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SoSe 2025
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Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Autophagy suppression via SRC induction represents a therapeutic vulnerability for BAP1-mutant cancersIn: Autophagy, 2025, in pressDOI (Open Access)
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Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high-grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical modelsIn: Cancer Communications, Jg. 45, 2025, Nr. 8, S. 966 – 970DOI (Open Access)
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Truncated DAPK Variants Restore Tumor Suppressor Activity and Synergize with Standard Therapies in High-Grade Serous Ovarian CancerIn: Cancers, Jg. 17, 2025, Nr. 12, 1910DOI (Open Access)
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GRB2 is a BECN1 interacting protein that regulates autophagyIn: Cell Death and Disease, Jg. 15, 2024, Nr. 1, 14DOI, Online Volltext (Open Access)
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Synergistic Sensitization of High-Grade Serous Ovarian Cancer Cells Lacking Caspase-8 Expression to Chemotherapeutics Using Combinations of Small-Molecule BRD4 and CDK9 InhibitorsIn: Cancers, Jg. 16, 2024, Nr. 1, 107DOI (Open Access)
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Correction : The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancerIn: Cellular and Molecular Life Sciences - CMLS, Jg. 80, 2023, Nr. 3, 64DOI (Open Access)
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Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancerIn: Cancer Communications, Jg. 44, 2023, Nr. 1, S. 101 – 126DOI (Open Access)
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A new perspective on immune evasion : Escaping immune surveillance by inactivating tumor suppressorsIn: Signal Transduction and Targeted Therapy, Jg. 7, 2022, Nr. 1, 15DOI, Online Volltext (Open Access)
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Nintedanib and Dasatinib Treatments Induce Protective Autophagy as a Potential Resistance Mechanism in MPM CellsIn: Frontiers in Cell and Developmental Biology, Jg. 10, 2022, 852812DOI, Online Volltext (Open Access)
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The non-apoptotic function of Caspase-8 in negatively regulating the CDK9-mediated Ser2 phosphorylation of RNA polymerase II in cervical cancerIn: Cellular and Molecular Life Sciences - CMLS, Jg. 79, 2022, Nr. 12, 597DOI (Open Access)
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A BAP1 synonymous mutation results in exon skipping, loss of function and worse patient prognosisIn: iScience, Jg. 24, 2021, Nr. 3, 102173DOI (Open Access)
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Monosomy 3 is linked to resistance to mek inhibitors in uveal melanomaIn: International Journal of Molecular Sciences (IJMS), Jg. 22, 2021, Nr. 13, 6727DOI (Open Access)
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Regulation of beclin 1-mediated autophagy by oncogenic tyrosine kinasesIn: International Journal of Molecular Sciences (IJMS), Jg. 21, 2020, Nr. 23, S. 9210DOI, Online Volltext (Open Access)
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TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancerIn: Cell Death Discovery, Jg. 6, 2020, Nr. 1, 12DOI (Open Access)
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Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and BrachytherapyIn: Frontiers in Oncology, Jg. 9, 2019, S. 742DOI (Open Access)
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Correction: : γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancersIn: OncoTarget, Jg. 10, 2019, Nr. 8, S. 916 – 916DOI (Open Access)
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Cullin 5 is a novel candidate tumor suppressor in renal cell carcinoma involved in the maintenance of genome stabilityIn: Oncogenesis, Jg. 8, 2019, Nr. 1, S. 4DOI (Open Access)
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Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand BreaksIn: Cell Reports, Jg. 25, 2018, Nr. 4, S. 1040 – 1050.e5DOI, Online Volltext (Open Access)
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Multistep regulation of TFEB by MTORC1In: Autophagy, Jg. 13, 2017, Nr. 3, S. 464 – 472DOI, Online Volltext (Open Access)
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An integrative somatic mutation analysis to identify pathways linked with survival outcomes across 19 cancer typesIn: Bioinformatics, Jg. 32, 2016, Nr. 11, S. 1643 – 1651
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Fibroblast growth factor receptor-dependent and -independent paracrine signaling by sunitinib-resistant renal cell carcinomaIn: Molecular and Cellular Biology (MCB), Jg. 36, 2016, Nr. 13, S. 1836 – 1855
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Macrophage PPARγ inhibits GPR132 to mediate the anti-tumor effects of rosiglitazoneIn: eLife, Jg. 5, 2016, S. e18501DOI (Open Access)
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Unique epigenetic gene profiles define human breast cancers with poor prognosisIn: OncoTarget, Jg. 7, 2016, Nr. 52, S. 85819 – 85831
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γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancersIn: OncoTarget, Jg. 7, 2016, Nr. 3, S. 2611 – 2628DOI (Open Access)
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Prospective evaluation of plasma levels of ANGPT2, TuM2PK, and VEGF in patients with renal cell carcinoma Urological oncologyIn: BMC Urology, Jg. 15, 2015, Nr. 1, S. 1 – 8DOI (Open Access)
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Spectrum of diverse genomic alterations define non-clear cell renal carcinoma subtypesIn: Nature Genetics, Jg. 47, 2015, Nr. 1, S. 13 – 21DOI (Open Access)
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N-Acetylcysteine boosts xenobiotic detoxification in shellfishIn: Aquatic Toxicology, Jg. 154, 2014, S. 131 – 140
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Nullifying the CDKN2AB locus promotes mutant K-ras lung tumorigenesisIn: Molecular Cancer Research, Jg. 12, 2014, Nr. 6, S. 912 – 923DOI (Open Access)
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A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinomaIn: Molecular Cancer Research, Jg. 11, 2013, Nr. 9, S. 1061 – 1071DOI, Online Volltext (Open Access)
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A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growthIn: Nature Communications, Jg. 4, 2013, S. 2035DOI (Open Access)
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Cooperation and antagonism among cancer genes: The renal cancer paradigmIn: Cancer Research, Jg. 73, 2013, Nr. 14, S. 4173 – 4179DOI, Online Volltext (Open Access)
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Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validationIn: The Lancet Oncology, Jg. 14, 2013, Nr. 2, S. 159 – 167DOI (Open Access)
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Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1In: Molecular and Cellular Biology (MCB), Jg. 33, 2013, Nr. 19, S. 3762 – 3779
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Simultaneous isolation of high-quality DNA, RNA, miRNA and proteins from tissues for genomic applicationsIn: Nature Protocols, Jg. 8, 2013, Nr. 11, S. 2240 – 2255DOI (Open Access)
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A validated tumorgraft model reveals activity of dovitinib against renal cell carcinomaIn: Science Translational Medicine, Jg. 4, 2012, Nr. 137, 137ra75DOI (Open Access)
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BAP1 loss defines a new class of renal cell carcinomaIn: Nature Genetics, Jg. 44, 2012, Nr. 7, S. 751 – 759DOI (Open Access)
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Chemical inhibition of RNA viruses reveals REDD1 as a host defense factorIn: Nature Chemical Biology, Jg. 7, 2011, Nr. 10, S. 712 – 719
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Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinomaIn: Molecular Cancer Research, Jg. 9, 2011, Nr. 9, S. 1255 – 1265DOI, Online Volltext (Open Access)
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Regulation of TFEB and V-ATPases by mTORC1In: The EMBO Journal, Jg. 30, 2011, Nr. 16, S. 3242 – 3258DOI (Open Access)
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Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic deathIn: Oncogene, Jg. 30, 2011, Nr. 18, S. 2147 – 2160DOI, Online Volltext (Open Access)
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Expression analysis of the fpr (ferredoxin-NADP⁺ reductase) gene in Pseudomonas putida KT2440In: Biochemical and Biophysical Research Communications (BBRC), Jg. 339, 2006, Nr. 4, S. 1246 – 1254
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Regulation of superoxide stress in Pseudomonas putida KT2440 is different from the SoxR paradigm in Escherichia coliIn: Biochemical and Biophysical Research Communications (BBRC), Jg. 341, 2006, Nr. 1, S. 51 – 56
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Antioxidants as Potentially Safe Antidotes for Organophosphorus PoisoningIn: Current Enzyme Inhibition, Jg. 1, 2005, Nr. 2, S. 147 – 156
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Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolatesIn: Antimicrobial Agents and Chemotherapy, Jg. 49, 2005, Nr. 7, S. 2746 – 2752DOI, Online Volltext (Open Access)
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Effect of fish meal replacement by plant protein sources on non-specific defence mechanisms and oxidative stress in gilthead sea bream (Sparus aurata)In: Aquaculture, Jg. 249, 2005, Nr. 1-4, S. 387 – 400DOI (Open Access)
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Fish tolerance to organophosphate-induced oxidative stress is dependent on the glutathione metabolism and enhanced by N-acetylcysteineIn: Aquatic Toxicology, Jg. 65, 2003, Nr. 4, S. 337 – 360
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Increased recovery of brain acetylcholinesterase activity in dichlorvos-intoxicated European eels Anguilla anguilla by bath treatment with N-acetylcysteineIn: Diseases of Aquatic Organisms, Jg. 55, 2003, Nr. 3, S. 237 – 245DOI (Open Access)
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Impaired glutathione redox status is associated with decreased survival in two organophosphate-poisoned marine bivalvesIn: Chemosphere, Jg. 47, 2002, Nr. 5, S. 485 – 497
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Glutathione-dependent resistance of the European eel Anguilla anguilla to the herbicide molinateIn: Chemosphere, Jg. 45, 2001, Nr. 4-5, S. 671 – 681
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Role of glutathione in thiobencarb resistance in the European eel Anguilla anguillaIn: Ecotoxicology and Environmental Safety, Jg. 46, 2000, Nr. 1, S. 51 – 56
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Ultrastructural morphogenesis of pectinid spat from the western Mediterranean : A way to differentiate seven generaIn: Journal of Shellfish Research, Jg. 17, 1998, Nr. 1-3, S. 123 – 130
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TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagyIn: Cell Cycle: Taylor & Francis, Jg. 10, 2011, Nr. 23, S. 3987 – 3988DOI, Online Volltext (Open Access)
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A Dual HiBiT-GFP-LC3 Lentiviral Reporter for Autophagy Flux AssessmentIn: Autophagy and Cancer: Methods and Protocols / Norberg, Helin; Norberg, Erik (Hrsg.). New York: Springer, 2022, S. 75 – 98
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SNPs and personalized medicine : Scrutinizing pathogenic synonymous mutations for precision oncologyIn: Single Nucleotide Polymorphisms: Human Variation and a Coming Revolution in Biology and Medicine / Sauna, Zuben E.; Kimchi-Sarfaty, Chava (Hrsg.). Cham: Springer International Publishing, 2022, S. 185 – 195