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Dr. rer. nat. Torben Knuschke

Institut für Medizinische Mikrobiologie am Universitätsklinikum Essen

Anschrift
Hufelandstr. 55
45122 Essen
Telefon
0201/723 3069
E-Mail
knuschke@uk-essen.de

Funktionen

  • Wiss. Mitarbeiter/in und Wiss. Assistent/in, Institut für Medizinische Mikrobiologie

Aktuelle Veranstaltungen

Keine aktuellen Veranstaltungen.

Vergangene Veranstaltungen (max. 10)

Keine vergangenen Veranstaltungen.

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Wenzek, Christina; Knuschke, Torben; Hönes, G. Sebastian; Boelen, Anita; Klopfleisch, Robert; Zwanziger, Denise; Heuer, Heike; Westendorf, Astrid; Möller, Lars; Führer, Dagmar
    Thyroid hormone receptor α signaling shapes innate and adaptive immune responses during viral infection
    In: European Thyroid Journal, 2025, in press
    DOI (Open Access)
  • Steinbach, Philine; Pastille, Eva; Kaumanns, Lara; Adamczyk, Alexandra; Sutter, Kathrin; Hansen, Wiebke; Dittmer, Ulf; Buer, Jan; Westendorf, Astrid M.; Knuschke, Torben
    Influenza virus infection enhances tumour-specific CD8+ T-cell immunity, facilitating tumour control
    In: PLoS Pathogens, Jg. 20, 2024, Nr. 1, e1011982
    DOI (Open Access)
  • Bialas, Nataniel; Sokolova, Viktoriya; van der Meer, Selina Beatrice; Knuschke, Torben; Ruks, Tatjana; Klein, Kai; Westendorf, Astrid; Epple, Matthias
    Bacteria (E. coli) take up ultrasmall gold nanoparticles (2 nm) as shown by different optical microscopic techniques (CLSM, SIM, STORM)
    In: Nano Select, Jg. 3, 2022, Nr. 10, S. 1407 – 1420
    DOI, Online Volltext (Open Access)
  • Wenzek, Christina; Steinbach, Philine; Wirsdörfer, Florian; Sutter, Kathrin; Boehme, Julia D.; Geffers, Robert; Klopfleisch, Robert; Bruder, Dunja; Jendrossek, Verena; Buer, Jan; Westendorf, Astrid; Knuschke, Torben
    CD47 restricts antiviral function of alveolar macrophages during influenza virus infection
    In: iScience, Jg. 25, 2022, Nr. 12, 105540
    DOI (Open Access)
  • Schwerdtfeger, Mara; Dickow, Julia; Schmitz, Yasmin; Francois, Sandra; Karakoese, Zehra; Malyshkina, Anna; Knuschke, Torben; Dittmer, Ulf; Sutter, Kathrin
    Immunotherapy With Interferon α11, But Not Interferon Beta, Controls Persistent Retroviral Infection
    In: Frontiers in Immunology, Jg. 12, 2022, 809774
    DOI, Online Volltext (Open Access)
  • Knuschke, Torben; Kollenda, Sebastian; Wenzek, Christina; Zelinskyy, Gennadiy; Steinbach, Philine; Dittmer, Ulf; Buer, Jan; Epple, Matthias; Westendorf, Astrid
    A combination of anti-pd-l1 treatment and therapeutic vaccination facilitates improved retroviral clearance via reactivation of highly exhausted t cells
    In: mBio, Jg. 12, 2021, Nr. 1, S. e02121 – 20
    DOI (Open Access)
  • David, Paul; Drabczyk-Pluta, Malgorzata; Pastille, Eva; Knuschke, Torben; Werner, Tanja; Honke, Nadine; Megger, Dominik A.; Akhmetzyanova, Ilseyar; Shaabani, Namir; Eyking-Singer, Annette; Cario, Elke; Kershaw, Olivia; Gruber, Achim D.; Tenbusch, Matthias; Dietze, Kirsten; Trilling, Mirko; Liu, Jia; Schadendorf, Dirk; Streeck, Hendrik; Lang, Karl S.; Xie, Youhua; Zimmer, Lisa; Sitek, Barbara; Paschen, Annette; Westendorf, Astrid; Dittmer, Ulf; Zelinskyy, Gennadiy
    Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology
    In: PLoS Pathogens, Jg. 16, 2020, Nr. 3, e1008340
    DOI (Open Access)
  • Scheffel, Florian; Knuschke, Torben; Otto, Lucas; Kollenda, Sebastian; Sokolova, Viktoriya; Cosmovici, Christine; Buer, Jan; Timm, Jörg; Epple, Matthias; Westendorf, Astrid
    Effective Activation of Human Antigen-Presenting Cells and Cytotoxic CD8+ T Cells by a Calcium Phosphate-Based Nanoparticle Vaccine Delivery System
    In: Vaccines, Jg. 8, 2020, Nr. 1, 110
    DOI, Online Volltext (Open Access)
  • Kollenda, Sebastian; Klose, Jasmin; Knuschke, Torben; Sokolova, Viktoriya; Schmitz, Jochen; Staniszewska, Magdalena; Costa, Pedro Fragoso; Herrmann, Ken; Westendorf, Astrid; Fendler, Wolfgang; Epple, Matthias
    In vivo biodistribution of calcium phosphate nanoparticles after intravascular, intramuscular, intratumoral, and soft tissue administration in mice investigated by small animal PET/CT
    In: Acta Biomaterialia, Jg. 109, 2020, S. 244 – 253
    DOI
  • Knuschke, Torben
    Influenzavirus - gefährliche Wandlungsfähigkeit : Hürden bei der Impfstoffentwicklung und die Rolle des angeborenen Immunsystems als alternativer Ansatzpunkt für neue Therapien
    In: Unikate: Berichte aus Forschung und Lehre, 2020, Nr. 54: Medizin: Infektionskrankheiten - ein globales Problem, S. 8 – 17
    DOI, Online Volltext (Open Access)
  • Heße, Carolin; Kollenda, Sebastian; Rotan, Olga; Pastille, Eva; Adamczyk, Alexandra; Wenzek, Christina; Hansen, Wiebke; Epple, Matthias; Buer, Jan; Westendorf, Astrid; Knuschke, Torben
    A tumor-peptide–based nanoparticle vaccine elicits efficient tumor growth control in antitumor immunotherapy
    In: Molecular Cancer Therapeutics, Jg. 18, 2019, Nr. 6, S. 1069 – 1080
    DOI (Open Access)
  • Sokolova, Viktoriya; Loza, Kateryna; Knuschke, Torben; Heinen-Weiler, J.; Jastrow, Holger; Hasenberg, Mike; Buer, Jan; Westendorf, Astrid; Gunzer, Matthias; Epple, Matthias
    A systematic electron microscopic study on the uptake of barium sulphate nano-, submicro-, microparticles by bone marrow-derived phagocytosing cells
    In: Acta Biomaterialia, Jg. 80, 2018, S. 352 – 363
    DOI
  • Knuschke, Torben; Rotan, Olga; Bayer, Wibke; Kollenda, Sebastian; Dickow, Julia; Sutter, Kathrin; Hansen, Wiebke; Dittmer, Ulf; Lang, Karl S.; Epple, Matthias; Buer, Jan; Westendorf, Astrid
    Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral Infection
    In: Frontiers in Immunology, Jg. 9, 2018, 614
    DOI (Open Access)
  • van der Meer, Selina; Knuschke, Torben; Frede, Annika; Schulze, Nina; Westendorf, Astrid; Epple, Matthias
    Avidin-conjugated calcium phosphate nanoparticles as a modular targeting system for the attachment of biotinylated molecules in vitro and in vivo
    In: Acta Biomaterialia, Jg. 57, 2017, S. 414 – 425
    DOI
  • Sokolova, Viktoriya; Shi, Zou; Huang, Shunmei; Du, Yanqin; Kopp, Mathis; Frede, Annika; Knuschke, Torben; Buer, Jan; Yang, Dongliang; Wu, Jun; Westendorf, Astrid; Epple, Matthias
    Delivery of the TLR ligand poly(I:C) to liver cells in vitro and in vivo by calcium phosphate nanoparticles leads to a pronounced immunostimulation
    In: Acta Biomaterialia, Jg. 64, 2017, S. 401 – 410
    DOI
  • Frede, Annika; Neuhaus, Bernhard; Knuschke, Torben; Wadwa, Munisch; Kollenda, Sebastian; Klopfleisch, Robert; Hansen, Wiebke; Buer, Jan; Bruder, Dunja; Epple, Matthias; Westendorf, Astrid
    Local delivery of siRNA-loaded calcium phosphate nanoparticles abates pulmonary inflammation
    In: Nanomedicine: Nanotechnology, Biology, and Medicine, Jg. 13, 2017, Nr. 8, S. 2395 – 2403
    DOI
  • Knuschke, Torben; Rotan, Olga; Bayer, Wibke; Sokolova, Viktoriya; Hansen, Wiebke; Sparwasser, Tim; Dittmer, Ulf; Epple, Matthias; Buer, Jan; Westendorf, Astrid M.
    Combination of nanoparticle‑based therapeutic vaccination and transient ablation of regulatory T cells enhances anti‑viral immunity during chronic retroviral infection
    In: Retrovirology, Jg. 13, 2016, 24
    DOI (Open Access)
  • Merches, Katja; Khairnar, Vishal; Knuschke, Torben; Shaabani, Namir; Honke, Nadine; Duhan, Vikas; Recher, Mike; Navarini, Alexander A.; Hardt, Cornelia; Häussinger, Dieter; Tümmler, Burkhard; Gulbins, Erich; Futerman, Anthony H.; Hoffmann, Daniel; Lang, Florian; Lang, Philipp A.; Westendorf, Astrid; Lang, Karl S.
    Virus-induced type i interferon deteriorates control of systemic pseudomonas aeruginosa infection
    In: Cellular Physiology and Biochemistry, Jg. 36, 2015, Nr. 6, S. 2379 – 2392
    DOI (Open Access)
  • Knuschke, Torben; Bayer, Wibke; Rotan, Olga; Sokolova, Viktoriya; Wadwa, Munisch; Kirschning, Carsten Jürgen; Hansen, Wiebke; Sparwasser, T.; Dittmer, Ulf; Epple, Matthias; Buer, Jan; Westendorf, Astrid
    Prophylactic and therapeutic vaccination with a nanoparticle-based peptide vaccine induces efficient protective immunity during acute and chronic retroviral infection
    In: Nanomedicine: Nanotechnology, Biology, and Medicine, Jg. 10, 2014, Nr. 8, S. 1787 – 1798
    DOI
  • Knuschke, Torben; Epple, Matthias; Westendorf, Astrid
    The type of adjuvant strongly influences the T-cell response during nanoparticle-based immunization
    In: Human Vaccines & Immunotherapeutics, Jg. 10, 2014, Nr. 1, S. 164 – 169
    DOI, Online Volltext (Open Access)
  • Knuschke, Torben; Sokolova, Viktoriya; Rotan, Olga; Wadwa, Munisch; Tenbusch, Matthias; Hansen, Wiebke; Staeheli, Peter; Epple, Matthias; Buer, Jan; Westendorf, Astrid M.
    Immunization with biodegradable nanoparticles efficiently induces cellular immunity and protects against influenza virus infection
    In: The Journal of Immunology (JI), Jg. 190, 2013, Nr. 12, S. 6221 – 6229
    DOI (Open Access)
  • Sokolova, Viktoriya; Kozlova, Diana; Knuschke, Torben; Buer, Jan; Westendorf, Astrid; Epple, Matthias
    Mechanism of the uptake of cationic and anionic calcium phosphate nanoparticles by cells
    In: Acta Biomaterialia, Jg. 9, 2013, Nr. 7, S. 7527 – 7535
    DOI
  • Sokolova, Viktoriya; Rotan, Olga; Klesing, Jan; Nalbant, Perihan; Buer, Jan; Knuschke, Torben; Westendorf, Astrid; Epple, Matthias
    Calcium phosphate nanoparticles as versatile carrier for small and large molecules across cell membranes
    In: Journal of Nanoparticle Research, Jg. 14, 2012, Nr. 6, 0910
    DOI
  • Kozlova, Diana; Chernousova, Svitlana; Knuschke, Torben; Buer, Jan; Westendorf, Astrid; Epple, Matthias
    Cell targeting by antibody-functionalized calcium phosphate nanoparticles
    In: Journal of Materials Chemistry, Jg. 22, 2012, Nr. 2, S. 396 – 404
    DOI
  • Ruhl, Marianne; Knuschke, Torben; Schewior, Kevin; Glavinic, Lejla; Neumann-Haefelin, Christoph; Chang, Dae-In; Klein, Marina; Heinemann, Falko M.; Tenckhoff, Hannelore; Wiese, Manfred; Horn, Peter A.; Viazov, Sergey; Spengler, Ulrich; Roggendorf, Michael; Scherbaum, Norbert; Nattermann, Jacob; Hoffmann, Daniel; Timm, Jörg; East German HCV Study Group
    CD8+ T-Cell Response Promotes Evolution of Hepatitis C Virus Nonstructural Proteins
    In: Gastroenterology, Jg. 140, 2011, Nr. 7, S. 2064 – 2073
    DOI
  • Fleissner, Diana; Frede, Annika; Knott, Markus; Knuschke, Torben; Geffers, Robert; Hansen, Wiebke; Dobos, Gustav; Langhorst, Jost; Buer, Jan; Westendorf, Astrid
    Generation and function of immunosuppressive human and murine CD8⁺ T cells by transforming growth factor-β and retinoic acid
    In: Immunology, Jg. 134, 2011, Nr. 1, S. 82 – 92
    DOI (Open Access)
  • Sokolova, Viktoriya; Knuschke, Torben; Buer, Jan; Westendorf, Astrid; Epple, Matthias
    Quantitative determination of the composition of multi-shell calcium phosphate-oligonucleotide nanoparticles and their application for the activation of dendritic cells
    In: Acta Biomaterialia, Jg. 7, 2011, Nr. 11, S. 4029 – 4036
    DOI
  • Sokolova, Victoriya; Knuschke, Torben; Kovtun, Anna; Buer, Jan; Epple, Matthias; Westendorf, Astrid
    The use of calcium phosphate nanoparticles encapsulating toll-like receptor ligands and the antigen hemagglutinin to induce dendritic cell maturation and T cell activation
    In: Biomaterials, Jg. 31, 2010, Nr. 21, S. 5627 – 5633
    DOI

    • Abstracts

  • Sokolova, Viktoriya; Shi, Zou; Huang, S.; Du, Y.; Kopp, Mathis; Frede, Annika; Knuschke, Torben; Buer, Jan; Yang, D.; Westendorf, Astrid; Epple, Matthias
    Session 5: Biomaterials - Inorganic : Calcium phosphate nanoparticles as a delivery of bioactive compounds to the liver and for imaging and vaccination
    Annual Conference of the German Society for Biomaterials e.V., 08,-10.11.2018, Braunschweig-Stöckheim,
    In: Biomedical engineering = Biomedizinische Technik. Berlin; Berlin1: de Gruyter, Jg. 64, 2019, Nr. s1: Abstracts of the 2018 Annual Meeting of the German Society for Biomaterials, S. 36 – 40
    DOI (Open Access)
  • Rotan, Olga; Sokolova, Viktoriya; Knuschke, Torben; Westendorf, Astrid; Buer, Jan; Epple, Matthias
    Prophylaktische Vakzinierung gegen Tumoren mit funktionalisierten Calciumphosphat-Nanopartikeln in einem murinen Tumortransplantations- Modell
    Annual conference of the German Society of Biomaterials (DGBM) , 06.-08.11.2014, Dresden,
    In: BioNanoMaterials. Berlin: De Gruyter, Jg. 15, 2014, Nr. Supplement, V5
    DOI
  • Knuschke, Torben; Bayer, Wibke; Rotan, O.; Sokolova, Viktoriya; Dittmer, Ulf; Epple, Matthias; Buer, Jan; Westendorf, Astrid
    Effective immunmodulation by biodegradable calcium phosphate nanoparticles confers strong antiviral protection
    65th Annual Meeting of the German Society for Hygiene and Microbiology (DGHM), 22.-25.09.2013, Rostock,
    In: International Journal of Medical Microbiology (IJMM). Amsterdam: Elsevier, Jg. 303, 2013, Nr. Suppl. 1, S. 38 – 38
  • Ruhl, M.; Knuschke, Torben; Wiese, M.; Tenckhoff, H.; Nattermann, J.; Spengler, U.; Roggendorf, Michael; Hoffmann, D.; Timm, Jörg
    703 Evidence for differential adaptation of Hepatitis C virus in populations with different HLA-class i-background
    In: Journal of Hepatology. Amsterdam; Copenhagen; Oxford: Elsevier, Jg. 52, 2010, Nr. Suppl. 1, S. S273
    DOI

    • Dissertation

  • Knuschke, Torben
    Etablierung und Charakterisierung von biodegradierbaren Calciumphosphat Nanopartikeln zur Induktion potenter anti-viraler T-Zellantworten
    Duisburg, Essen, 2012
    Online Volltext, Online Volltext

    • Habilitation

  • Knuschke, Torben
    Effektive Immunmodulation durch therapeutischeVakzinierung mithilfe von Calcium PhosphatNanopartikeln
    Duisburg ; Essen, 2024

    • Poster / Posterbeiträge

  • Steinbach, Philine; Sutter, Kathrin; Westendorf, Astrid; Buer, Jan; Knuschke, Torben
    Respiratory but not systemic viral infection induces tumour growth inhibition through CD8+T-cell activation
    Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI) ; 26-29 September, 2023, Strasbourg, France,
    In: European Journal of Immunology. Hoboken: Wiley, Jg. 53, 2023, Nr. S2, Special issue: Abstracts: Joint Conference of the Société Française d'Immunologie (SFI) and the Deutsche Gesellschaft für Immunologie (DGfI), 26–29 September, 2023, Strasbourg, France, S. 189
    DOI (Open Access)