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Wissenschaftliche/r Mitarbeiter/in, Institut für Virologie
Aktuelle Veranstaltungen
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WiSe 2025
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SoSe 2025
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WiSe 2024
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Dietary lipid overload creates a suppressive environment that impedes the antiviral functions of NK cellsIn: iScience, Jg. 28, 2025, Nr. 5, 112396DOI (Open Access)
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Diketopiperazine/piperidine alkaloid as a potential broad-spectrum coronaviral entry inhibitor identified by supercomputer-based virtual screening from a large natural product-based libraryIn: Biomedicine & Pharmacotherapy, Jg. 183, 2025, 117841DOI (Open Access)
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Functional B cell deficiency promotes intrahepatic HBV replication and impairs the development of anti-HBV T cell responsesIn: Hepatology International, Jg. 19, 2025, Nr. 1, S. 93 – 105
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Identification of nsp16 inhibitors of SARS -CoV-2, SARS -CoV-1 and MERS-CoV from FDA-approved drugs using in silico and in vitro methodsIn: Biomedicine & Pharmacotherapy, Jg. 189, 2025, 118246DOI (Open Access)
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Interferon-induced immune signatures are associated with suppression of HEV infection in porcine cell culture modelsIn: Emerging Microbes & Infections, Jg. 14, 2025, Nr. 1, 2525269DOI (Open Access)
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Iron improves the antiviral activity of NK cellsIn: Frontiers in Immunology, Jg. 15, 2025, 1526197DOI, Online Volltext (Open Access)
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Regulatory T cells suppress TLR9-induced formation of intrahepatic myeloid-cell aggregates for T cell population expansion in liverIn: Medical Microbiology and Immunology, Jg. 214, 2025, Nr. 1, 24
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Divergent autoantibody and cytokine levels in COVID-19 sepsis patients influence survivalIn: Journal of Medical Virology, Jg. 96, 2024, Nr. 10, e29935DOI (Open Access)
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IFNα Subtypes in HIV Infection and ImmunityIn: Viruses, Jg. 16, 2024, Nr. 3, 364DOI, Online Volltext (Open Access)
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Identification of nitrile-containing isoquinoline-related natural product derivatives as coronavirus entry inhibitors in silico and in vitroIn: Biomedicine & Pharmacotherapy, Jg. 180, 2024, 117517DOI (Open Access)
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Influenza virus infection enhances tumour-specific CD8+ T-cell immunity, facilitating tumour controlIn: PLoS Pathogens, Jg. 20, 2024, Nr. 1, e1011982DOI (Open Access)
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Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cellsIn: Cell Reports Medicine, Jg. 5, 2024, Nr. 4, 101483DOI (Open Access)
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Reduced vacuolar ATPase protects mice from Friend virus infection : An unintended but instructive effect in Hif-2afl miceIn: Journal of Cell Science, Jg. 137, 2024, Nr. 12, jcs261893DOI, Online Volltext (Open Access)
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The interferon-regulated host factor hnRNPA0 modulates HIV-1 production by interference with LTR activity, mRNA trafficking, and programmed ribosomal frameshiftingIn: Journal of Virology, Jg. 98, 2024, Nr. 7, e0053424
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A systematic comparison reveals dynamic differences in early adaptive immune responses of acute-resolving versus chronic HBV replicationIn: Journal of Medical Virology, Jg. 95, 2023, Nr. 3, e28670DOI (Open Access)
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Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell folliclesIn: PLoS Pathogens, Jg. 19, 2023, Nr. 10, e1011725DOI (Open Access)
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Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patientsIn: Frontiers in Immunology, Jg. 14, 2023, 1236374DOI, Online Volltext (Open Access)
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SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infectionIn: Virologica Sinica, Jg. 38, 2023, Nr. 4, S. 606 – 619DOI (Open Access)
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Targeted mutations in IFNα2 improve its antiviral activity against various virusesIn: mBio, Jg. 14, 2023, Nr. 6, e02357-23DOI, Online Volltext (Open Access)
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Tg1.4HBV-s-rec mice, a crossbred hepatitis B virus-transgenic model, develop mild hepatitisIn: Scientific Reports, Jg. 13, 2023, Nr. 1, 22829DOI, Online Volltext (Open Access)
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A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy functionIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Jg. 119, 2022, Nr. 34, e2202653119DOI (Open Access)
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CD47 restricts antiviral function of alveolar macrophages during influenza virus infectionIn: iScience, Jg. 25, 2022, Nr. 12, 105540DOI (Open Access)
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Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infectionIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Jg. 119, 2022, Nr. 8, e2111600119DOI (Open Access)
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Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected IndividualsIn: Frontiers in Immunology, Jg. 13, 2022, 936918DOI, Online Volltext (Open Access)
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Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized miceIn: AIDS, Jg. 36, 2022, Nr. 3, S. 325 – 336
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IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph NodesIn: Frontiers in Immunology, Jg. 13, 2022DOI (Open Access)
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IFNα subtype-specific susceptibility of HBV in the course of chronic infectionIn: Frontiers in Immunology, Jg. 13, 2022, 1017753DOI (Open Access)
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Immunotherapy With Interferon α11, But Not Interferon Beta, Controls Persistent Retroviral InfectionIn: Frontiers in Immunology, Jg. 12, 2022, 809774DOI, Online Volltext (Open Access)
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SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration stepsIn: Frontiers in Immunology, Jg. 13, 2022, 935800DOI (Open Access)
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Superior antiviral activity of IFNβ in genital HSV-1 infectionIn: Frontiers in Cellular and Infection Microbiology, Jg. 12, 2022, 949036DOI, Online Volltext (Open Access)
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The Bovine Seminal Plasma Protein PDC-109 Possesses Pan-Antiviral ActivityIn: Viruses, Jg. 14, 2022, Nr. 9, 2031DOI, Online Volltext (Open Access)
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The Role of the Inhibitory Ligand HVEM and Its Receptors CD160 and BTLA in the Regulation of Anti-retroviral T Cell ResponsesIn: Frontiers in Virology, Jg. 2, 2022, 836291DOI, Online Volltext (Open Access)
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Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound nkt cell impairmentIn: mBio, Jg. 12, 2021, Nr. 2, S. e00085 – 21DOI (Open Access)
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Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World SettingIn: Frontiers in Immunology, Jg. 12, 2021, 802858DOI (Open Access)
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Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ SignalingIn: Hepatology, Jg. 73, 2021, Nr. 2, S. 486 – 502
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Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers associated with HBsAg lossIn: eBioMedicine, Jg. 69, 2021, 103464DOI (Open Access)
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TLR4 Transactivates CD8⁺ T Lymphocytes upon Acute Sterile Tissue InjuryIn: ImmunoHorizons, Jg. 5, 2021, Nr. 5, S. 298 – 306DOI, Online Volltext (Open Access)
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A Crowned Killer’s Résumé : Genome, Structure, Receptors, and Origin of SARS-CoV-2In: Virologica Sinica, 2020DOI (Open Access)
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Die Einmischer: Interferone : Wie sie die Immunantwort beeinflussen, um Viren effektiv zu bekämpfenIn: Unikate: Berichte aus Forschung und Lehre, 2020, Nr. 54: Medizin: Infektionskrankheiten - ein globales Problem, S. 18 – 27DOI, Online Volltext (Open Access)
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Erratum for Westmeier et al., "Impaired Cytotoxic CD8⁺ T Cell Response in Elderly COVID-19 Patients"In: mBio, Jg. 11, 2020, Nr. 5, S. 02243 – 02220DOI (Open Access)
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HIV infection does not alter interferon α/β receptor 2 expression on mucosal immune cellsIn: PLoS ONE, Jg. 15, 2020, Nr. 1, S. e0218905DOI, Online Volltext (Open Access)
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Impaired cytotoxic CD8⁺ T cell response in elderly COVID-19 patientsIn: mBio, Jg. 11, 2020, Nr. 5, S. e02243 – 20DOI (Open Access)
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Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoVIn: Journal of Medical Virology, Jg. 92, 2020, Nr. 5, S. 491 – 494DOI, Online Volltext (Open Access)
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Qualitative differences between the IFNα subtypes and IFNβ influence chronic mucosal HIV-1 pathogenesisIn: PLoS Pathogens, Jg. 16, 2020, Nr. 10, S. 1008986DOI (Open Access)
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SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell DifferentiationIn: Journal of Innate Immunity, Jg. 12, 2020, Nr. 5, S. 399 – 409DOI (Open Access)
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Susceptibility of SARS-CoV-2 to UV irradiationIn: American Journal of Infection Control, Jg. 48, 2020, Nr. 10, S. 1273 – 1275DOI, Online Volltext (Open Access)
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Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activitiesIn: Emerging Microbes & Infections, Jg. 8, 2019, Nr. 1, S. 1763 – 1776DOI (Open Access)
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Characterization of Endogenous SERINC5 Protein as Anti-HIV-1 FactorIn: Journal of Virology, Jg. 93, 2019, Nr. 24, S. e01221 – 19DOI (Open Access)
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Chronic retroviral infection of mice promotes tumor development, but CD137 agonist therapy restores effective tumor immune surveillanceIn: Cancer Immunology, Immunotherapy, Jg. 68, 2019, Nr. 3, S. 479 – 488DOI, Online Volltext (Open Access)
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Concurrent administration of IFNα14 and cART in TKO-BLT mice enhances suppression of HIV-1 viremia but does not eliminate the latent reservoirIn: Scientific Reports, Jg. 9, 2019, S. 18089DOI, Online Volltext (Open Access)
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Different Biological Activities of Specific Interferon Alpha SubtypesIn: mSphere, Jg. 4, 2019, Nr. 4, e00127 - 19DOI (Open Access)
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Diverse immunomodulatory effects of individual IFNα subtypes on virus-specific CD8⁺ T cell responsesIn: Frontiers in Immunology, Jg. 10, 2019, 2255DOI, Online Volltext (Open Access)
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Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunityIn: FEMS Microbiology Reviews, Jg. 43, 2019, Nr. 5, S. 435 – 456DOI, Online Volltext (Open Access)
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Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope ProteinsIn: Cell Reports, Jg. 27, 2019, Nr. 7, S. 2092 – 2104.e10DOI (Open Access)
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PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic miceIn: Antiviral Research, Jg. 161, 2019, S. 134 – 143
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Plasmacytoid dendritic cells respond to Epstein-Barr virus infection with a distinct type I interferon subtype profileIn: Blood Advances, Jg. 3, 2019, Nr. 7, S. 1129 – 1144DOI (Open Access)
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An advanced BLT-humanized mouse model for extended HIV-1 cure studiesIn: AIDS, Jg. 32, 2018, Nr. 1, S. 1 – 10DOI, Online Volltext (Open Access)
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Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotypeIn: Hepatology, Jg. 67, 2018, Nr. 4, S. 1237 – 1252DOI (Open Access)
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Impact of immune suppressive agents on the BK-Polyomavirus non coding control regionIn: Antiviral Research, Jg. 159, 2018, S. 68 – 76
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Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral InfectionIn: Frontiers in Immunology, Jg. 9, 2018, 614DOI (Open Access)
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Interferon α subtypes in HIV infectionIn: Cytokine & Growth Factor Reviews, Jg. 40, 2018, S. 13 – 18
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Different antiviral effects of IFNα and IFNβ in an HBV mouse modelIn: Immunobiology, Jg. 222, 2017, Nr. 3, S. 562 – 570
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Different antiviral effects of IFNα subtypes in a mouse model of HBV infectionIn: Scientific Reports, Jg. 7, 2017, Nr. 1, S. 334DOI, Online Volltext (Open Access)
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Expression pattern of individual IFNA subtypes in chronic HIV infectionIn: Journal of Interferon & Cytokine Research, Jg. 37, 2017, Nr. 12, S. 541 – 549
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Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infectionIn: Scientific Reports, Jg. 7, 2017, S. 7785DOI (Open Access)
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Human pDCs display sex-specific differences in type I interferon subtypes and interferon α/β receptor expressionIn: European Journal of Immunology, Jg. 47, 2017, Nr. 2, S. 251 – 256
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Hypoxia-inducible factor 1α is essential for macrophage-mediated erythroblast proliferation in acute friend retrovirus infectionIn: Scientific Reports, Jg. 7, 2017, art. no. 17236DOI (Open Access)
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Inhibition of catecholamine degradation ameliorates while chemical sympathectomy aggravates the severity of acute Friend retrovirus infection in miceIn: Brain, Behavior and Immunity, Jg. 54, 2016, S. 252 – 259
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Insufficient natural killer cell responses against retroviruses : How to improve NK cell killing of retrovirus-infected cellsIn: Retrovirology, Jg. 13, 2016, Nr. 1, 77DOI (Open Access)
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Interferon alpha subtype-specific suppression of HIV-1 infection in vivoIn: Journal of Virology, Jg. 90, 2016, Nr. 13, S. 6001 – 6013DOI (Open Access)
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Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infectionIn: Retrovirology, Jg. 12, 2015, Nr. 1, 66DOI (Open Access)
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Interferon-α subtypes in an ex vivo model of acute HIV-1 infection : expression, potency and effector mechanismsIn: PLoS Pathogens, Jg. 11, 2015, Nr. 11, S. e1005254DOI (Open Access)
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TLR ligand induced IL-6 counter-regulates the anti-viral CD8+ T cell response during an acute retrovirus infectionIn: Scientific Reports, Jg. 5, 2015, 10501DOI, Online Volltext (Open Access)
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Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitroIn: International Immunology, Jg. 26, 2014, Nr. 1, S. 35 – 46
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Distinct roles of NK cells in viral immunity during different phases of acute Friend retrovirus infectionIn: Retrovirology, Jg. 10, 2013, Nr. 1, 127DOI (Open Access)
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IFN-α subtypes : Distinct biological activities in anti-viral therapyIn: British Journal of Pharmacology (BJP), Jg. 168, 2013, Nr. 5, S. 1048 – 1058DOI (Open Access)
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IFN-α treatment inhibits acute friend retrovirus replication primarily through the antiviral effector molecule Apobec3In: The Journal of Immunology (JI), Jg. 190, 2013, Nr. 4, S. 1583 – 1590
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Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral responseIn: Cell Reports, Jg. 4, 2013, Nr. 4, S. 689 – 696DOI (Open Access)
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Role of hypoxia inducible factor-1 α for interferon synthesis in mouse dendritic cellsIn: Biological Chemistry, Jg. 394, 2013, Nr. 4, S. 495 – 505
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Interferon-alpha Subtype 11 Activates NK Cells and Enables Control of Retroviral InfectionIn: PLoS Pathogens, Jg. 8, 2012, Nr. 8, S. e1002868DOI, Online Volltext (Open Access)
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Distinct antiviral activities of IFN-α subtypesIn: Immunotherapy, Jg. 3, 2011, Nr. 7, S. 813 – 816
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Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8⁺ T cells and reduces chronic retroviral set pointsIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Jg. 108, 2011, Nr. 6, S. 2420 – 2425DOI (Open Access)
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Virus-Specific CD8+ T Cells Upregulate Programmed Death-1 Expression during Acute Friend Retrovirus Infection but Are Highly Cytotoxic and Control Virus ReplicationIn: The Journal of Immunology (JI), Jg. 187, 2011, Nr. 7, S. 3730 – 3737
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CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signalsIn: Molecular Immunology, Jg. 47, 2010, Nr. 6, S. 1255 – 1261
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Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced diseaseIn: The Journal of Immunology (JI), Jg. 185, 2010, Nr. 10, S. 6179 – 6189DOI (Open Access)
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Distinct type I interferon subtypes differentially stimulate T cell responses in HIV1-infected individuals
DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,In: HIV Medicine. Hoboken: Wiley-Blackwell, Jg. 24, 2023, Nr. 1, S. 92 -
Effects of type I interferons on HIV latency
DÖAK 2023 / German-Austrian AIDS Conference, Bonn, Germany, 23-25 March 2023,In: HIV Medicine. Hoboken: Wiley-Blackwell, Jg. 24, 2023, Nr. S1, S. 82 -
Respiratory but not systemic viral infection induces tumour growth inhibition through CD8+T-cell activation
Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI) ; 26-29 September, 2023, Strasbourg, France,In: European Journal of Immunology. Hoboken: Wiley, Jg. 53, 2023, Nr. S2, Special issue: Abstracts: Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI), 26–29 September, 2023, Strasbourg, France, S. 189DOI (Open Access)