Titel

Autoren

Zeitschrift

Datum

Disturbed metabolic adaptation drives natural killer cell dysfunction in association with nosocomial infection during human sepsis 

van der Wurff A, Gambusz M, Budeus B, Claus M, Watzl C, Miteva D, Scicluna BP, Rubio I, Siakaeva E, Zinsmeister F, Vonderhagen S, Klenke N, Herbstreit F, Schmidt K, Berger MM, Brenner T, Dudda M, Flohé SB

EBioMedicine

2026

Profiling the dysregulated immune response in sepsis: overcoming challenges to achieve the goal of precision medicine

Cajander S, Kox M, Scicluna BP, Weigand MA, Mora RA, Flohé SB, et al.

Lancet Respir Med

2024

TLR2-induced CD8+ T-cell deactivation shapes dendritic cell differentiation in the bone marrow during sepsis

Antoni A.C., Pylaeva E., Budeus B., Jablonska J., Klein-Hitpaß L., Dudda M., Flohé S.B.

Front Immunol

2022

Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge

Winkler MS, Skirecki T, Brunkhorst FM, Cajander S, Cavaillon JM, Ferrer R, et al.

EBioMedicine

2021

Major Surgical Trauma Impairs the Function of Natural Killer Cells but Does Not Affect Monocyte Cytokine Synthesis

Müller-Heck R.M., Bösken B., Michiels I., Dudda M., Jäger M., and Flohé S.B.

Life

2021

TLR4 transactivates CD8+ T lymphocytes upon acute sterile tissue injury

Wienhöfer, L., Marker, M., Antoni, A. C., Sutter, K., Sander, A., Dudda, M., Flohé, S. B.

Immunohorizons

2021

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

Osuchowski MF, Winkler MS, Skirecki T, Cajander S, Shankar-Hari M, Lachmann G, et al.

Lancet Respir Med

2020

SARS-CoV-2/COVID-19: Evolving Reality, Global Response, Knowledge Gaps, and Opportunities

Osuchowski MF, Aletti F, Cavaillon JM, Flohé SB, Giamarellos-Bourboulis EJ, Huber-Lang M, et al.

Shock

2020

An inverse relationship between c-kit/CD117 and mTOR confers NK cell dysregulation late after severe injury

Bösken B., Hepner-Schefczyk M., Vonderhagen S., Dudda M., Flohé S. B.

Front Immunol

2020

Current gaps in sepsis immunology: new opportunities for translational research

Rubio I, Osuchowski MF, Shankar-Hari M, Skirecki T, Winkler MS, Lachmann G, et al.

The Lancet Infectious Diseases

2019

Surgical vacuum filter-derived stromal cells are superior in proliferation to human bone marrow aspirate

Henze K., Herten M., Haversath M., Busch A., Brandau S., Hackel A., Flohé S. B., Jäger M.

Stem Cell Res. Ther.

2019

Circulating growth/differentiation factor 15 is associated with human CD56(bright) natural killer cell dysfunction and nosocomial infection in severe systemic inflammation

Kleinertz, H., Hepner-Schefczyk, M., Ehnert, S., Claus, M., Halbgebauer, R., Boller, L., Huber-Lang, M., Cinelli, P., Kirschning, C., Flohé, S., Sander, A., Waydhas, C., Vonderhagen, S., Jäger, M., Dudda, M., Watzl, C., Flohé, S. B.

EBioMedicine

2019

Sphingosine 1-Phosphate- and C-C Chemokine Receptor 2-Dependent Activation of CD4+ Plasmacytoid Dendritic Cells in the Bone Marrow Contributes to Signs of Sepsis-Induced Immunosuppression

Smirnov, A., Pohlmann S., Nehring M., Ali S., Mann-Nüttel R., Scheu S., Antoni A. C., Hansen W., Buettner M., Gardiasch M. J., Westendorf A. M., Wirsdörfer F., Pastille E., Dudda M., Flohé, S. B.

Front. Immunol.

2017

Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function

Petri R.M., Hackel A., Hahnel K., Dumitru C.A., Bruderek K., Flohé S.B., Paschen A., Lang S., Brandau S.

Stem Cell Reports

2017

Human bone marrow mesenchymal stromal/stem cells acquire immunostimulatory properties upon cross-talk with natural killer cells and might improve the immune function of immunocompromised patients

Cui R., Rekasi H., Hepner-Schefczyk M., Fessmann K., Petri R.M., Bruderek K., Brandau S., Jäger M. Flohé S.B.

Stem Cell Res. Ther.

2016

Dendritic cell-like cells accumulate in regenerating murine skeletal muscle after injury and boost adaptive immune responses only upon a microbial challenge

Wirsdörfer F., Bangen J.M., Pastille E., Schmitz D., Flohé S., Schumak B., Flohé S.B.

PLoS One

2016

Invasive Surgery Impairs the Regulatory Function of Human CD56bright Natural Killer Cells in Response to Staphylococcus aureus. Suppression of Interferon-gamma Synthesis

Reinhardt R., Pohlmann S., Kleinertz H., Hepner-Schefczyk M., Paul A., Flohe S.B.

PLoS One

2015

Breaking the co-operation between bystander T-cells and Natural Killer cells prevents the development of immunosuppression after traumatic skeletal muscle injury in mice

Wirsdörfer F., Bangen J.M., Pastille E., Hansen W., Flohé S.B.

Clin. Sci. (Lond)

2015

A disturbed interaction with accessory cells upon opportunistic infection with Pseudomonas aeruginosa contributes to an impaired IFN-γ production of NK cells in the lung during sepsis-induced immunosuppression

Pastille E., Pohlmann S., Reib A., Wirsdörfer F., Flohé S.B.

Innate Immun.

2015