resistance of combined radiotherapy plus BRAFV⁶⁰⁰E inhibition in melanomaIn: European Journal of Cancer (EJC) , Jg. 109 2019, S. 137 – 153
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Targeting the Immunomodulatory CD73/Adenosine System to Improve the Therapeutic Gain of RadiotherapyIn: Frontiers in Immunology , Jg. 10 2019, S. 698DOI, Online Volltext (Open Access)
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The CD73/Ado System - A New Player in RT Induced Adverse Late EffectsIn: Cancers , Jg. 11 2019, Nr. 10, S. 1578DOI, Online Volltext (Open Access)
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Combining Radiotherapy and Immunotherapy in Lung Cancer : Can We Expect Limitations Due to Altered Normal Tissue Toxicity?In: International Journal of Molecular Sciences (IJMS) , Jg. 20 2018, Nr. 1, S. 24DOI, Online Volltext (Open Access)
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Mentoring in a medical faculty : A chance for organisational learningIn: International Journal of Learning and Change , Jg. 10 2018, Nr. 3, S. 198 – 219
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New Insights into Protein Kinase B/Akt Signaling : Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation ResponseIn: Cancers , Jg. 10 2018, Nr. 3, S. 78DOI (Open Access)
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Relating Linear Energy Transfer to the Formation and Resolution of DNA Repair Foci After Irradiation with Equal Doses of X-ray Photons, Plateau, or Bragg-Peak ProtonsIn: International Journal of Molecular Sciences (IJMS) , Jg. 19 2018, Nr. 12, S. 3779DOI, Online Volltext (Open Access)
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Restraining Akt1 Phosphorylation Attenuates the Repair of Radiation-Induced DNA Double-Strand Breaks and Reduces the Survival of Irradiated Cancer CellsIn: International Journal of Molecular Sciences (IJMS) , Jg. 19 2018, Nr. 8, S. 2233DOI (Open Access)
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Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxiaIn: Cancer Letters , Jg. 439 2018, S. 24 – 38
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The Mitochondrial Citrate Carrier (SLC25A1) Sustains Redox Homeostasis and Mitochondrial Metabolism Supporting Radioresistance of Cancer Cells With Tolerance to Cycling Severe HypoxiaIn: Frontiers in Oncology , Jg. 8 2018, S. 170DOI, Online Volltext (Open Access)
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Activating Akt1 mutations alter DNA double strand break repair and radiosensitivityIn: Scientific Reports , Jg. 7 2017, S. 42700DOI (Open Access)
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Down-Regulation of CD62L Shedding in T Cells by CD39+ Regulatory T Cells Leads to Defective Sensitization in Contact Hypersensitivity ReactionsIn: Journal of Investigative Dermatology , Jg. 137 2017, Nr. 1, S. 106 – 114DOI (Open Access)
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Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC) : Cellular mechanisms of radioresistance and clinical relevanceIn: Cancer Letters , Jg. 386 2017, S. 87 – 99
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Heart dose exposure as prognostic marker after radiotherapy for resectable stage IIIA/B non-small-cell lung cancer : secondary analysis of a randomized trialIn: Annals of Oncology , Jg. 28 2017, Nr. 5, S. 1084 – 1089DOI (Open Access)
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Hypoxia enhances immunosuppression by inhibiting CD4+ Effector T cell function and promoting treg activityIn: Cellular Physiology and Biochemistry , Jg. 41 2017, Nr. 4, S. 1271 – 1284DOI (Open Access)
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Investigation on tissue specific effects of pro-apoptotic micro RNAs revealed miR-147b as a potential biomarker in ovarian cancer prognosisIn: OncoTarget , Jg. 8 2017, Nr. 12, S. 18773 – 18791DOI (Open Access)
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Loss of CD73 prevents accumulation of alternatively activated macrophages and the formation of prefibrotic macrophage clusters in irradiated lungsIn: The FASEB Journal , Jg. 31 2017, Nr. 7, S. 2869 – 2880DOI (Open Access)
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Mesenchymal stem cell therapy protects lungs from radiation-induced endothelial cell loss by restoring superoxide dismutase 1 expressionIn: Antioxidants and Redox Signaling , Jg. 26 2017, Nr. 11, S. 563 – 582DOI (Open Access)
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Modeling DNA damage-induced pneumopathy in mice : insight from danger signaling cascadesIn: Radiation Oncology , Jg. 12 2017, S. 142DOI (Open Access)
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Progression-related loss of stromal Caveolin 1 levels fosters the growth of human PC3 xenografts and mediates radiation resistanceIn: Scientific Reports , Jg. 7 2017, S. 41138DOI (Open Access)
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The Focinator v2-0-Graphical Interface, Four Channels, Colocalization Analysis and Cell Phase IdentificationIn: Radiation Research , Jg. 188 2017, Nr. 1, S. 114 – 120
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Deubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanismsIn: Cell Death and Disease , Jg. 7 2016, Nr. 1, e2039DOI (Open Access)
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Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung FibrosisIn: Cancer Research , Jg. 76 2016, Nr. 10, S. 3045 – 3056DOI (Open Access)
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RHAMM splice variants confer radiosensitivity in human breast cancer cell linesIn: OncoTarget , Jg. 7 2016, Nr. 16, S. 21428 – 21440DOI (Open Access)
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Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxiaIn: Radiation Oncology , Jg. 11 2016, Nr. 1, S. 75 – 87DOI (Open Access)
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Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling HypoxiaIn: Antioxidants and Redox Signaling , Jg. 25 2016, Nr. 2, S. 89 – 107
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The Role of Lymphocytes in Radiotherapy-Induced Adverse Late Effects in the LungIn: Frontiers in Immunology , Jg. 7 2016, S. 591DOI (Open Access)
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Therapy with multipotent mesenchymal stromal cells protects lungs from radiation-induced injury and reduces the risk of lung metastasisIn: Antioxidants and Redox Signaling , Jg. 24 2016, Nr. 2, S. 53 – 69
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Covalent-Allosteric Kinase InhibitorsIn: Angewandte Chemie International Edition , Jg. 54 2015, Nr. 35, S. 10313 – 10316
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Endothelial Caveolin-1 regulates the radiation response of epithelial prostate tumorsIn: Oncogenesis , Jg. 4 2015, S. e148DOI (Open Access)
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Fanconi anemia, complementation group A (FancA) overexpression confers radioresistance to oral keratinocytesIn: European Journal of Cancer (EJC) , Jg. 51 2015, Nr. Suppl.3, S. 121 – S121
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Prognostic model for long-term survival of locally advanced non-small-cell lung cancer patients after neoadjuvant radiochemotherapy and resection integrating clinical and histopathologic factorsIn: BMC Cancer , Jg. 15 2015, Nr. 1, S. 363DOI (Open Access)
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Regulatory T Cell–Derived Adenosine Induces Dendritic Cell Migration through the Epac-Rap1 PathwayIn: The Journal of Immunology (JI) , Jg. 194 2015, Nr. 8, S. 3735 – 3744
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The Focinator - a new open-source tool for high-throughput foci evaluation of DNA damageIn: Radiation Oncology 2015, Nr. 10, S. 163 – 174DOI (Open Access)
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Dihydroartemisinin is a hypoxia-active anti-cancer drug in colorectal carcinoma cellsIn: Frontiers in Oncology , Jg. 4 2014, S. 116DOI (Open Access)
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FancA overexpression confers radioresistance to cells of head and neck squamous cell carcinomaIn: European Journal of Cancer (EJC) , Jg. 50 2014, Nr. Suppl. 5, S. 229
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Fortschritt durch „Wissensfusionen“ : Medizinische Strahlenforschung an der Universität Duisburg-EssenIn: Unikate: Berichte aus Forschung und Lehre 2014, Nr. 45: Fusionen : Was sagen die Fakultäten?, S. 38 – 49DOI, Online Volltext (Open Access)
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Importance of Mcl-1 and the Mcl-1-modulating enzyme USP9x for radiosensitivity in prostate cancer cellsIn: European Journal of Cancer (EJC) , Jg. 50 2014, Nr. Suppl. 5, S. S225 – S226
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Importance of stromal caveolin-1 for tumor growth and radiosensitivity of epithelial tumorsIn: European Journal of Cancer (EJC) , Jg. 50 2014, Nr. 5 Suppl., S. 224
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Mesenchymal stem cell therapy antagonizes radiation-induced endothelial cell damage and metastasisIn: European Journal of Cancer (EJC) , Jg. 50 2014, Nr. Suppl. 5, S. 221
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Molecular mechanisms of the antineoplastic action of erufosine in hypoxic tumor cellsIn: European Journal of Cancer (EJC) , Jg. 50 2014, Nr. 5 Suppl., S. 223
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Nestin(+) tissue-resident multipotent stem cells contribute to tumor progression by differentiating into pericytes and smooth muscle cells resulting in blood vessel remodelingIn: Frontiers in Oncology 2014, Nr. 4, S. 169DOI (Open Access)
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Second EACR Conference on Cell Death in Cancer, Amsterdam, The Netherlands, 30 January–1 February 2014In: Cell Death and Differentiation , Jg. 21 2014, Nr. 7, S. 1180 – 1182
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The membrane-targeted alkylphosphocholine erufosine interferes with survival signals from the extracellular matrixIn: Anti-Cancer Agents in Medicinal Chemistry , Jg. 14 2014, Nr. 4, S. 578 – 591
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Thorax irradiation triggers a local and systemic accumulation of immunosuppressive CD4+ FoxP3+ regulatory T cellsIn: Radiation Oncology , Jg. 9 2014, Nr. 1, 98DOI (Open Access)
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Chronic intermittent hypoxia triggers adaptive changes that promote protection against cell deathIn: European Journal of Cancer (EJC) , Jg. 49 2013, Nr. Suppl. 2, S. 101
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Immunomodulation in response to radiation-induced lung injuryIn: Cancer Research , Jg. 73 2013, Nr. Suppl. 8, S. 79
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Molecular mechanisms of resistance to protein kinase B inhibitors of the alkylphosphocholine familyIn: European Journal of Cancer (EJC) , Jg. 49 2013, Nr. Suppl. 2, S. S171 – S172
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Radiation-induced Normal Tissue Damage require the Settlement of circulating Tumor cellsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 189 2013, Nr. Suppl. 1, S. 125
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Targeting apoptosis pathways by Celecoxib in cancerIn: Cancer Letters , Jg. 332 2013, Nr. 2, S. 313 – 324
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The deubiquitinase USP9x modulates sensitivity to radiation-induced apoptosis by stabilizing Mcl-1 levelsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 189 2013, Nr. Suppl. 1, S. 126 – 126
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Thorax irradiation triggers local and systemic immune changesIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 189 2013, Nr. Suppl. 1, S. 125 – 126
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Effects of ionizing radiation in combination with Erufosine on T98G glioblastoma xenograft tumours: A study in NMRI nu/nu miceIn: Radiation Oncology , Jg. 7 2012, Nr. 1, S. 172DOI, Online Volltext (Open Access)
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First EACR Conference on Cell Death in Cancer, Amsterdam, Netherlands, 26–28 January 2012In: Cell Death and Differentiation , Jg. 19 2012, Nr. 8, S. 1408 – 1410
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Radiation-induced changes in breathing frequency and lung histology of C57BL/6J mice are time- and dose-dependentIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 188 2012, Nr. 3, S. 274 – 281
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Radiation-induced changes in the Respiratory rate and Lung histology of the C57BL/6J Mice are time-and dose-dependentIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 188 2012, Nr. Suppl. 1, S. 147
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Targeting hypoxia-induced radiation resistance using cyclic endoperoxidesIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 188 2012, Nr. Suppl. 1, S. 119 – 119
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The Action of Small GTPases Rab11 and Rab25 in Vesicle Trafficking During Cell MigrationIn: Cellular Physiology and Biochemistry , Jg. 29 2012, Nr. 5-6, S. 647 – 656
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The Intrinsic Apoptosis Pathways as a Target in Anticancer TherapyIn: Current Pharmaceutical Biotechnology , Jg. 13 2012, Nr. 8, S. 1426 – 1438
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Anti-apoptotic Bcl-2 fails to form efficient complexes with pro-apoptotic Bak to protect from Celecoxib-induced apoptosisIn: Biochemical Pharmacology , Jg. 81 2011, Nr. 1, S. 32 – 42
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Apoptosis induction and tumor cell repopulation : The yin and yang of radiotherapyIn: Radiation Oncology , Jg. 6 2011, Nr. 1, S. 176DOI, Online Volltext (Open Access)
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Dihydroartemisinin is a hypoxia active anticancer drug that interferes with the cytotoxic action of radiotherapyIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 187 2011, Nr. Suppl. 1, S. 121 – 122
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New insights into the molecular pathology of radiation-induced pneumopathyIn: Radiotherapy and Oncology (The Green Journal) , Jg. 101 2011, Nr. 1, S. 86 – 92
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Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21 cip1/waf1In: PLoS ONE , Jg. 6 2011, Nr. 12 , Art. Nr. e28828DOI (Open Access)
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369 Dihydroartemisinin is a hypoxia active anticancer drug : [Poster Session]In: European Journal of Cancer / EJC Supplements , Jg. 8 2010, Nr. 5, S. 94
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Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathwaysIn: Biochemical Pharmacology , Jg. 79 2010, Nr. 2, S. 122 – 129
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Differential effects of anti-apoptotic Bcl-2 family members Mcl-1, Bcl-2, and Bcl-xL on Celecoxib-induced apoptosisIn: Biochemical Pharmacology , Jg. 79 2010, Nr. 1, S. 10 – 20
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Dihydroartemisinin induces apoptosis by a bak-dependent intrinsic pathwayIn: Molecular Cancer Therapeutics , Jg. 9 2010, Nr. 9, S. 2497 – 2510DOI (Open Access)
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Effectiveness of molecularly targeted triple-combination therapies
16. Jahreskongress der Deutschen Gesellschaft für Radioonkologie Radioonkologie • Medizinische Physik • Strahlenbiologie Magdeburg, 3. bis 6. Juni 2010,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 186 2010, Nr. Suppl. 1, S. 124 -
Emerging targets for the modulation of apoptosis resistance in anticancer treatmentIn: European Journal of Oncology Pharmacy , Jg. 4 2010, Nr. 2, S. 6 – 8
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The Akt-inhibitor Erufosine induces apoptotic cell death in prostate cancer cells and increases the short term effects of ionizing radiationIn: Radiation Oncology , Jg. 5 2010, Nr. 1, S. 108DOI, Online Volltext (Open Access)
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Defects in DNA Damage Response Reinforce Proton Beam Specific Radiosensitivity of Cancer Cells
29. Kongress der Deutschen Gesellschaft für Radioonkologie (DEGRO), 22. bis 24. Juni 2023, Kassel, Germany,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 199 2023, Nr. Suppl. 1, S. S36 – S37DOI (Open Access) -
Gibt es unterschiedliche Verteilungsmuster zwischen strahlen- oder immuninduzierten Pneumonitiden in Abhängigkeit von der Dosisverteilung?In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 199 2023, Nr. Suppl. 1, S. S167 – S168DOI (Open Access)
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KDM5B's role in creating radiation synthetic vulnerabilities and its effects on sequential therapy combinations
48th Annual Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF): Virtual, Innsbruck, 23-26 February 2022,In: Experimental Dermatology , Jg. 31 2022, Nr. 2, S. e9 – e10 -
Ensuring fuels for DNA repair : Analysis of irradiated cancer cells reveals mitochondrial shutdownIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 197 2021, Nr. Suppl. 1, S. 200
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Modeling common aspects of the metabolic response of cancer cells to ionizing radiation
AACR Annual Meeting 2021, April 10-15, 2021 and May 17-21, 2021, Philadelphia, PA, USA,In: Cancer Research , Jg. 81 2021, Nr. Suppl. 13, 3065 -
Senescence and associated cytokines are critical drivers of inherent radioresistance in HNSCC
ESTRO 2020 - Online Congress, 28 November to 1 December 2020,In: Radiotherapy and Oncology (The Green Journal) , Jg. 152 2021, S. 246 -
The Role of KDM5B in the Development of radiation-synthetic Vulnerability and its Effect on sequential Therapy CombinationsIn: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 19 2021, Nr. Suppl. 4, S. 74
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The citrate carrier SLC25A1 acts as master regulator of metabolic reprogramming and offers an innovative strategy for metabolic induction of HRness and synthetic lethality approaches with radiotherapyIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 197 2021, Nr. Suppl. 1, S. 48 – S49
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CD4+T-Lymphocytes impact macrophage polarization in irradiated lungs and promote progression of radiation-induced lung fibrosis
26. Jahrestagung der Deutschen Gesellschaft für Radioonkologie (DEGRO) ; 24. - 28. Juni 2020, Wiesbaden, Germany,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 196 2020, Nr. 1 Supplement: Abstracts DEGRO 2020, S. S26 – S27DOI (Open Access) -
Cancer metabolism: a radio-oncology perspective
ESTRO 2020 - Online Congress, 28 November to 1 December 2020,In: Radiotherapy and Oncology (The Green Journal) , Jg. 152 2020, Nr. Supplement 1, S. 276 -
Cross talk between T lymphocytes and macrophages promotes progression of radiation induced lung fibrosis
Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24; Philadelphia, USA,In: Cancer Research , Jg. 80 2020, Nr. Suppl. 16, S. LB – 071DOI (Open Access) -
Evaluation der dosimetrischen Auswirkungen der geometrischen Variation der Tumor Treating Field (TTF) Elektroden-Positionierung in der PriCoTTF-Phase I/II Studie
26. Jahrestagung der Deutschen Gesellschaft für Radioonkologie (DEGRO) ; 24. Juni - 28. Juni 2020, Wiesbaden, Germany,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 196 2020, Nr. 1 Supplement: Abstracts DEGRO 2020, S. S65DOI (Open Access) -
How Caveolin-1 regulates the ceramide-mediated radiation-response of endothelial cells in the context of tumor-stroma-interactions
26. Jahrestagung der Deutschen Gesellschaft für Radioonkologie (DEGRO) ; 24. - 28. Juni 2020, Wiesbaden, Germany,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 196 2020, Nr. 1 Supplement: Abstracts DEGRO 2020, S. S214DOI (Open Access) -
Inhibition of the mitochondrial citrate carrier SLC25A1 induces a DNA repair defect and increases cancer cell radiosensitivity
26. Jahrestagung der Deutschen Gesellschaft für Radioonkologie (DEGRO) ; 24. - 28. Juni 2020, Wiesbaden, Germany,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 196 2020, Nr. 1 Supplement: Abstracts DEGRO 2020, S. S184DOI (Open Access) -
Radiation-induced senescence as potential target for normal tissue protection
26. Jahrestagung der Deutschen Gesellschaft für Radioonkologie (DEGRO) ; 24. - 28. Juni 2020, Wiesbaden, Germany,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 196 2020, Nr. 1 Supplement: Abstracts DEGRO 2020, S. S184DOI (Open Access) -
Combined inhibition of GSH levels and sanitization of dNTPs is effective in eradicating cancer cells exposed to acute hypoxia or chronic cycling severe hypoxiaIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 194 2018, Nr. Suppl. 1, S. 172DOI (Open Access)
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Fibroblasts mediate tumor cell death through tunneling nanotubes in response to ionizing radiation
84th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) and the 20th Annual Meeting of the Association of the Clinical Pharmacology Germany (VKliPha) ; 26 February – 1 March 2018 , Göttingen,In: Naunyn-Schmiedeberg's Archives of Pharmacology , Jg. 391 2018, Nr. 1, Supplement, S. S12 -
How stromal Caveolin-1 alters the radiation response of prostate tumors
24. Jahrestagung der Deutschen Gesellschaft für Radioonkologie, 21. Juni 2018 - 24. Juni 2018, Leipzig,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 194 2018, Nr. 1 Supplement, Abstracts DEGRO 2018, S. S171 – S172DOI (Open Access) -
Radiation-induced Ccl2 signaling fosters vascular dysfunction and endothelial cell lossIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 194 2018, Nr. Suppl. 1, S. 99DOI (Open Access)
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Role of T lymphocytes in radiation-induced lung fibrosis-the good, the bad and the ugly!?
24. Jahrestagung der Deutschen Gesellschaft für Radioonkologie, 21. Juni 2018 - 24. Juni 2018, Leipzig,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 194 2018, Nr. 1 Supplement, Abstracts DEGRO 2018, S. 99DOI (Open Access) -
Targeting of antioxidant-associated mitochondrial transport systems overcomes chronic-cycling hypoxia-induced radioresistance
33. Deutscher Krebskongress - Perspektiven verändern Krebs - Krebs verändert Perspektiven. Diagnose - Therapie - (Über-)Leben ; Berlin, 21.-24. Februar 2018,In: Oncology Research and Treatment , Jg. 41 2018, Nr. Suppl. 1, S. 150DOI (Open Access) -
Targeting of the mitochondrial citrate carrier (SLC25A1) lowers antioxidant defense systems and increases radiosensitivity of hypoxic cancer cellsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 194 2018, Nr. Suppl. 1, S. 30DOI (Open Access)
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The immunoregulatory CD73/Adenosine system limits successful radiotherapy
24. Jahrestagung der Deutschen Gesellschaft für Radioonkologie, 21. Juni 2018 - 24. Juni 2018, Leipzig,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 194 2018, Nr. 1 Supplement, Abstracts DEGRO 2018, S. 95DOI (Open Access) -
Dihydroartemisinin shows similar anti-neoplastic activity in hypoxia in apoptosis-proficient and apoptosis-deficient HCT116 cellsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 191 2015, Nr. Suppl.1, S. 79 – S80
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Inherent radioresistance of head and neck squamous cell carcinoma cells : principal component analysis identifies cellular senescence as a crucial driver
21. Jahrestagung der Deutschen Gesellschaft für Radioonkologie, 25. Juni 2015, Hamburg,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 191 2015, Nr. Suppl.1, S. 121 -
Loss or therapeutic inhibition of extracellular adenosine production by ecto-5 -nucleotidase (CD73) attenuates radiation-induced lung fibrosis
21. Jahrestagung der Deutschen Gesellschaft für Radioonkologie, 25. Juni 2015, Hamburg,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 191 2015, Nr. Suppl.1, S. 14 – S15 -
Loss or therapeutic inhibition of extracellular adenosine production by ecto-5 -nucleotidase(CD73) attenuates radiation-induced lung fibrosis
European Cancer Congress (ECC 2015), 25.-29.09.2015, Wien,In: European Journal of Cancer (EJC) , Jg. 51 2015, Nr. Supplement 3, S. S117 – S118 -
Rekursive Partitions-Analyse prognostischer Faktoren für das Langzeit-Überleben nach trimodaler Therapie von Patienten mit lokal fortgeschrittenem NSCLC
21. Jahrestagung der Deutschen Gesellschaft für Radioonkologie, 25. Juni 2015, Hamburg,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 191 2015, Nr. Suppl. 1, S. 23 -
Senescence-like responses in irradiated melanoma cellsIn: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 13 2015, Nr. Suppl.2, S. 34
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Signalling networks associated with FancA mediated radioresistance in cells of head and neck squamous cell carcinoma
21. Jahrestagung der Deutschen Gesellschaft für Radioonkologie, 25. Juni 2015, Hamburg,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 191 2015, Nr. Suppl.1, S. 77 -
Stromal Caveolin-1 regulates radiosensitivity of epithelial prostate tumorsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 191 2015, Nr. Suppl. 1, S. S27
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The influence of FancA overexpression on radioresistance in oral keratinocytes and HNSCC cellsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 191 2015, Nr. Suppl.1, S. 90
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The role of protein kinase B alpha (Akt1) in the cellular response to ionizing radiationIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 191 2015, Nr. Suppl.1, S. S74 – S75
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Chronic intermittent hypoxia triggers adaptive changes that promote protection against cell deathIn: European Journal of Cancer (EJC) , Jg. 50 2014, Nr. Suppl. 5, S. 51
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Membranaktive Alkylphosphcholine sind hypoxieaktive Krebstherapeutika
20. Jahreskongress der Deutschen Gesellschaft für Radioonkologie (DEGRO), 3. bis 6. Juli 2014, Düsseldorf,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 190 2014, Nr. Suppl. 1, S. 79 – 80 -
Mesenchymale Stammzell-Therapie zur Radioprotektion des Lungen-Gewebes
20. Jahreskongress der Deutschen Gesellschaft für Radioonkologie (DEGRO), 3. bis 6. Juli 2014, Düsseldorf,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 190 2014, Nr. Suppl. 1, S. 15 -
Myeloid cell leukemia-1 and ubiquitin-specific protease 9x improve cells survival in irradiated A172 glioblastoma cellsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 190 2014, Nr. Suppl. 1, S. 80
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Prognostisches Modell für das Langzeit-Überleben von Patienten mit lokal fortgeschrittenem nicht-kleinzelligen Lungenkarzinom (NSCLC) nach neoadjuvanter Radiochemotherapie (RT/CT) und Resektion
20. Jahreskongress der Deutschen Gesellschaft für Radioonkologie (DEGRO), 3. bis 6. Juli 2014, Düsseldorf,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 190 2014, Nr. Suppl 1, S. 17 -
Radiation mediated cell death of esophagous squamous cell carcinoma cells is enhanced by down-regulation of stromal hyaluronan synthase 2
80th Annual Meeting of Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie, April 1-3, 2014, Hannover, Germany,In: Naunyn-Schmiedeberg's Archives of Pharmacology , Jg. 387 2014, Nr. Suppl. 1, S. 90 -
Thorax irradiation triggers a local and systemic accumulation of immunosuppressive CD4+FoxP3+regulatory T cells
20. Jahreskongress der Deutschen Gesellschaft für Radioonkologie (DEGRO), 03.-06.07.2014, Düsseldorf,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 190 2014, Nr. Suppl.1: Abstract-Band DEGRO 2014, S. 59 – 60 -
Whole thorax irradiation initiates a local and systemic accumulation of immunosuppressive FoxP3+regulatory T cells
23rd Biennial Congress of the European Association for Cancer Research, 05.–08.07.2014, München,In: European Journal of Cancer (EJC) , Jg. 50 2014, Nr. Suppl. 5, S. S223 -
Dihydroartemisinin exerts context-dependent lethal effects in combination with ionizing radiation
19. Jahreskongress der Deutschen Gesellschaft für Radioonkologie; 9. bis 12. Mai 2013, Berlin,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 189 2013, Nr. SUPPL. 1, S. 128 – 129 -
1118 Potential Role of Lymphocytes During DNA Damage-induced PneumopathyIn: European Journal of Cancer (EJC) , Jg. 48 2012, Nr. Suppl. 5, S. S269
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465 Vascular Remodeling of Tumor Blood Vessels as a Result of Anti-angiogenic Therapy : the Role of Vascular Wall-resident Mesenchymal Stem Cells Within These ProcessesIn: European Journal of Cancer (EJC) , Jg. 48 2012, Nr. Supplement 5, S. S112
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Concerted Action of Rab11 and Rab25 in Vesicle Trafficking During Cell MigrationIn: European Journal of Cancer (EJC) , Jg. 48 2012, S. S112
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Lymphocytes play a role in radiation-induced pneumopathyIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 188 2012, Nr. Suppl.1: Abstract-Band DEGRO 2014, S. 126 – 127
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Caspase-3-dependent cleavage and nuclear translocation of Heat Shock Protein 90 beta in apoptosis
51th Annual Meeting Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie Mainz, March 23 – 25, 2010,In: Naunyn-Schmiedeberg's Archives of Pharmacology , Jg. 381 2010, Nr. Suppl. 1, S. 59 -
A Dual HiBiT-GFP-LC3 Lentiviral Reporter for Autophagy Flux AssessmentIn: Autophagy and Cancer: Methods and Protocols / Norberg, Helin; Norberg, Erik (Hrsg.) 2022, S. 75 – 98
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Studying Autophagy In Vivo in the Mammary Gland and in Xenograft SamplesIn: Autophagy and Cancer: Methods and Protocols / Norberg, Helin; Norberg, Erik (Hrsg.) 2022, S. 255 – 272
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Inhibierung der AKT-abhängigen Regulation der antioxidant defense erhöht die Radiosensitivität von Krebszellen
28. Kongress der Deutschen Gesellschaft für Radioonkologie ; DEGRO 2022 ; 26. bis 28.05.2022, Stuttgart, Germany,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 198 2022, Nr. Supplement 1, S. S157DOI (Open Access) -
The citrate carrier SLC25A1 acts as regulator of metabolic reprogramming offering an innovative strategy for synthetic lethality approaches with radiotherapy
28. Kongress der Deutschen Gesellschaft für Radioonkologie ; DEGRO 2022 ; 26. bis 28.05.2022, Stuttgart, Germany,In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 198 2022, Nr. Supplement 1, S. S152 – S153DOI (Open Access) -
Abstract PO-022: Inhibition of the citrate carrier SLC25A1 affects repair of radiation-induced DNA damage, increases radiosensitivity, and enhances lethality of IR in combination with DNA repair defects or DSB inhibitors
AACR Virtual Special Conference on Radiation Science and Medicine; March 2-3, 2021, Online,In: Clinical Cancer Research , Jg. 27 2021, Nr. 8, Supplement, S. PO – 022DOI (Open Access)