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Research Center One Health Ruhr - Metabolism, Senescence & Autophagy
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Hufelandstrasse 55
45147 Essen
45147 Essen
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Professor/in, One Health Ruhr - Metabolism, Senescence & Autophagy
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Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidationIn: Nature Communications, Jg. 16, 2025, Nr. 1, 1774DOI, Online Volltext (Open Access)
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GEMCAT : A new algorithm for gene expression-based prediction of metabolic alterationsIn: NAR Genomics and Bioinformatics, Jg. 7, 2025, Nr. 1, lqaf003DOI, Online Volltext (Open Access)
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TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescenceIn: The EMBO Journal, Jg. 44, 2025, Nr. 23, S. 7119 – 7153DOI, Online Volltext (Open Access)
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Automated Liquid Handling Extraction and Rapid Quantification of Underivatized Amino Acids and Tryptophan Metabolites from Human Serum and Plasma Using Dual-Column U(H)PLC-MRM-MS and Its Application to Prostate Cancer StudyIn: Metabolites, Jg. 14, 2024, Nr. 7, 370DOI, Online Volltext (Open Access)
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Development of new approach methods for the identification and characterization of endocrine metabolic disruptors : A PARC projectIn: Frontiers in Toxicology, Jg. 5, 2023, 1212509DOI (Open Access)
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Particle ID : A Multiplexed Hydrogel Bead Platform for Biomedical ApplicationsIn: ACS Applied Materials & Interfaces, Jg. 15, 2023, Nr. 48, S. 55346 – 55357DOI (Open Access)
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Phosphoproteomics Profiling Defines a Target Landscape of the Basophilic Protein Kinases AKT, S6K, and RSK in Skeletal MyotubesIn: Journal of Proteome Research, Jg. 22, 2023, Nr. 3, S. 768 – 789DOI, Online Volltext (Open Access)
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Proteome Coverage after Simultaneous Proteo-Metabolome Liquid-Liquid ExtractionIn: Journal of Proteome Research, Jg. 22, 2023, Nr. 3, S. 951 – 966DOI (Open Access)
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Rebalancing of mitochondrial homeostasis through an NAD⁺-SIRT1 pathway preserves intestinal barrier function in severe malnutritionIn: eBioMedicine, Jg. 96, 2023, 104809DOI (Open Access)
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Cardiac PI3K p110a attenuation delays aging and extends lifespanIn: Cell Stress: The Journal of the European Research Institute for Integrated Cellular Pathology, Jg. 6, 2022, Nr. 8, S. 72 – 75DOI (Open Access)
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Comparative Assessment of Quantification Methods for Tumor Tissue PhosphoproteomicsIn: Analytical Chemistry, Jg. 94, 2022, Nr. 31, S. 10893 – 10906DOI (Open Access)
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Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and LongevityIn: Circulation, Jg. 145, 2022, Nr. 25, S. 1853 – 1866DOI (Open Access)
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PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signalingIn: Nature Communications, Jg. 13, 2022, Nr. 1, 2982DOI (Open Access)
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Combined Metabolic and Chemical (CoMetChem) Labeling Using Stable Isotopes : a Strategy to Reveal Site-Specific Histone Acetylation and Deacetylation Rates by LC-MSIn: Analytical Chemistry, Jg. 93, 2021, Nr. 38, S. 12872 – 12880DOI (Open Access)
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Finding new edges: Systems approaches to MTOR signalingIn: Biochemical Society Transactions, Jg. 49, 2021, Nr. 1, S. 41 – 54DOI (Open Access)
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G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signalingIn: Cell, Jg. 184, 2021, Nr. 3, S. 655 – 674.e27DOI (Open Access)
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹In: Autophagy, Jg. 17, 2021, Nr. 1, S. 1 – 382DOI (Open Access)
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The TSC Complex-mTORC1 Axis : From Lysosomes to Stress Granules and BackIn: Frontiers in Cell and Developmental Biology, Jg. 9, 2021, 751892DOI (Open Access)
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The szt2 interactome unravels new functions of the kicstor complexIn: Cells, Jg. 10, 2021, Nr. 10, 2711DOI (Open Access)
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mTORC1 Crosstalk With Stress Granules in Aging and Age-Related DiseasesIn: Frontiers in Aging, Jg. 2, 2021, 761333DOI (Open Access)
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Breaking the Interface : Efficient Extraction of Magnetic Beads from Nanoliter Droplets for Automated Sequential ImmunoassaysIn: Analytical Chemistry, Jg. 92, 2020, Nr. 15, S. 10283 – 10290DOI (Open Access)
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IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor ProgressionIn: Cell, Jg. 182, 2020, Nr. 5, S. 1252 – 1270.e34DOI (Open Access)
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Podocytes maintain high basal levels of autophagy independent of mtor signalingIn: Autophagy, Jg. 16, 2020, Nr. 11, S. 1932 – 1948DOI (Open Access)
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Partially non-homogeneous dynamic Bayesian networks based on Bayesian regression models with partitioned design matricesIn: Bioinformatics, Jg. 35, 2019, Nr. 12, S. 2108 – 2117DOI (Open Access)
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The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical mannerIn: Life Science Alliance, Jg. 2, 2019, Nr. 2, e201800257DOI (Open Access)
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Tomatidine, a novel antiviral compound towards dengue virusIn: Antiviral Research, Jg. 161, 2019, S. 90 – 99DOI (Open Access)
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CGEF-1 regulates mTORC1 signaling during adult longevity and stress response in C. elegansIn: OncoTarget, Jg. 9, 2018, Nr. 11, S. 9581 – 9595DOI (Open Access)
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Correction: Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease (Proceedings of the National Academy of Sciences of the United States of America (2008) 105 (11299-11304) DOI: 10.1073/pnas.0801457105)In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Jg. 115, 2018, Nr. 15, S. E3600DOI (Open Access)
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TGFβ-signaling and FOXG1-expression are a hallmark of astrocyte lineage diversity in the murine ventral and dorsal forebrainIn: Frontiers in Cellular Neuroscience, Jg. 12, 2018, 448DOI (Open Access)
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Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradationIn: OncoImmunology, Jg. 7, 2018, Nr. 12, e1486353DOI (Open Access)
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Differential control of ageing and lifespan by isoforms and splice variants across the mTOR networkIn: Essays in Biochemistry, Jg. 61, 2017, Nr. 3, S. 349 – 368DOI, Online Volltext (Open Access)
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Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoidsIn: The Journal of Cell Biology (JCB), Jg. 216, 2017, Nr. 6, S. 1567 – 1577DOI (Open Access)
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PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagyIn: Autophagy, Jg. 13, 2017, Nr. 3, S. 486 – 505DOI (Open Access)
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A systems study reveals concurrent activation of AMPK and mTOR by amino acidsIn: Nature Communications, Jg. 7, 2016, 13254DOI (Open Access)
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Tumor-intrinsic PD-L1 signals regulate cell growth, pathogenesis, and autophagy in ovarian cancer and melanomaIn: Cancer Research, Jg. 76, 2016, Nr. 23, S. 6964 – 6974DOI, Online Volltext (Open Access)
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Functional proteomics identifies acinus L as a direct insulin- and amino acid-dependent mammalian target of rapamycin complex 1 (mTORC1) substrateIn: Molecular and Cellular Proteomics (MCP), Jg. 14, 2015, Nr. 8, S. 2042 – 2055DOI (Open Access)
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Molecular mechanisms of mTOR regulation by stressIn: Molecular and Cellular Oncology, Jg. 2, 2015, Nr. 2, e970489DOI (Open Access)
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Nutrigenomics: Toward a cross-disciplinary understanding of nutrient-driven networks in health and disease : What can we learn from the study of cross-talk in complex protein kinase and metabolic networks?In: Aktuelle Ernährungsmedizin, Jg. 40, 2015, Nr. 2, S. 88 – 92
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TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal TransitionIn: Developmental Cell, Jg. 32, 2015, Nr. 5, S. 617 – 630DOI (Open Access)
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PI3K-p110-alpha-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2In: Journal of Neurochemistry, Jg. 130, 2014, Nr. 2, S. 255 – 267
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T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8⁺CD28⁺ T cells but not in CD8⁺CD28⁻ T cellsIn: Experimental Gerontology, Jg. 54, 2014, S. 75 – 83
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Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer CellsIn: Cell, Jg. 154, 2013, Nr. 4, S. 859 – 874DOI (Open Access)
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A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 RegulationIn: Science Signaling, Jg. 5, 2012, Nr. 217, S. ra25
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A modelling-experimental approach reveals insulin receptor substrate (IRS)-dependent regulation of adenosine monosphosphate-dependent kinase (AMPK) by insulinIn: The FEBS Journal, Jg. 279, 2012, Nr. 18, S. 3314 – 3328DOI (Open Access)
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Response to Comment on “A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation”: Building a Model of the mTOR Signaling Network with a Potentially Faulty ToolIn: Science Signaling, Jg. 5, 2012, Nr. 232, S. lc4
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Bile Proteomic Profiles Differentiate Cholangiocarcinoma From Primary Sclerosing Cholangitis and CholedocholithiasisIn: Hepatology, Jg. 53, 2011, Nr. 3, S. 875 – 884
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Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and diseaseIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Jg. 105, 2008, Nr. 32, S. 11299 – 11304DOI, Online Volltext (Open Access)
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PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosisIn: PLoS ONE, Jg. 2, 2007, Nr. 11, e1217DOI (Open Access)
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The MprF protein is required for lysinylation of phospholipids in listerial membranes and confers resistance to cationic antimicrobial peptides (CAMPs) on Listeria monocytogenesIn: Molecular Microbiology, Jg. 62, 2006, Nr. 5, S. 1325 – 1339DOI (Open Access)
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LRBA balances antigen presentation and T-cell responses via autophagy by binding to PIK3R4 and FYCO12024DOI (Open Access)
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TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescence2024DOI (Open Access)
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The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress2024DOI (Open Access)
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Translational Control by Amino Acids and EnergyIn: Handbook of Cell Signaling / Bradshaw, Ralph A.; Dennis, Edward A. (Hrsg.). Amsterdam: Academic Press, Jg. 3, 2009, S. 2285 – 2293
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Modulators of the interaction of astrin and raptor, and uses thereof in cancer therapy [Patentschrift]2013
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Method for modeling, optimizing, parameterizing, testing and/or validating a dynamic network or network perturbation [Patentschrift]2011