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Prof. Dr. Eric Metzen

Universitätsklinikum Essen - Institut für Physiologie -

Anschrift
Hufelandstraße 55
45122 Essen
Webseite
http://www.uni-due.de/physiologie/

Funktionen

  • Universitätsprofessor/in, Institut für Physiologie

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Schreiber, Timm; Koll, Nora; Padberg, Claudia; de los Reyes, Buena; Quinting, Theresa; Malyshkina, Anna; Metzen, Eric; Sutter, Kathrin; Fandrey, Joachim; Winning, Sandra
    Reduced vacuolar ATPase protects mice from Friend virus infection : An unintended but instructive effect in Hif-2afl mice
    In: Journal of Cell Science, Jg. 137, 2024, Nr. 12, jcs261893
    DOI, Online Volltext (Open Access)
  • Dueva, Rositsa; Krieger, Lisa Marie; Li, Fanghua; Luo, Daxian; Xiao, Huaping; Stuschke, Martin; Metzen, Eric; Iliakis, George
    Chemical Inhibition of RPA by HAMNO Alters Cell Cycle Dynamics by Impeding DNA Replication and G2-to-M Transition but Has Little Effect on the Radiation-Induced DNA Damage Response
    In: International Journal of Molecular Sciences (IJMS), Jg. 24, 2023, Nr. 19, 14941
    DOI, Online Volltext (Open Access)
  • Hamidi, Akram; Wolf, Alexandra; Dueva, Rositsa; Kaufmann, Melanie; Göpelt, Kirsten; Iliakis, George; Metzen, Eric
    Depletion of HIF-1α by Inducible Cre/loxP Increases the Sensitivity of Cultured Murine Hepatocytes to Ionizing Radiation in Hypoxia
    In: Cells, Jg. 11, 2022, Nr. 10, 1671
    DOI, Online Volltext (Open Access)
  • Ocklenburg, Tobias; Neumann, Fabian; Wolf, Alexandra; Vogel, Julia; Göpelt, Kirsten; Baumann, Melanie; Baumann, Jennifer; Kranz, Philip; Metzen, Eric; Brockmeier, Ulf
    In oxygen-deprived tumor cells ERp57 provides radioprotection and ensures proliferation via c-Myc, PLK1 and the AKT pathway
    In: Scientific Reports, Jg. 11, 2021, Nr. 1, 7199
    DOI, Online Volltext (Open Access)
  • Küper, Alina; Baumann, Jennifer; Göpelt, Kirsten; Baumann, Melanie; Sänger, Christopher; Metzen, Eric; Kranz, Philip; Brockmeier, Ulf
    Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis
    In: Cell Death and Disease, Jg. 12, 2021, Nr. 1, 82
    DOI, Online Volltext (Open Access)
  • Bernardini, André; Wolf, Alexandra; Brockmeier, Ulf; Riffkin, Helena; Metzen, Eric; Acker-Palmer, Amparo; Fandrey, Joachim; Acker, Helmut
    Carotid body type I cells engage flavoprotein and Pin1 for oxygen sensing
    In: American Journal of Physiology: Cell Physiology, Jg. 318, 2020, Nr. 4, S. C719 – C731
    DOI (Open Access)
  • Kranz, Philip; Sänger, Christopher; Wolf, Alexandra; Baumann, Jennifer; Metzen, Eric; Baumann, Melanie; Göpelt, Kirsten; Brockmeier, Ulf
    Tumor cells rely on the thiol oxidoreductase PDI for PERK signaling in order to survive ER stress
    In: Scientific Reports, Jg. 10, 2020, Nr. 1, S. 15299
    DOI, Online Volltext (Open Access)
  • Classen, Fabian; Kranz, Philip; Riffkin, Helena; Pompsch, Mosche; Wolf, Alexandra; Göpelt, Kirsten; Baumann, Melanie; Baumann, Jennifer; Brockmeier, Ulf; Metzen, Eric
    Autophagy induced by ionizing radiation promotes cell death over survival in human colorectal cancer cells
    In: Experimental Cell Research, Jg. 374, 2019, Nr. 1, S. 29 – 37
    DOI (Open Access)
  • Pompsch, Mosche; Vogel, Julia; Classen, Fabian; Kranz, Philip; Iliakis, George; Riffkin, Helena; Brockmeier, Ulf; Metzen, Eric
    The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia.
    In: BMC Cancer, Jg. 18, 2018, S. 1190
    DOI (Open Access)
  • Kranz, Philip; Neumann, Fabian; Wolf, Alexandra; Classen, Fabian; Pompsch, Mosche; Ocklenburg, Tobias; Baumann, Jennifer; Janke, Kirsten; Baumann, Melanie; Goepelt, Kirsten; Riffkin, Helena; Metzen, Eric; Brockmeier, Ulf
    PDI is an essential redox-sensitive activator of PERK during the unfolded protein response (UPR).
    In: Cell Death and Disease, Jg. 8, 2017, Nr. 8, e2986
    DOI (Open Access)
  • Schütze, Alexandra; Vogeley, Christian; Gorges, Tobias; Twarock, Sören; Butschan, Jonas; Babayan, Anna; Klein, Diana; Knauer, Shirley; Metzen, Eric; Müller, Volkmar; Jendrossek, Verena; Pantel, Klaus; Milde-Langosch, Karin; Fischer, Jens W.; Röck, Katharina
    RHAMM splice variants confer radiosensitivity in human breast cancer cell lines
    In: OncoTarget, Jg. 7, 2016, Nr. 16, S. 21428 – 21440
    DOI (Open Access)
  • Matschke, Johann; Riffkin, Helena; Klein, Diana; Handrick, René; Lüdemann, Lutz; Metzen, Eric; Shlomi, Tomer; Stuschke, Martin; Jendrossek, Verena
    Targeted Inhibition of Glutamine-Dependent Glutathione Metabolism Overcomes Death Resistance Induced by Chronic Cycling Hypoxia
    In: Antioxidants and Redox Signaling, Jg. 25, 2016, Nr. 2, S. 89 – 107
    DOI
  • Hussmann, Melanie; Janke, Kirsten; Kranz, Philip; Neumann, Fabian; Mersch, Evgenija; Baumann, Melanie; Goepelt, Kirsten; Brockmeier, Ulf; Metzen, Eric
    Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics
    In: OncoTarget, Jg. 6, 2015, Nr. 36, S. 39247 – 39261
    DOI (Open Access)
  • Bernardini, Andre; Brockmeier, Ulf; Metzen, Eric; Berchner-Pfannschmidt, Utta; Harde, E.; Acker-Palmer, Amparo; Papkovsky, Dmitri B.; Acker, Helmut; Fandrey, Joachim
    Type I cell ROS kinetics under hypoxia in the intact mouse carotid body ex vivo : a FRET-based study
    In: American Journal of Physiology: Lung Cellular and Molecular Physiology, Jg. 308, 2015, Nr. 1, S. C61 – C67
    DOI
  • Janke, Kirsten; Brockmeier, Ulf; Kuhlmann, Katja; Eisenacher, Martin; Nolde, Jan; Meyer, Helmut E.; Mairbäurl, Heimo; Metzen, Eric
    Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2)
    In: Journal of Cell Science, Jg. 126, 2013, Nr. 12, S. 2629 – 2640
    DOI
  • Jin, Fengyan; Brockmeier, Ulf; Otterbach, Friedrich; Metzen, Eric
    New insight into the SDF-1/CXCR4 axis in a breast carcinoma model : Hypoxia-induced endothelial SDF-1 and tumor cell CXCR4 are required for tumor cell intravasation
    In: Molecular Cancer Research, Jg. 10, 2012, Nr. 8, S. 1021 – 1031
    DOI
  • Su, Yun; Loos, Martin; Giese, Natalia; Metzen, Eric; Büchler, Markus W.; Friess, Helmut; Kornberg, Arno; Büchler, Peter
    Prolyl hydroxylase-2 (PHD2) exerts tumor-suppressive activity in pancreatic cancer
    In: Cancer, Jg. 118, 2012, Nr. 4, S. 960 – 972
    DOI
  • Jin, Fengyan; Ji, Huifan; Jia, Chunshu; Brockmeier, Ulf; Hermann, Dirk M.; Metzen, Eric; Zhu, Yingqiao; Chi, Baorong
    Synergistic Antitumor Effects of Endostar in Combination with Oxaliplatin via Inhibition of HIF and CXCR4 in the Colorectal Cell Line SW1116
    In: PLoS ONE, Jg. 7, 2012, Nr. 10, S. e47161
    DOI (Open Access)
  • Jin, F.; Metzen, Eric; Hermann, Dirk M.
    LDL attenuates basal and VEGF165-induced endothelial proliferation, migration and tube formation in vitro
    In: European Journal of Neurology, Jg. 18, 2011, Nr. Suppl. 2, S. 105 – 105
  • Ströfer, Mareike; Jelkmann, Wolfgang; Metzen, Eric; Brockmeier, Ulf; Dunst, Jürgen; Depping, Reinhard
    Stabilisation and Knockdown of HIF - Two Distinct Ways Comparably Important in Radiotherapy
    In: Cellular Physiology and Biochemistry, Jg. 28, 2011, Nr. 5, S. 805 – 812
    DOI
  • Patak, Pauline; Jin, Fengyan; Schäfer, Simon; Metzen, Eric; Hermann, Dirk
    The ATP-binding cassette transporters ABCB1 and ABCC1 are not regulated by hypoxia in immortalised human brain microvascular endothelial cells
    In: Experimental and Translational Stroke Medicine, Jg. 3, 2011, Nr. 12
    DOI, Online Volltext (Open Access)
  • Brockmeier, Ulf; Platzek, Corinna; Schneider, Kirsten; Patak, Pauline; Bernardini, André; Fandrey, Joachim; Metzen, Eric
    The Function of Hypoxia-Inducible Factor (HIF) Is Independent of the Endoplasmic Reticulum Protein OS-9
    In: PLoS ONE, Jg. 6, 2011, Nr. 4, S. e19151
    DOI, Online Volltext (Open Access)
  • Metzen, Eric; Schneider, Kirsten
    How to Manipulate Cellular O2 Sensing
    In: Chemistry and Biology, Jg. 17, 2010, Nr. 4, S. 314 – 315
    DOI
  • Su, Y.; Loos, M.; Giese, N.; Hines, O.J.; Diebold, I.; Görlach, A.; Metzen, Eric; Pastorekova, S.; Friess, H.; Büchler, P.
    PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer
    In: British Journal of Cancer (BJC), Jg. 103, 2010, Nr. 10, S. 1571 – 1579
    DOI, Online Volltext (Open Access)

    • Abstracts

  • Schwartz, M.; Otto, Teresa; Brockmeier, U.; Lauterbach, S.; Metzen, Eric; Gulbins, Erich; Carpinteiro, Alexander; Scheerer, N.; Fandrey, Joachim
    Effects of nitric oxide on hematogenous metastasis
    9th International Luebeck Conference Pathophysiology and Pharmacology of Erythropoietin and other Hemopoietic Grow Factors, 13 - 15 July 2012, Lübeck, Germany,
    In: American Journal of Hematology. Hoboken: Wiley-Blackwell - STM, Jg. 87, 2012, Nr. 10, S. E112 – E112
    DOI

    • Beiträge in Sammelwerken und Tagungsbänden

  • Bernardini, Andre; Brockmeier, Ulf; Metzen, Eric; Berchner-Pfannschmidt, Utta; Harde, Eva; Acker-Palmer, Amparo; Papkovsky, Dmitri; Acker, Helmut; Fandrey, Joachim
    Measurement of ROS levels and membrane potential dynamics in the intact carotid body ex vivo
    In: Arterial Chemoreceptors in Physiology and Pathophysiology / XVIIIth Meeting of the International Society for Arterial Chemoreception ; Leeds, June 30 - July 3, 2014 / Peers, Chris; Kumar, Prem; Wyatt, Christopher; Gauda, Estelle; Nurse, Colin A.; Prabhakar, Nanduri (Hrsg.). Cham: Springer, 2015, S. 55 – 59
    DOI