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Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRAIn: Nature Communications Jg. 15 (2024) Nr. 1, 63Online Volltext: dx.doi.org/ (Open Access)
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KIT ATP-Binding Pocket/Activation Loop Mutations in GI Stromal Tumor : Emerging Mechanisms of Kinase Inhibitor EscapeIn: Journal of Clinical Oncology (JCO) Jg. 42 (2024) Nr. 12, S. 1439 - 1449Online Volltext: dx.doi.org/
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Plasma Sequencing for Patients with GIST : Limitations and Opportunities in an Academic SettingIn: Cancers Jg. 14 (2022) Nr. 22, 5496Online Volltext: dx.doi.org/ (Open Access)
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Resistance to avapritinib in pdgfra-driven gist is caused by secondary mutations in the pdgfra kinase domainIn: Cancer Discovery Jg. 11 (2021) Nr. 1, S. 108 - 125Online Volltext: dx.doi.org/ (Open Access)
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Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal tumors (GISTs)In: Clinical Sarcoma Research Jg. 9 (2019) 3Online Volltext: dx.doi.org/ (Open Access)
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Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797SIn: Chemical Science Jg. 10 (2019) Nr. 46, S. 10789 - 10801Online Volltext: dx.doi.org/ (Open Access)
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KIT-Dependent and KIT-Independent Genomic Heterogeneity of Resistance in Gastrointestinal Stromal Tumors : TORC1/2 Inhibition as Salvage StrategyIn: Molecular Cancer Therapeutics Jg. 18 (2019) Nr. 11, S. 1985 - 1996Online Volltext: dx.doi.org/ (Open Access)
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Indazole-Based covalent inhibitors to target drug-resistant epidermal growth factor receptorIn: Journal of Medicinal Chemistry Jg. 60 (2017) Nr. 6, S. 2361 - 2372Online Volltext: dx.doi.org/
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Inhibitors to overcome secondary mutations in the stem cell factor receptor KITIn: Journal of Medicinal Chemistry Jg. 60 (2017) Nr. 21, S. 8801 - 8815Online Volltext: dx.doi.org/
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Effect of secondary KIT mutations on growth of GIST cells in the absence of selective pressure by imatinib in isogenic models of imatinib resistanceIn: Journal of Clinical Oncology (JCO) Jg. 32 (2014) Nr. 15 Suppl., S. 10555Online Volltext: dx.doi.org/
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Phase i study of panobinostat and imatinib in patients with treatment-refractory metastatic gastrointestinal stromal tumorsIn: British Journal of Cancer (BJC) Jg. 110 (2014) Nr. 5, S. 1155 - 1162Online Volltext: dx.doi.org/ (Open Access)
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Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growthIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 110 (2013) Nr. 9, S. 3501 - 3506Online Volltext: dx.doi.org/
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DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal TumorsIn: Cancer Research Jg. 73 (2013) Nr. 12, S. 3661 - 3670Online Volltext: dx.doi.org/
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IAP gene alterations and therapeutic modulation of IAPs by Smac mimetics in GIST
Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie, 18.-22. Oktober 2013, Wien, Österreich,In: Onkologie Jg. 36 (2013) Nr. Suppl. 7, S. 245 - 246 -
Secondary KIT mutations negatively impact cell growth in a novel isogenic model of imatinib-resistance in GIST
Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie, 18.-22. Oktober 2013, Wien, Österreich,In: Onkologie Jg. 36 (2013) Nr. Suppl. 7, S. 178 - 179 -
Inhibitors of Apoptosis Proteins (IAPs) in gastrointestinal stromal tumors - a therapeutic target?In: Onkologie Jg. 35 (2012) Nr. Suppl. 6, S. 249
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P53 modulation as a therapeutic strategy in gastrointestinal stromal tumorsIn: PLoS ONE Jg. 7 (2012) Nr. 5,Online Volltext: dx.doi.org/ (Open Access)
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Phase I trial of panobinostat (P) and imatinib (IM) in patients with treatment-refractory gastrointestinal stromal tumors (GIST)In: Journal of Clinical Oncology (JCO) Jg. 30 (2012) Nr. Suppl. 15, S. 10032
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ROR2 is a novel prognostic biomarker and a potential therapeutic target in leiomyosarcoma and gastrointestinal stromal tumourIn: The Journal of Pathology Jg. 227 (2012) Nr. 2, S. 223 - 233Online Volltext: dx.doi.org/
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Inhibition of the Ras/Raf/MAPK-pathway in GIST : Therapeutic potential?In: Onkologie Jg. 34 (2011) Nr. Suppl. 6, S. 235 - 235
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The BH3-mimetic ABT-263 enhances the apoptotic response of GIST cells to KIT-inhibitory treatmentsIn: Onkologie Jg. 34 (2011) Nr. Suppl. 6, S. 254
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Effective therapeutic sensitization of gastrointestinal stromal tumors by a BH3 mimeticIn: European Journal of Cancer / EJC Supplements Jg. 8 (2010) Nr. 7, S. 69 - 70Online Volltext: dx.doi.org/
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Proapoptotic activity of bortezomib in gastrointestinal stromal tumor cellsIn: Cancer Research Jg. 70 (2010) Nr. 1, S. 150 - 159Online Volltext: dx.doi.org/
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Therapeutic Potential of Mdm2 Inhibition in Malignant Germ Cell TumoursIn: European Urology Jg. 57 (2010) Nr. 4, S. 679 - 687Online Volltext: dx.doi.org/
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Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumorsIn: Cancer Research Jg. 69 (2009) Nr. 17, S. 6941 - 6950Online Volltext: dx.doi.org/ (Open Access)
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Evaluation of mismatch repair deficiency as predictive biomarker in novel sarcoma cell line models
Gemeinsame Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie ; 01.-04. Oktober 2021, Hybrid-Kongress,In: Oncology Research and Treatment Jg. 44 (2021) Nr. Supplement 2, S. 186Online Volltext: dx.doi.org/ (Open Access) -
Comprehensive profile of platelet derived growth factor receptor alpha (PDGFRA) mutations in gastrointestinal stromal tumors
Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, USA,In: Cancer Research Jg. 80 (2020) Nr. 16: Supplement, S. 3005Online Volltext: dx.doi.org/ -
Targeting the PI3K-and MAPK pathway in high grade leiomyosarcoma
Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie ; 28. September - 2. Oktober 2018, Wien,In: Oncology Research and Treatment Jg. 41 (2018) Nr. Suppl. 4, S. 300Online Volltext: dx.doi.org/ (Open Access) -
Targeting glucose metabolism by 2-Deoxyglucose in Gastrointestinal Stromal Tumors
Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie, 18.-22. Oktober 2013, Wien, Österreich,In: Onkologie Jg. 36 (2013) Nr. Suppl. 7, S. 246Online Volltext: dx.doi.org/ -
Inhibitors of apoptosis (IAPs) in gastrointestinal stromal tumorsIn: Cancer Research Jg. 72 (2012) Nr. 8, Suppl., S. 3855 - 3855Online Volltext: dx.doi.org/