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Prof. Dr. med. Dobromir Dobrev

14

Funktionen

Institutsdirektor/in, Institut für Pharmakologie

Aktuelle Veranstaltungen

WiSe 2025

Vergangene Veranstaltungen (max. 10)

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

Artikel in Zeitschriften

Poppenborg, Theresa; Saljic, Arnela; Bruns, Florian; Abu-Taha, Issam; Dobrev, Dobromir; Fender, Anke C.

A short history of the atrial NLRP3 inflammasome and its distinct role in atrial fibrillation

In: Journal of Molecular and Cellular Cardiology, Jg. 202, 2025, S. 13 – 23

DOI (Open Access)
Savarese, Gianluigi; Lindberg, Felix; Cannata, Antonio; Adamo, Marianna; Ambrosio, Giuseppe; Ameri, Pietro; Anker, Markus S.; Bäck, Magnus; Bayes-Genis, Antoni; Ben Gal, Tuvia; Braunschweig, Frieder; Chioncel, Ovidiu; D'Elia, Emilia; El-Tamimi, Hassan; Filippatos, Gerasimos; Girerd, Nicolas; Hill, Loreena; Jankowska, Ewa; Khunti, Kamlesh; Lewis, Basil S.; Moura, Brenda; Amir, Offer; Paolillo, Stefania; Piepoli, Massimo; Shehab, Abdulla; Simpson, Maggie; Skouri, Hadi; Stolfo, Davide; Tocchetti, Carlo Gabriele; Vitale, Cristiana; Volterrani, Maurizio; von Haehling, Stephan; Wassmann, Sven; Yilmaz, Mehmet Birhan; Kaski, Juan Carlos; Dobrev, Dobromir; Metra, Marco; Rosano, Giuseppe M.C.

Adherence to guideline‐directed medical treatments in heart failure : A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Cardiovascular Pharmacotherapy

In: European Journal of Heart Failure, 2025, in press

DOI (Open Access)
Sandner, Sigrid; Gaudino, Mario; Agewall, Stefan; Bonalumi, Giorgia; Bonaros, Nikolaos; Czerny, Martin; Jeppsson, Anders; Milojevic, Milan; Niessner, Alexander; Parolari, Alessandro; Sulzgruber, Patrick; Tamargo, Juan; Thielmann, Matthias Klaus; Wassmann, Sven; Zientara, Alicja; Dobrev, Dobromir

Antithrombotic therapy after coronary artery bypass graft surgery : a Clinical Consensus Statement of the ESC Working Group on Cardiovascular Surgery, the ESC Working Group on Cardiovascular Pharmacotherapy, and the European Association for Cardio-Thoracic Surgery (EACTS)

In: European Journal of Cardio-Thoracic Surgery, Jg. 67, 2025, Nr. 8, ezaf243

DOI (Open Access)
Yuan, Yue; Martsch, Pascal; Chen, Xiaohui; Martinez, Enrique; Li, Luge; Song, Jia; Poppenborg, Theresa; Bruns, Florian; Kim, Jong Hwan; Kamler, Markus; Martin, James F; Abu-Taha, Issam; Dobrev, Dobromir; Li, Na

Atrial cardiomyocyte-restricted cleavage of gasdermin D promotes atrial arrhythmogenesis

In: European Heart Journal, Jg. 46, 2025, Nr. 13, S. 1250 – 1262

DOI (Open Access)
Weerts, Jerremy; Țica, Otilia; Aranyo, Julia; Basile, Christian; Borizanova-Petkova, Angelina; Borovac, Josip Andjelo; Camilli, Massimiliano; Eichenlaub, Martin; Fiori, Emiliano; Van Loon, Tim; Withaar, Coenraad; Zakarkaitė, Diana; Zink, Matthias D.; Adamo, Marianna; Aimo, Alberto; Arbelo, Elena; Bisbal Van Bylen, Felipe; Farmakis, Dimitrios T.; Dobrev, Dobromir; Čelutkienė, Jelena; Böhm, Michael; Coats, Andrew; Metra, Marco; Rosano, Giuseppe; Ruschitzka, Frank; Bayes-Genis, Antoni; Kotecha, Dipak

Atrial cardiomyopathy : From healthy atria to atrial failure. A clinical consensus statement of the Heart Failure Association of the ESC

In: European Journal of Heart Failure, 2025, in press

DOI (Open Access)
Doehner, Wolfram; Boriani, Giuseppe; Potpara, Tatjana; Blomstrom-Lundqvist, Carina; Passman, Rod; Sposato, Luciano A.; Dobrev, Dobromir; Freedman, Ben; Van Gelder, Isabelle C.; Glotzer, Taya V.; Healey, Jeff S.; Karapanayiotides, Theodore; Lip, Gregory Y. H.; Merino, Jose Luis; Ntaios, George; Schnabel, Renate B.; Svendsen, Jesper H.; Svennberg, Emma; Wachter, Rolf; Haeusler, Karl Georg; Camm, A John

Atrial fibrillation burden in clinical practice, research, and technology development : A clinical consensus statement of the European Society of Cardiology Council on Stroke and the European Heart Rhythm Association

In: EP Europace, Jg. 27, 2025, Nr. 3, euaf019

DOI (Open Access)
Lerchner, Tobias; Mincu, Raluca; Bühning, Florian; Vogel, Julia; Klingel, Karin; Meetschen, Mathias; Schlosser, Thomas Wilfried; Haubold, Johannes; Umutlu, Lale; Dobrev, Dobromir; Totzeck, Matthias; Rassaf, Tienush; Michel, Lars

Cardiac magnetic resonance imaging in patients with suspected myocarditis from immune checkpoint inhibitor therapy : A real-world observational study

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 56, 2025, 101581

DOI (Open Access)
Klingenberg, Roland; Leiherer, Andreas; Dobrev, Dobromir; Kaski, Juan C.; Levkau, Bodo; März, Winfried; Sossalla, Samuel; Von Eckardstein, Arnold; Drexel, Heinz

Ceramides in cardiovascular disease : emerging role as independent risk predictors and novel therapeutic targets

In: Cardiovascular Research, Jg. 121, 2025, Nr. 9, S. 1345 – 1358

DOI (Open Access)
Khorasani, Najme; Ni, Haibo; Saucerman, Jeffrey J; Dobrev, Dobromir; Morotti, Stefano; Grandi, Eleonora

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca²⁺ in driving atrial fibrillation-associated fibrosis

In: Journal of Physiology, 2025, in press

DOI
Meier, Stefan; Dobrev, Dobromir; Volders, Paul G. A.; Heijman, Jordi

Computational modelling of the pro- and antiarrhythmic effects of atrial high rate-dependent trafficking of small-conductance calcium-activated potassium channels

In: Journal of Physiology, 2025, in press

DOI (Open Access)
Mittendorff, Claudia; Abu-Taha, Issam; Kassler, Lena; Hustedt, Tobias; Wolf, Stephanie; Bode, Johannes G.; Kamler, Markus; Dobrev, Dobromir; Fender, Anke C.

Correction: Thrombin receptor PAR4 cross-activates the tyrosine kinase c-met in atrial cardiomyocytes

In: Naunyn-Schmiedeberg's Archives of Pharmacology, Jg. 398, 2025, Nr. 3, S. 3181 – 3182

DOI (Open Access)
Mittendorff, Claudia; Abu-Taha, Issam; Kassler, Lena; Hustedt, Tobias; Wolf, Stephanie; Bode, Johannes G.; Kamler, Markus; Dobrev, Dobromir; Fender, Anke C.

Correction: Thrombin receptor PAR4 cross‑activates the tyrosine kinase c‑met in atrial cardiomyocytes

In: Naunyn-Schmiedeberg's Archives of Pharmacology, Jg. 398, 2025, Nr. 10, S. 14547 – 14548

DOI (Open Access)
Dobrev, Dobromir; Tamargo, Juan; Szymański, Piotr

Critical medications in cardiology : strategic policy of the European Medicines Agency

In: European Heart Journal, Jg. 46, 2025, Nr. 26, S. 2491 – 2493

DOI (Open Access)
Luedde, Mark; Agewall, Stefan; Ambrosio, Giuseppe; Bayes-Genis, Antoni; Borghi, Claudio; Cerbai, Elisabetta; Dan, Gheorghe A.; Drexel, Heinz; Ferdinandy, Péter; Grove, Erik Lerkevang; Kaski, Juan Carlos; Klingenberg, Roland; Morais, Joao; Parker, William; Petrie, Mark C.; Rocca, Bianca; Semb, Anne Grete; Senni, Michele; Sohns, Christian; Sulzgruber, Patrick; Tamargo, Juan; Metra, Marco; Böhm, Michael; Dobrev, Dobromir; Sossalla, Samuel

European Journal of Heart Failure consensus statement : Heart failure pharmacotherapy for patients with heart failure with reduced ejection fraction and concomitant atrial fibrillation: Review of evidence and call to action

In: European Journal of Heart Failure, 2025, in press

DOI (Open Access)
Isaksen, Jonas L.; Nørregaard, Malene; Manninger, Martin; Dobrev, Dobromir; Jespersen, Thomas; Hermans, Ben; Heijman, Jordi; Plank, Gernot; Scherr, Daniel; Pock, Thomas; Thambawita, Vajira; Riegler, Michael A.; Kanters, Jørgen K.; Linz, Dominik

Evaluating artificial intelligence-enabled medical tests in cardiology : Best practice

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 60, 2025, 101783

DOI (Open Access)
Li, Luge; Coarfa, Cristian; Yuan, Yue; Abu-Taha, Issam; Wang, Xiaolei; Song, Jia; Zeng, Yuying; Chen, Xiaohui; Koirala, Amrit; Grimm, Sandra L.; Kamler, Markus; McClendon, Lisa K.; Tallquist, Michelle; Nattel, Stanley; Dobrev, Dobromir; Li, Na

Fibroblast-Restricted Inflammasome Activation Promotes Atrial Fibrillation and Heart Failure With Diastolic Dysfunction

In: JACC: Basic to Translational Science, Jg. 10, 2025, Nr. 7, 101244

DOI (Open Access)
Brand, Theresa; Baumgarten, Bettina Tanitha; Denzinger, Sabrina; Reinders, Yvonne; Kleindl, Miriam; Schanbacher, Constanze; Funk, Florian; Gedik, Nilgün; Jabbasseh, Mahmood; Kleinbongard, Petra; Dudek, Jan; Szendroedi, Julia; Tolstik, Elen; Schuh, Kai; Krüger, Martina; Dobrev, Dobromir; Cuello, Friederike; Sickmann, Albert; Schmitt, Joachim P.; Lorenz, Kristina

From Ca²⁺ dysregulation to heart failure : β-adrenoceptor activation by RKIP postpones molecular damages and subsequent cardiac dysfunction in mice carrying mutant PLNR⁹C by correction of aberrant Ca²⁺-handling

In: Pharmacological Research, Jg. 211, 2025, 107558

DOI (Open Access)
Xie, An; Kang, Gyeoung-Jin; Liu, Hong; Kim, Eun Ji; Feng, Feng; Dobrev, Dobromir; Dudley, Samuel C.

Lysosomal Ca²⁺ Release Through TRPML1 Governs Ventricular Arrhythmia After Myocardial Infarction

In: Circulation: Arrhythmia and Electrophysiology, Jg. 18, 2025, Nr. 11, e013964

DOI (Open Access)
Keefe, Joshua A.; Aguilar-Sanchez, Yuriana; Navarro-Garcia, J. Alberto; Ong, Isabelle; Li, Luge; Paasche, Amelie; Abu-Taha, Issam; Tekook, Marcel A.; Bruns, Florian; Zhao, Shuai; Kamler, Markus; Shen, Ying H.; Chelu, Mihail G.; Li, Na; Dobrev, Dobromir; Wehrens, Xander H.T.

Macrophage-mediated IL-6 signaling drives ryanodine receptor–2 calcium leak in postoperative atrial fibrillation

In: The Journal of Clinical Investigation (JCI), Jg. 135, 2025, Nr. 9, e187711

DOI (Open Access)
Kaser, Susanne; Dobrev, Dobromir; Rocca, Bianca; Kaski, Juan Carlos; Agewall, Stefan; Drexel, Heinz

Management of dyslipidaemia in patients with comorbidities : facing the challenge: type 1 diabetes mellitus

In: European Heart Journal - Cardiovascular Pharmacotherapy, Jg. 11, 2025, Nr. 4, S. 380 – 386

DOI (Open Access)
Frühwald, Lisa; Fasching, Peter; Dobrev, Dobromir; Kaski, Juan Carlos; Borghi, Claudio; Wassmann, Sven; Huber, Kurt; Semb, Anne Grete; Agewall, Stefan; Drexel, Heinz

Management of dyslipidaemia in patients with comorbidities : facing the challenge Value and limitations of lipid lowering drugs in liver disease Effects/Interactions of lipid-lowering agents on/with the liver

In: European Heart Journal - Cardiovascular Pharmacotherapy, Jg. 11, 2025, Nr. 2, S. 164 – 173

DOI (Open Access)
Herrera, Nathaniel T.; Ni, Haibo; Smith, Charlotte E. R.; Wu, Yixuan; Dobrev, Dobromir; Morotti, Stefano; Grandi, Eleonora

Mechanistic insights into sex differences in atrial electrophysiology and arrhythmia vulnerability through sex-specific computational models

In: Journal of Physiology, 2025, in press

DOI (Open Access)
Tamargo, Juan; Agewall, Stefan; Ambrosio, Giuseppe; Borghi, Claudio; Cerbai, Elisabetta; Dan, Gheorghe A.; Drexel, Heinz; Ferdinandy, Péter; Grove, Erik Lerkevang; Klingenberg, Roland; Morais, Joao; Parker, William; Rocca, Bianca; Sulzgruber, Patrick; Semb, Anne Grete; Sossalla, Samuel; Kaski, Juan Carlos; Dobrev, Dobromir

New pharmacological agents and novel cardiovascular pharmacotherapy strategies in 2024

In: European Heart Journal - Cardiovascular Pharmacotherapy, Jg. 11, 2025, Nr. 3, S. 292 – 317

DOI (Open Access)
Noujaim, Sami F.; Dobrev, Dobromir

Non-neuronal ventricular cardiomyocyte-located nicotinergic acetylcholine receptors cause remodelling and arrhythmias

In: European Heart Journal, Jg. 46, 2025, Nr. 13, S. 1247 – 1249

DOI
Merino, Jose L.; Tamargo, Juan; Blomström-Lundqvist, Carina; Boriani, Giuseppe; Crijns, Harry J G M; Dobrev, Dobromir; Goette, Andreas; Hohnloser, Stefan H.; Naccarelli, Gerald V.; Reiffel, James A.; Tfelt-Hansen, Jacob; Martínez-Cossiani, Marcel; Camm, A John; Almendral Garrote, Jesus M.; Średniawa, Beata; Kułakowski, Piotr; Savelieva, Irina; Potpara, Tatjana; Gorenek, Bulent; Zamorano, Jose L.

Practical compendium of antiarrhythmic drugs : A clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology

In: EP Europace, Jg. 27, 2025, Nr. 8, euaf076

DOI (Open Access)
Behr, Elijah R; Winkel, Bo Gregers; Ensam, Bode; Alfie, Alberto; Arbelo, Elena; Berry, Colin; Cerrone, Marina; Conte, Giulio; Crotti, Lia; Gonzalez Corcia, Cecilia M; Kaski, Juan Carlos; Nademanee, Koonlawee; Postema, Pieter G; Priori, Silvia; Probst, Vincent; Sarquella-Brugada, Georgia; Schulze-Bahr, Eric; Tadros, Rafik; Wilde, Arthur; Tfelt-Hansen, Jacob; Wolpert, Christian; Cuesta, Alejandro; Damman, Peter; Dobrev, Dobromir; Drago, Fabrizio; Haugaa, Kristina; Krahn, Andrew; Krause, Ulrich; Lambiase, Pier D; Napolitano, Carlo; Odening, Katja E; Shimizu, Wataru; Veltmann, Christian

The diagnostic role of pharmacological provocation testing in cardiac electrophysiology : A clinical consensus statement of the European Heart Rhythm Association (EHRA) and the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC, the ESC Working Group on Cardiovascular Pharmacotherapy, the Association of Paediatric and Congenital Cardiology (AEPC), the Paediatric & Congenital Electrophysiology Society (PACES), the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS)

In: EP Europace, Jg. 27, 2025, Nr. 4, euaf067

DOI (Open Access)
Abu-Taha, Issam; Wiesmann, Frauke; Dobrev, Dobromir; Fender, Anke

Thrombin engages neutrophil-derived secretion products to upregulate interleukin-6 production in atrial cardiomyocytes and the heart

In: Romanian Journal of Cardiology, Jg. 35, 2025, Nr. 3, S. 188 – 193

DOI (Open Access)
Mittendorff, Claudia; Abu-Taha, Issam; Kassler, Lena; Hustedt, Tobias; Wolf, Stephanie; Bode, Johannes G.; Kamler, Markus; Dobrev, Dobromir; Fender, Anke C.

Thrombin receptor PAR4 cross-activates the tyrosine kinase c-met in atrial cardiomyocytes

In: Naunyn-Schmiedeberg's Archives of Pharmacology, Jg. 398, 2025, Nr. 3, S. 2783 – 2796

DOI (Open Access)
Song, Jia; Wu, Jiao; Robichaux, Dexter J.; Li, Tingting; Wang, Shuyue; Arredondo Sancristobal, Maria J.; Dong, Bingning; Dobrev, Dobromir; Karch, Jason; Thomas, Sandhya S.; Li, Na

A High-Protein Diet Promotes Atrial Arrhythmogenesis via Absent-in-Melanoma 2 Inflammasome

In: Cells, Jg. 13, 2024, Nr. 2, 108

DOI (Open Access)
Hiram, Roddy; Xiong, Feng; Naud, Patrice; Xiao, Jiening; Sosnowski, Deanna K; Le Quilliec, Ewen; Saljic, Arnela; Abu-Taha, Issam H; Kamler, Markus; LeBlanc, Charles-Alexandre; Al-U’Datt, Doa’a G F; Sirois, Martin G; Hebert, Terence E; Tanguay, Jean-François; Tardif, Jean-Claude; Dobrev, Dobromir; Nattel, Stanley

An inflammation resolution–promoting intervention prevents atrial fibrillation caused by left ventricular dysfunction

In: Cardiovascular Research, Jg. 120, 2024, Nr. 4, S. 345 – 359

DOI
Goette, Andreas; Corradi, Domenico; Dobrev, Dobromir; Aguinaga, Luis; Cabrera, Jose-Angel; Chugh, Sumeet S.; de Groot, Joris R.; Soulat-Dufour, Laurie; Fenelon, Guilherme; Hatem, Stephane N.; Jalife, Jose; Lin, Yenn-Jiang; Lip, Gregory Y H; Marcus, Gregory M.; Murray, Katherine T.; Pak, Hui-Nam; Schotten, Ulrich; Takahashi, Naohiko; Yamaguchi, Takanori; Zoghbi, William A.; Nattel, Stanley; Mont, Lluis; Akar, Joseph G.; Akoum, Nazem; Althoff, Till; Diaz, Juan Carlos; Guichard, Jean-Baptiste; Jadidi, Amir; Kalman, Jonathan; Lim, Han; Teixeira, Ricardo Alkmim

Atrial cardiomyopathy revisited-evolution of a concept: : a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS)

In: EP Europace, Jg. 26, 2024, Nr. 9

DOI (Open Access)
Vinciguerra, Manlio; Dobrev, Dobromir; Nattel, Stanley

Atrial fibrillation : Pathophysiology, genetic and epigenetic mechanisms

In: The Lancet Regional Health - Europe, Jg. 37, 2024, 100785

DOI (Open Access)
Kalarus, Zbigniew; Mairesse, Georges H; Sokal, Adam; Boriani, Giuseppe; Średniawa, Beata; Casado-Arroyo, Ruben; Wachter, Rolf; Frommeyer, Gerrit; Traykov, Vassil; Dagres, Nikolaos; Lip, Gregory Y H; Boersma, Lucas; Peichl, Petr; Dobrev, Dobromir; Bulava, Alan; Blomström-Lundqvist, Carina; de Groot, Natasja M S; Schnabel, Renate; Heinzel, Frank; van Gelder, Isabelle C; Carbuccichio, Corrado; Shah, Dipen; Eckardt, Lars

Correction to: Searching for atrial fibrillation: looking harder, looking longer, and in increasingly sophisticated ways. An EHRA position paper

In: EP Europace, Jg. 26, 2024, Nr. 6, euae167

DOI (Open Access)
Kupusovic, Jana; Kessler, Lukas; Kazek, Sandra; Chodyla, Michal Kamil; Umutlu, Lale; Zarrad, Fadi; Nader, Michael; Fendler, Wolfgang; Varasteh, Zohreh; Herrmann, Ken; Dobrev, Dobromir; Wakili, Reza; Rassaf, Tienush; Siebermair, Johannes; Rischpler, Christoph

Delayed ⁶⁸Ga-FAPI-46 PET/MR imaging confirms ongoing fibroblast activation in patients after acute myocardial infarction

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 50, 2024, 101340

DOI (Open Access)
Michel, Lars; Jehn, Stefanie; Dykun, Iryna; Anker, Markus S.; Ferdinandy, Peter; Dobrev, Dobromir; Rassaf, Tienush; Mahabadi, Amir Abbas; Totzeck, Matthias

Detectable troponin below the 99th percentile predicts survival in patients undergoing coronary angiography

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 52, 2024, 101419

DOI, Online Volltext (Open Access)
Fleischer, Michael; Szepanowski, Rebecca D.; Pesara, Valeria; Bihorac, Julia Sophie; Oehler, Beatrice; Dobrev, Dobromir; Kleinschnitz, Christoph; Fender, Anke C.

Direct neuronal protection by the protease-activated receptor PAR4 antagonist ML354 after experimental stroke in mice

In: British Journal of Pharmacology (BJP), Jg. 181, 2024, Nr. 18, S. 3364 – 3379

DOI (Open Access)
Zhang, Xianwei; Wu, Yixuan; Smith, Charlotte E.R.; Louch, William E.; Morotti, Stefano; Dobrev, Dobromir; Grandi, Eleonora; Ni, Haibo

Enhanced Ca²⁺-Driven Arrhythmogenic Events in Female Patients With Atrial Fibrillation: Insights From Computational Modeling

In: JACC Clinical Electrophysiology, Jg. 10, 2024, Nr. 11, S. 2371 – 2391

DOI (Open Access)
Pelliccia, Francesco; Zimarino, Marco; Giordano, Melania; Dobrev, Dobromir

Feasibility of anticoagulation on demand after percutaneous coronary intervention in high-bleeding risk patients with paroxysmal atrial fibrillation : the INTERMITTENT registry

In: European Heart Journal - Digital Health, Jg. 5, 2024, Nr. 5, S. 637 – 642

DOI (Open Access)
Saljic, Arnela; Heijman, Jordi; Dobrev, Dobromir

From Atrial Small-conductance Calcium-activated Potassium Channels to New Antiarrhythmics

In: European Cardiology Review, Jg. 19, 2024, e26

DOI (Open Access)
Sayour, Nabil V; Paál, Ágnes M; Ameri, Pietro; Meijers, Wouter C; Minotti, Giorgio; Andreadou, Ioanna; Lombardo, Antonella; Camilli, Massimiliano; Drexel, Heinz; Grove, Erik Lerkevang; Dan, Gheorghe Andrei; Ivanescu, Andreea; Semb, Anne Grete; Savarese, Gianluigi; Dobrev, Dobromir; Crea, Filippo; Kaski, Juan-Carlos; de Boer, Rudolf A; Ferdinandy, Péter; Varga, Zoltán V

Heart failure pharmacotherapy and cancer : Pathways and pre-clinical/clinical evidence

In: European Heart Journal, Jg. 45, 2024, Nr. 14, S. 1224 – 1240

DOI (Open Access)
Jungen, Christiane; Rattka, Manuel; Bohnen, Jan; Mavrakis, Evangelos; Vlachopoulou, Dimitra; Dorna, Sebastian; Rudolph, Isabel; Kohn, Christina; Dobrev, Dobromir; Rassaf, Tienush; Mathew, Shibu

Impact of overweight and obesity on radiation dose and outcome in patients undergoing pulmonary vein isolation by cryoballoon and pulsed field ablation

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 55, 2024, 101516

DOI (Open Access)
Navarro-Garcia, Jose Alberto; Bruns, Florian; Moore, Oliver M.; Tekook, Marcel A.; Dobrev, Dobromir; Miyake, Christina Y.; Wehrens, Xander H.T.

In Vivo Cardiac Electrophysiology in Mice : Determination of Atrial and Ventricular Arrhythmic Substrates

In: Current Protocols, Jg. 4, 2024, Nr. 2, e994

DOI
Mann, Constantin; van Alst, Carolin; Gorressen, Simone; Nega, Rachel; Dobrev, Dobromir; Grandoch, Maria; Fender, Anke C.

Ischemia does not provoke the full immune training repertoire in human cardiac fibroblasts

In: Naunyn-Schmiedeberg's Archives of Pharmacology, Jg. 397, 2024, Nr. 9, S. 7201 – 7212

DOI (Open Access)
Linz, Dominik; Andrade, Jason G.; Arbelo, Elena; Boriani, Giuseppe; Breithardt, Guenter; Camm, A. John; Caso, Valeria; Nielsen, Jens Cosedis; De Melis, Mirko; De Potter, Tom; Dichtl, Wolfgang; Diederichsen, Søren Zoega; Dobrev, Dobromir; Doll, Nicolas; Duncker, David; Dworatzek, Elke; Eckardt, Lars; Eisert, Christoph; Fabritz, Larissa; Farkowski, Michal; Filgueiras-Rama, David; Goette, Andreas; Guasch, Eduard; Hack, Guido; Hatem, Stéphane; Haeusler, Karl Georg; Healey, Jeff S.; Heidbuechel, Hein; Hijazi, Ziad; Hofmeister, Lucas H.; Hove-Madsen, Leif; Huebner, Thomas; Kääb, Stefan; Kotecha, Dipak; Malaczynska-Rajpold, Katarzyna; Merino, José Luis; Metzner, Andreas; Mont, Lluís; Ng, Ghulam Andre; Oeff, Michael; Parwani, Abdul Shokor; Puererfellner, Helmut; Ravens, Ursula; Rienstra, Michiel; Sanders, Prashanthan; Scherr, Daniel; Schnabel, Renate; Schotten, Ulrich; Sohns, Christian; Steinbeck, Gerhard; Steven, Daniel; Toennis, Tobias; Tzeis, Stylianos; van Gelder, Isabelle C.; van Leerdam, Roderick H.; Vernooy, Kevin; Wadhwa, Manish; Wakili, Reza; Willems, Stephan; Witt, Henning; Zeemering, Stef; Kirchhof, Paulus

Longer and better lives for patients with atrial fibrillation : The 9th AFNET/EHRA consensus conference

In: EP Europace, Jg. 26, 2024, Nr. 4, euae070

DOI (Open Access)
Mayer, Gert; Dobrev, Dobromir; Kaski, Juan Carlos; Semb, Anne Grete; Huber, Kurt; Zirlik, Andreas; Agewall, Stefan; Drexel, Heinz

Management of dyslipidaemia in patients with comorbidities : Facing the challenge

In: European Heart Journal - Cardiovascular Pharmacotherapy, Jg. 10, 2024, Nr. 7, S. 608 – 613

DOI
Tamargo, Juan; Agewall, Stefan; Borghi, Claudio; Ceconi, Claudio; Cerbai, Elisabetta; Dan, Gheorghe A; Ferdinandy, Péter; Grove, Erik Lerkevang; Rocca, Bianca; Magavern, Emma; Sulzgruber, Patrick; Semb, Anne Grete; Sossalla, Samuel; Niessner, Alexander; Kaski, Juan Carlos; Dobrev, Dobromir

New pharmacological agents and novel cardiovascular pharmacotherapy strategies in 2023

In: European Heart Journal - Cardiovascular Pharmacotherapy, Jg. 10, 2024, Nr. 3, S. 219 – 244

DOI, Online Volltext (Open Access)
Haller, Paul M.; Kazem, Niema; Agewall, Stefan; Borghi, Claudio; Ceconi, Claudio; Dobrev, Dobromir; Cerbai, Elisabetta; Grove, Erik Lerkevang; Kaski, Juan Carlos; Lewis, Basil S.; Niessner, Alexander; Rocca, Bianca; Rosano, Giuseppe; Savarese, Gianluigi; Schnabel, Renate B.; Semb, Anne Grete; Sossalla, Samuel; Wassmann, Sven; Sulzgruber, Patrick

Oral anticoagulation in patients with left ventricular thrombus : a systematic review and meta-analysis

In: European Heart Journal - Cardiovascular Pharmacotherapy, Jg. 10, 2024, Nr. 5, S. 444 – 453

DOI
Vonderlin, Nadine; Siebermair, Johannes; Mahabadi, Amir Abbas; Dobrev, Dobromir; Rassaf, Tienush; Wakili, Reza; Kochhaeuser, S.

Outcome after ablation of atypical atrial flutter : Is induction a feasible approach?

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 54, 2024, 101489

DOI (Open Access)
Delcea, Caterina; Buzea, Catalin Adrian; Dobrev, Dobromir; Andrei Dan, Gheorghe

Prognostic roles of neutrophil–lymphocyte, monocyte-lymphocyte and platelet-lymphocyte ratios for long-term all-cause mortality in heart failure

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 54, 2024, 101502

DOI (Open Access)
Radico, Francesco; Biancari, Fausto; D'Ascenzo, Fabrizio; Saia, Francesco; Luzi, Giampaolo; Bedogni, Francesco; Amat-Santos, Ignacio J.; De Marzo, Vincenzo; Dimagli, Arnaldo; Mäkikallio, Timo; Stabile, Eugenio; Blasco-Turrión, Sara; Testa, Luca; Barbanti, Marco; Tamburino, Corrado; Porto, Italo; Fabiocchi, Franco; Conrotto, Federico; Pelliccia, Francesco; Costa, Giuliano; Stefanini, Giulio G.; Macchione, Andrea; La Torre, Michele; Bendandi, Francesco; Juvonen, Tatu; Pasceri, Vincenzo; Wańha, Wojciech; Benedetto, Umberto; Miraldi, Fabio; Dobrev, Dobromir; Zimarino, Marco

Red blood cell transfusion and mortality after transcatheter aortic valve implantation via transapical approach : A propensity-matched comparison from the TRITAVI registry

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 53, 2024, 101460

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Niskala, Alisha; Heijman, Jordi; Dobrev, Dobromir; Jespersen, Thomas; Saljic, Arnela

Targeting the NLRP3 inflammasome signalling for the management of atrial fibrillation

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Dobrev, Dobromir; Rocca, Bianca; Kaski, Juan-Carlos

The ESC Working Group on cardiovascular pharmacotherapy : Continuity through transformation

In: European Heart Journal - Cardiovascular Pharmacotherapy, Jg. 10, 2024, Nr. 7, S. 571

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Betz, Konstanze; Giordano, Melania; Hillmann, Henrike Aenne Katrin; Duncker, David; Dobrev, Dobromir; Linz, Dominik

The impact of Twitter/X promotion on visibility of research articles : Results of the #TweetTheJournal study

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 50, 2024, 101328

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Mehdizadeh, Mozhdeh; Naud, Patrice; Abu-Taha, Issam H; Hiram, Roddy; Xiong, Feng; Xiao, Jiening; Saljic, Arnela; Kamler, Markus; Vuong-Robillard, Nhung; Thorin, Eric; Ferbeyre, Gerardo; Tardif, Jean-Claude; Sirois, Martin G; Tanguay, Jean Francois; Dobrev, Dobromir; Nattel, Stanley

The role of cellular senescence in profibrillatory atrial remodelling associated with cardiac pathology

In: Cardiovascular Research, Jg. 120, 2024, Nr. 5, S. 506 – 518

DOI, Online Volltext (Open Access)
Kleeschulte, Sonja; Fischinger, Vivien; Öhlke, Lisa; Bode, Johannes; Kamler, Markus; Dobrev, Dobromir; Grandoch, Maria; Fender, Anke C.

The thrombin receptor PAR4 supports visceral adipose tissue inflammation

In: Naunyn-Schmiedeberg's Archives of Pharmacology, 2024

DOI (Open Access)
Gigante, Bruna; Tamargo, Juan; Agewall, Stefan; Atar, Dan; ten Berg, Jurrien; Campo, Gianluca; Cerbai, Elisabetta; Christersson, Christina; Dobrev, Dobromir; Ferdinandy, Péter; Geisler, Tobias; Gorog, Diana A.; Grove, Erik L.; Kaski, Juan Carlos; Rubboli, Andrea; Wassmann, Sven; Wallen, Håkan; Rocca, Bianca

Update on antithrombotic therapy and body mass : A clinical consensus statement of the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy and the European Society of Cardiology Working Group on Thrombosis

In: European Heart Journal - Cardiovascular Pharmacotherapy, Jg. 10, 2024, Nr. 7, S. 614 – 645

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Gawałko, Monika; Saljic, Arnela; Li, Na; Abu-Taha, Issam; Jespersen, Thomas; Linz, Dominik; Nattel, Stanley; Heijman, Jordi; Fender, Anke; Dobrev, Dobromir

Adiposity-associated atrial fibrillation : Molecular determinants, mechanisms, and clinical significance

In: Cardiovascular Research, Jg. 119, 2023, Nr. 3, S. 614 – 630

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Vonderlin, Nadine; Siebermair, Johannes; Mahabadi, Amir Abbas; Pesch, Elena; Köhler, Miriam; Dobrev, Dobromir; Janosi, Rolf Alexander; Rassaf, Tienush; Wakili, Reza

Characterization of temporal electrical activity patterns for detection of critical isthmus regions of recurrent atypical atrial flutter

In: Clinical Cardiology, Jg. 46, 2023, Nr. 5, S. 574 – 583

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Song, Jia; Navarro-Garcia, Jose Alberto; Wu, Jiao; Saljic, Arnela; Abu-Taha, Issam; Li, Luge; Lahiri, Satadru K.; Keefe, Joshua A.; Aguilar-Sanchez, Yuriana; Moore, Oliver M.; Yuan, Yue; Wang, Xiaolei; Kamler, Markus; Mitch, William E.; Ruiz-Hurtado, Gema; Hu, Zhaoyong; Thomas, Sandhya S.; Dobrev, Dobromir; Wehrens, Xander Ht; Li, Na

Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation

In: The Journal of Clinical Investigation (JCI), Jg. 133, 2023, Nr. 19, e167517

DOI (Open Access)
Heijman, Jordi; Dobrev, Dobromir

Determinants and therapeutic potential of calcium handling abnormalities in atrial fibrillation : what can we learn from computer models?

In: Journal of Physiology, Jg. 601, 2023, Nr. 13, Special Issue: Cell diversity and signalling in the cardiovascular system, S. 2545 – 2546

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Grandi, Eleonora; Navedo, Manuel F.; Saucerman, Jeffrey J.; Bers, Donald M.; Chiamvimonvat, Nipavan; Dixon, Rose E.; Dobrev, Dobromir; Gomez, Ana M.; Harraz, Osama F.; Hegyi, Bence; Jones, David K.; Krogh-Madsen, Trine; Murfee, Walter Lee; Nystoriak, Matthew A.; Posnack, Nikki G.; Ripplinger, Crystal M.; Veeraraghavan, Rengasayee; Weinberg, Seth

Diversity of cells and signals in the cardiovascular system

In: Journal of Physiology, Jg. 601, 2023, Nr. 13: Special Issue: Cell diversity and signalling in the cardiovascular system, S. 2547 – 2592

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Wang, Xiaolei; Song, Jia; Yuan, Yue; Li, Luge; Abu-Taha, Issam; Heijman, Jordi; Sun, Liang; Dobrev, Shokoufeh; Kamler, Markus; Xie, Liang; Wehrens, Xander H.T.; Horrigan, Frank T.; Dobrev, Dobromir; Li, Na

Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis

In: Circulation Research, Jg. 133, 2023, Nr. 1, S. e1 – e16

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Herrera, Nathaniel T.; Zhang, Xianwei; Ni, Haibo; Maleckar, Mary M.; Heijman, Jordi; Dobrev, Dobromir; Grandi, Eleonora; Morotti, Stefano

Dual effects of the small-conductance Ca²⁺-activated K⁺ current on human atrial electrophysiology and Ca²⁺-driven arrhythmogenesis : An in silico study

In: American Journal of Physiology: Heart and Circulatory Physiology, Jg. 325, 2023, Nr. 4, S. H896 – H908

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Heijman, Jordi; Zhou, Xiaobo; Morotti, Stefano; Molina, Cristina E.; Abu-Taha, Issam H.; Tekook, Marcel; Jespersen, Thomas; Zhang, Yiqiao; Dobrev, Shokoufeh; Milting, Hendrik; Gummert, Jan; Karck, Matthias; Kamler, Markus; El-Armouche, Ali; Saljic, Arnela; Grandi, Eleonora; Nattel, Stanley; Dobrev, Dobromir

Enhanced Ca₂₊-Dependent SK-Channel Gating and Membrane Trafficking in Human Atrial Fibrillation

In: Circulation Research, Jg. 132, 2023, Nr. 9, S. E116 – E133

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Meier, Stefan; Grundland, Adaïa; Dobrev, Dobromir; Volders, Paul G. A.; Heijman, Jordi

In silico analysis of the dynamic regulation of cardiac electrophysiology by Kv11.1 ion-channel trafficking

In: Journal of Physiology, Jg. 601, 2023, Nr. 13, Special Issue: Cell diversity and signalling in the cardiovascular system, S. 2711 – 2731

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Dobrev, Dobromir; Heijman, Jordi; Hiram, Roddy; Li, Na; Nattel, Stanley

Inflammatory signalling in atrial cardiomyocytes : A novel unifying principle in atrial fibrillation pathophysiology

In: Nature Reviews Cardiology, Jg. 20, 2023, Nr. 3, S. 145 – 167

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Ni, Haibo; Morotti, Stefano; Zhang, Xianwei; Dobrev, Dobromir; Grandi, Eleonora

Integrative human atrial modelling unravels interactive protein kinase A and Ca²⁺/calmodulin-dependent protein kinase II signalling as key determinants of atrial arrhythmogenesis

In: Cardiovascular Research, Jg. 119, 2023, Nr. 13, S. 2294 – 2311

DOI (Open Access)
Ferdinandy, Péter; Andreadou, Ioanna; Baxter, Gary F.; Bøtker, Hans Erik; Davidson, Sean M.; Dobrev, Dobromir; Gersh, Bernard J.; Heusch, Gerd; Lecour, Sandrine; Ruiz-Meana, Marisol; Zuurbier, Coert J.; Hausenloy, Derek J.; Schulz, Rainer

Interaction of Cardiovascular Nonmodifiable Risk Factors, Comorbidities and Comedications With Ischemia/Reperfusion Injury and Cardioprotection by Pharmacological Treatments and Ischemic Conditioning

In: Pharmacological Reviews, Jg. 75, 2023, Nr. 1, S. 159 – 216

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Tamargo, Juan; Agewall, Stefan; Borghi, Claudio; Ceconi, Claudio; Cerbai, Elisabetta; Dan, Gheorghe A; Ferdinandy, Péter; Grove, Erik Lerkevang; Rocca, Bianca; Sulzgruber, Patrick; Semb, Anne Grete; Sossalla, Samuel; Niessner, Alexander; Kaski, Juan Carlos; Dobrev, Dobromir

New pharmacological agents and novel cardiovascular pharmacotherapy strategies in 2022

In: European Heart Journal - Cardiovascular Pharmacotherapy, Jg. 9, 2023, Nr. 4, S. 353 – 370

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Kupusovic, J.; Weber, M.; Bruns, F.; Kessler, Lukas; Pesch, E.; Bohnen, J.; Dobrev, Dobromir; Rassaf, Tienush; Wakili, Reza; Rischpler, Christoph; Siebermair, Johannes

PET/CT-identified atrial hypermetabolism is an index of atrial inflammation in patients with atrial fibrillation

In: Journal of Nuclear Cardiology, Jg. 30, 2023, Nr. 5, S. 1761 – 1772.

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Perike, Srikanth; Gonzalez-Gonzalez, Francisco J.; Abu-Taha, Issam; Damen, Frederick W.; Hanft, Laurin M.; Lizama, Ken S.; Aboonabi, Anahita; Capote, Andrielle E.; Aguilar-Sanchez, Yuriana; Levin, Benjamin; Han, Zhenbo; Sridhar, Arvind; Grand, Jacob; Martin, Jody; Akar, Joseph G.; Warren, Chad M.; John Solaro, R.; Ong, Sang-Ging; Darbar, Dawood; McDonald, Kerry S.; Goergen, Craig J.; Wolska, Beata M.; Dobrev, Dobromir; Wehrens, Xander H T; McCauley, Mark D.

PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation

In: Circulation Research, Jg. 133, 2023, Nr. 9, S. 758 – 771

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Grammatika Pavlidou, Nefeli; Dobrev, Shokoufeh; Beneke, Kira; Reinhardt, Franziska; Pecha, Simon; Jacquet, Eric; Abu-Taha, Issam H.; Schmidt, Constanze; Voigt, Niels; Kamler, Markus; Schnabel, Renate B.; Baczkó, Istvan; Garnier, Anne; Reichenspurner, Hermann; Nikolaev, Viacheslav O.; Dobrev, Dobromir; Molina, Cristina Elisa

Phosphodiesterase 8 governs cAMP/PKA-dependent reduction of L-type calcium current in human atrial fibrillation : a novel arrhythmogenic mechanism

In: European Heart Journal, Jg. 44, 2023, Nr. 27, S. 2483 – 2494

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Saljic, Arnela; Heijman, Jordi; Dobrev, Dobromir

Recent Advances in Antiarrhythmic Drug Therapy

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Kalarus, Zbigniew; Mairesse, Georges H; Sokal, Adam; Boriani, Giuseppe; Średniawa, Beata; Arroyo, Ruben Casado; Wachter, Rolf; Frommeyer, Gerrit; Traykov, Vassil; Dagres, Nikolaos; Lip, Gregory Y H; Boersma, Lucas; Peichl, Petr; Dobrev, Dobromir; Bulava, Alan; Blomström-Lundqvist, Carina; de Groot, Natasja M S; Schnabel, Renate; Heinzel, Frank; Van Gelder, Isabelle C; Carbuccichio, Corrado; Shah, Dipen; Eckardt, Lars

Searching for atrial fibrillation : looking harder, looking longer, and in increasingly sophisticated ways. An EHRA position paper’

In: EP Europace, Jg. 25, 2023, Nr. 1, S. 185 – 198

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Kaski, Juan Carlos; Niessner, Alexander; Dobrev, Dobromir; Rocca, Bianca

The European Society of Cardiology working group on cardiovascular pharmacotherapy

In: European Heart Journal, Jg. 44, 2023, Nr. 42, S. 4400 – 4402

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Drexel, Heinz; Tamargo, Juan; Kaski, Juan Carlos; Lewis, Basil S.; Saely, Christoph H.; Fraunberger, Peter; Dobrev, Dobromir; Komiyama, Maki; Plattner, Thomas; Agewall, Stefan; Hasegawa, Koji

Triglycerides revisited: is hypertriglyceridaemia a necessary therapeutic target in cardiovascular disease?

In: European Heart Journal - Cardiovascular Pharmacotherapy, Jg. 9, 2023, Nr. 6, S. 570 – 582

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Kupusovic, Jana; Kessler, Lukas; Bruns, Florian; Bohnen, Jan-Eric; Nekolla, Stephan G.; Weber, Manuel; Lauenroth, Anna; Rattka, Manuel; Herrmann, Ken; Dobrev, Dobromir; Rassaf, Tienush; Wakili, Reza; Rischpler, Christoph; Siebermair, Johannes

Visualization of fibroblast activation using ⁶⁸Ga-FAPI PET/CT after pulmonary vein isolation with pulsed field compared with cryoballoon ablation

In: Journal of Nuclear Cardiology, Jg. 30, 2023, Nr. 5, S. 2018 – 2028

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Caldonazo, Tulio; Kirov, Hristo; Dobrev, Dobromir; Borger, Michael A.; Kiehntopf, Michael; Doenst, Torsten

Vorhofflimmern nach herzchirurgischen Eingriffen : Zusammenfassung der einer Metaanalyse

In: Zeitschrift für Herz-, Thorax- und Gefäßchirurgie (ZHTG), Jg. 37, 2023, Nr. 2, S. 106 – 112

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Coats, Andrew J. S.; Heymans, Stephane; Farmakis, Dimitrios; Anker, Stefan D.; Backs, Johannes; Bauersachs, Johann; de Boer, Rudolf A.; Čelutkienė, Jelena; Cleland, John G. F.; Dobrev, Dobromir; van Gelder, Isabelle C.; von Haehling, Stephan; Hindricks, Gerhard; Jankowska, Ewa; Kotecha, Dipak; van Laake, Linda W.; Lainscak, Mitja; Lund, Lars H.; Lunde, Ida Gjervold; Lyon, Alexander R.; Manouras, Aristomenis; Miličić, Davor; Mueller, Christian; Polovina, Marija; Ponikowski, Piotr; Rosano, Giuseppe; Seferović, Petar M.; Tschöpe, Carsten; Wachter, Rolf; Ruschitzka, Frank

Atrial disease and heart failure : The common soil hypothesis proposed by the Heart Failure Association of the European Society of Cardiology

In: European Heart Journal, Jg. 43, 2022, Nr. 9, S. 863 – 867

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Keefe, Joshua A; Wehrens, Xander H T; Dobrev, Dobromir

Common disease-promoting signalling pathways in heart failure and atrial fibrillation : putative underlying mechanisms and potential therapeutic consequences

In: Cardiovascular Research, Jg. 118, 2022, Nr. 11, S. 2397 – 2399

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Harlaar, Niels; Dekker, Sven O.; Zhang, Juan; Snabel, Rebecca R.; Veldkamp, Marieke W.; Verkerk, Arie O.; Fabres, Carla Cofiño; Schwach, Verena; Lerink, Lente J. S.; Rivaud, Mathilde R.; Mulder, Aat A.; Corver, Willem E.; Goumans, Marie José T. H.; Dobrev, Dobromir; Klautz, Robert J. M.; Schalij, Martin J.; Veenstra, Gert Jan C.; Passier, Robert; van Brakel, Thomas J.; Pijnappels, Daniël A.; de Vries, Antoine A. F.

Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation

In: Nature Biomedical Engineering, Jg. 6, 2022, Nr. 4, S. 389 – 402

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Saljic, Arnela; Heijman, Jordi; Dobrev, Dobromir

Emerging Antiarrhythmic Drugs for Atrial Fibrillation

In: International Journal of Molecular Sciences (IJMS), Jg. 23, 2022, Nr. 8, 4096

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Tamargo, Juan; Kjeldsen, Keld Per; Delpón, Eva; Semb, Anne Grete; Cerbai, Elisabetta; Dobrev, Dobromir; Savarese, Gianluigi; Sulzgruber, Patrick; Rosano, Giuseppe; Borghi, Claudio; Wassman, Seven; Torp-Pedersen, Christian Tobias; Agewall, Stefan; Drexel, Heinz; Baumgartner, Iris; Lewis, Basil; Ceconi, Claudio; Kaski, Juan Carlos; Niessner, Alexander

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease : A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy

In: European Heart Journal - Cardiovascular Pharmacotherapy, Jg. 8, 2022, Nr. 4, S. 406 – 419

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Ni, Li; Lahiri, Satadru K.; Nie, Jiali; Pan, Xiaolu; Abu-Taha, Issam; Reynolds, Julia O.; Campbell, Hannah M.; Wang, Haihao; Kamler, Markus; Schmitz, Wilhelm; Müller, Frank Ulrich; Li, Na; Wei, Xiang; Wang, Dao Wen; Dobrev, Dobromir; Wehrens, Xander H. T.

Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice

In: Cardiovascular Research, Jg. 118, 2022, Nr. 13, S. 2805 – 2818

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Fender, Anke C.; Dobrev, Dobromir

Geschlechtsspezifische Unterschiede in der Pharmakologie

In: Aktuelle Kardiologie, Jg. 11, 2022, Nr. 1, S. 62 – 66

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Gawałko, Monika; Agbaedeng, Thomas A; Saljic, Arnela; Müller, Dominik N; Wilck, Nicola; Schnabel, Renate; Penders, John; Rienstra, Michiel; van Gelder, Isabelle; Jespersen, Thomas; Schotten, Ulrich; Crijns, Harry J G M; Kalman, Jonathan M; Sanders, Prashanthan; Nattel, Stanley; Dobrev, Dobromir; Linz, Dominik

Gut microbiota, dysbiosis and atrial fibrillation : Arrhythmogenic mechanisms and potential clinical implications

In: Cardiovascular Research, Jg. 118, 2022, Nr. 11, S. 2415 – 2427

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Keefe, Joshua A.; Navarro-Garcia, Jose Alberto; Ni, Li; Reilly, Svetlana; Dobrev, Dobromir; Wehrens, Xander H. T.

In-depth characterization of a mouse model of postoperative atrial fibrillation

In: The Journal of Cardiovascular Aging, Jg. 2, 2022, Nr. 4, 40

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Heijman, Jordi; Dobrev, Dobromir

Molecular determinants and therapeutic potential of focal ectopic activity : more than meets the Iti

In: European Heart Journal, 2022, ehac357

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Tedeschi, Andrea; Ammirati, Enrico; Contri, Nicolina; Dobrev, Dobromir; Conti, Nicolina

Recent highlights on acute myocardial infarction and takotsubo syndrome from the International Journal of Cardiology : Heart & Vasculature

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 43, 2022, 101155

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Fender, Anke C.; Dobrev, Dobromir

Recent highlights on thrombosis and hemostasis from the International Journal of Cardiology : Heart & Vasculature

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 43, 2022, 101145

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Benjamin Fyenbo, Daniel; Charlotte Frederiksen, Tanja; Linz, Dominik; Jespersen, Thomas; Dobrev, Dobromir; Gislason, Gunnar; Betz, Konstanze; Saljic, Arnela; Nielsen Holck, Emil

Researchers in cardiology : Why and how to get on Twitter?

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 40, 2022, 101010

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Pesch, E.; Riesinger, L.; Vonderlin, Nadine; Kupusovic, J.; Köhler, Miriam; Bruns, F.; Janosi, Rolf Alexander; Kochhäuser, S.; Dobrev, Dobromir; Rassaf, Tienush; Wakili, Reza; Siebermair, Johannes

Role of catheter location on local impedance measurements and clinical outcome with the new direct sense technology in cardiac ablation procedures

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 42, 2022, 101109

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Yamazaki, Masatoshi; Tomii, Naoki; Tsuneyama, Koichi; Takanari, Hiroki; Niwa, Ryoko; Honjo, Haruo; Kodama, Itsuo; Arafune, Tatsuhiko; Makita, Naomasa; Sakuma, Ichiro; Dobrev, Dobromir; Nattel, Stanley; Tsuji, Yukiomi

Rotors anchored by refractory islands drive torsades de pointes in an experimental model of electrical storm

In: Heart Rhythm, Jg. 19, 2022, Nr. 2

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Linz, Benedikt; Norup Hertel, Julie; Hendriks, Jeroen; Saljic, Arnela; Dobrev, Dobromir; Baumert, Mathias; Jespersen, Thomas; Linz, Dominik

Sleep apnea and atrial fibrillation : challenges in clinical and translational research

In: Expert Review of Cardiovascular Therapy, Jg. 20, 2022, Nr. 2, S. 101 – 109

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Mehra, Reena; Chung, Mina K.; Olshansky, Brian; Dobrev, Dobromir; Jackson, Chandra L.; Kundel, Vaishnavi; Linz, Dominik; Redeker, Nancy S.; Redline, Susan; Sanders, Prashanthan; Somers, Virend K.

Sleep-Disordered Breathing and Cardiac Arrhythmias in Adults: Mechanistic Insights and Clinical Implications : A Scientific Statement From the American Heart Association

In: Circulation, Jg. 146, 2022, Nr. 9, S. E119 – E136

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Saljic, Arnela; Grandi, Eleonora; Dobrev, Dobromir

TGF-β1-induced endothelial-mesenchymal transition : a potential contributor to fibrotic remodeling in atrial fibrillation?

In: The Journal of Clinical Investigation (JCI), Jg. 132, 2022, Nr. 13, e161070

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Saljic, Arnela; Norup Hertel, Julie; Leonhardt, Caroline; Dalgas Nissen, Sarah; Dobrev, Dobromir; Jepps, Thomas A.; Jespersen, Thomas; Michael Sattler, Stefan

The impact of an atrial septal defect on the progression of atrial tachypacing-induced atrial fibrillation in a Danish Landrace pig : A case report

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 40, 2022, 101054

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Sutanto, Henry; Dobrev, Dobromir; Heijman, Jordi

Angiotensin receptor-neprilysin inhibitor (ARNI) and cardiac arrhythmias

In: International Journal of Molecular Sciences (IJMS), Jg. 22, 2021, Nr. 16, 8994

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Grandi, Eleonora; Dobrev, Dobromir

Atrial fibrillation in a dish : insights into atrial arrhythmogenesis from induced pluripotent stem cell-derived cardiomyocytes

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Hulsurkar, Mohit M.; Lahiri, Satadru K.; Moore, Oliver; Moreira, Lucia M.; Abu-Taha, Issam; Kamler, Markus; Dobrev, Dobromir; Nattel, Stanley; Reilly, Svetlana; Wehrens, Xander H.T.

Atrial-Specific LKB1 Knockdown Represents a Novel Mouse Model of Atrial Cardiomyopathy With Spontaneous Atrial Fibrillation

In: Circulation, Jg. 144, 2021, Nr. 11, S. 909 – 912

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Wagner, Michael; Sadek, Mirna S.; Dybkova, Nataliya; Mason, Fleur E.; Klehr, Johann; Firneburg, Rebecca; Cachorro, Eleder; Richter, Kurt; Klapproth, Erik; Kuenzel, Stephan R.; Lorenz, Kristina; Heijman, Jordi; Dobrev, Dobromir; El-Armouche, Ali; Sossalla, Samuel; Kämmerer, Susanne

Cellular mechanisms of the anti-arrhythmic effect of cardiac pde2 overexpression

In: International Journal of Molecular Sciences (IJMS), Jg. 22, 2021, Nr. 9, S. 4816

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Nattel, Stanley; Lip, Gregory Y H; Filgueiras-Rama, David; Dobrev, Dobromir

Challenges and opportunities in improving the management of atrial fibrillation : recent research advances and their clinical translation

In: Cardiovascular Research, Jg. 117, 2021, Nr. 7, S. 1609 – 1611

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Künzel, Stephan R.; Hoffmann, Maximilian; Weber, Silvio; Künzel, Karolina; Kämmerer, Susanne; Günscht, Mario; Klapproth, Erik; Rausch, Johanna S.E.; Sadek, Mirna S.; Kolanowski, Tomasz; Meyer-Roxlau, Stefanie; Piorkowski, Christopher; Tugtekin, Sems M.; Rose-John, Stefan; Yin, Xiaoke; Mayr, Manuel; Kuhlmann, Jan Dominik; Wimberger, Pauline; Grützmann, Konrad; Herzog, Natalie; Küpper, Jan-Heiner; O’Reilly, Molly; Kabir, S. Nashitha; Sommerfeld, Laura C.; Guan, Kaomei; Wielockx, Ben; Fabritz, Larissa; Nattel, Stanley; Ravens, Ursula; Dobrev, Dobromir; Wagner, Michael; El-Armouche, Ali; O'Reilly, Molly

Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation

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Fender, Anke C.; Gawalko, Monika; Dobrev, Dobromir

Direct oral anticoagulation and severe obesity – One size fits all?

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 37, 2021, 100923

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Linz, Dominik; Gawałko, Monika; Sanders, Prashanthan; Penders, John; Li, Na; Nattel, Stanley; Dobrev, Dobromir

Does gut microbiota affect atrial rhythm? : Causalities and speculations

In: European Heart Journal, Jg. 42, 2021, Nr. 35, S. 3521 – 3525

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Fabritz, Larissa; Crijns, Harry J. G. M.; Guasch, Eduard; Goette, Andreas; Häusler, Karl Georg; Kotecha, Dipak; Lewalter, Thorsten; Meyer, Christian; Potpara, Tatjana S.; Rienstra, Michiel; Schnabel, Renate B.; Willems, Stephan; Breithardt, Guenter; Camm, A. John; Chan, Anthony; Chua, Winnie; De Melis, Mirko; Dimopoulou, Christina; Dobrev, Dobromir; Easter, Christina; Eckardt, Lars; Haase, Doreen; Hatem, Stephane; Healey, Jeff S.; Heijman, Jordi; Hohnloser, Stefan H.; Huebner, Thomas; Ilyas, Bushra Saeed; Isaacs, Aaron; Kutschka, Ingo; Leclercq, Christophe; Lip, Gregory Y. H.; Marinelli, Elena Andreassi; Merino, Jose L.; Mont, Lluís; Nabauer, Michael; Oldgren, Jonas; Pürerfellner, Helmut; Ravens, Ursula; Savelieva, Irina; Sinner, Moritz F.; Sitch, Alice; Smolnik, Rüdiger; Steffel, Jan; Stein, Kenneth; Stoll, Monika; Svennberg, Emma; Thomas, Dierk; Van Gelder, Isabelle C.; Vardar, Burcu; Wakili, Reza; Wieloch, Mattias; Zeemering, Stef; Ziegler, Paul D.; Heidbuchel, Hein; Hindricks, Gerhard; Schotten, Ulrich; Kirchhof, Paulus

Dynamic risk assessment to improve quality of care in patients with atrial fibrillation : The 7th AFNET/EHRA Consensus Conference

In: EP Europace, Jg. 23, 2021, Nr. 3, S. 329 – 344

DOI (Open Access)
Odening, Katja E; Gomez Laris, Ana Elisa; Dobrev, Dobromir; Fabritz, Larissa; Heinzel, Frank R; Mangoni, Matteo E; Molina, Cristina E; Sacconi, Leonardo; Smith, Godfrey; Stengl, Milan; Thomas, Dierk; Zaza, Antonio; Remme, Carol Ann; Heijman, Jordi

ESC working group on cardiac cellular electrophysiology position paper : relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research

In: EP Europace, Jg. 23, 2021, Nr. 11, S. 1795 – 1814

DOI (Open Access)
Ravens, Ursula; Gomez, Ana M.; Heijman, Jordi; Remme, Carol Ann; Dobrev, Dobromir; Smith, Godfrey; Volders, Paul G A; Cerbai, Elisabetta; Eisner, David A.; Casadei, Barbara; Zaza, Antonio; Richard, Sylvain; Mugelli, Alessandro; Vassort, Guy; Brown, Hilary F.; Sipido, Karin R.

Edward Carmeliet (1930-2021)-channelling scientific curiosity : a tribute from the ESC Working Group on Cardiac Cellular Electrophysiology†

In: Cardiovascular Research, Jg. 117, 2021, Nr. 14, S. e171 – e173

DOI, Online Volltext (Open Access)
Qi, Xiao-Yan; Vahdati Hassani, Faezeh; Hoffmann, Dennis; Xiao, Jiening; Xiong, Feng; Villeneuve, Louis R.; Ljubojevic-Holzer, Senka; Kamler, Markus; Abu-Taha, Issam; Heijman, Jordi; Bers, Donald M.; Dobrev, Dobromir; Nattel, Stanley

Inositol Trisphosphate Receptors and Nuclear Calcium in Atrial Fibrillation

In: Circulation Research, Jg. 128, 2021, Nr. 5, S. 619 – 635

DOI (Open Access)
Trosclair, Krystle; Si, Man; Watts, Megan; Gautier, Nicole M.; Voigt, Niels; Traylor, James; Bitay, Miklós; Baczko, Istvan; Dobrev, Dobromir; Hamilton, Kathryn A.; Bhuiyan, Md. Shenuarin; Dominic, Paari; Glasscock, Edward

Kv1.1 potassium channel subunit deficiency alters ventricular arrhythmia susceptibility, contractility, and repolarization

In: Physiological Reports, Jg. 9, 2021, Nr. 1, e14702

DOI (Open Access)
Garnier, Anne; Bork, Nadja I.; Jacquet, Eric; Zipfel, Svante; Muñoz-Guijosa, Christian; Baczkó, Istvan; Reichenspurner, Hermann; Donzeau-Gouge, Patrick; Maier, Lars S.; Dobrev, Dobromir; Girdauskas, Evaldas; Nikolaev, Viacheslav O.; Fischmeister, Rodolphe; Molina, Cristina E.

Mapping genetic changes in the cAMP-signaling cascade in human atria

In: Journal of Molecular and Cellular Cardiology, Jg. 155, 2021, S. 10 – 20

DOI, Online Volltext (Open Access)
Scott Jr, Larry; Fender, Anke C; Saljic, Arnela; Li, Luge; Chen, Xiaohui; Wang, Xiaolei; Linz, Dominik; Lang, Jilu; Hohl, Mathias; Twomey, Darragh; Pham, Thuy T; Diaz-Lankenau, Rodrigo; Chelu, Mihail G; Kamler, Markus; Entman, Mark L; Taffet, George E; Sanders, Prashanthan; Dobrev, Dobromir; Li, Na

NLRP3 inflammasome is a key driver of obesity-induced atrial arrhythmias

In: Cardiovascular Research, Jg. 117, 2021, Nr. 7, S. 1746 – 1759

DOI, Online Volltext (Open Access)
Gawałko, Monika; Dobrev, Dobromir

Pericardial adipose tissue : An emerging biomarker of atrial fibrillation?

In: International Journal of Cardiology, Jg. 331, 2021, S. 122 – 123

DOI
Aguilar, Martin; Dobrev, Dobromir; Nattel, Stanley

Postoperative Atrial Fibrillation : Features, Mechanisms, and Clinical Management

In: Cardiac Electrophysiology Clinics, Jg. 13, 2021, Nr. 1, S. 123 – 132

DOI
Campbell, Hannah; Aguilar-Sanchez, Yuriana; Quick, Ann P.; Dobrev, Dobromir; Wehrens, Xander H. T.

SPEG: A key regulator of cardiac calcium homeostasis

In: Cardiovascular Research, Jg. 117, 2021, Nr. 10, S. 2175 – 2185

DOI (Open Access)
Gawałko, Monika; Dobrev, Dobromir

Surgery-related cardiac stress : A susceptibility test of late atrial fibrillation recurrence?

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 32, 2021, S. 100693

DOI (Open Access)
Wang, Xiaolei; Chen, Xiaohui; Dobrev, Dobromir; Li, Na

The crosstalk between cardiomyocyte calcium and inflammasome signaling pathways in atrial fibrillation

In: Pflügers Archiv: European Journal of Physiology, Jg. 473, 2021, S. 389 – 405

DOI (Open Access)
Betz, Konstanze; Knuf, Franziska; Duncker, David; Giordano, Melania; Dobrev, Dobromir; Linz, Dominik

The impact of Twitter promotion on future citation rates : The #TweetTheJournal study

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 33, 2021, 100776

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

The virtual patient : Estimating the health utility of aspirin in simulated populations

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 36, 2021, 100857

DOI (Open Access)
Nattel, Stanley; Sager, Philip T.; Hüser, Jörg; Heijman, Jordi; Dobrev, Dobromir

Why translation from basic discoveries to clinical applications is so difficult for atrial fibrillation and possible approaches to improving it

In: Cardiovascular Research, Jg. 117, 2021, Nr. 7, S. 1616 – 1631

DOI (Open Access)
Sutanto, Henry; Cluitmans, Matthijs J.M.; Dobrev, Dobromir; Volders, Paul G.A.; Bébarová, Markéta; Heijman, Jordi

Acute effects of alcohol on cardiac electrophysiology and arrhythmogenesis : Insights from multiscale in silico analyses

In: Journal of Molecular and Cellular Cardiology, Jg. 146, 2020, S. 69 – 83

DOI (Open Access)
Liu, Tao; Xiong, Feng; Qi, Xiao-Yan; Xiao, Jiening; Villeneuve, Louis; Abu-Taha, Issam; Dobrev, Dobromir; Huang, Congxin; Nattel, Stanley

Altered calcium handling produces reentry-promoting action potential alternans in atrial fibrillation-remodeled hearts

In: JCI Insight, Jg. 5, 2020, Nr. 8, e133754

DOI (Open Access)
Berlin, Sarah; Goette, Andreas; Summo, Luciana; Lossie, Janine; Gebauer, Alexander; Al-Saady, Naab; Calo, Leonardo; Naccarelli, Gerald; Schunck, Wolf-Hagen; Fischer, Robert; Camm, A.John; Dobrev, Dobromir

Assessment of OMT-28, a synthetic analog of omega-3 epoxyeicosanoids, in patients with persistent atrial fibrillation : Rationale and design of the PROMISE-AF phase II study

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 29, 2020, S. 100573

DOI (Open Access)
Heijman, Jordi; Phina Muna, Azinwi; Veleva, Tina; Molina, Cristina E.; Sutanto, Henry; Tekook, Marcel A.; Wang, Qiongling; Abu-Taha, Issam Hissam; Gorka, Marcel; Künzel, Stephan; El-Armouche, Ali; Reichenspurner, Hermann C.K.; Kamler, Markus; Nikolaev, Viacheslav O.; Ravens, Ursula; Li, Na; Nattel, Stanley; Wehrens, Xander H. T.; Dobrev, Dobromir

Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation

In: Circulation Research, Jg. 127, 2020, Nr. 8, S. 1036 – 1055

DOI, Online Volltext (Open Access)
Veltmann, Christian; Dobrev, Dobromir

Berücksichtigung QTc-verlängerndes Potenzial : „Vor Einleitung einer Therapie mit Antibiotika, Antipsychotika, Antiarrhythmika soll die Gefahr einer klinisch relevanten QTc-Verlängerung geprüft werden“

In: Der Kardiologe, Jg. 14, 2020, S. 32 – 34

DOI
Fender, Anke C.; Dobrev, Dobromir

Breaking bad : Higher risk of osteoporosis with vitamin K antagonists compared to direct oral anticoagulants in patients with atrial fibrillation

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 27, 2020, S. 100487

DOI (Open Access)
Gawałko, Monika; Kapłon-Cieślicka, Agnieszka; Hohl, Mathias; Dobrev, Dobromir; Linz, Dominik

COVID-19 associated atrial fibrillation : Incidence, putative mechanisms and potential clinical implications

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 30, 2020, S. 100631

DOI (Open Access)
Reil, Jan-Christian; Reil, Gert-Hinrich; Kovács, Árpád; Sequeira, Vasco; Waddingham, Mark T.; Lodi, Maria; Herwig, Melissa; Ghaderi, Shahrooz; Kreusser, Michael M.; Papp, Zoltán; Voigt, Niels; Dobrev, Dobromir; Meyhöfer, Svenja; Langer, Harald F.; Maier, Lars S.; Linz, Dominik; Mügge, Andreas; Hohl, Mathias; Steendijk, Paul; Hamdani, Nazha

CaMKII activity contributes to homeometric autoregulation of the heart : A novel mechanism for the Anrep effect

In: Journal of Physiology, 2020

DOI, Online Volltext (Open Access)
Sutanto, Henry; Lyon, Aurore; Lumens, Joost; Schotten, Ulrich; Dobrev, Dobromir; Heijman, Jordi

Cardiomyocyte calcium handling in health and disease : Insights from in vitro and in silico studies

In: Progress in Biophysics and Molecular Biology, Jg. 157, 2020, S. 54 – 75

DOI (Open Access)
Tomasovic, Angela; Brand, Theresa; Schanbacher, Constanze; Kramer, Sofia; Hümmert, Martin W.; Godoy, Patricio; Schmidt-Heck, Wolfgang; Nordbeck, Peter; Ludwig, Jonas; Homann, Susanne; Wiegering, Armin; Shaykhutdinov, Timur; Kratz, Christoph; Knüchel, Ruth; Müller-Hermelink, Hans-Konrad; Rosenwald, Andreas; Frey, Norbert; Eichler, Jutta; Dobrev, Dobromir; El-Armouche, Ali; Hengstler, Jan G.; Müller, Oliver J.; Hinrichs, Karsten; Cuello, Friederike; Zernecke, Alma; Lorenz, Kristina

Interference with ERK-dimerization at the nucleocytosolic interface targets pathological ERK1/2 signaling without cardiotoxic side-effects

In: Nature Communications, Jg. 11, 2020, Nr. 1, S. 1733

DOI (Open Access)
Siebermair, Johannes; Lehner, Sebastian; Sattler, Stefan M.; Rizas, Konstantinos D.; Beckmann, Britt-Maria; Becker, Alexander; Schiller, Julia; Metz, Corona; Zacherl, Mathias; Vonderlin, Nadine; Rassaf, Tienush; Dobrev, Dobromir; Rischpler, Christoph; Kääb, Stefan; Hacker, Marcus; Todica, Andrei; Wakili, Reza

Left-ventricular innervation assessed by ¹²³I-SPECT/CT is associated with cardiac events in inherited arrhythmia syndromes

In: International Journal of Cardiology, 2020

DOI
Campbell, Hannah M.; Quick, Ann P.; Abu-Taha, Issam; Chiang, David Y.; Kramm, Carlos F.; Word, Tarah A.; Brandenburg, Sören; Hulsurkar, Mohit; Alsina, Katherina M.; Liu, Hui-Bin; Martin, Brian; Uhlenkamp, Dennis; Moore, Oliver M.; Lahiri, Satadru K.; Corradini, Eleonora; Kamler, Markus; Heck, Albert J R; Lehnart, Stephan E.; Dobrev, Dobromir; Wehrens, Xander H T

Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation

In: Circulation, Jg. 142, 2020, Nr. 12, S. 1159 – 1172

DOI (Open Access)
Kozieł, Monika; Simovic, Stefan; Pavlovic, Nikola; Nedeljkovic, Milan; Paparisto, Vilma; Music, Ljilja; Goshev, Evgenii; Dan, Anca Rodica; Manola, Sime; Kusljugic, Zumreta; Trendafilova, Elina; Dobrev, Dobromir; Dan, Gheorghe-Andrei; Lip, Gregory Y.H.; Potpara, Tatjana S.

Management of patients with newly-diagnosed atrial fibrillation : Insights from the BALKAN-AF survey

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 26, 2020, S. 100461

DOI (Open Access)
Nattel, Stanley; Heijman, Jordi; Zhou, Liping; Dobrev, Dobromir

Molecular Basis of Atrial Fibrillation Pathophysiology and Therapy : A Translational Perspective

In: Circulation Research, Jg. 127, 2020, Nr. 1, S. 51 – 72

DOI (Open Access)
Hermans, Astrid N. L.; van der Velden, Rachel M. J.; Gawalko, Monika; Verhaert, Dominique V. M.; Desteghe, Lien; Duncker, David; Manninger, Martin; Heidbuchel, Hein; Pisters, Ron; Hemels, Martin; Pison, Laurent; Sohaib, Afzal; Sultan, Arian; Steven, Daniel; Wijtvliet, Petra; Tieleman, Robert; Gupta, Dhiraj; Dobrev, Dobromir; Svennberg, Emma; Crijns, Harry J. G. M.; Pluymaekers, Nikki A. H. A.; Hendriks, Jeroen M.; Linz, Dominik

On-demand mobile health infrastructures to allow comprehensive remote atrial fibrillation and risk factor management through teleconsultation

In: Clinical Cardiology, Jg. 43, 2020, Nr. 11, S. 1232 – 1239

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Repurposing traditional immunomodulators to target the inflammatory burden of atherosclerosis

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 28, 2020, S. 100535

DOI (Open Access)
Linz, Dominik; Dobrev, Dobromir

Sleep apnea and atrial fibrillation : Update 2020

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 31, 2020, S. 100681

DOI (Open Access)
Dobrev, Dobromir; Potpara, Tatjana S.

Smart device-based detection of atrial fibrillation: Opportunities and challenges in the emerging world of digital health

In: International Journal of Cardiology, Jg. 302, 2020, S. 108 – 109

DOI
Mujović, Nebojša; Dobrev, Dobromir; Marinković, Milan; Russo, Vincenzo; Potpara, Tatjana S.

The role of amiodarone in contemporary management of complex cardiac arrhythmias

In: Pharmacological Research, Jg. 151, 2020, S. 104521

DOI
Fender, Anke C.; Kleeschulte, Sonja; Stolte, Svenja; Leineweber, Katja; Kamler, Markus; Bode, Johannes; Li, Na; Dobrev, Dobromir

Thrombin receptor PAR4 drives canonical NLRP3 inflammasome signaling in the heart

In: Basic Research in Cardiology, Jg. 115, 2020, Nr. 2, S. 10

DOI, Online Volltext (Open Access)
Barefield, David Y.; McNamara, James W.; Lynch, Thomas L.; Kuster, Diederik W.D.; Govindan, Suresh; Haar, Lauren; Wang, Yang; Taylor, Erik N.; Lorenz, John N.; Nieman, Michelle L.; Zhu, Guangshuo; Luther, Pradeep K.; Varró, Andras; Dobrev, Dobromir; Ai, Xun; Janssen, Paul M.L.; Kass, David A.; Jones, Walter Keith; Gilbert, Richard J.; Sadayappan, Sakthivel

Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury

In: Journal of Molecular and Cellular Cardiology, Jg. 129, 2019, S. 236 – 246

DOI (Open Access)
Heijman, Jordi; Dobrev, Dobromir

Bayesian network analyses in atrial fibrillation – A path to better therapies?

In: International Journal of Cardiology (IJC) Heart & Vasculature, 2019

DOI (Open Access)
Grandi, Eleonora; Dobrev, Dobromir; Heijman, Jordi

Computational modeling: What does it tell us about atrial fibrillation therapy?

In: International Journal of Cardiology, Jg. 287, 2019, S. 155 – 161

DOI, Online Volltext (Open Access)
Belau, Fabian; Metzner, Katharina; Christ, Torsten; Ravens, Ursula; Schaefer, Michael; Künzel, Stephan; Li, Wener; Wettwer, Erich; Dobrev, Dobromir; El-Armouche, Ali; Kämmerer, Susanne

DPP10 is a new regulator of Nav1.5 channels in human heart

In: International Journal of Cardiology, Jg. 284, 2019, S. 68 – 73

DOI
Wakili, Reza; Riesinger, Lisa; Fender, Anke C.; Dobrev, Dobromir

Double Jeopardy: Will the new trials tell us how to manage patients with atrial fibrillation and coronary artery disease?

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 23, 2019, S. 100369

DOI (Open Access)
Goette, Andreas; Auricchio, Angelo; Boriani, Giuseppe; Braunschweig, Frieder; Terradellas, Josep Brugada; Burri, Haran; Camm, A. John; Crijns, Harry; Dagres, Nikolaos; Deharo, Jean-Claude; Dobrev, Dobromir; Hatala, Robert; Hindricks, Gerhard; Hohnloser, Stefan H.; Leclercq, Christophe; Lewalter, Thorsten; Lip, Gregory Y. H.; Merino, Jose Luis; Mont, Lluis; Prinzen, Frits; Proclemer, Alessandro; Pürerfellner, Helmut; Savelieva, Irina; Schilling, Richard; Steffel, Jan; van Gelder, Isabelle C.; Zeppenfeld, Katja; Zupan, Igor; Heidbüchel, Hein; ESC Scientific Document Group

EHRA White Paper : Knowledge Gaps in Arrhythmia Management-Status 2019

In: EP Europace, Jg. 21, 2019, Nr. 7, S. 993 – 994

DOI, Online Volltext (Open Access)
Alsina, Katherina M.; Hulsurkar, Mohit; Brandenburg, Sören; Kownatzki-Danger, Daniel; Lenz, Christof; Urlaub, Henning; Abu-Taha, Issam; Kamler, Markus; Chiang, David Y.; Lahiri, Satadru K.; Reynolds, Julia O.; Quick, Ann P.; Scott, Larry; Word, Tarah A.; Gelves, Maria D.; Heck, Albert J R; Li, Na; Dobrev, Dobromir; Lehnart, Stephan E.; Wehrens, Xander H T; Urlaub, Hennig; Scott Jr., Larry

Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation

In: Circulation, Jg. 140, 2019, Nr. 8, S. 681 – 693

DOI (Open Access)
Sutanto, Henry; Laudy, Lian; Clerx, Michael; Dobrev, Dobromir; Crijns, Harry J.G.M.; Heijman, Jordi

Maastricht antiarrhythmic drug evaluator (MANTA) : A computational tool for better understanding of antiarrhythmic drugs

In: Pharmacological Research, Jg. 148, 2019

DOI (Open Access)
Linz, Dominik; Baumert, Mathias; Desteghe, Lien; Kadhim, Kadhim; Vernooy, Kevin; Kalman, Jonathan M.; Dobrev, Dobromir; Arzt, Michael; Sastry, Manu; Crijns, Harry J.G.M.; Schotten, Ulrich; Cowie, Martin R.; McEvoy, R. Doug; Heidbuchel, Hein; Hendriks, Jeroen; Sanders, Prashanthan; Lau, Dennis H.

Nightly sleep apnea severity in patients with atrial fibrillation : Potential applications of long-term sleep apnea monitoring

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 24, 2019, S. 100424

DOI (Open Access)
Dobrev, Dobromir; Aguilar, Martin; Heijman, Jordi; Guichard, Jean-Baptiste; Nattel, Stanley

Postoperative atrial fibrillation : mechanisms, manifestations and management

In: Nature Reviews Cardiology, Jg. 16, 2019, Nr. 7, S. 417 – 436

DOI
Linz, Dominik; Elliott, Adrian D.; Hohl, Mathias; Malik, Varun; Schotten, Ulrich; Dobrev, Dobromir; Nattel, Stanley; Böhm, Michael; Floras, John; Lau, Dennis H.; Sanders, Prashanthan

Role of autonomic nervous system in atrial fibrillation

In: International Journal of Cardiology, Jg. 287, 2019, S. 181 – 188

DOI
Scott, Larry; Li, Na; Dobrev, Dobromir

Role of inflammatory signaling in atrial fibrillation

In: International Journal of Cardiology, Jg. 287, 2019, S. 195 – 200

DOI, Online Volltext (Open Access)
Fender, Anke C.; Wakili, Reza; Dobrev, Dobromir

Straight to the heart : Pleiotropic antiarrhythmic actions of oral anticoagulants

In: Pharmacological Research, Jg. 145, 2019, S. 104257

DOI, Online Volltext (Open Access)
Kaya, Elif; Siebermair, Johannes; Azizy, Obayda; Dobrev, Dobromir; Rassaf, Tienush; Wakili, Reza

Use of pulsed electron avalanche knife (PEAK) PlasmaBlade™ in patients undergoing implantation of subcutaneous implantable cardioverter-defibrillator

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 24, 2019, S. 100390

DOI (Open Access)
Dobrev, Dobromir; Lorenz, Kristina

Age-dependent increase in c-Jun N-terminal kinase-2 activity : Does this help to understand Ca2+ -calmodulin-dependent protein-kinase II-mediated atrial arrhythmogenesis in human atrial fibrillation?

In: Cardiovascular Research, Jg. 114, 2018, Nr. 5, S. 641 – 642

DOI (Open Access)
Dan, Gheorghe-Andrei; Dobrev, Dobromir

Antiarrhythmic drugs for atrial fibrillation : Imminent impulses are emerging

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 21, 2018, S. 11 – 15

DOI (Open Access)
Sutanto, Henry; Dobrev, Dobromir; Grandi, Eleonora; Volders, Paul G.A.; Heijman, Jordi

Calcium-dependent regulation of potassium channels in cardiac electrophysiology : A computational study

In: Biophysical Journal, Jg. 114, 2018, Nr. 3, Supplement 1, S. 473a

DOI (Open Access)
Linz, Dominik; Hohl, Mathias; Dobrev, Dobromir

Can cystatin C-based estimated glomerular filtration rate help to guide individualized risk factor modification programs?

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 19, 2018, S. 100 – 101

DOI (Open Access)
Chen, Gong; Chelu, Mihail G.; Dobrev, Dobromir; Li, Na

Cardiomyocyte inflammasome signaling in cardiomyopathies and atrial fibrillation : Mechanisms and potential therapeutic implications

In: Frontiers in Physiology, Jg. 9, 2018, S. 1115

DOI (Open Access)
Ammirati, Enrico; Dobrev, Dobromir

Conventional Troponin-I versus high-sensitivity troponin-T : Performance and incremental prognostic value in non-ST-elevation acute myocardial infarction patients with negative CK-MB based on a real-world multicenter cohort

In: International Journal of Cardiology (IJC) Heart & Vasculature, Jg. 20, 2018, S. 38 – 39

DOI (Open Access)
Joos, J.P.; Saadatmand, A.R.; Schnabel, C.; Viktorinová, I.; Brand, T.; Kramer, M.; Nattel, S.; Dobrev, Dobromir; Tomancak, P.; Backs, J.; Kleinbongard, Petra; Heusch, Gerd; Lorenz, Kristina; Koch, E.; Weber, S.; El-Armouche, A.

Ectopic expression of S28A-mutated Histone H3 modulates longevity, stress resistance and cardiac function in Drosophila

In: Scientific Reports, Jg. 8, 2018, Nr. 1, S. 2940

DOI (Open Access)
Tsuji, Yukiomi; Dobrev, Dobromir

Electrical storm : Mechanistic and therapeutic considerations to avoid death in the survivors

In: Journal of Thoracic Disease, Jg. 10, 2018, Nr. Suppl. 33, S. S4053 – S4056

DOI (Open Access)
Heijman, Jordi; Dobrev, Dobromir; Crijns, Harry J.G.M.

Electrocardiographic characteristics associated with atrial fibrillation – What do they tell us?

In: International Journal of Cardiology, Jg. 266, 2018, S. 143 – 144

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Yao, Chunxia; Veleva, Tina; Scott, Larry Jr.; Cao, Shuyi; Li, Luge; Chen, Gong; Jeyabal, Prince; Pan, Xiaolu; Alsina, Katherina M.; Abu-Taha, Issam; Ghezelbash, Shokoufeh; Reynolds, Corey L.; Shen, Ying H.; LeMaire, Scott A.; Schmitz, Wilhelm; Müller, Frank U.; El-Armouche, Ali; Eissa, N. Tony; Beeton, Christine; Nattel, Stanley; Wehrens, Xander H. T.; Dobrev, Dobromir; Li, Na

Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation

In: Circulation, Jg. 138, 2018, Nr. 20, S. 2227 – 2242

DOI, Online Volltext (Open Access)
Molina, Cristina E.; Jacquet, Eric; Ponien, Prishila; Muñoz-Guijosa, Christian; Baczkó, Istvan; Maier, Lars S; Donzeau-Gouge, Patrick; Dobrev, Dobromir; Fischmeister, Rodolphe; Garnier, Anne

Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart

In: Cardiovascular Research, Jg. 114, 2018, Nr. 2, S. 247 – 258

DOI (Open Access)
Ellinwood, Nicholas; Dobrev, Dobromir; Morotti, Stefano; Grandi, Eleonora

In silico assessment of atrial fibrillation-selectivity of ikur inhibitors : Role of variability in disease-associated remodeling

In: Biophysical Journal, Jg. 114, 2018, Nr. 3, Suppl. 1, S. 473a – 474a

DOI (Open Access)
Kotecha, Dipak; Breithardt, Günter; Camm, A. John; Lip, Gregory Y.H.; Schotten, Ulrich; Ahlsson, Anders; Arnar, David; Atar, Dan; Auricchio, Angelo; Bax, Jeroen; Benussi, Stefano; Blomstrom-Lundqvist, Carina; Borggrefe, Martin; Boriani, Giuseppe; Brandes, Axel; Calkins, Hugh; Casadei, Barbara; Castellá, Manuel; Chua, Winnie; Crijns, Harry; Dobrev, Dobromir; Fabritz, Larissa; Feuring, Martin; Freedman, Ben; Gerth, Andrea; Goette, Andreas; Guasch, Eduard; Haase, Doreen; Hatem, Stephane; Haeusler, Karl Georg; Heidbuchel, Hein; Hendriks, Jeroen; Hunter, Craig; Kääb, Stefan; Kespohl, Stefanie; Landmesser, Ulf; Lane, Deirdre A.; Lewalter, Thorsten; Mont, Lluís; Nabauer, Michael; Nielsen, Jens C.; Oeff, Michael; Oldgren, Jonas; Oto, Ali; Pison, Laurent; Potpara, Tatjana; Ravens, Ursula; Richard-Lordereau, Isabelle; Rienstra, Michiel; Savelieva, Irina; Schnabel, Renate; Sinner, Moritz F.; Sommer, Philipp; Themistoclakis, Sakis; Van Gelder, Isabelle C.; Vardas, Panagiotis E.; Verma, Atul; Wakili, Reza; Weber, Evelyn; Werring, David; Willems, Stephan; Ziegler, André; Hindricks, Gerhard; Kirchhof, Paulus

Integrating new approaches to atrial fibrillation management : The 6th AFNET/EHRA Consensus Conference

In: EP Europace, Jg. 20, 2018, Nr. 3, S. 395 – 407

DOI (Open Access)
Heijman, Jordi; Dobrev, Dobromir

Ion channels as part of macromolecular multiprotein complexes : Clinical significance

In: Herzschrittmachertherapie und Elektrophysiologie, Jg. 29, 2018, Nr. 1, S. 30 – 35

DOI (Open Access)
Dobrev, Dobromir; Wehrens, Xander H. T.

Mouse Models of Cardiac Arrhythmias

In: Circulation Research, Jg. 123, 2018, Nr. 3, S. 332 – 334

DOI, Online Volltext (Open Access)
Heijman, Jordi; Kirchner, Dorit; Kunze, Franziska; Chrétien, Eva Maria; Michel-Reher, Martina B.; Voigt, Niels; Knaut, Michael; Michel, Martin C.; Ravens, Ursula; Dobrev, Dobromir

Muscarinic type-1 receptors contribute to IK,ACh in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation

In: International Journal of Cardiology, Jg. 255, 2018, S. 61 – 68

DOI, Online Volltext (Open Access)
Grandi, Eleonora; Dobrev, Dobromir

Non-ion channel therapeutics for heart failure and atrial fibrillation : Are CaMKII inhibitors ready for clinical use?

In: Journal of Molecular and Cellular Cardiology, Jg. 121, 2018, S. 300 – 303

DOI, Online Volltext (Open Access)
Yao, Chunxia; van der Sangen, Niels; Heck, Albert; Langer, Barbara; Buxton, Samuel; Dobrev, Dobromir; Alsina, Katherina; Hulsurkar, Mohit; Chiang, David; Wehrens, Xander

Novel role of the protein phosphatase 1 regulatory subunit PPP1R3A in atrial fibrillation

In: Journal of Molecular and Cellular Cardiology, Jg. 124, 2018, S. 108

DOI
Molina, Cristina E.; Abu-Taha, Issam H.; Wang, Qiongling; Roselló-Díez, Elena; Kamler, Marcus; Nattel, Stanley; Ravens, Ursula; Wehrens, Xander H. T.; Hove-Madsen, Leif; Heijman, Jordi; Dobrev, Dobromir

Profibrotic, electrical, and calcium-handling remodeling of the atria in heart failure patients with and without atrial fibrillation

In: Frontiers in Physiology, Jg. 9, 2018, S. 1383

DOI (Open Access)
Abu-Taha, Issam H.; Heijman, Jordi; Feng, Yuxi; Vettel, Christiane; Dobrev, Dobromir; Wieland, Thomas

Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins : an update

In: Laboratory Investigation, Jg. 98, 2018, Nr. 2, S. 190 – 197

DOI (Open Access)
Sutanto, Henry; Dobrev, Dobromir; Heijman, Jordi

Resveratrol : an effective pharmacological agent to prevent inflammation-induced atrial fibrillation?

In: Naunyn-Schmiedeberg's Archives of Pharmacology, Jg. 391, 2018, Nr. 11, S. 1163 – 1167

DOI (Open Access)
Dobrev, Dobromir

Sex-specific density of ventricular SK currents : is this a general feature of SK channel function?

In: Journal of Physiology, Jg. 596, 2018, Nr. 18, S. 4287 – 4288

DOI, Online Volltext (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Switching off the jitters : Dabigatran as a candidate approach to halt atrial fibrillation?

In: International Journal of Cardiology, Jg. 271, 2018, S. 254 – 255

DOI
Fender, Anke C.; Dobrev, Dobromir

The not-so-sweet problem of hearts aflutter : Dissecting stroke risk in atrial fibrillation with concomitant diabetes

In: International Journal of Cardiology, Jg. 268, 2018, S. 153 – 154

DOI
Heijman, Jordi; Guichard, Jean-Baptiste; Dobrev, Dobromir; Nattel, Stanley

Translational challenges in atrial fibrillation

In: Circulation Research, Jg. 122, 2018, Nr. 5, S. 752 – 773

DOI (Open Access)
Landstrom, Andrew P.; Dobrev, Dobromir; Wehrens, Xander H.T.

Calcium Signaling and Cardiac Arrhythmias

In: Circulation Research, Jg. 120, 2017, Nr. 12, S. 1969 – 1993

DOI, Online Volltext (Open Access)
Dobrev, Dobromir; Wehrens, Xander H. T.

Calcium-mediated cellular triggered activity in atrial fibrillation

In: Journal of Physiology, Jg. 595, 2017, Nr. 12, S. 4001 – 4008

DOI
Neef, Stefan; Heijman, Jordi; Otte, Kristian; Dewenter, Matthias; Saadatmand, Ali R.; Meyer-Roxlau, Stefanie; Antos, Christopher L.; Backs, Johannes; Dobrev, Dobromir; Wagner, Michael; Maier, Lars S.; El-Armouche, Ali

Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity

In: Naunyn-Schmiedeberg's Archives of Pharmacology, Jg. 390, 2017, Nr. 8, S. 857 – 862

DOI
Nattel, Stanley; Dobrev, Dobromir

Controversies about Atrial Fibrillation Mechanisms : Aiming for Order in Chaos and Whether it Matters

In: Circulation Research, Jg. 120, 2017, Nr. 9, S. 1396 – 1398

DOI (Open Access)
Meyer-Roxlau, Stefanie; Lämmle, Simon; Opitz, Annett; Künzel, Stephan; Joos, Julius P.; Neef, Stefan; Sekeres, Karolina; Sosalla, Samuel T.; Schöndube, Friedrich; Alexiou, Konstantin; Maier, Lars S.; Dobrev, Dobromir; Guan, Kaomei; Weber, Silvio; El-Armouche, Ali

Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation

In: Basic Research in Cardiology, Jg. 112, 2017, Nr. 4

DOI
Goette, Andreas; Kalman, Jonathan M.; Aguinaga, Luis; Akar, Joseph; Cabrera, Jose Angel; Chen, Shih Ann; Chugh, Sumeet S.; Corradi, Domenico; D'Avila, Andre; Dobrev, Dobromir; Fenelon, Guilherme; Gonzalez, Mario; Hatem, Stephane N.; Helm, Robert; Hindricks, Gerhard; Ho, Siew Yen; Hoit, Brian; Jalife, Jose; Kim, Young-Hoon; Lip, Gregory Y.H.; Ma, Chang-Sheng; Marcus, Gregory M.; Murray, Katherine; Nogami, Akihiko; Sanders, Prashanthan; Uribe, William; Van Wagoner, David R.; Nattel, Stanley

EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies : definition, characterization, and clinical implication

In: Heart Rhythm, Jg. 14, 2017, Nr. 1, S. e3 – e40

DOI, Online Volltext (Open Access)
Veleva, Tina; Scott, Larry; Dobrev, Dobromir; Li, Na; Wehrens, Xander H.T.; Müller, Frank U.; Yao, Chunxia; Nattel, Stanley

Enhanced Activation of Inflammasome Promotes Atrial Fibrillation

In: Journal of Molecular and Cellular Cardiology, Jg. 112, 2017, S. 147

DOI
Ellinwood, Nicholas; Dobrev, Dobromir; Morotti, Stefano; Grandi, Eleonora

Erratum to: "Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity"

In: Chaos, Jg. 27, 2017, Nr. 10, 109902

DOI (Open Access)
Meyer-Roxlau, Stefanie; Lämmle, Simon; Opitz, Annett; Künzel, Stephan; Joos, Julius P.; Neef, Stefan; Sekeres, Karolina; Sossalla, Samuel; Schöndube, Friedrich; Alexiou, Konstantin; Maier, Lars S.; Dobrev, Dobromir; Guan, Kaomei; Weber, Silvio; El-Armouche, Ali

Erratum to: Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation

In: Basic Research in Cardiology, Jg. 112, 2017, Nr. 5

DOI
Ellinwood, Nicholas; Dobrev, Dobromir; Morotti, Stefano; Grandi, Eleonora

In silico assessment of efficacy and safety of Ikur inhibitors in chronic atrial fibrillation : Role of kinetics and state-dependence of drug binding

In: Frontiers in Pharmacology, Jg. 8, 2017, Nr. NOV, S. 799

DOI (Open Access)
Heijman, Jordi; Dobrev, Dobromir

Inhibition of small-conductance Ca²⁺-Activated K⁺ channels : The long-Awaited breakthrough for antiarrhythmic drug therapy of atrial fibrillation?

In: Circulation: Arrhythmia and Electrophysiology, Jg. 10, 2017, Nr. 10, S. e005776

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Schmidt, Constanze; Wiedmann, Felix; Zhou, Xiao-Bo; Heijman, Jordi; Voigt, Niels; Ratte, Antonius; Lang, Siegfried; Kallenberger, Stefan M.; Campana, Chiara; Weymann, Alexander; De Simone, Raffaele; Szabo, Gabor; Ruhparwar, Arjang; Kallenbach, Klaus; Karck, Matthias; Ehrlich, Joachim R.; Baczkó, István; Borggrefe, Martin; Ravens, Ursula; Dobrev, Dobromir; Katus, Hugo A.; Thomas, Dierk

Inverse remodelling of K2P 3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation : Implications for patient-specific antiarrhythmic drug therapy

In: European Heart Journal, Jg. 38, 2017, Nr. 22, S. 1764 – 1774

DOI
Heijman, Jordi; Ghezelbash, Shokoufeh; Dobrev, Dobromir

Investigational antiarrhythmic agents : promising drugs in early clinical development

In: Expert Opinion on Investigational Drugs, Jg. 26, 2017, Nr. 8, S. 897 – 907

DOI, Online Volltext (Open Access)
Chen, Yu; Surinkaew, Sirirat; Naud, Patrice; Qi, Xiao-Yan; Gillis, Marc-Antoine; Shi, Yan-Fen; Tardif, Jean-Claude; Dobrev, Dobromir; Nattel, Stanley

JAK-STAT signalling and the atrial fibrillation promoting fibrotic substrate

In: Cardiovascular Research, Jg. 113, 2017, Nr. 3, S. 310 – 320

DOI
Wakili, Reza; Dobrev, Dobromir

Late-breaking trials : Atrial fibrillation

In: Dialogues in Cardiovascular Medicine, Jg. 22, 2017, Nr. 3, S. 42 – 43
Abu-Taha, Issam H.; Heijman, Jordi; Hippe, Hans-Jörg; Wolf, Nadine M.; El-Armouche, Ali; Nikolaev, Viacheslav O.; Schäfer, Marina; Würtz, Christina M.; Neef, Stefan; Voigt, Niels; Baczkó, István; Varró, András; Müller, Marion; Meder, Benjamin; Katus, Hugo A.; Spiger, Katharina; Vettel, Christiane; Lehmann, Lorenz H.; Backs, Johannes; Skolnik, Edward Y.; Lutz, Susanne; Dobrev, Dobromir; Wieland, Thomas

Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure

In: Circulation, Jg. 135, 2017, Nr. 9, S. 881 – 897

DOI (Open Access)
Chiamvimonvat, Nipavan; Chen-Izu, Ye; Clancy, Colleen E.; Deschenes, Isabelle; Dobrev, Dobromir; Heijman, Jordi; Izu, Leighton; Qu, Zhilin; Ripplinger, Crystal M.; Vandenberg, Jamie I.; Weiss, James N.; Koren, Gideon; Banyasz, Tamas; Grandi, Eleonora; Sanguinetti, Michael C.; Bers, Donald M.; Nerbonne, Jeanne M.

Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics

In: Journal of Physiology, Jg. 595, 2017, Nr. 7, S. 2229 – 2252

DOI (Open Access)
Wakili, Reza; Dobrev, Dobromir

Response to: “The emerging role of hybrid ablation for ablation” by Spartialis M. et al.

In: International Journal of Cardiology, Jg. 249, 2017, S. 258

DOI
Ellinwood, Nicholas; Dobrev, Dobromir; Morotti, Stefano; Grandi, Eleonora

Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity

In: Chaos, Jg. 27, 2017, Nr. 9, 093918

DOI (Open Access)
Heijman, Jordi; Ghezelbash, Shokoufeh; Wehrens, Xander H.T.; Dobrev, Dobromir

Serine/Threonine Phosphatases in Atrial Fibrillation

In: Journal of Molecular and Cellular Cardiology, Jg. 103, 2017, S. 110 – 120

DOI, Online Volltext (Open Access)
Ji, Yuan; Varkevisser, Rosanne; Opacic, Dragan; Bossu, Alexandre; Kuiper, Marion; Beekman, Jet D M; Yang, Sihyung; Khan, Azinwi Phina; Dobrev, Dobromir; Voigt, Niels; Wang, Michael Zhuo; Verheule, Sander; Vos, Marc A; van der Heyden, Marcel A G

The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models

In: British Journal of Pharmacology (BJP), Jg. 174, 2017, Nr. 15, S. 2576 – 2590

DOI (Open Access)
Kirchhof, Paulus; Benussi, Stefano; Kotecha, Dipak; Ahlsson, Anders; Atar, Dan; Casadei, Barbara; Castella, Manuel; Diener, Hans Christoph; Heidbuchel, Hein; Hendriks, Jeroen; Hindricks, Gerhard; Manolis, Antonis S; Oldgren, Jonas; Popescu, Bogdan Alexandru; Schotten, Ulrich; Van Putte, Bart; Vardas, Panagiotis; Agewall, Stefan; Camm, John; Baron Esquivias, Gonzalo; Budts, Werner; Carerj, Scipione; Casselman, Filip; Coca, Antonio; De Caterina, Raffaele; Deftereos, Spiridon; Dobrev, Dobromir; Ferro, José M; Filippatos, Gerasimos; Fitzsimons, Donna; Gorenek, Bulent; Guenoun, Maxine; Hohnloser, Stefan H; Kolh, Philippe; Lip, Gregory Y H; Manolis, Athanasios; McMurray, John; Ponikowski, Piotr; Rosenhek, Raphael; Ruschitzka, Frank; Savelieva, Irina; Sharma, Sanjay; Suwalski, Piotr; Tamargo, Juan Luis; Taylor, Clare J; Van Gelder, Isabelle C; Voors, Adriaan A; Windecker, Stephan; Zamorano, Jose Luis; Zeppenfeld, Katja

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

In: European Heart Journal, Jg. 37, 2016, Nr. 38, S. 2893 – 2962

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Kirchhof, Paulus; Benussi, Stefano; Kotecha, Dipak; Ahlsson, Anders; Atar, Dan; Casadei, Barbara; Castella, Manuel; Diener, Hans Christoph; Heidbuchel, Hein; Hendriks, Jeroen; Hindricks, Gerhard; Manolis, Antonis S; Oldgren, Jonas; Popescu, Bogdan Alexandru; Schotten, Ulrich; Van Putte, Bart; Vardas, Panagiotis; Agewall, Stefan; Camm, John; Baron Esquivias, Gonzalo; Budts, Werner; Carerj, Scipione; Casselman, Filip; Coca, Antonio; De Caterina, Raffaele; Deftereos, Spiridon; Dobrev, Dobromir; Ferro, José M; Filippatos, Gerasimos; Fitzsimons, Donna; Gorenek, Bulent; Guenoun, Maxine; Hohnloser, Stefan H; Kolh, Philippe; Lip, Gregory Y H; Manolis, Athanasios; McMurray, John; Ponikowski, Piotr; Rosenhek, Raphael; Ruschitzka, Frank; Savelieva, Irina; Sharma, Sanjay; Suwalski, Piotr; Tamargo, Juan Luis; Taylor, Clare J; Van Gelder, Isabelle C; Voors, Adriaan A; Windecker, Stephan; Zamorano, Jose Luis; Zeppenfeld, Katja

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

In: European Journal of Cardio-Thoracic Surgery, Jg. 50, 2016, Nr. 5, S. e1 – e88

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Kirchhof, Paulus; Benussi, Stefano; Kotecha, Dipak; Ahlsson, Anders; Atar, Dan; Casadei, Barbara; Castella, Manuel; Diener, Hans Christoph; Heidbuchel, Hein; Hendriks, Jeroen; Hindricks, Gerhard; Manolis, Antonis S; Oldgren, Jonas; Popescu, Bogdan Alexandru; Schotten, Ulrich; Van Putte, Bart; Vardas, Panagiotis; Agewall, Stefan; Camm, John; Baron Esquivias, Gonzalo; Budts, Werner; Carerj, Scipione; Casselman, Filip; Coca, Antonio; De Caterina, Raffaele; Deftereos, Spiridon; Dobrev, Dobromir; Ferro, José M; Filippatos, Gerasimos; Fitzsimons, Donna; Gorenek, Bulent; Guenoun, Maxine; Hohnloser, Stefan H; Kolh, Philippe; Lip, Gregory Y H; Manolis, Athanasios; McMurray, John; Ponikowski, Piotr; Rosenhek, Raphael; Ruschitzka, Frank; Savelieva, Irina; Sharma, Sanjay; Suwalski, Piotr; Tamargo, Juan Luis; Taylor, Clare J; Van Gelder, Isabelle C; Voors, Adriaan A; Windecker, Stephan; Zamorano, Jose Luis; Zeppenfeld, Katja

2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS

In: EP Europace, Jg. 18, 2016, Nr. 11, S. 1609 – 1678

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Kirchhof, Paulus; Breithardt, Günter; Bax, Jeroen; Benninger, Gerlinde; Blomstrom-Lundqvist, Carina; Boriani, Giuseppe; Brandes, Axel; Brown, Helen; Brueckmann, Martina; Calkins, Hugh; Calvert, Melanie; Christoffels, Vincent; Crijns, Harry; Dobrev, Dobromir; Ellinor, Patrick; Fabritz, Larissa; Fetsch, Thomas; Freedman, S. Ben; Gerth, Andrea; Goette, Andreas; Guasch, Eduard; Hack, Guido; Haegeli, Laurent; Hatem, Stephane; Haeusler, Karl Georg; Heidbüchel, Hein; Heinrich-Nols, Jutta; Hidden-Lucet, Francoise; Hindricks, Gerd; Juul-Möller, Steen; Kääb, Stefan; Kappenberger, Lukas; Kespohl, Stefanie; Kotecha, Dipak; Lane, Deirdre A.; Leute, Angelika; Lewalter, Thorsten; Meyer, Ralf; Mont, Lluis; Münzel, Felix; Nabauer, Michael; Nielsen, Jens C.; Oeff, Michael; Oldgren, Jonas; Oto, Ali; Piccini, Jonathan P.; Pilmeyer, Art; Potpara, Tatjana; Ravens, Ursula; Reinecke, Holger; Rostock, Thomas; Rustige, Joerg; Savelieva, Irene; Schnabel, Renate; Schotten, Ulrich; Schwichtenberg, Lars; Sinner, Moritz F.; Steinbeck, Gerhard; Stoll, Monika; Tavazzi, Luigi; Themistoclakis, Sakis; Tse, Hung Fat; van Gelder, Isabelle C.; Vardas, Panagiotis E.; Varpula, Timo; Vincent, Alphons; Werring, David; Willems, Stephan; Ziegler, André; Lip, Gregory Y. H.; Camm, A. John

A roadmap to improve the quality of atrial fibrillation managementconference : proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus

In: EP Europace, Jg. 18, 2016, Nr. 1, S. 37 – 50

DOI (Open Access)
Ferrari, R.; Bertini, Matteo; Blomstrom-Lundqvist, Carina; Dobrev, Dobromir; Kirchhof, Paulus; Pappone, Carlo; Ravens, Ursula; Tamargo, Juan Luis; Tavazzi, Luigi; Vicedomini, Gabriele G.

An update on atrial fibrillation in 2014 : From pathophysiology to treatment

In: International Journal of Cardiology, Jg. 203, 2016, S. 22 – 29

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Voigt, Niels; Dobrev, Dobromir

Atrial-Selective Potassium Channel Blockers

In: Cardiac Electrophysiology Clinics, Jg. 8, 2016, Nr. 2, S. 411 – 421

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Heijman, Jordi; Dobrev, Dobromir

Challenges to the translation of basic science findings to atrial fibrillation therapies

In: Future Cardiology, Jg. 12, 2016, Nr. 3, S. 251 – 254

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Yan Qi, Xiao; Nattel, Stanley; Dobrev, Dobromir; Heijman, Jordi

Computational Analysis of Heart-Failure-Related Remodeling of Cytosolic and Nuclear Calcium Handling in the Canine Atrial Cardiomyocyte

In: Biophysical Journal, Jg. 110, 2016, Nr. 3, Suppl.1, S. 435a

DOI (Open Access)
Heijman, Jordi; Erfanian Abdoust, Pegah; Voigt, Niels; Nattel, Stanley; Dobrev, Dobromir

Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation

In: Journal of Physiology, Jg. 594, 2016, Nr. 3, S. 537 – 553

DOI
Schotten, U; Dobrev, Dobromir; Platonov, P G; Kottkamp, H; Hindricks, G

Current controversies in determining the main mechanisms of atrial fibrillation

In: Journal of Internal Medicine, Jg. 279, 2016, Nr. 5, S. 428 – 438

DOI
Nattel, Stanley; Dobrev, Dobromir

Deciphering the fundamental mechanisms of atrial fibrillation : a quest for over a century

In: Cardiovascular Research, Jg. 109, 2016, Nr. 4, S. 465 – 466

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Heijman, Jordi; Dobrev, Dobromir; Molina, Cristina E

Differences in Left Versus Right Ventricular Electrophysiological Properties in Cardiac Dysfunction and Arrhythmogenesis

In: Arrhythmia & Electrophysiology Review, Jg. 5, 2016, Nr. 1, S. 14 – 19

DOI (Open Access)
Smith, Sakima A; Hughes, Langston D; Kline, Crystal F; Kempton, Amber N; Dorn, Lisa E; Curran, Jerry; Makara, Michael; Webb, Tyler R; Wright, Patrick; Voigt, Niels; Binkley, Philip F; Janssen, Paul M L; Kilic, Ahmet; Carnes, Cynthia A; Dobrev, Dobromir; Rasband, Matthew N; Hund, Thomas J; Mohler, Peter J

Dysfunction of the β2-spectrin-based pathway in human heart failure

In: American Journal of Physiology: Heart and Circulatory Physiology, Jg. 310, 2016, Nr. 11, S. H1583 – H1591

DOI (Open Access)
Goette, Andreas; Kalman, Jonathan M.; Aguinaga, Luis; Akar, Joseph; Cabrera, Jose Angel; Chen, Shih Ann; Chugh, Sumeet S.; Corradi, Domenico; D׳Avila, Andre; Dobrev, Dobromir; Fenelon, Guilherme; Gonzalez, Mario; Hatem, Stephane N.; Helm, Robert; Hindricks, Gerhard; Ho, Siew Yen; Hoit, Brian; Jalife, Jose; Kim, Young-Hoon; Lip, Gregory Y.H.; Ma, Chang-Sheng; Marcus, Gregory M.; Murray, Katherine; Nogami, Akihiko; Sanders, Prashanthan; Uribe, William; Van Wagoner, David R.; Nattel, Stanley

EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: : definition, characterisation, and clinical implication

In: Journal of Arrhythmia, Jg. 32, 2016, Nr. 4, S. 247 – 278

DOI (Open Access)
Goette, Andreas; Kalman, Jonathan M; Aguinaga, Luis; Akar, Joseph; Cabrera, Jose Angel; Chen, Shih Ann; Chugh, Sumeet S; Corradi, Domenico; D'Avila, Andre; Dobrev, Dobromir; Fenelon, Guilherme; Gonzalez, Mario; Hatem, Stephane N; Helm, Robert; Hindricks, Gerhard; Ho, Siew Yen; Hoit, Brian; Jalife, Jose; Kim, Young-Hoon; Lip, Gregory Y H; Ma, Chang-Sheng; Marcus, Gregory M; Murray, Katherine; Nogami, Akihiko; Sanders, Prashanthan; Uribe, William; Van Wagoner, David R; Nattel, Stanley; Centurion, Osmar A; Kuck, Karl-Heinz; Patton, Kristen K; Sapp, John L; Stiles, Martin; Svendsen, Jesper Hastrup; Upadhyay, Gaurav A; Shantsila, Alena

EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies : definition, characterization, and clinical implication

In: EP Europace, Jg. 18, 2016, Nr. 10, S. 1455 – 1490

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Nattel, Stanley; Dobrev, Dobromir

Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation

In: Nature Reviews Cardiology, Jg. 13, 2016, Nr. 10, S. 575 – 590

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Na, Li; Wehrens, Xander Ht T; Dobrev, Dobromir

PITX2 : a master regulator of cardiac channelopathy in atrial fibrillation?

In: Cardiovascular Research, Jg. 109, 2016, Nr. 3, S. 345 – 347

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Chiang, David Y; Heck, Albert J R; Dobrev, Dobromir; Wehrens, Xander H T

Regulating the regulator : Insights into the cardiac protein phosphatase 1 interactome

In: Journal of Molecular and Cellular Cardiology, Jg. 101, 2016, S. 165 – 172

DOI, Online Volltext (Open Access)
Schmidt, Constanze; Wiedmann, Felix; Voigt, Niels; Zhou, Xiao-Bo; Heijman, Jordi; Lang, Siegfried; Albert, Virginia; Kallenberger, Stefan; Ruhparwar, Arjang; Szabó, Gábor; Kallenbach, Klaus; Karck, Matthias; Borggrefe, Martin; Biliczki, Peter; Ehrlich, Joachim R; Baczkó, István; Lugenbiel, Patrick; Schweizer, Patrick A; Donner, Birgit C; Katus, Hugo A; Dobrev, Dobromir; Thomas, Dierk

Response to Letter Regarding Article, "Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation"

In: Circulation, Jg. 133, 2016, Nr. 11, S. e440 – 441

DOI, Online Volltext (Open Access)
Stathopoulou, Konstantina; Cuello, Friederike; Eaton, Philip; Carrier, Lucie; Eschenhagen, Thomas; Sadayappan, Sakthivel; Dobrev, Dobromir; Voigt, Niels; Wijnker, Paul J. M.; Schröder, Ewald; Donzelli, Sonia; Buck, Friedrich; van der Velden, Jolanda; Diering, Simon; Richter, Florian; Piasecki, Angelika; Heidler, Juliana; Wittig, Ilka

S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure

In: The FASEB Journal, Jg. 30, 2016, Nr. 5, S. 1849 – 1864

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Hartmann, Nico; Mason, Fleur E; Braun, Inga; Pabel, Steffen; Voigt, Niels; Schotola, Hanna; Fischer, Thomas H; Dobrev, Dobromir; Danner, Bernhard C; Renner, André; Gummert, Jan; Belardinelli, Luiz; Frey, Norbert; Maier, Lars S; Hasenfuss, Gerd; Sossalla, Samuel

The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology

In: Journal of Molecular and Cellular Cardiology, Jg. 94, 2016, S. 95 – 106

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Heijman, Jordi; Schirmer, Ilona; Dobrev, Dobromir

The multiple proarrhythmic roles of cardiac calcium-handling abnormalities : triggered activity, conduction abnormalities, beat-to-beat variability, and adverse remodelling

In: EP Europace, Jg. 18, 2016, Nr. 10, S. 1452 – 1454

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Heijman, Jordi; Nattel, Stanley; Dobrev, Dobromir; Wehrens, Xander H.T.; Melka, Jonathan; Algalarrando, Vincent

The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation : a critical analysis

In: Cardiovascular Research, Jg. 109, 2016, Nr. 4, S. 467 – 479

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Priori, Silvia G; Blomström-Lundqvist, Carina; Mazzanti, Andrea; Blom, Nico; Borggrefe, Martin; Camm, John; Elliott, Perry Mark; Fitzsimons, Donna; Hatala, Robert; Hindricks, Gerhard; Kirchhof, Paulus; Kjeldsen, Keld; Kuck, Karl-Heinz; Hernandez-Madrid, Antonio; Nikolaou, Nikolaos; Norekvål, Tone M; Spaulding, Christian; Van Veldhuisen, Dirk J; Kolh, Philippe; Lip, Gregory Y H; Agewall, Stefan; Barón-Esquivias, Gonzalo; Boriani, Giuseppe; Budts, Werner; Bueno, Héctor; Capodanno, Davide; Carerj, Scipione; Crespo-Leiro, Maria G; Czerny, Martin; Deaton, Christi; Dobrev, Dobromir; Erol, Çetin; Galderisi, Maurizio; Gorenek, Bulent; Kriebel, Thomas; Lambiase, Pier; Lancellotti, Patrizio; Lane, Deirdre A; Lang, Irene; Manolis, Athanasios J; Morais, Joao; Moreno, Javier; Piepoli, Massimo F; Rutten, Frans H; Sredniawa, Beata; Zamorano, Jose L; Zannad, Faiez

2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death : The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the Europe

In: EP Europace, Jg. 17, 2015, Nr. 11, S. 1601 – 1687

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Chiang, David Y.; Lebesgue, Nicolas; Beavers, David L.; Alsina, Katherina M.; Damen, J. Mirjam A.; Voigt, Niels; Dobrev, Dobromir; Wehrens, Xander H.T.; Scholten, Arjen

Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients

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Ghezelbash, Shokoufeh; Molina, Cristina E; Dobrev, Dobromir

Altered atrial metabolism : an underappreciated contributor to the initiation and progression of atrial fibrillation

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Application of the RIMARC algorithm to a large data set of action potentials and clinical parameters for risk prediction of atrial fibrillation

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Harada, Masahide; Tadevosyan, Artavazd; Qi, Xiaoyan; Xiao, Jiening; Liu, Tao; Voigt, Niels; Karck, Matthias; Kamler, Markus; Kodama, Itsuo; Murohara, Toyoaki; Dobrev, Dobromir; Nattel, Stanley

Atrial Fibrillation Activates AMP-Dependent Protein Kinase and its Regulation of Cellular Calcium Handling : Potential Role in Metabolic Adaptation and Prevention of Progression

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Calcium Handling Abnormalities as a Target for Atrial Fibrillation Therapeutics : How Close to Clinical Implementation?

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Counteracting Protein Kinase Activity in the Heart : The Multiple Roles of Protein Phosphatases

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Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia

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Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation

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Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial Remodeling

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Chiang, David Y; Zhang, Min; Voigt, Niels; Alsina, Katherina M; Jakob, Heinz G.; Martin, James F; Dobrev, Dobromir; Wehrens, Xander H T; Li, Na

Identification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation

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Innovative therapeutics for atrial fibrillation : Imminent breakthroughs or much ado about nothing?

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Irregular rhythm and atrial metabolism are key for the evolution of proarrhythmic atrial remodeling in atrial fibrillation

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Loss of Cardiomyocyte Integrin-Linked Kinase Produces an Arrhythmogenic Cardiomyopathy in Mice

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Voigt, Niels; Pearman, Charles M.; Dobrev, Dobromir; Dibb, Katharine M.

Methods for isolating atrial cells from large mammals and humans

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New antiarrhythmic targets in atrial fibrillation

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Nucleoside Diphosphate Kinase B–Activated Intermediate Conductance Potassium Channels Are Critical for Neointima Formation in Mouse Carotid Arteries

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The European Network for Translational Research in Atrial Fibrillation (EUTRAF) : Objectives and initial results

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Tools to Keep the Clock Ticking : Molecular approaches to treat Sinus Node Dysfunction

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Upregulation of K(2P)3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation

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Calcium dysregulation in atrial fibrillation : the role of CaMKII

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Cardiac CaM Kinase II genes δ and γ contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy

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Heijman, Jordi; Voigt, Niels; Carlsson, Leif G.; Dobrev, Dobromir

Cardiac safety assays

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Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

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Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation

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Detailed characterization of microRNA changes in a canine heart failure model : Relationship to arrhythmogenic structural remodeling

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GW25-e5168 Impaired Post-Transcriptional Regulation of RyR2 by microRNA-106b-25 Cluster Promotes Atrial Fibrillation

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Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation

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Kardiovaskuläre Pharmakotherapie : Risiken und Nebenwirkungen

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Loss of MicroRNA-106b-25 Cluster Promotes Atrial Fibrillation by Enhancing Ryanodine Receptor Type-2 Expression and Calcium Release

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MicroRNA regulation and cardiac calcium signaling : Role in cardiac disease and therapeutic potential

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Rat engineered heart tissue : a novel tool in the safety pharmacology toolkit?

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Role of RyR2 phosphorylation in heart failure and arrhythmias : Controversies around ryanodine receptor phosphorylation in cardiac disease

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Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog

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Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model

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Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes

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The clinical profile and pathophysiology of atrial fibrillation : Relationships among clinical features, epidemiology, and mechanisms

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Atrial fibrillation promotion by endurance exercise : demonstration and mechanistic exploration in an animal model

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Electrical storm : recent pathophysiological insights and therapeutic consequences

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Function and regulation of serine/threonine phosphatases in the healthy and diseased heart

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Voigt, Niels; Heijman, Jordi; Trausch, Anne; Mintert-Jancke, Elisa; Pott, Lutz; Ravens, Ursula; Dobrev, Dobromir

Impaired Na+-dependent regulation of acetylcholine-activated inward-rectifier K+ current modulates action potential rate dependence in patients with chronic atrial fibrillation

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Isolation of human atrial myocytes for simultaneous measurements of Ca2+ transients and membrane currents.

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MicroRNA29 : a mechanistic contributor and potential biomarker in atrial fibrillation

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Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization

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Levay, Magdolna; Krobert, Kurt Allen; Wittig, Karola; Voigt, Niels; Bermudez, Marcel; Wolber, Gerhard; Dobrev, Dobromir; Levy, Finn Olav; Wieland, Thomas

NSC23766, a widely used inhibitor of Rac1 activation, additionally Acts as a competitive antagonist at muscarinic acetylcholine receptors

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New directions in antiarrhythmic drug therapy for atrial fibrillation

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Oxidized Ca2+/Calmodulin-Dependent Protein Kinase II Triggers Atrial Fibrillation

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Personalized management of atrial fibrillation : Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference

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Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes

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Pleiotropic actions of amiodarone : still puzzling after half a century

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Heijman, Jordi; Heusch, Gerd; Dobrev, Dobromir

Pleiotropic effects of antiarrhythmic agents : dronedarone in the treatment of atrial fibrillation

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Heijman, Jordi; Voigt, Niels; Abu-Taha, Issam H; Dobrev, Dobromir

Rhythm control of atrial fibrillation in heart failure

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Safety and efficacy of vernakalant for acute cardioversion of atrial fibrillation : an update

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T-type calcium current contributes to escape automaticity and governs the occurrence of lethal arrhythmias after atrioventricular block in mice

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Voigt, Niels; Dobrev, Dobromir

The biology of human pulmonary veins : does it help us to better understand AF pathophysiology in patients?

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Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options : a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference

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Quantification of G protein Gαs subunit splice variants in different human tissues and cells using pyrosequencing

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Vorworte / Nachworte

Goette, Andreas; De Caterina, Raffaele; de Groot, Joris R.; Dobrev, Dobromir

Atrial fibrillation does not equal atrial fibrillation : The important prognostic implications of new-onset atrial fibrillation

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 56, 2025, 101572

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Bruns, Florian; Dobrev, Dobromir; Fender, Anke

Diabetes and atrial fibrillation: Causality is still a black-box

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 58, 2025, 101669

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Bruns, Florian; Märte, Hannah; Dobrev, Dobromir; Fender, Anke

Recent highlights from the International Journal of Cardiology Heart & Vasculature : cardiometabolic disease

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 60, 2025, 101779

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Linz, Dominik; Dobrev, Dobromir

Recent highlights from the International Journal of Cardiology Heart & Vasculature : Stroke prevention and rhythm control in patients with atrial fibrillation

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 61, 2025, 101816

DOI (Open Access)
Fender, Anke C.; Bruns, Florian; Dobrev, Dobromir

Sex and atrial fibrillation-associated risk estimation and management

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 423, 2025, 133000

DOI
Lerchner, Tobias; Fender, Anke; Dobrev, Dobromir; Rassaf, Tienush; Michel, Lars

The inflammatory and nutritional status in patients with dilated cardiomyopathy : Different impact for distinct phenogroups?

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 56, 2025, 101610

DOI (Open Access)
Dobrev, Dobromir; Fender, Anke C.

Inflammatory gut-heart interactions : Is there a link between inflammatory bowel disease and atrial fibrillation?

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 55, 2024, Nr. 12, 101537

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Protease-activated receptor 2 at the intersection of thrombo-inflammation and beyond

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 52, 2024, 101403

DOI (Open Access)
Pelliccia, Francesco; Montalto, Emanuela; Zimarino, Marco; Dobrev, Dobromir

Recent highlights from the International Journal of Cardiology Heart & Vasculature : Transcatheter aortic valve implantation

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 55, 2024, 101518

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Recent highlights from the International Journal of Cardiology Heart & Vasculature : Basic and translational research

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 53, 2024, 101452

DOI (Open Access)
Bruns, Florian; Dobrev, Dobromir; Fender, Anke C.

Recent highlights from the International Journal of Cardiology Heart and Vasculature : Spatiotemporal and functional immunoprofiling and its theranostic potential

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 53, 2024, 101468

DOI (Open Access)
Linz, Dominik; Dobrev, Dobromir

Recent highlights from the International Journal of Cardiology heart & Vasculature: Comprehensive management of atrial fibrillation

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 53, 2024, 101478

DOI (Open Access)
Heijman, Jordi; Dobrev, Dobromir

Spexin Hormone Signaling and Atrial Fibrillation : The Knowns and Unknowns

In: Circulation. Baltimore; New York, NY; Dallas: American Heart Association, Jg. 150, 2024, Nr. 2, S. 128 – 131

DOI
Fender, Anke C.; Dobrev, Dobromir

Towards improved detection of subclinical atrial fibrillation : Who could benefit from targeted screening?

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 55, 2024, Nr. 12, 101550

DOI (Open Access)
Saljic, Arnela; Hansen, Malthe Emil Høtbjerg; Dobrev, Dobromir

Botulinum toxin for prevention of post-operative atrial fibrillation

In: Naunyn-Schmiedeberg's Archives of Pharmacology. Berlin: Springer, Jg. 396, 2023, Nr. 3, S. 385 – 388

DOI (Open Access)
Gawałko, Monika; Linz, Dominik; Dobrev, Dobromir

Does weight matter in cryoballoon ablation?

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 47, 2023, 101251

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Evolving insights into the pleiotropic cardioprotective mechanisms of SGLT2 inhibitors

In: Naunyn-Schmiedeberg's Archives of Pharmacology. Berlin: Springer, Jg. 396, 2023, Nr. 4, S. 589 – 592

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Recent highlights from the International Journal of Cardiology Heart & Vasculature on challenges for adequate stroke prevention in patients with atrial fibrillation

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 48, 2023, 101259

DOI (Open Access)
Tedeschi, Andrea; Ammirati, Enrico; Conti, Nicolina; Dobrev, Dobromir

Recent highlights on coronary artery disease from the International Journal of Cardiology Heart & Vasculature

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 49, 2023, 101295

DOI (Open Access)
Conti, Nicolina; Ammirati, Enrico; Tedeschi, Andrea; Dobrev, Dobromir

Recent highlights on myocarditis and cardiomyopathies from the International Journal of Cardiology and International Journal of Cardiology : Heart & Vasculature

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 49, 2023, 101315

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Recent highlights on specific aspects of oral anticoagulation in difficult clinical scenarios from the International Journal of Cardiology Heart & Vasculature

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 48, 2023, 101260

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Recent highlights on the mechanistic basis of cardiovascular remodeling from the International Journal of Cardiology Heart & Vasculature

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 47, 2023, 101248

DOI (Open Access)
Linz, Dominik; Dobrev, Dobromir

Recent highlights on the prevalence and role of sleep disordered breathing in cardiovascular diseases from the International Journal of Cardiology Heart & Vasculature

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 49, 2023, 101287

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

A Gut Feeling : Lipopolysaccharide Links Gut Dysbiosis With Inflammatory Atrial Cardiomyopathy, Obesity, and Atrial Fibrillation

In: Canadian Journal of Cardiology. Amsterdam: Elsevier, Jg. 38, 2022, Nr. 12, S. 1976 – 1978

DOI, Online Volltext (Open Access)
Bruns, Florian; Dobrev, Dobromir

Assessment of atrial function by echocardiography : Can this be used to assess the arrhythmogenic atrial substrate?

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 362, 2022, S. 190 – 191

DOI
Cai, Minsi; Schotten, Ulrich; Dobrev, Dobromir; Heijman, Jordi

Atrial fibrillation substrate development before, during and after cardiac surgery : Who is to blame for late post-operative atrial fibrillation?

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 365, 2022, S. 44 – 46

DOI, Online Volltext (Open Access)
Tsuji, Yukiomi; Dobrev, Dobromir

Chronic total occlusion of infarct-related artery : A bystander or a risk factor of electrical storm?

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 359, 2022, S. 36 – 37

DOI
Gawałko, Monika; Dobrev, Dobromir

Fat chance for POAF? : Pericardial adipose tissue and the arrhythmogenic substrate for postoperative atrial fibrillation

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 39, 2022, 101000

DOI (Open Access)
Fender, Anke C.; Bruns, Florian; Dobrev, Dobromir

Minding the gap – Heterogeneity of antithrombotic treatment preferences in complex scenarios in absence of evidence-based guidelines

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 348, 2022, S. 83 – 84

DOI
Bruns, Florian; Dobrev, Dobromir; Fender, Anke C.

Persisting stroke risk in patients with atrial fibrillation despite proper anticoagulation : Unmet clinical needs

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 368, 2022, S. 39 – 40

DOI
Conti, Nicolina; Ammirati, Enrico; Tedeschi, Andrea; Dobrev, Dobromir

Recent highlights on myocarditis, cardiovascular complications of COVID-19, and cardiomyopathies from the International Journal of Cardiology: Heart & Vasculature

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 43, 2022, 101154

DOI (Open Access)
Gillis, Anne M.; Dobrev, Dobromir

Targeting the RyR2 to Prevent Atrial Fibrillation

In: Circulation: Arrhythmia and Electrophysiology. Philadelphia, Pa.: NLM (Medline), Jg. 15, 2022, Nr. 10, e011514

DOI
Fender, Anke C.; Dobrev, Dobromir

The temporal context of oral anticoagulation outcome in atrial fibrillation

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, 2022, 101051

DOI (Open Access)
Linz, Dominik; Dobrev, Dobromir

A disproportional rise in the growing submission rate to International Journal of Cardiology Heart & Vasculature during the COVID‑19 pandemic

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 33, 2021, S. 100749

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Childhood infection and modern malnutrition : Do childhood infections create an inflammatory foundation for atherosclerosis in adult life?

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 35, 2021, 100840

DOI (Open Access)
Gawałko, Monika; Linz, Dominik; Dobrev, Dobromir

Gut-microbiota derived TMAO : A risk factor, a mediator or a bystander in the pathogenesis of atrial fibrillation?

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 34, 2021, 100818

DOI (Open Access)
Tsuji, Yukiomi; Dobrev, Dobromir

Implantable cardioverter-defibrillator therapy in primary versus secondary prevention : Reliable prediction of appropriate therapies and mortality is still an unmet need

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 32, 2021, S. 100740

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Nitric oxide as a fragile switch between cardioprotection and cardiac injury

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 343, 2021, S. 102 – 103

DOI
Linz, Dominik; Linz, Benedikt; Homberg, Marloes; Bouman, Esther; Dobrev, Dobromir; Hendriks, Jeroen M.; Simons, Sami O.

Obstructive respiratory events during procedural sedation and analgesia : Another WHY to routinely screen for sleep apnea before catheter ablation of atrial fibrillation

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 33, 2021, 100783

DOI (Open Access)
Aguilar, Martin; Heijman, Jordi; Dobrev, Dobromir; Nattel, Stanley

One Ring to Rule Them All : Continuous Monitoring of Patients With Secondary Atrial Fibrillation Points to a Unifying Underlying Mechanism

In: Canadian Journal of Cardiology. Amsterdam: Elsevier, Jg. 37, 2021, Nr. 5, S. 686 – 689

DOI
Gawałko, Monika; Dobrev, Dobromir

Oral anticoagulation and therapy of atrial flutter : Discontinuation of anticoagulation revisited

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 333, 2021, S. 117 – 118

DOI
Dobrev, Dobromir; Dudley, Samuel C

Oxidative stress: a baystander or a causal contributor to atrial remodelling and fibrillation?

In: Cardiovascular Research. Oxford: Oxford University Press (OUP), Jg. 117, 2021, Nr. 11, S. 2291 – 2293

DOI (Open Access)
Linz, Dominik; Linz, Benedikt; Dobrev, Dobromir; Baumert, Mathias; Hendriks, Jeroen M.; Pepin, Jean-Louis; Jespersen, Thomas

Personalized management of sleep apnea in patients with atrial fibrillation : An interdisciplinary and translational challenge

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 35, 2021, 100843

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Potential antiarrhythmic actions of anticoagulants : Do they exist and can they be clinically unmasked?

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 331, 2021, S. 73 – 74

DOI
Song, Jia; Dobrev, Dobromir; Li, Na

Proteomics : A promising approach to discover new biomarkers for atrial fibrillation

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 345, 2021, S. 125 – 126

DOI, Online Volltext (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Soluble fibrin monomer complex as a candidate sentinel for adverse events in patients with heart failure

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 32, 2021, S. 100712

DOI (Open Access)
Heijman, Jordi; Rahm, Ann-Kathrin; Dobrev, Dobromir

Stretching the limits of antiarrhythmic drug therapy : The promise of small-conductance calcium-activated potassium channel blockers

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 37, 2021, 100924

DOI (Open Access)
Riesinger, Lisa M.; Wakili, Reza; Dobrev, Dobromir

Stroke prevention of atrial fibrillation : Improving geographic under-use of contemporary antithrombotic approaches remains a challenge

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 34, 2021, S. 100785

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

The anticoagulation dilemma and future treatment avenues in patients with breast cancer and atrial fibrillation

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 323, 2021, S. 194 – 196

DOI
Ehrlich, Joachim R.; Dobrev, Dobromir

Therapy-refractory AF : A clear unmet need for the development of novel antiarrhythmic drugs

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 331, 2021, S. 114 – 115

DOI
Fender, Anke C.; Dobrev, Dobromir

Contemporary plaque imaging for risk stratification of coronary artery disease : Are we getting there?

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 31, 2020, S. 100678

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Coronary clot composition after myocardial infarction : Thrombus age matters

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 26, 2020, S. 100450

DOI (Open Access)
Nedios, Sotirios; Dobrev, Dobromir

Electrocardiographic sex-related differences in patients with atrial fibrillation : Do they allow a better risk stratification?

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 307, 2020, S. 73 – 74

DOI
Fender, Anke C.; Dobrev, Dobromir

Heart failure with preserved ejection fraction meets atrial fibrillation : Is enhanced inflammasome signaling a major common mechanism leading to these two frequent diseases?

In: Heart Rhythm. New York: Elsevier, Jg. 17, 2020, Nr. 6, S. 1034 – 1035

DOI
Fender, Anke C.; Dobrev, Dobromir

One for all and all for one? : The dilemma of optimal management of atrial fibrillation with cardiac co-morbidities

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 299, 2020, S. 175 – 176

DOI
Fender, Anke C.; Dobrev, Dobromir

Pleiotropic actions of ticagrelor versus clopidogrel – Do molecular differences translate into superior clinical efficacy after myocardial infarction?

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, 2020, Article-No: 100508

DOI (Open Access)
Dan, Gheorghe-Andrei; Dobrev, Dobromir

Polypill revisited – Unity in diversity

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 29, 2020, S. 100607

DOI (Open Access)
Barrios Espinosa, Cristian; Hemels, Martin E.W.; Dobrev, Dobromir; Heijman, Jordi

Recurrence of atrial fibrillation following non-cardiac surgery or acute illness : A common but rarely detected complication

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 29, 2020, S. 100609

DOI (Open Access)
Gawałko, Monika; Jespersen, Thomas; Dobrev, Dobromir; Linz, Dominik

The gut microbial-derived metabolite trimethylamine N-oxide : A missing link between lifestyle-components and atrial fibrillation?

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 29, 2020, S. 100581

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Anticoagulation in difficult settings RELOADed : Evidence for applicability of direct oral anticoagulants in patients with atrial fibrillation, renal impairment and cancer

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 23, 2019, S. 100374

DOI (Open Access)
Dobrev, Dobromir

Atrial Ca²⁺/calmodulin-dependent protein kinase II : A druggable master switch of atrial fibrillation-associated atrial remodeling?

In: Heart Rhythm. New York: Elsevier, Jg. 16, 2019, Nr. 7, S. 1089 – 1090

DOI
Linz, Dominik; Sanders, Prashanthan; Pitman, Bradley; Dobrev, Dobromir; Lau, Dennis H.

Atrial fibrillation in sub-Saharan Africa : The knowns and unknowns?

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 22, 2019, S. 212 – 213

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Bound to bleed: How altered albumin binding may dictate warfarin treatment outcome

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 22, 2019, S. 214 – 215

DOI (Open Access)
Sutanto, H.; Dobrev, Dobromir; Heijman, Jordi

Genome-wide association studies of atrial fibrillation : Finding meaning in the life of risk loci

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 24, 2019, S. 100397

DOI (Open Access)
Linz, Dominik; Ammirati, Enrico; Dan, Gheorghe-Andrei; Heijman, Jordi; Dobrev, Dobromir

Highlights from the II International Journal of Cardiology Heart & Vasculature : Heart failure, atrial fibrillation, coronary artery disease and myocardial infarction

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 25, 2019, S. 100443

DOI (Open Access)
Linz, Dominik; Dobrev, Dobromir

Outcome of atrial fibrillation ablation in pulmonary hypertension : Is pulmonary hypertension a modifiable risk factor?

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 23, 2019, S. 100360

DOI (Open Access)
Ciuculete, Denisa Corina; Dobrev, Dobromir; Dan, G.-Andrei

Prognostic value of biomarkers of impaired metabolism in heart failure patients with reduced ejection fraction

In: International Journal of Cardiology (IJC) Heart & Vasculature. Amsterdam; Amsterdam; Amsterdam [u.a.]; Shannon: Elsevier, Jg. 25, 2019, S. 100441

DOI (Open Access)
Dobrev, Dobromir; Fender, Anke C.; Wehrens, Xander H.T.

Pro-arrhythmic RyR2 channels in heart failure : Do their localisation and mechanism of activation really matter?

In: Cardiovascular Research. Oxford: Oxford University Press (OUP), Jg. 114, 2018, Nr. 11, S. 1428 – 1429

DOI (Open Access)
Tsuji, Yukiomi; Dobrev, Dobromir

Prognostic impact of electrical storm in patients with implantable cardioverter defibrillators : mechanistic and therapeutic considerations to reduce the risk of death

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 255, 2018, S. 101 – 102

DOI, Online Volltext (Open Access)
Li, Na; Dobrev, Dobromir

Targeting atrial fibrillation promoting atrial structural remodeling : is this a viable strategy in patients with heart failure?

In: Naunyn-Schmiedeberg's Archives of Pharmacology. Berlin: Springer, Jg. 391, 2018, Nr. 3, S. 231 – 233

DOI (Open Access)
Fender, Anke C.; Dobrev, Dobromir

Dynamic balance of platelet reactivity in atrial fibrillation PARtially unravelled

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 243, 2017, S. 272 – 273

DOI
Li, Na; Dobrev, Dobromir

Hyperuricemia : a causal player or a bystander linking inflammatory signaling and atrial fibrillation?

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 231, 2017, S. 177 – 178

DOI
Wakili, Reza; Dobrev, Dobromir

Role of triggers and substrate in heart failure based atrial fibrillation : is pulmonary vein isolation still the cornerstone of atrial fibrillation therapy?

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 243, 2017, S. 276 – 278

DOI
Heijman, Jordi; Dobrev, Dobromir; Crijns, Harry J.G.M.

Targeting supraventricular ectopic complexes : which approach should be used and how does it affect atrial fibrillation?

In: International Journal of Cardiology. Amsterdam: Elsevier, Jg. 244, 2017, S. 202 – 203

DOI (Open Access)
Dobrev, Dobromir

Unique cardiomyocyte ultrastructure in atria : role of T tubules in subcellular Ca²⁺ signaling and atrial arrhythmogenesis

In: Heart Rhythm. New York: Elsevier, Jg. 14, 2017, Nr. 2, S. 282 – 283

DOI
Heijman, Jordi; Wehrens, X H T; Dobrev, Dobromir

Atrial arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia – is there a mechanistic link between sarcoplasmic reticulum Ca2+ leak and re‐entry?

In: Acta Physiologica. Weinheim: Wiley-Blackwell, Jg. 207, 2013, Nr. 2, S. 208 – 211

DOI
Heijman, Jordi; Dobrev, Dobromir

KCNQ1 autoantibodies : another way to regulate IKs

In: Cardiovascular Research. Oxford: Oxford University Press (OUP), Jg. 98, 2013, Nr. 3, S. 329 – 331

DOI

Abstracts

Khorasani, Najme; Ni, Haibo; Dobrev, Dobromir; Morotti, Stefano; Grandi, Eleonora

Computational Modeling Identifies Estrogen Protective Mechanisms Against Atrial Fibrosis

In: Circulation Research. New York; Philadelphia; Baltimore: Lippincott Williams and Wilkins, Jg. 137, 2025, Nr. Suppl_1, Fri161

DOI
Navarro Garcia, Jose; Zhao, Shuai; Lahiri, Satadru; Ruiz-Hurtado, Gema; Dobrev, Dobromir; Wehrens, Xander

Oxidazed LDL and LOX-1 mediates Atrial Fibrillation in Chronic Kidney Disease

In: Circulation Research. New York; Philadelphia; Baltimore: Lippincott Williams and Wilkins, Jg. 137, 2025, Nr. Suppl_1, Fri085

DOI
Ni, Haibo; Khorasani, Najme; Wu, Yixuan; Morotti, Stefano; Dobrev, Dobromir; Grandi, Eleonora

Computational modeling identifies increased background Ca2+ influx as a potential promoter of arrhythmogenic Ca2+ instability in atrial fibrillation

In: Biophysical Journal. Amsterdam: Elsevier, Jg. 123, 2024, Nr. 3, Suppl. 1, S. 384A – 384A

DOI
Wehrens, X; Keefe, J A; Aguilar-Sanchez, Y; Ong, I; Navarro-Garcia, J A; Paasche, A; Abu-Taha, I; Tekook, M; Bruns, F; Barazi, D; Kamler, Markus; Shen, H Y; Dobrev, Dobromir

Macrophage-mediated interleukin-6 signaling drives ryanodine receptor-2 calcium leak in postoperative atrial fibrillation
European Society of Cardiology Congress (ESC) 2024, 30 August – 02 September 2024, London, UK,

In: European Heart Journal. Oxford: Oxford University Press (OUP), Jg. 45, 2024, Nr. Supplement 1, ehae6663765

DOI
Herrera, Nathaniel T.; Ni, Haibo; Dobrev, Dobromir; Morotti, Stefano; Grandi, Eleonora

Sex-specific contribution of small-conductance Ca2+-activated K+ current to atrial electrophysiology and arrhythmogenesis

In: Biophysical Journal. Amsterdam: Elsevier, Jg. 122, 2023, Nr. 3, Supplement 1, S. 382A
Mittendorff, C.; Abu-Taha, I.; Kamler, Markus; Dobrev, Dobromir; Fender, A.

Upregulation of protease-activated receptors contributes to the molecular atrial substrate associated with post-operative atrial fibrillation (POAF)
8th German Pharm-Tox Summit 2023, 06.-09.03.2023, Ulm,

In: Naunyn-Schmiedeberg's Archives of Pharmacology. Berlin: Springer, Jg. 396, 2023, Nr. Supplement 1: 8th German Pharm-Tox Summit 2023 Abstracts of the 89. Jahrestagung der Deutschen Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie (DGPT) in Zusammenarbeit mit der AGAH, S. S42 – S43

DOI (Open Access)
Fogli Iseppe, Alex; Morotti, Stefano; Tekook, Marcel; Hoffmann, Dennis; Edwards, Andrew G.; Dobrev, Dobromir; Grandi, Eleonora

A Modeling Framework for Investigating the Role of Human Atrial Fibroblast Calcium Signaling in Fibrogenesis

In: Biophysical Journal. Amsterdam: Elsevier, Jg. 120, 2021, Nr. 3, Supplement 1, S. 53a – 54a

DOI (Open Access)
Kupusovic, J.; Weber, Manuel; Kessler, Lukas; Pesch, E.; Riesinger, L.; Wakili, Reza; Dobrev, Dobromir; Rischpler, Christoph; Rassaf, Tienush; Siebermair, Johannes

Increased FDG uptake in AF individuals suggesting atrial inflammation visualized by FDG PET/CT with glucose uptake suppression protocols

In: European Heart Journal. Oxford: Oxford University Press (OUP), Jg. 42, 2021, Nr. Supplement_1, ehab724.0324

DOI (Open Access)
Mittendorf, C.; Poertner, J.; Kassler, L.; Puzicha, T.; Kamler, Markus; Dobrev, Dobromir; Fender, A.

Thrombin receptor PAR4 coordinates inflammatory stress platforms in diabetic atria
87th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) ; 1 March – 3 March 2021, Digital,

In: Naunyn-Schmiedeberg's Archives of Pharmacology. Berlin: Springer, Jg. 394, 2021, Nr. Suppl. 1, S. S6

DOI (Open Access)
Dülk, R.; Mason, F. E.; Schönhals, S.; Dobrev, Dobromir; Zimmermann, W. H.; Rickert-Sperling, S.; Voigt, Niels

Abnormal cellular electrophysiology and calcium handling in iPSC-CMs from a patient with tetralogy of Fallot
84th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) and the 20th Annual Meeting of the Association of the Clinical Pharmacology Germany (VKliPha) ; 26 February – 1 March 2018. Göttingen,

In: Naunyn-Schmiedeberg's Archives of Pharmacology. Berlin: Springer, Jg. 391, 2018, Nr. 1, Supplement, S. S18

DOI
Moretti, Stefano; Ellinwood, Nicholas; Ni, Haibo; Koivumäki, Jussi T.; Maleckar, Mary M.; Heijman, Jordi; Dobrev, Dobromir; Grandi, Eleonora

Effects of Modulation of Small-Conductance Calcium-Activated Potassium Current on Atrial Electrophysiology and Arrhythmogenesis : A Population-Based Computational Study
62nd Annual Meeting of the Biophysical Society ; February 17-21, 2018, San Francisco,

In: Biophysical Journal. Amsterdam: Elsevier, Jg. 114, 2018, Nr. 3, Suppl. 1, S. 473a

DOI (Open Access)
Dobrev, Dobromir

Proarrhythmic Subcellular Signaling in Atrial Fibrillation : Role of Calcium Dependent Potassium Channels
23rd World Congress on Heart Disease, 27-29July 2018, Boston,

In: Cardiology. Basel: Karger, Jg. 140, 2018, Nr. Suppl. 1, S. 79

DOI (Open Access)
Eschenhagen, T; Carrier, L; Cuello, F; Boontje, N; Stathopoulou, K; Voigt, Niels; Buck, F; Schröder, Elisabeth; Dobrev, Dobromir; Van Der Velden, J

P678: S-glutathiolation of cMyBP-C reduces its phosphorylation and contributes to impairment of cardiac myocyte contractile function

In: Cardiovascular Research. Oxford: Oxford University Press (OUP), Jg. 103, 2014, S. S123 – S124

DOI (Open Access)

Beiträge in Sammelwerken und Tagungsbänden

Saljic, Arnela; Dobrev, Dobromir; Heijman, Jordi

New antiarrhythmic drugs and new targets for antiarrhythmic drugs

In: Antiarrhythmic Drugs / Martínez-Rubio, Antoni; Tamargo, Juan; Dan, G.-Andrei (Hrsg.). Cham: Springer Nature, 2024, S. 283 – 310

DOI
Heijman, Jordi; Dobrev, Dobromir

Arrhythmias

In: Comprehensive Pharmacology: Volume 4: Endocrinology, Cardiovascular, Hematopoietic, Urinary and Respiratory Pharmacology / Kenakin, Terrence P.; Michel, Martin C.; Bewick, Gavin. San Diego: Elsevier, Jg. 4, 2022, S. 432 – 468

DOI
Li, Na; Dobrev, Dobromir

Cardiac Inflammasome and Arrhythmia

In: Cardiovascular Signaling in Health and Disease / Parinandi, Narasimham L.; Hund, Thomas J.. Cham: Springer International Publishing, 2022, S. 259 – 285

DOI
Nattel, Stanley; Heijman, Jordi; Voigt, Niels; Wehrens, Xander H.T.; Dobrev, Dobromir

The Molecular Pathophysiology of Atrial Fibrillation

In: Cardiac Electrophysiology: From Cell to Bedside / Zipes, Douglas P.; Jalife, José; Stevenson, William G. (Hrsg.). Philadelphia, PA: Elsevier, 2018, S. 396 – 408

DOI
Dobrev, Dobromir; Voigt, Niels; Nattel, Stanley

Cholinergic and Constitutive Regulation of Atrial Potassium Channel

In: Cardiac Electrophysiology: From Cell to Bedside / Zipes, Douglas P.; Jalife, José. Philadelphia, Pa.: Elsevier Inc., 2014, S. 383 – 391

DOI
Voigt, Niels; Abu-Taha, Issam; Hejman, Jordi; Dobrev, Dobromir

Constitutive Activity of the Acetylcholine-Activated Potassium Current IK,ACh in Cardiomyocytes

In: Pharmacology & Therapeutics of Constitutively Active Receptors / Tao, Ya-Xiong (Hrsg.). Burlington: Elsevier Science, 2014, S. 393 – 409

DOI
Nattel, Stanley; Voigt, Niels; Dobrev, Dobromir

The Molecular Pathophysiology of Atrial Fibrillation

In: Cardiac Electrophysiology: From Cell to Bedside / Zipes, Douglas P.; Jalife, José (Hrsg.). Philadelphia, Pa.: Elsevier Inc., 2013, S. 449 – 458

DOI

ZIM

Zentrum für Informations- und Mediendienste

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Prof. Dr. med. Dobromir Dobrev

14

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Institutsdirektor/in, Institut für Pharmakologie

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WiSe 2025

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SoSe 2025

WiSe 2024

SoSe 2024

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Beiträge in Sammelwerken und Tagungsbänden