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2024 WS
- Prinzipien der zellulären Signaltransduktion (*)
- Wahlfach: Molekulare Infektionsbiologie (WP)
- Molekular- und Zellbiologie für Biomediziner
- Molekular- und Zellbiologie für Biomediziner (PV)
- Seminar für Molekularbiologie / Zellbiologie u. experimentelle Krebsforschung (mit Gastsprechern) (*)
- Anleitung zu selbständigem wissenschaftlichen Arbeiten (*)
- Vorlesung des GRK 1739 (mit Gastsprechern)
- Molekulare Immunologie (*)
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2024 SS
- Wahlfach: Molekulare Infektionsbiologie (WP)
- Neue Literatur der Zell- und Molekularbiologie für Med. Biologen
- Praktikum Zell- und Molekularbiologie für med. Biologen (Bachelor) (PV)
- Prinzipien der zellulären Signaltransduktion (*)
- Seminar für Molekularbiologie / Zellbiologie u. experimentelle Krebsforschung (mit Gastsprechern) (*)
- Anleitung zu selbständigem wissenschaftlichen Arbeiten (*)
- Vorlesung des GRK 1739 (mit Gastsprechern)
- Molekulare Immunologie (*)
- Molekulare Mechanismen bakterieller Infektionen (*)
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2023 WS
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Acid Sphingomyelinase Activation and ROS Generation Potentiate Antiproliferative Effects of Mitomycin in HCCIn: International Journal of Molecular Sciences (IJMS) Jg. 25 (2024) Nr. 22, 12175Online Volltext: dx.doi.org/ (Open Access)
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Acid sphingomyelinase inhibition induces cerebral angiogenesis post-ischemia/reperfusion in an oxidative stress-dependent way and promotes endothelial survival by regulating mitochondrial metabolismIn: Cell Death and Disease Jg. 15 (2024) Nr. 9, 650Online Volltext: dx.doi.org/ (Open Access)
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BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathwayIn: Science Advances Jg. 10 (2024) Nr. 36, eadn9361Online Volltext: dx.doi.org/ (Open Access)
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Caveolin-1 affects early mycobacterial infection and apoptosis in macrophages and miceIn: Tuberculosis Jg. 147 (2024) 102493Online Volltext: dx.doi.org/ (Open Access)
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Fluoxetine and Sertraline Potently Neutralize the Replication of Distinct SARS-CoV-2 VariantsIn: Viruses Jg. 16 (2024) Nr. 4, 545Online Volltext: dx.doi.org/ (Open Access)
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Phosphatidic acid is involved in regulation of autophagy in neurons in vitro and in vivoIn: Pflügers Archiv: European Journal of Physiology (2024) in pressOnline Volltext: dx.doi.org/ (Open Access)
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Signaling roles of sphingolipids in the ischemic brain and their potential utility as therapeutic targetsIn: Neurobiology of Disease Jg. 201 (2024) 106682Online Volltext: dx.doi.org/ (Open Access)
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Sphingosine Prevents Rhinoviral InfectionsIn: International Journal of Molecular Sciences (IJMS) Jg. 25 (2024) Nr. 5, 2486Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Sphingosine is involved in PAPTP-induced death of pancreas cancer cells by interfering with mitochondrial functionsIn: Journal of Molecular Medicine Jg. 102 (2024) Nr. 7, S. 947 - 959Online Volltext: dx.doi.org/ (Open Access)
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Sphingosine kills intracellular Pseudomonas aeruginosa and Staphylococcus aureusIn: Pathogens and Disease Jg. 82 (2024) ftae016Online Volltext: dx.doi.org/ (Open Access)
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Treatment of Staphylococcus aureus infection with sphingosine in ex vivo perfused and ventilated lungsIn: The Journal of Heart and Lung Transplantation Jg. 43 (2024) Nr. 1, S. 100 - 110Online Volltext: dx.doi.org/ (Open Access)
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Tribute to Andrea Huwiler (1966–2023)In: Pflügers Archiv: European Journal of Physiology (2024) in pressOnline Volltext: dx.doi.org/ (Open Access)
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A VirB4 ATPase of the mobile accessory genome orchestrates core genome-encoded features of physiology, metabolism, and virulence of Pseudomonas aeruginosa TBCF10839In: Frontiers in Cellular and Infection Microbiology Jg. 13 (2023) 1234420Online Volltext: dx.doi.org/ (Open Access)
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Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinomaIn: Journal of Molecular Medicine Jg. 101 (2023) Nr. 7, S. 891 - 903Online Volltext: dx.doi.org/ (Open Access)
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Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s diseaseIn: Nature Communications Jg. 14 (2023) Nr. 1, 1631Online Volltext: dx.doi.org/ (Open Access)
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Medications Modulating the Acid Sphingomyelinase/Ceramide System and 28-Day Mortality among Patients with SARS-CoV-2: An Observational StudyIn: Pharmaceuticals Jg. 16 (2023) Nr. 8, 1107Online Volltext: dx.doi.org/ (Open Access)
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Reduced Sphingosine in Cystic Fibrosis Increases Susceptibility to Mycobacterium abscessus InfectionsIn: International Journal of Molecular Sciences (IJMS) Jg. 24 (2023) Nr. 18, 14004Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Risk of Death in Individuals Hospitalized for COVID-19 With and Without Psychiatric Disorders : An Observational Multicenter Study in FranceIn: Biological Psychiatry Global Open Science Jg. 3 (2023) Nr. 1, S. 56 - 67Online Volltext: dx.doi.org/ (Open Access)
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Role of Tyrosine Nitrosylation in Stress-Induced Major Depressive Disorder: Mechanisms and ImplicationsIn: International Journal of Molecular Sciences (IJMS) Jg. 24 (2023) Nr. 19, 14626Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Simultaneous targeting of mitochondrial Kv1.3 and lysosomal acid sphingomyelinase amplifies killing of pancreatic ductal adenocarcinoma cells in vitro and in vivoIn: Journal of Molecular Medicine Jg. 101 (2023) Nr. 3, S. 295 - 310Online Volltext: dx.doi.org/ (Open Access)
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Sphingolipids in thyroid eye diseaseIn: Frontiers in Endocrinology Jg. 14 (2023) 1170884Online Volltext: dx.doi.org/ (Open Access)
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Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesiclesIn: Basic Research in Cardiology Jg. 117 (2022) Nr. 1, 43Online Volltext: dx.doi.org/ (Open Access)
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Antidepressant Use and Its Association with 28-Day Mortality in Inpatients with SARS-CoV-2 : Support for the FIASMA Model against COVID-19In: Journal of Clinical Medicine (JCM) Jg. 11 (2022) Nr. 19, 5882Online Volltext: dx.doi.org/ (Open Access)
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Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungsIn: PLoS ONE Jg. 17 (2022) e0271620Online Volltext: dx.doi.org/ (Open Access)
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Antiviral and Anti-Inflammatory Activities of Fluoxetine in a SARS-CoV-2 Infection Mouse ModelIn: International Journal of Molecular Sciences (IJMS) Jg. 23 (2022) Nr. 21, S. 13623Online Volltext: dx.doi.org/ (Open Access)
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Association between FIASMA psychotropic medications and reduced risk of intubation or death in individuals with psychiatric disorders hospitalized for severe COVID-19 : an observational multicenter studyIn: Translational Psychiatry Jg. 12 (2022) 90Online Volltext: dx.doi.org/ (Open Access)
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Association between benzodiazepine receptor agonist use and mortality in patients hospitalised for COVID-19 : a multicentre observational studyIn: Epidemiology and Psychiatric Sciences Jg. 31 (2022) e18Online Volltext: dx.doi.org/ (Open Access)
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CFTR modulator therapy alters plasma sphingolipid profiles in people with cystic fibrosisIn: Journal of Cystic Fibrosis Jg. 21 (2022) Nr. 4, S. 713 - 720Online Volltext: dx.doi.org/
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Cell-intrinsic ceramides determine T cell function during melanoma progressionIn: eLife Jg. 11 (2022) e83073Online Volltext: dx.doi.org/ (Open Access)
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Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in miceIn: The Journal of Biological Chemistry (JBC) Jg. 298 (2022) Nr. 8, 102185Online Volltext: dx.doi.org/ (Open Access)
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Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality : Results from 49,089 COVID-19 inpatientsIn: Molecular Psychiatry Jg. 27 (2022) Nr. 3, S. 1278 - 1280Online Volltext: dx.doi.org/ (Open Access)
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Inhibition of a Mitochondrial Potassium Channel in Combination with Gemcitabine and Abraxane Drastically Reduces Pancreatic Ductal Adenocarcinoma in an Immunocompetent Orthotopic Murine ModelIn: Cancers Jg. 14 (2022) Nr. 11, 2618Online Volltext: dx.doi.org/ (Open Access)
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Lung Transplantation for Adult Respiratory Distress Syndrome after SARS-CoV-2 InfectionIn: The Thoracic and Cardiovascular Surgeon Reports Jg. 11 (2022) Nr. 1, S. e23 - e26Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple MyelomaIn: Cancers Jg. 14 (2022) Nr. 8, 1955Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Molecular targets of endothelial phosphatidic acid regulating major depressive disorderIn: Journal of Neurochemistry Jg. 163 (2022) Nr. 4, S. 357 - 369Online Volltext: dx.doi.org/ (Open Access)
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Paraoxonase 2 (PON2) Deficiency Reproduces Lipid Alterations of Diabetic and Inflammatory Glomerular Disease and Affects TRPC6 SignalingIn: Cells Jg. 11 (2022) Nr. 22, 3625Online Volltext: dx.doi.org/ (Open Access)
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Pharmacological modulation of Kv1.3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL modelIn: Journal of Experimental & Clinical Cancer Research Jg. 41 (2022) Nr. 1, 64Online Volltext: dx.doi.org/ (Open Access)
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Pharmacological targeting of the mitochondrial calcium-dependent potassium channel KCa3.1 triggers cell death and reduces tumor growth and metastasis in vivoIn: Cell Death and Disease Jg. 13 (2022) Nr. 12, 1055Online Volltext: dx.doi.org/ (Open Access)
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Sphingolipid control of cognitive functions in health and diseaseIn: Progress in Lipid Research Jg. 86 (2022) 101162Online Volltext: dx.doi.org/
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Sphingosine as a new antifungal agent against Candida and Aspergillus spp.In: International Journal of Molecular Sciences (IJMS) Jg. 23 (2022) Nr. 24, 15510Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasmaIn: Journal of Molecular Medicine Jg. 100 (2022) Nr. 10, S. 1493 - 1508Online Volltext: dx.doi.org/ (Open Access)
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The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesisIn: eLife Jg. 11 (2022) e77975Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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The acid sphingomyelinase/ceramide system in COVID-19In: Molecular Psychiatry Jg. 27 (2022) Nr. 1, S. 307 - 314Online Volltext: dx.doi.org/ (Open Access)
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Acid ceramidase rescues cystic fibrosis mice from pulmonary infectionsIn: Infection and Immunity Jg. 89 (2021) Nr. 2, S. e00677 - 20Online Volltext: dx.doi.org/ (Open Access)
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Acid sphingomyelinase promotes SGK1-dependent vascular calcificationIn: Clinical Science Jg. 135 (2021) Nr. 3, S. 515 - 534Online Volltext: dx.doi.org/ (Open Access)
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Antimicrobial coating prevents ventilator-associated pneumonia in a 72 hour large animal modelIn: Journal of Surgical Research Jg. 267 (2021) S. 424 - 431Online Volltext: dx.doi.org/
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Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter StudyIn: Clinical Pharmacology & Therapeutics Jg. 110 (2021) Nr. 6, S. 1498 - 1511Online Volltext: dx.doi.org/ (Open Access)
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Burn Injury Impairs Neutrophil Chemotaxis Through Increased CeramideIn: Shock Jg. 56 (2021) Nr. 1, S. 125 - 132Online Volltext: dx.doi.org/
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Cocaine attenuates acid sphingomyelinase activity during establishment of addiction-related behavior : A translational study in rats and monkeysIn: Addiction Biology Jg. 26 (2021) Nr. 3, S. e12955Online Volltext: dx.doi.org/ (Open Access)
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Corrigendum to: “Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the family”In: Redox Biology Jg. 45 (2021) 102036Online Volltext: dx.doi.org/ (Open Access)
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Ex vivo assay to evaluate the efficacy of drugs targeting sphingolipids in preventing SARS-CoV-2 infection of nasal epithelial cellsIn: STAR Protocols Jg. 2 (2021) Nr. 1, S. 100356Online Volltext: dx.doi.org/ (Open Access)
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Inhaled sphingosine has no adverse side effects in isolated ventilated and perfused pig lungsIn: Scientific Reports Jg. 11 (2021) Nr. 1, 18607Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cellsIn: The Journal of Biological Chemistry (JBC) Jg. 296 (2021) 100701Online Volltext: dx.doi.org/ (Open Access)
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Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosisIn: The Journal of Biological Chemistry (JBC) Jg. 296 (2021) 100650Online Volltext: dx.doi.org/ (Open Access)
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Mitochondrial K⁺ channels and their implications for disease mechanismsIn: Pharmacology & Therapeutics Jg. 227 (2021) 107874Online Volltext: dx.doi.org/
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Mrna expression of smpd1 encoding acid sphingomyelinase decreases upon antidepressant treatmentIn: International Journal of Molecular Sciences (IJMS) Jg. 22 (2021) Nr. 11, 5700Online Volltext: dx.doi.org/ (Open Access)
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Neutral Sphingomyelinase is an Affective Valence-Dependent Regulator of Learning and MemoryIn: Cerebral Cortex Jg. 31 (2021) Nr. 2, S. 1316 - 1333Online Volltext: dx.doi.org/
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Neutral ceramidase is a marker for cognitive performance in rats and monkeysIn: Pharmacological Reports Jg. 73 (2021) Nr. 1, S. 73 - 84Online Volltext: dx.doi.org/ (Open Access)
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Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defectsIn: Molecular Psychiatry Jg. 26 (2021) Nr. 12, S. 7403 - 7416Online Volltext: dx.doi.org/ (Open Access)
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New Molecular Targets for Antidepressant DrugsIn: Pharmaceuticals Jg. 14 (2021) Nr. 9, 894Online Volltext: dx.doi.org/ (Open Access)
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P. aeruginosa induced lipid peroxidation causes ferroptotic cell death in airwaysIn: Cellular Physiology and Biochemistry Jg. 55 (2021) Nr. 5, S. 590 - 604Online Volltext: dx.doi.org/ (Open Access)
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Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19 : Current evidence and potential mechanismsIn: Molecular Psychiatry Jg. 26 (2021) Nr. 12, S. 7098 - 7099Online Volltext: dx.doi.org/ (Open Access)
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Staphylococcus aureus α-Toxin Induces Acid Sphingomyelinase Release From a Human Endothelial Cell LineIn: Frontiers in Microbiology Jg. 12 (2021) 694489Online Volltext: dx.doi.org/ (Open Access)
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The Anti-Infectious Role of Sphingosine in Microbial DiseasesIn: Cells Jg. 10 (2021) Nr. 5, 1105Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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The Role of Acid Sphingomyelinase Inhibition in Repetitive Mild Traumatic Brain InjuryIn: Journal of Surgical Research Jg. 259 (2021) S. 296 - 304Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin DIn: Cells Jg. 9 (2020) Nr. 11, S. 2406Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Acid Sphingomyelinase Inhibition Mitigates Histopathological and Behavioral Changes in a Murine Model of Traumatic Brain InjuryIn: Journal of Neurotrauma Jg. 37 (2020) Nr. 17, S. 1902 - 1909Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe diseaseIn: Nature Communications Jg. 11 (2020) Nr. 1, S. 1338Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Acid sphingomyelinase regulates TH2 cytokine release and bronchial asthmaIn: Allergy Jg. 75 (2020) Nr. 3, S. 603 - 615Online Volltext: dx.doi.org/ (Open Access)
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Anxiety and Depression Are Related to Higher Activity of Sphingolipid Metabolizing Enzymes in the Rat BrainIn: Cells Jg. 9 (2020) Nr. 5, S. 1239Online Volltext: dx.doi.org/ (Open Access)
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Arterial Medial Calcification through Enhanced small Extracellular Vesicle Release in Smooth Muscle-Specific Asah1 Gene Knockout MiceIn: Scientific Reports Jg. 10 (2020) Nr. 1, S. 1645Online Volltext: dx.doi.org/ (Open Access)
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Ceramides affect alcohol consumption and depressive-like and anxiety-like behavior in a brain region- and ceramide species-specific way in male miceIn: Addiction Biology Jg. 25 (2020) Nr. 6, S. e12847Online Volltext: dx.doi.org/ (Open Access)
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Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitroIn: Journal of Lipid Research Jg. 61 (2020) Nr. 6, S. 896 - 910Online Volltext: dx.doi.org/ (Open Access)
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Doxycycline-coated silicone breast implants reduce acute surgical-site infection and inflammationIn: Plastic and Reconstructive Surgery Jg. 146 (2020) Nr. 5, S. 1029 - 1041Online Volltext: dx.doi.org/
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Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemiaIn: Basic Research in Cardiology Jg. 115 (2020) Nr. 6, S. 64Online Volltext: dx.doi.org/ (Open Access)
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Importance of Acid Sphingomyelinase in Subendothelial Accumulation of Exosomes and Inflammatory Response in Mouse Carotid ArteriesIn: The FASEB Journal Jg. 34 (2020) Nr. S1,Online Volltext: dx.doi.org/ (Open Access)
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Insight into the mechanism of cytotoxicity of membrane-permeant psoralenic Kv1.3 channel inhibitors by chemical dissection of a novel member of the familyIn: Redox Biology Jg. 37 (2020) 101705Online Volltext: dx.doi.org/ (Open Access)
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Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial CellsIn: Cell Reports Medicine Jg. 1 (2020) Nr. 8, S. 100142Online Volltext: dx.doi.org/ (Open Access)
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Podocytopathy and Nephrotic Syndrome in Mice with Podocyte-Specific Deletion of the Asah1 Gene : Role of Ceramide Accumulation in GlomeruliIn: The American Journal of Pathology Jg. 190 (2020) Nr. 6, S. 1211 - 1223Online Volltext: dx.doi.org/ (Open Access)
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Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic FibrosisIn: American Journal of Respiratory and Critical Care Medicine (AJRCCM) Jg. 202 (2020) Nr. 8, S. 1133 - 1145Online Volltext: dx.doi.org/ (Open Access)
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Role of 1-Deoxysphingolipids in docetaxel neurotoxicityIn: Journal of Neurochemistry Jg. 154 (2020) Nr. 6,Online Volltext: dx.doi.org/ (Open Access)
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Serotonin – lipid interactions and their role in behaviorIn: Handbook of Behavioral Neuroscience Jg. 31 (2020) S. 289 - 308Online Volltext: dx.doi.org/
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Sphingosine is able to prevent and eliminate Staphylococcus epidermidis biofilm formation on different orthopedic implant materials in vitroIn: Journal of Molecular Medicine Jg. 98 (2020) Nr. 2, S. 209 - 219Online Volltext: dx.doi.org/ (Open Access)
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Sphingosine kills bacteria by binding to cardiolipinIn: The Journal of Biological Chemistry (JBC) Jg. 295 (2020) Nr. 22, S. 7686 - 7696Online Volltext: dx.doi.org/ (Open Access)
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Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2In: The Journal of Biological Chemistry (JBC) Jg. 295 (2020) Nr. 45, S. 15174 - 15182Online Volltext: dx.doi.org/ (Open Access)
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The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in MiceIn: Cells Jg. 9 (2020) Nr. 5, S. 1244Online Volltext: dx.doi.org/ (Open Access)
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Therapeutic Inhaled Sphingosine for Treating Lung Infection in a Mouse Model of Critical IllnessIn: Cellular Physiology and Biochemistry Jg. 54 (2020) Nr. 5, S. 1054 - 1067Online Volltext: dx.doi.org/ (Open Access)
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Veno-Venous Extracorporeal Membrane Oxygenation in Adult Patients with Sickle Cell Disease and Acute Chest Syndrome : a Single-Center ExperienceIn: Hemoglobin Jg. 44 (2020) Nr. 2, S. 71 - 77Online Volltext: dx.doi.org/
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Voltage-Gated Potassium Channels as Regulators of Cell DeathIn: Frontiers in Cell and Developmental Biology Jg. 8 (2020) 611853Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Acid Sphingomyelinase-Ceramide System in Bacterial InfectionsIn: Cellular Physiology and Biochemistry Jg. 52 (2019) Nr. 2, S. 280 - 301Online Volltext: dx.doi.org/ (Open Access)
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Acid sphingomyelinase controls dopamine activity and responses to appetitive stimuli in miceIn: Brain Research Bulletin Jg. 146 (2019) S. 310 - 319Online Volltext: dx.doi.org/
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Acid sphingomyelinase deficiency ameliorates farber diseaseIn: International Journal of Molecular Sciences (IJMS) Jg. 20 (2019) Nr. 24, S. 6253Online Volltext: dx.doi.org/ (Open Access)
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Amitriptyline Reduces Inflammation and Mortality in a Murine Model of Sepsis.In: Cellular Physiology and Biochemistry Jg. 52 (2019) Nr. 3, S. 565 - 579Online Volltext: dx.doi.org/ (Open Access)
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Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and CoagulopathyIn: Shock Jg. 51 (2019) Nr. 3, S. 356 - 363Online Volltext: dx.doi.org/ (Open Access)
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Autophagy augmentation alleviates cigarette smoke-induced CFTR-dysfunction, ceramide-accumulation and COPD-emphysema pathogenesisIn: Free Radical Biology and Medicine Jg. 131 (2019) S. 81 - 97Online Volltext: dx.doi.org/
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Clinical development of sphingosine as anti-bacterial drug : Inhalation of sphingosine in mini pigs has no adverse side effectsIn: Cellular Physiology and Biochemistry Jg. 53 (2019) Nr. 6, S. 1015 - 1028Online Volltext: dx.doi.org/ (Open Access)
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Enhanced alcohol preference and anxiolytic alcohol effects in Niemann-Pick disease model in miceIn: Frontiers in Neurology Jg. 10 (2019) Nr. JUL, S. 731Online Volltext: dx.doi.org/ (Open Access)
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Monitoring the sphingolipid de novo synthesis by stable-isotope labeling and liquid chromatography-mass spectrometryIn: Frontiers in Cell and Developmental Biology Jg. 7 (2019) 210Online Volltext: dx.doi.org/ (Open Access)
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Pharmacological Inhibition of Acid Sphingomyelinase Ameliorates Experimental Autoimmune EncephalomyelitisIn: Neurosignals Jg. 27 (2019) Nr. S1, S. 20 - 31Online Volltext: dx.doi.org/ (Open Access)
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Secretory Acid Sphingomyelinase in the Serum of Medicated Patients Predicts the Prospective Course of DepressionIn: Journal of Clinical Medicine (JCM) Jg. 8 (2019) Nr. 6, 846Online Volltext: dx.doi.org/ (Open Access)
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Signalling Effects Induced by Acid Ceramidase in Human Epithelial Or Leukemic Cell LinesIn: Cellular Physiology and Biochemistry Jg. 52 (2019) Nr. 5, S. 1092 - 1102Online Volltext: dx.doi.org/ (Open Access)
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Specific inhibition of the NLRP3 inflammasome as an antiinflammatory strategy in cystic fibrosisIn: American Journal of Respiratory and Critical Care Medicine (AJRCCM) Jg. 200 (2019) Nr. 11, S. 1381 - 1391Online Volltext: dx.doi.org/
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Sphingosine-coating of plastic surfaces prevents ventilator-associated pneumoniaIn: Journal of Molecular Medicine Jg. 97 (2019) Nr. 8, S. 1195 - 1211Online Volltext: dx.doi.org/ (Open Access)
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The Role of Chemoprophylactic Agents in Modulating Platelet Aggregability After Traumatic Brain InjuryIn: Journal of Surgical Research Jg. 244 (2019) S. 1 - 8Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramideIn: Molecular Psychiatry Jg. 23 (2018) Nr. 12, S. 2324 - 2346Online Volltext: dx.doi.org/ (Open Access)
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Antidepressants regulate autophagy by targeting acid sphingomyelinaseIn: Molecular Psychiatry Jg. 23 (2018) Nr. 12, S. 2251Online Volltext: dx.doi.org/
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Bioactive lipids and redox signaling: Molecular mechanism and disease pathogenesisIn: Antioxidants and Redox Signaling Jg. 28 (2018) Nr. 10, S. 911 - 915Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Blockade of experimental multiple sclerosis by inhibition of the acid sphingomyelinase/ceramide systemIn: Neurosignals Jg. 25 (2018) Nr. 1, S. 88 - 97Online Volltext: dx.doi.org/ (Open Access)
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Chronic psychosocial stress in mice is associated with increased acid sphingomyelinase activity in liver and serum and with hepatic C16:0-ceramide accumulationIn: Frontiers in Psychiatry Jg. 9 (2018) S. 496Online Volltext: dx.doi.org/ (Open Access)
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Crosstalk between sphingomyelinases and reactive oxygen species in mycobacterial infectionIn: Antioxidants and Redox Signaling Jg. 28 (2018) Nr. 10, S. 935 - 948Online Volltext: dx.doi.org/
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Derivatization of common antidepressant drugs increases inhibition of acid sphingomyelinase and reduces induction of phospholipidosisIn: Journal of Neural Transmission Jg. 125 (2018) Nr. 12, S. 1837 - 1845Online Volltext: dx.doi.org/
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Doxycycline-Coated Silicone Breast Implant Reduces Surgical Site Infections Compared with Standard Gentamycin/Cefazolin/Bacitracin WashIn: Journal of the American College of Surgeons Jg. 227 (2018) Nr. Suppl. 1, S. S206 - S207Online Volltext: dx.doi.org/
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Endocytosis of red blood cell microparticles by pulmonary endothelial cells is mediated by Rab5In: Shock Jg. 49 (2018) Nr. 3, S. 288 - 294Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Highlight : Sphingolipids in infectious biology and immunologyIn: Biological Chemistry Jg. 399 (2018) Nr. 10, S. 1113 - 1113Online Volltext: dx.doi.org/
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Mycobacterial Infection is Promoted by Neutral Sphingomyelinase 2 Regulating a Signaling Cascade Leading to Activation of β1-IntegrinIn: Cellular Physiology and Biochemistry Jg. 51 (2018) Nr. 4, S. 1815 - 1829Online Volltext: dx.doi.org/ (Open Access)
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Pathological manifestations of Farber disease in a new mouse modelIn: Biological Chemistry Jg. 399 (2018) Nr. 10, S. 1183 - 1202Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Peripheral Acid Sphingomyelinase Activity Is Associated with Biomarkers and Phenotypes of Alcohol Use and Dependence in Patients and Healthy ControlsIn: International Journal of Molecular Sciences (IJMS) Jg. 19 (2018) Nr. 12, S. 4028Online Volltext: dx.doi.org/ (Open Access)
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Pulmonary infection of cystic fibrosis mice with Staphylococcus aureus requires expression of α-toxinIn: Biological Chemistry Jg. 399 (2018) Nr. 10, S. 1203 - 1213Online Volltext: dx.doi.org/
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Regulation of Staphylococcus aureus Infection of Macrophages by CD44, Reactive Oxygen Species, and Acid SphingomyelinaseIn: Antioxidants and Redox Signaling Jg. 28 (2018) Nr. 10, S. 916 - 934Online Volltext: dx.doi.org/ (Open Access)
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Sphingolipids and innate immunity : a new approach to infection in the post-antibiotic era?In: Surgical Infections Jg. 19 (2018) Nr. 8, S. 792 - 803Online Volltext: dx.doi.org/
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Sphingolipids as targets for inhalation treatment of cystic fibrosisIn: Advanced Drug Delivery Reviews Jg. 133 (2018) S. 66 - 75Online Volltext: dx.doi.org/
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Sphingolipids in early viral replication and innate immune activationIn: Biological Chemistry Jg. 399 (2018) Nr. 10, S. 1115 - 1123Online Volltext: dx.doi.org/
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Staphylococcus aureus alpha-toxin disrupts endothelial-cell tight junctions via acid sphingomyelinase and ceramideIn: Infection and Immunity Jg. 86 (2018) Nr. 1, S. e00606 - 17Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Targeting the potassium channel Kv1.3 kills glioblastoma cellsIn: Neurosignals Jg. 25 (2018) Nr. 1, S. 26 - 38Online Volltext: dx.doi.org/ (Open Access)
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The function of sphingomyelinases in mycobacterial infectionsIn: Biological Chemistry Jg. 399 (2018) Nr. 10, S. 1125 - 1133Online Volltext: dx.doi.org/
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The role of sphingolipids in psychoactive drug use and addictionIn: Journal of Neural Transmission Jg. 125 (2018) Nr. 4, S. 651 - 672Online Volltext: dx.doi.org/
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Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASMIn: Neuron Jg. 100 (2018) Nr. 3, S. 762Online Volltext: dx.doi.org/ (Open Access)
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Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASMIn: Neuron Jg. 100 (2018) Nr. 1, S. 167 - 182.e9Online Volltext: dx.doi.org/ (Open Access)
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Acid Sphingomyelinase Inhibition Reduces the Harmful Effects of Repetitive Mild Traumatic Brain InjuryIn: Journal of the American College of Surgeons Jg. 225 (2017) Nr. 4, Suppl. 2, S. e174Online Volltext: dx.doi.org/
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Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung InflammationIn: Annals of Surgery Jg. 265 (2017) Nr. 1, S. 218 - 226Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelinationIn: PLoS ONE Jg. 12 (2017) Nr. 6, S. e0178622Online Volltext: dx.doi.org/ (Open Access)
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Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosisIn: Molecular Metabolism Jg. 6 (2017) Nr. 5, S. 416 - 427Online Volltext: dx.doi.org/ (Open Access)
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Alternative splicing of SMPD1 coding for acid sphingomyelinase in major depressionIn: Journal of Affective Disorders Jg. 209 (2017) S. 10 - 15Online Volltext: dx.doi.org/
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Amitriptyline treatment ameliorates septic shock and improves survivalIn: Shock Jg. 47 1 (2017) Nr. 6, S. 91 - 91
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Amitriptyline treatment prvents the coagulopathy of sepsisIn: Shock Jg. 47 (2017) Nr. 6 Suppl.1, S. 46 - 47
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Bronchoalveolar Lavage Microvesicles Protect Burn-Injured Mice from Pulmonary InfectionIn: Journal of the American College of Surgeons Jg. 225 (2017) Nr. 4, S. 538 - 547Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Burn injury influences the T cell homeostasis in a butyrate-acid sphingomyelinase dependent mannerIn: Cellular Immunology Jg. 313 (2017) S. 25 - 31Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Contribution of p62 to Phenotype Transition of Coronary Arterial Myocytes with Defective AutophagyIn: Cellular Physiology and Biochemistry Jg. 41 (2017) Nr. 2, S. 555 - 568Online Volltext: dx.doi.org/ (Open Access)
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Direct pharmacological targeting of a mitochondrial ion channel eliminates cancer cells in vivoIn: European Biophysics Journal Jg. 46 (2017) Nr. Suppl. 1, S. 77 - S77
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Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivoIn: Cancer Cell Jg. 31 (2017) Nr. 4, S. 516 - 531.e10Online Volltext: dx.doi.org/ (Open Access)
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Doxycycline Impregnated Silicone Implants Are a Novel Strategy to Reduce Incidence of Breast Implant InfectionIn: Journal of the American College of Surgeons Jg. 225 (2017) Nr. 4, Suppl. 1, S. S162Online Volltext: dx.doi.org/
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Endocytosis of red blood cell microparticels by endothelial cells is mediated by RAB5In: Shock Jg. 47 (2017) Nr. 6 Suppl. 1, S. 14 - 14
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Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial functionIn: Nature Communications Jg. 8 (2017) S. 480Online Volltext: dx.doi.org/ (Open Access)
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Glucosylceramide Critically Contributes to the Host Defense of Cystic Fibrosis LungsIn: Cellular Physiology and Biochemistry Jg. 41 (2017) Nr. 3, S. 1208 - 1218Online Volltext: dx.doi.org/ (Open Access)
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Implication of CD38 gene in autophagic degradation of collagen I in mouse coronary arterial myocytesIn: Frontiers in Bioscience (FBS): Landmark Jg. 22 (2017) S. 558 - 569
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Inflammatory cells, ceramides, and expression of proteases in perivascular adipose tissue adjacent to human abdominal aortic aneurysmsIn: Journal of Vascular Surgery Jg. 65 (2017) Nr. 4, S. 1171 - 1179.e1Online Volltext: dx.doi.org/ (Open Access)
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Lipids in psychiatric disorders and preventive medicineIn: Neuroscience & Biobehavioral Reviews Jg. 76 (2017) S. 336 - 362Online Volltext: dx.doi.org/ (Open Access)
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Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in ObesityIn: Cellular Physiology and Biochemistry Jg. 43 (2017) Nr. 2, S. 445 - 456Online Volltext: dx.doi.org/ (Open Access)
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Melanoma cell metastasis via P-selectin-mediated activation of acid sphingomyelinase in plateletsIn: Clinical and Experimental Metastasis Jg. 34 (2017) Nr. 1, S. 25 - 35Online Volltext: dx.doi.org/
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Neutrophils Kill Reactive Oxygen Species-Resistant Pseudomonas aeruginosa by SphingosineIn: Cellular Physiology and Biochemistry Jg. 43 (2017) Nr. 4, S. 1603 - 1616Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Paradoxical antidepressant effects of alcohol are related to acid sphingomyelinase and its control of sphingolipid homeostasisIn: Acta Neuropathologica Jg. 133 (2017) Nr. 3, S. 463 - 483Online Volltext: dx.doi.org/ (Open Access)
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Regulation of Arthritis Severity by the Acid SphingomyelinaseIn: Cellular Physiology and Biochemistry Jg. 43 (2017) Nr. 4, S. 1460 - 1471Online Volltext: dx.doi.org/ (Open Access)
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Sphingosine rescues aged mice from pulmonary pseudomonas infectionIn: Journal of Surgical Research Jg. 219 (2017) S. 354 - 359Online Volltext: dx.doi.org/
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Sphingosine's role in epithelial host defense : a natural antimicrobial and novel therapeuticIn: Biochimie Jg. 141 (2017) S. 91 - 96Online Volltext: dx.doi.org/
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Staphylococcus aureus survives in cystic fibrosis macrophages, forming a reservoir for chronic pneumoniaIn: Infection and Immunity Jg. 85 (2017) Nr. 5, S. e00883-16-1 - e00883-16-11Online Volltext: dx.doi.org/ (Open Access)
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Staphylococcus aureus α-Toxin Induces Inflammatory Cytokines via Lysosomal Acid Sphingomyelinase and CeramidesIn: Cellular Physiology and Biochemistry Jg. 43 (2017) Nr. 6, S. 2170 - 2184Online Volltext: dx.doi.org/ (Open Access)
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The sphingosine 1-phosphate breakdown product, (2E)-hexadecenal, forms protein adducts and glutathione conjugates in vitroIn: Journal of Lipid Research Jg. 58 (2017) Nr. 8, S. 1648 - 1660Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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β1-Integrin Accumulates in Cystic Fibrosis Luminal Airway Epithelial Membranes and Decreases Sphingosine, Promoting Bacterial InfectionsIn: Cell Host & Microbe Jg. 21 (2017) Nr. 6, S. 707 - 718.e8Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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A sphingolipid mechanism for behavioral extinctionIn: Journal of Neurochemistry Jg. 137 (2016) Nr. 4, S. 589 - 603Online Volltext: dx.doi.org/ (Open Access)
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Acid Sphingomyelinase (ASM) is a Negative Regulator of Regulatory T Cell (Treg) DevelopmentIn: Cellular Physiology and Biochemistry Jg. 39 (2016) Nr. 3, S. 985 - 995Online Volltext: dx.doi.org/ (Open Access)
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Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte StorageIn: Cellular Physiology and Biochemistry Jg. 39 (2016) Nr. 1, S. 331 - 340Online Volltext: dx.doi.org/ (Open Access)
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Amitriptyline Usage Exacerbates the Immune Suppression Following Burn InjuryIn: Shock Jg. 46 (2016) Nr. 5, S. 541 - 548Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in HepatocytesIn: PLoS ONE Jg. 11 (2016) Nr. 8, S. e0161443Online Volltext: dx.doi.org/ (Open Access)
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Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activationIn: OncoTarget Jg. 7 (2016) Nr. 45, S. 73229 - 73241Online Volltext: dx.doi.org/ (Open Access)
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Frontline Science : Sphingosine rescues burn-injured mice from pulmonary Pseudomonas aeruginosa infectionIn: Journal of Leukocyte Biology (JLB) Jg. 100 (2016) Nr. 6, S. 1233 - 1237Online Volltext: dx.doi.org/
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Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphateIn: Journal of Hepatology Jg. 64 (2016) Nr. 1, S. 60 - 68Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T CellsIn: The Journal of Immunology (JI) Jg. 197 (2016) Nr. 8, S. 3130 - 3141Online Volltext: dx.doi.org/ (Open Access)
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Inhibition of neutral sphingomyelinase protects mice against systemic tuberculosisIn: Frontiers in Bioscience Jg. 8 (2016) S. 311 - 325Online Volltext: dx.doi.org/
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Ischemia/Reperfusion Injury Alters Sphingolipid Metabolism in the GutIn: Cellular Physiology and Biochemistry Jg. 39 (2016) Nr. 4, S. 1262 - 1270Online Volltext: dx.doi.org/ (Open Access)
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Lack of Sphingosine Causes Susceptibility to Pulmonary Staphylococcus Aureus Infections in Cystic FibrosisIn: Cellular Physiology and Biochemistry Jg. 38 (2016) Nr. 6, S. 2094 - 2102Online Volltext: dx.doi.org/ (Open Access)
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Long-Term Pulmonal Therapy of Cystic Fibrosis-Patients with AmitriptylineIn: Cellular Physiology and Biochemistry Jg. 39 (2016) Nr. 2, S. 565 - 572Online Volltext: dx.doi.org/ (Open Access)
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Melatonin Acts as an Antidepressant by Inhibition of the Acid Sphingomyelinase/Ceramide SystemIn: Neurosignals Jg. 24 (2016) Nr. 1, S. 48 - 58Online Volltext: dx.doi.org/ (Open Access)
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Pharmacological targeting of ion channels for cancer therapy : In vivo evidencesIn: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Jg. 1863 (2016) Nr. 6 B, S. 1385 - 1397Online Volltext: dx.doi.org/ (Open Access)
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Quantitative Determination of Ceramide Molecular Species in Dendritic CellsIn: Cellular Physiology and Biochemistry Jg. 39 (2016) Nr. 4, S. 1608 - 1617Online Volltext: dx.doi.org/ (Open Access)
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Regulation of Neuronal Stem Cell Proliferation in the Hippocampus by Endothelial CeramideIn: Cellular Physiology and Biochemistry Jg. 39 (2016) Nr. 2, S. 701 - 801Online Volltext: dx.doi.org/ (Open Access)
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Role of Acid Sphingomyelinase in the Regulation of Social Behavior and MemoryIn: PLoS ONE Jg. 11 (2016) Nr. 9, S. e0162498Online Volltext: dx.doi.org/ (Open Access)
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Role of Acid Sphingomyelinase-Induced Signaling in Melanoma Cells for Hematogenous Tumor MetastasisIn: Cellular Physiology and Biochemistry Jg. 38 (2016) Nr. 1, S. 1 - 14Online Volltext: dx.doi.org/ (Open Access)
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Role of Janus-Kinases in Major Depressive DisorderIn: Neurosignals Jg. 24 (2016) Nr. 1, S. 71 - 80Online Volltext: dx.doi.org/ (Open Access)
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A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depressionIn: Journal of Neurochemistry Jg. 134 (2015) Nr. 2, S. 183 - 192Online Volltext: dx.doi.org/
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Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsisIn: Journal of Molecular Medicine Jg. 93 (2015) Nr. 6, S. 675 - 689Online Volltext: dx.doi.org/ (Open Access)
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Alterations of plasma glycerophospholipid and sphingolipid species in male alcohol-dependent patientsIn: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Jg. 1851 (2015) Nr. 11, S. 1501 - 1510Online Volltext: dx.doi.org/
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Brain membrane lipids in major depression and anxiety disordersIn: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Jg. 1851 (2015) Nr. 8, S. 1052 - 1065Online Volltext: dx.doi.org/ (Open Access)
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Ceramide and sphingosine in pulmonary infectionsIn: Biological Chemistry Jg. 396 (2015) Nr. 6-7, S. 611 - 620Online Volltext: dx.doi.org/
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Ceramide in the regulation of eryptosis, the suicidal erythrocyte deathIn: Apoptosis Jg. 2 (2015) Nr. 5, S. 758 - 767Online Volltext: dx.doi.org/
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Conjugated Bilirubin Triggers Anemia by Inducing Erythrocyte DeathIn: Hepatology Jg. 61 (2015) Nr. 1, S. 275 - 284Online Volltext: dx.doi.org/ (Open Access)
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Correction : Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon IrradiationIn: PLoS ONE Jg. 10 (2015) Nr. 12, S. e0146210Online Volltext: dx.doi.org/ (Open Access)
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Early effects of the antineoplastic agent salinomycin on mitochondrial functionIn: Cell Death and Disease Jg. 6 (2015) Nr. 10, e1930Online Volltext: dx.doi.org/ (Open Access)
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Endothelial Nlrp3 inflammasome activation associated with lysosomal destabilization during coronary arteritisIn: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Jg. 1853 (2015) Nr. 2, S. 396 - 408Online Volltext: dx.doi.org/ (Open Access)
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Engineered liposomes sequester bacterial exotoxins and protect from severe invasive infections in miceIn: Nature Biotechnology Jg. 33 (2015) Nr. 1, S. 81 - 88Online Volltext: dx.doi.org/
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Highlight : molecular medicine of sphingolipidsIn: Biological Chemistry Jg. 396 (2015) Nr. 6-7, S. 569 - 571Online Volltext: dx.doi.org/
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Highly sensitive isotope-dilution liquid-chromatography-electrospray ionization-tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegansIn: Talanta: The International Journal of Pure and Applied Analytical Chemistry Jg. 144 (2015) S. 71 - 79Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major DepressionIn: Neurosignals Jg. 23 (2015) Nr. 1, S. 84 - 92Online Volltext: dx.doi.org/ (Open Access)
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Inhibition of acidic sphingomyelinase reduces established hepatic fibrosis in miceIn: Hepatology Research Jg. 45 (2015) Nr. 3, S. 305 - 314Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Interclonal gradient of virulence in the Pseudomonas aeruginosa pangenome from disease and environmentIn: Environmental Microbiology Jg. 17 (2015) Nr. 1, S. 29 - 46Online Volltext: dx.doi.org/ (Open Access)
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Pseudomonas aeruginosa Pyocyanin Induces Neutrophil Death via Mitochondrial Reactive Oxygen Species and Mitochondrial Acid SphingomyelinaseIn: Antioxidants and Redox Signaling Jg. 22 (2015) Nr. 13, S. 1097 - 1110Online Volltext: dx.doi.org/ (Open Access)
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Regulation of hematogenous tumor metastasis by acid sphingomyelinaseIn: EMBO Molecular Medicine Jg. 7 (2015) Nr. 6, S. 714 - 734Online Volltext: dx.doi.org/ (Open Access)
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Sphingolipids in liver injury, repair and regenerationIn: Biological Chemistry Jg. 396 (2015) Nr. 6-7, S. 633 - 643Online Volltext: dx.doi.org/
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Sphingolipids in major depressionIn: Neurosignals Jg. 23 (2015) S. 49 - 58Online Volltext: dx.doi.org/ (Open Access)
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Sphingosine Prevents Adherence of Pseudomonas Aeruginosa to Endotracheal Tubes : A Novel Strategy to Prevent Ventilator-Associated PneumoniaIn: Journal of the American College of Surgeons Jg. 221 (2015) Nr. 4 Suppl., S. S44Online Volltext: dx.doi.org/
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Targeting a mitochondrial potassium channel to fight cancerIn: Cell Calcium Jg. 58 (2015) Nr. 1, S. 131 - 138Online Volltext: dx.doi.org/
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Virus-induced type i interferon deteriorates control of systemic pseudomonas aeruginosa infectionIn: Cellular Physiology and Biochemistry Jg. 36 (2015) Nr. 6, S. 2379 - 2392Online Volltext: dx.doi.org/ (Open Access)
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Acid Sphingomyelinase Regulates Platelet Cell Membrane Scrambling, Secretion, and Thrombus FormationIn: Arteriosclerosis, Thrombosis, and Vascular Biology Jg. 34 (2014) Nr. 1, S. 61 - 71Online Volltext: dx.doi.org/
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Activation of Nlrp3 inflammasomes enhances macrophage lipid-deposition and migration : Implication of a novel role of inflammasome in atherogenesisIn: PLoS ONE Jg. 9 (2014) Nr. 1, S. e87552Online Volltext: dx.doi.org/ (Open Access)
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Defective autophagosome trafficking contributes to impaired autophagic flux in coronary arterial myocytes lacking CD38 geneIn: Cardiovascular Research Jg. 102 (2014) Nr. 1, S. 68 - 78Online Volltext: dx.doi.org/
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Differential activation of acid sphingomyelinase and ceramide release determines invasiveness of Neisseria meningitidis into brain endothelial cellsIn: PLoS Pathogens Jg. 10 (2014) Nr. 6, S. e1004160Online Volltext: dx.doi.org/ (Open Access)
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Effects of green tea compound epigallocatechin-3-gallate against Stenotrophomonas maltophilia infection and biofilmIn: PLoS ONE Jg. 9 (2014) Nr. 4, S. e92876Online Volltext: dx.doi.org/ (Open Access)
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Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogonsIn: Frontiers in Physiology (2014) Nr. 5, S. 331Online Volltext: dx.doi.org/ (Open Access)
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Invariant natural killer T (iNKT) cells prevent autoimmunity, but induce pulmonary inflammation in cystic fibrosisIn: Cellular Physiology and Biochemistry Jg. 34 (2014) Nr. 1, S. 56 - 70Online Volltext: dx.doi.org/ (Open Access)
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Loss of cystic fibrosis transmembrane conductance regulator impairs lung endothelial cell barrier function and increases susceptibility to microvascular damage from cigarette smokeIn: Pulmonary Circulation Jg. 4 (2014) Nr. 2, S. 260 - 268Online Volltext: dx.doi.org/ (Open Access)
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Method to Simultaneously Determine the Sphingosine 1-Phosphate Breakdown Product (2E)-Hexadecenal and Its Fatty Acid Derivatives Using Isotope-Dilution HPLC–Electrospray Ionization–Quadrupole/Time-of-Flight Mass SpectrometryIn: Analytical Chemistry Jg. 86 (2014) Nr. 18, S. 9065 - 9073Online Volltext: dx.doi.org/
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Mitochondrial ion channels as oncological targetsIn: Oncogene Jg. 33 (2014) Nr. 49, S. 5569 - 5581Online Volltext: dx.doi.org/
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Regulation of the inflammasome by ceramide in cystic fibrosis lungsIn: Cellular Physiology and Biochemistry Jg. 34 (2014) Nr. 1, S. 45 - 55Online Volltext: dx.doi.org/ (Open Access)
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Role of acid sphingomyelinase in the regulation of mast cell functionIn: Clinical & Experimental Allergy Jg. 44 (2014) Nr. 1, S. 79 - 90Online Volltext: dx.doi.org/
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Sex-dependent decrease of sphingomyelinase activity during alcohol withdrawal treatmentIn: Cellular Physiology and Biochemistry Jg. 34 (2014) S. 71 - 81Online Volltext: dx.doi.org/ (Open Access)
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Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosaIn: EMBO Molecular Medicine Jg. 6 (2014) Nr. 9, S. 1205 - 1214Online Volltext: dx.doi.org/ (Open Access)
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The ceramide system as a novel antidepressant targetIn: Trends in Pharmacological Sciences Jg. 35 (2014) Nr. 6, S. 293 - 304Online Volltext: dx.doi.org/
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The common acid sphingomyelinase polymorphism p.G508R is associated with self-reported allergyIn: Cellular Physiology and Biochemistry Jg. 34 (2014) Nr. 1, S. 82 - 91Online Volltext: dx.doi.org/ (Open Access)
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Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugsIn: Nature Medicine Jg. 19 (2013) Nr. 7, S. 934 - 938Online Volltext: dx.doi.org/
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Ceramide in cystic fibrosisIn: Clinical Lipidology Jg. 8 (2013) Nr. 6, S. 681 - 691Online Volltext: dx.doi.org/
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Ceramide mediates lung fibrosis in cystic fibrosisIn: Biochemical and Biophysical Research Communications (BBRC) Jg. 434 (2013) Nr. 4, S. 705 - 709Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Characterization of Acid Sphingomyelinase Activity in Human Cerebrospinal FluidIn: PLoS ONE Jg. 8 (2013) Nr. 5, S. e62912Online Volltext: dx.doi.org/ (Open Access)
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Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemiaIn: Leukemia Jg. 27 (2013) Nr. 8, S. 1782 - 1785Online Volltext: dx.doi.org/
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Effect of bacterial peptidoglycan on erythrocyte death and adhesion to endothelial cellsIn: International Journal of Medical Microbiology (IJMM) Jg. 303 (2013) Nr. 4, S. 182 - 189Online Volltext: dx.doi.org/
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Examination of orbital tissues in murine models of graves' disease reveals expression of UCP-1 and the TSHR in retrobulbar adipose tissuesIn: Hormone and Metabolic Research Jg. 45 (2013) Nr. 6, S. 401 - 407Online Volltext: dx.doi.org/
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Glioma Cell Death Induced by Irradiation or Alkylating Agent Chemotherapy Is Independent of the Intrinsic Ceramide PathwayIn: PLoS ONE Jg. 8 (2013) Nr. 5, S. e63527Online Volltext: dx.doi.org/ (Open Access)
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Intracellular ion channels and cancerIn: Frontiers in Physiology Jg. 4 (2013) S. 227Online Volltext: dx.doi.org/
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It takes a CAD to kill a tumor cell with a LMPIn: Cancer Cell Jg. 24 (2013) Nr. 3, S. 279 - 281Online Volltext: dx.doi.org/ (Open Access)
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Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytesIn: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Jg. 1833 (2013) Nr. 12, S. 3288 - 3236Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Targeting the ceramide system in cancerIn: Cancer Letters Jg. 332 (2013) Nr. 2, S. 286 - 294Online Volltext: dx.doi.org/
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Therapy of CF-patients with amitriptyline and placebo-a randomised, double-blind, placebo-controlled phase IIb multicenter, cohort-studyIn: Cellular Physiology and Biochemistry Jg. 31 (2013) Nr. 4-5, S. 505 - 512Online Volltext: dx.doi.org/ (Open Access)
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Wirkungsvolle Lipide : Sphingolipide, bakterielle Infektionen und zystische FibroseIn: Unikate: Berichte aus Forschung und Lehre (2013) Nr. 44: Medizin: 50 Jahre Universitätsklinikum Essen, S. 22 - 31Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Functional implications of novel human acid sphingomyelinase splice variantsIn: PLoS ONE Jg. 7 (2012) Nr. 4, S. e35467Online Volltext: dx.doi.org/ (Open Access)
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Induction of Apoptosis in Macrophages via Kv1.3 and Kv1.5 Potassium ChannelsIn: Current Medicinal Chemistry Jg. 19 (2012) Nr. 31, S. 5394 - 5404Online Volltext: dx.doi.org/
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Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cellsIn: EMBO Molecular Medicine Jg. 4 (2012) Nr. 7, S. 577 - 593Online Volltext: dx.doi.org/ (Open Access)
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Oxidative stress triggers Ca²⁺-dependent lysosome trafficking and activation of acid sphingomyelinaseIn: Cellular Physiology and Biochemistry Jg. 30 (2012) Nr. 4, S. 815 - 826Online Volltext: dx.doi.org/ (Open Access)
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Physiology of potassium channels in the inner membrane of mitochondriaIn: Pflügers Archiv: European Journal of Physiology Jg. 463 (2012) Nr. 2, S. 231 - 246Online Volltext: dx.doi.org/
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Role of CD95 in pulmonary inflammation and infection in cystic fibrosisIn: Journal of Molecular Medicine Jg. 90 (2012) Nr. 9, S. 1011 - 1023Online Volltext: dx.doi.org/
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Role of kinase suppressor of ras-1 in lipopolysaccharide-induced acute lung injuryIn: Cellular Physiology and Biochemistry Jg. 30 (2012) Nr. 4, S. 905 - 914Online Volltext: dx.doi.org/
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Sphingomyelinase-induced adhesion of eryptotic erythrocytes to endothelial cellsIn: American Journal of Physiology: Cell Physiology Jg. 303 (2012) Nr. 9, S. C991 - C999Online Volltext: dx.doi.org/
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A Novel Mechanism Involved in the Pathogenesis of Graves Ophthalmopathy (GO) : Clathrin Is a Possible Targeting Molecule for Inhibiting Local Immune Response in the OrbitIn: The Journal of Clinical Endocrinology & Metabolism (JCEM) Jg. 96 (2011) Nr. 11, S. E1727 - 1736Online Volltext: dx.doi.org/
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Activation of the Permeability Transition Pore by Bax via Inhibition of the Mitochondrial BK ChannelIn: Cellular Physiology and Biochemistry Jg. 27 (2011) Nr. 3-4, S. 191 - 200Online Volltext: dx.doi.org/
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Activity of Secretory Sphingomyelinase Is Increased in Plasma of Alcohol‐Dependent PatientsIn: Alcoholism: Clinical and Experimental Research Jg. 35 (2011) Nr. 10, S. 1852 - 1859Online Volltext: dx.doi.org/
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Acute intratracheal Pseudomonas aeruginosa infection in cystic fibrosis mice is age-independentIn: Respiratory Research Jg. 12 (2011)Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Ceramide formation as a target in beta-cell survival and functionIn: Expert Opinion on Therapeutic Targets Jg. 15 (2011) Nr. 9, S. 1061 - 1071Online Volltext: dx.doi.org/
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Ceramide in Chemotherapy of TumorsIn: Recent Patents on Anti-Cancer Drug Discovery Jg. 6 (2011) Nr. 3, S. 284 - 293Online Volltext: dx.doi.org/
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DC-SIGN Mediated Sphingomyelinase-Activation and Ceramide Generation Is Essential for Enhancement of Viral Uptake in Dendritic CellsIn: PLoS Pathogens Jg. 7 (2011) Nr. 2, S. e1001290Online Volltext: dx.doi.org/ (Open Access)
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Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infectionsIn: Nature Medicine Jg. 17 (2011) Nr. 3, S. 341 - 346Online Volltext: dx.doi.org/
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Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts : Novel insights into the molecular mechanisms of Bax-induced apoptosisIn: Cell Death and Differentiation Jg. 18 (2011) Nr. 3, S. 427 - 438Online Volltext: dx.doi.org/
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Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosisIn: American Journal of Respiratory Cell and Molecular Biology Jg. 42 (2010) Nr. 6, S. 716 - 724Online Volltext: dx.doi.org/
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Alterations in Ceramide Concentration and pH Determine the Release of Reactive Oxygen Species by Cftr-Deficient Macrophages on InfectionIn: The Journal of Immunology (JI) Jg. 184 (2010) Nr. 9, S. 5104 - 5111Online Volltext: dx.doi.org/
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An investigation of the occurrence and properties of the mitochondrial intermediate-conductance Ca²⁺-activated K⁺ channel mtKCₐ3.1In: Biochimica et Biophysica Acta (BBA) - Bioenergetics Jg. 1797 (2010) Nr. 6-7, S. 1260 - 1267Online Volltext: dx.doi.org/ (Open Access)
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Ceramide in pseudomonas aeruginosa infections and cystic fibrosisIn: Cellular Physiology and Biochemistry Jg. 26 (2010) Nr. 1, S. 57 - 66Online Volltext: dx.doi.org/ (Open Access)
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Ceramide in suicidal death of erythrocytesIn: Cellular Physiology and Biochemistry Jg. 26 (2010) Nr. 1, S. 21 - 28Online Volltext: dx.doi.org/ (Open Access)
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Contribution of the mitochondrial potassium channel Kv1.3 to the regulation of programmed cell deathIn: Biochimica et Biophysica Acta (BBA) - Bioenergetics Jg. 1797 (2010) Nr. Supplement, S. 132 - 133Online Volltext: dx.doi.org/ (Open Access)
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Contribution of voltage-gated potassium channels to the regulation of apoptosisIn: FEBS Letters Jg. 584 (2010) Nr. 10, S. 2049 - 2056Online Volltext: dx.doi.org/ (Open Access)
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Enhanced eryptosis of erythrocytes from gene-targeted mice lacking annexin A7In: Pflügers Archiv: European Journal of Physiology Jg. 460 (2010) Nr. 3, S. 667 - 676Online Volltext: dx.doi.org/
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Functional inhibitors of acid sphingomyelinase (FIASMAS) : A novel pharmacological group of drugs with broad clinical applicationsIn: Cellular Physiology and Biochemistry Jg. 26 (2010) Nr. 1, S. 9 - 20Online Volltext: dx.doi.org/ (Open Access)
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Increased acid sphingomyelinase activity in peripheral blood cells of acutely intoxicated patients with alcohol dependenceIn: Alcoholism: Clinical and Experimental Research Jg. 34 (2010) Nr. 1, S. 46 - 50Online Volltext: dx.doi.org/
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Lipids control mucus production in cystic fibrosisIn: Nature Medicine Jg. 16 (2010) Nr. 3, S. 267 - 268Online Volltext: dx.doi.org/
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Role of Kv1.3 mitochondrial potassium channel in apoptotic signalling in lymphocytesIn: Biochimica et Biophysica Acta (BBA) - Bioenergetics Jg. 1797 (2010) Nr. 6-7, S. 1251 - 1259Online Volltext: dx.doi.org/ (Open Access)
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Sphingomyelinase dependent apoptosis of dendritic cells following treatment with amyloid peptidesIn: Journal of Neuroimmunology Jg. 219 (2010) Nr. 1-2, S. 81 - 89Online Volltext: dx.doi.org/
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Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic functionIn: The Journal of Biological Chemistry (JBC) Jg. 285 (2010) Nr. 51, S. 40240 - 40251Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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The Role of Sphingolipids and Ceramide in Pulmonary Inflammation in Cystic FibrosisIn: Open Respiratory Medicine Journal Jg. 4 (2010) S. 39 - 47Online Volltext: dx.doi.org/
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Triggering of dendritic cell apoptosis by xanthohumolIn: Molecular Nutrition and Food Research Jg. 54 (2010) Nr. Suppl. 2, S. 214 - S224Online Volltext: dx.doi.org/
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Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosisIn: Nature Medicine Jg. 14 (2008) Nr. 4, S. 382 - 391Online Volltext: dx.doi.org/ (Open Access)
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Gründung einer Arbeitsgruppe „Lymphknotenmetastasierung“ am Westdeutschen Tumorzentrum (WTZE), Universitätsklinikum EssenIn: Der Urologe Jg. 46 (2007) Nr. 9, S. 1257 - 1260Online Volltext: dx.doi.org/
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Proapoptotische Antikörper als neue TumortherapeutikaIn: Der Urologe Jg. 46 (2007) Nr. 9, S. 1262 - 1265Online Volltext: dx.doi.org/
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Viele Wege führen in die Zelle : die Interaktion von Pathogenen mit humanen WirtszellenIn: Essener Unikate: Berichte aus Forschung und Lehre (2006) Nr. 27 : Medizin – Immunologie, S. 28 - 33Online Volltext (Open Access)
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Lipid signaling : Facets of a versatile cell communication strategy in health and diseaseIn: Pflügers Archiv: European Journal of Physiology Jg. 476 (2024) Nr. 12, S. 1777 - 1778Online Volltext: dx.doi.org/ (Open Access)
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Antidepressant Use and Its Association with 28-Day Mortality in Inpatients with SARS-CoV-2 : Support for the FIASMA Model against COVID-19
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Issue Information
57th Annual Scientic Meeting of the European Society for Clinical Investigation, 07.-09-06.2023, Prague,In: European Journal of Clinical Investigation Jg. 53 (2023) Nr. S1, Special Issue: 57TH ANNUAL SCIENTIFIC MEETING – 7–9 June 2023, Prague, Czech Republic, 57ASM - 25Online Volltext: dx.doi.org/ (Open Access) -
Elexacaftor tezacaftor ivacaftor therapy alters plasma sphingolipid profiles in people with cystic fibrosis
ERS International Congress ; 4-6 September 2022, Barcelona, Spain and online,In: European Respiratory Journal (ERJ) (2022)Online Volltext: dx.doi.org/ -
Regulatory Role of Ceramide/mTOR Signaling in Exosome Secretion from Smooth Muscle Cells during Arterial Stiffening and Medial CalcificationIn: The FASEB Journal Jg. 34 (2020) Nr. S1,Online Volltext: dx.doi.org/ (Open Access)
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The role and mechanism of voltage-gated potassium channel, Kv1.3, in pancreatic ductal adenocarcinoma (PDAC)
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Development of sphingosine-coupled oxygen carriers as novel drugs for treating pneumonia
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Docetaxel increases the levels of neurotoxic deoxysphingolipids in mice DRGIn: Journal of Neurochemistry Jg. 150 (2019) Nr. S1, S. 245Online Volltext: dx.doi.org/ (Open Access)
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Novel use of the lysosomal enzyme acid ceramidase for the treatment of inflammatory lung diseases, including cystic fibrosisIn: Molecular Genetics and Metabolism Jg. 114 (2015) Nr. 2, S. S104 - S105Online Volltext: dx.doi.org/
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Effects of nitric oxide on hematogenous metastasis
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Role of the acid sphingomyelinase in hematogenous tumor metastasis in a mouse model
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Role of the antigenic stimulation in the pathogenesis of chronic lymphocytic leukemia
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New Therapeutic Options in Pulmonal Diseases : Sphingolipids and Modulation of Sphingolipid MetabolismIn: Drug Delivery and Targeting / Schäfer-Korting, Monika; Schubert, Ulrich S. (Hrsg.) 2023, S. 289 - 312Online Volltext: dx.doi.org/
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Analysis of lipids in ceramide-enriched membrane domainsIn: Lipid Rafts: Methods and Protocols / Bieberich, Erhard (Hrsg.) 2021, S. 207 - 213Online Volltext: dx.doi.org/
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Mass Spectrometric Determination of Fatty Aldehydes Exemplified by Monitoring the Oxidative Degradation of (2E)-Hexadecenal in HepG2 Cell LysatesIn: Lipidomics / Wood, Paul (Hrsg.) 2017, S. 147 - 158Online Volltext: dx.doi.org/
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Acid SphingomyelinaseIn: Sphingolipids: Basic Science and Drug Development / Gulbins, Erich; Petrache, Irena 2013, S. 77 - 88Online Volltext: dx.doi.org/
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Ceramide in cystic fibrosisIn: Sphingolipids in Disease / Gulbins, Erich; Petrache, Irina 2013, S. 265 - 274Online Volltext: dx.doi.org/
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Functional inhibitors of acid sphingomyelinase (FIASMAs)In: Sphingolipids in Health and Disease / Gulbins, Erich; Petrache, Irena 2013, S. 169 - 186Online Volltext: dx.doi.org/
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Sphingolipids in psychiatric disorders and pain syndromesIn: Sphingolipids in Disease / Gulbins, Erich; Petrache, Irina (Hrsg.) 2013, S. 431 - 456Online Volltext: dx.doi.org/
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3D topology and arrangement of proteins inside ceramide-rich domainsIn: Biophotonics: photonic solutions for better health care II / Popp, Jürgen; SPIE photonics Europe, 12 - 16 April 2010, Brussels, Belgium 2010Online Volltext: dx.doi.org/
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3D-Visualisierung und Kolokalisation von Proteinen und ceramidreichen DomänenIn: Bildverarbeitung für die Medizin 2010: Algorithmen - Systeme - Anwendungen / Workshop Bildverarbeitung für die Medizin (BVM 2010), 14. bis 16. März 2010, Aachen / Deserno, Thomas M.; Handels, Heinz; Meinzer, Hans-Peter; Tolxdorff, Thomas (Hrsg.) 2010, S. 211 - 215Online Volltext (Open Access)