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Universitätsstr. 1-5
45141 Essen
45141 Essen
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S03 S01 A50
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Funktionen
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Universitätsprofessor/in, Entwicklungsbiologie
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Vorsitzende, Prüfungsausschuss Biologie
Aktuelle Veranstaltungen
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2022 SS
- Molekulare Entwicklungsbiologie
- Molekulare Mechanismen der Organentwicklung (Vorlesung)
- Anleitung zum wissenschaftlichen Arbeiten
- Molekulare Mechanismen der Organentwicklung (Seminar)
- Einführung in die Entwicklungsbiologie
- ZJA40201 Einführung in die Entwicklungsbiologie
- Literaturseminar Progress in Developmental Biology
- ZJA40201 Einführung in die Entwicklungsbiologie
- Übungen zur Allgemeinen Zoologie (zoologische Mikroskopierübungen)
Vergangene Veranstaltungen (max. 10)
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2021 WS
- Anleitung zum wiss. Arbeiten
- Zoologische Mikroskopierübung für LA Ba und MedBio B.Sc.
- Literaturseminar "Progress in Developmental Biology"
- Embryogenese (MedBio/Bio 5Semester)
- Allgemeine Methoden (Bachelor Bio)
- Modern Biomedicine/Beispiele biologischer Forschung (Teil 1)
- Allgemeine Methoden Praktikum (Bachelor Bio); Priorität für G1 oder G2
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2021 SS
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Epigenetic mechanisms mediating cell state transitions in chondrocytesIn: Journal of Bone and Mineral Research (JBMR) Jg. 36 (2021) Nr. 5, S. 968 - 985
ISSN: 0884-0431; 1523-4681Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
Heparan sulfate deficiency in cartilage : Enhanced bmp-sensitivity, proteoglycan production and an anti-apoptotic expression signature after loadingIn: International Journal of Molecular Sciences (IJMS) Jg. 22 (2021) Nr. 7, S. 3726
ISSN: 1422-0067; 1661-6596Online Volltext: dx.doi.org/ (Open Access) -
An altered heparan sulfate structure in the articular cartilage protects against osteoarthritisIn: Osteoarthritis and Cartilage Jg. 28 (2020) Nr. 7, S. 977 - 987
ISSN: 1522-9653; 1063-4584Online Volltext: dx.doi.org/ (Open Access) -
An altered heparan sulfate structure in the articular cartilage protects against osteoarthritisIn: Osteoarthritis and Cartilage (2020)
ISSN: 1063-4584; 1522-9653Online Volltext: dx.doi.org/ (Open Access) -
Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfateIn: Matrix Biology Jg. 39 (2020) S. 43 - 59
ISSN: 1569-1802; 0945-053XOnline Volltext: dx.doi.org/ (Open Access) -
Wnt5a is a transcriptional target of Gli3 and Trps1 at the onset of chondrocyte hypertrophyIn: Developmental Biology Jg. 457 (2020) Nr. 1, S. 104 - 118
ISSN: 0012-1606; 1095-564XOnline Volltext: dx.doi.org/ (Open Access) -
A network of trans-cortical capillaries as mainstay for blood circulation in long bonesIn: Nature Metabolism Jg. 1 (2019) Nr. 2, S. 236 - 250
ISSN: 2522-5812Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
A newly discovered stem cell that keeps bones growingIn: Nature Jg. 567 (2019) Nr. 7747, S. 178 - 179
ISSN: 0028-0836; 1476-4687Online Volltext: dx.doi.org/ (Open Access) -
Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bonesIn: PLoS ONE Jg. 14 (2019) Nr. 8, S. e0218230
ISSN: 1932-6203 -
Four-jointed knock-out delays renal failure in an ADPKD model with kidney injuryIn: The Journal of Pathology Jg. 249 (2019) Nr. 1, S. 114 - 125
ISSN: 1096-9896; 0022-3417; 0368-3494Online Volltext: dx.doi.org/ (Open Access) -
Signaling systems affecting the severity of multiple osteochondromasIn: Bone: Official Journal of the International Bone and Mineral Society (IBMS) Jg. 111 (2018) S. 71 - 81
ISSN: 1873-2763; 8756-3282Online Volltext: dx.doi.org/ (Open Access) -
Epigenetic regulation of chondrocyte differentiationIn: Mechanisms of Development Jg. 145 (2017) S. S141
ISSN: 0925-4773; 1872-6356Online Volltext: dx.doi.org/ -
OVERLOAD of joints and its role in osteoarthritis : Towards understanding and preventing progression of primary osteoarthritis; English versionIn: Zeitschrift für Rheumatologie Jg. 76 (2017) Nr. Suppl. 1, S. 1 - 4
ISSN: 0340-1855; 1435-1250Online Volltext: dx.doi.org/ -
Regulation of calvarial osteogenesis by concomitant de-repression of GLI3 and activation of IHH targetsIn: Frontiers in Physiology Jg. 8 (2017) S. 1036
ISSN: 1664-042XOnline Volltext: dx.doi.org/ (Open Access) -
Altered heparan sulfate structure in Glce-/- mice leads to increased Hedgehog signaling in endochondral bonesIn: Matrix Biology Jg. 49 (2016) S. 82 - 92
ISSN: 1569-1802; 0945-053XOnline Volltext: dx.doi.org/ -
Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustionIn: Journal of Experimental Medicine (JEM) Jg. 213 (2016) Nr. 12, S. 2759 - 2772
ISSN: 1540-9538; 0022-1007Online Volltext: dx.doi.org/ (Open Access) -
Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavageIn: The FASEB Journal / Experimental Biology ; Transforming the future through science ; Chicago, April 22-26, 2017 Jg. 30 (2016) Nr. 2, S. 727 - 737
ISSN: 0892-6638; 1530-6860Online Volltext: dx.doi.org/ -
Anoctamin-6 Controls Bone Mineralization by Activating the Calcium Transporter NCX1In: The Journal of Biological Chemistry (JBC) Jg. 290 (2015) Nr. 10, S. 6270 - 6280
ISSN: 0021-9258; 1083-351XOnline Volltext: dx.doi.org/ (Open Access) -
Hypertrophe Chondrozyten : Programmierter Zelltod oder Stammzellreservoir?In: Zeitschrift für Rheumatologie Jg. 74 (2015) Nr. 10, S. 898 - 901
ISSN: 0340-1855; 1435-1250Online Volltext: dx.doi.org/ -
Involvement of Ca2+ Activated Cl- Channel Ano6 in Platelet Activation and ApoptosisIn: Cellular Physiology and Biochemistry Jg. 37 (2015) Nr. 5, S. 1934 - 1944
ISSN: 1015-8987; 1421-9778Online Volltext: dx.doi.org/ (Open Access) -
OVERLOAD – Rolle der Gelenküberlastung in der primären Arthrose : Die Krankheitsprogression verstehen und vermeidenIn: Zeitschrift für Rheumatologie Jg. 74 (2015) Nr. 7, S. 618 - 621
ISSN: 0340-1855; 1435-1250Online Volltext: dx.doi.org/ -
Sweet on hedgehogs : Regulatory roles of heparan sulfate proteoglycans in hedgehog-dependent cell proliferation and differentiationIn: Current Protein and Peptide Science Jg. 16 (2015) Nr. 1, S. 66 - 76
ISSN: 1389-2037Online Volltext: dx.doi.org/ -
Gene expression profiling reveals similarities between the spatial architectures of postnatal articular and growth plate cartilageIn: PLoS ONE Jg. 9 (2014) Nr. 7, S. 0103061
ISSN: 1932-6203Online Volltext: dx.doi.org/ (Open Access) -
Heparan sulfate as a regulator of endochondral ossification and osteochondroma developmentIn: Matrix Biology Jg. 34 (2014) S. 55 - 63
ISSN: 1569-1802; 0945-053XOnline Volltext: dx.doi.org/ (Open Access) -
Inactivation of Patched1 in murine chondrocytes causes spinal fusion without inflammationIn: Arthritis & Rheumatology Jg. 66 (2014) Nr. 4, S. 831 - 840
ISSN: 2326-5191; 2326-5205Online Volltext: dx.doi.org/ -
Reprint of: Heparan sulfate as a regulator of endochondral ossification and osteochondroma developmentIn: Matrix Biology Jg. 35 (2014) S. 239 - 247
ISSN: 1569-1802; 0945-053XOnline Volltext: dx.doi.org/ (Open Access) -
Signaling Domain of Sonic Hedgehog as Cannibalistic Calcium-Regulated Zinc-PeptidaseIn: PLoS Computational Biology Jg. 10 (2014) Nr. 7, S. e1003707
ISSN: 1553-7358; 1553-734XOnline Volltext: dx.doi.org/ (Open Access) -
Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissuesIn: Journal of Bone and Mineral Research (JBMR) Jg. 28 (2013) Nr. 2, S. 246 - 259
ISSN: 0884-0431; 1523-4681Online Volltext: dx.doi.org/ -
The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosisIn: Cell Cycle Jg. 12 (2013) Nr. 14, S. 2219 - 2232
ISSN: 1551-4005Online Volltext: dx.doi.org/ -
Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 and Shox2 in miceIn: PLoS ONE Jg. 7 (2012) Nr. 8, S. e43553
ISSN: 1932-6203Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
Loss-of-function of Gli3 in mice causes abnormal frontal bone morphology and premature synostosis of the interfrontal sutureIn: Frontiers in Physiology Jg. 3 (2012) Nr. MAY, S. 121
ISSN: 1664-042XOnline Volltext: dx.doi.org/ (Open Access) -
Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing BoneIn: PLoS Genetics Jg. 8 (2012) Nr. 5, S. e1002711
ISSN: 1553-7390; 1553-7404Online Volltext: dx.doi.org/ (Open Access) -
Sonic hedgehog signaling during adrenal developmentIn: Molecular and Cellular Endocrinology Jg. 351 (2012) Nr. 1, S. 19 - 27
ISSN: 0303-7207Online Volltext: dx.doi.org/ -
BMP signaling balances proliferation and differentiation of muscle satellite cell descendants.In: BMC Cell Biology Jg. 12 (2011) S. 26
ISSN: 1471-2121Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytesIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 107 (2010) Nr. 5, S. 2054 - 2059
ISSN: 1091-6490; 0027-8424Online Volltext: dx.doi.org/ Online Volltext (Open Access) -
Expression patterns of sulfatase genes in the developing mouse embryoIn: Developmental Dynamics Jg. 239 (2010) Nr. 6, S. 1779 - 1788
ISSN: 0002-9106; 1097-0177Online Volltext: dx.doi.org/ -
Gli2 activator function in preosteoblasts is sufficient to mediate Ihh-dependent osteoblast differentiation, whereas the repressor function of Gli2 is dispensable for endochondral ossification.In: Developmental Dynamics Jg. 239 (2010) Nr. 6, S. 1818 - 1826
ISSN: 1058-8388Online Volltext: dx.doi.org/ -
The resorption of nanocrystalline calcium phosphates by osteoclast-like cellsIn: Acta Biomaterialia Jg. 6 (2010) Nr. 8, S. 3223 - 3233
ISSN: 1878-7568; 1742-7061Online Volltext: dx.doi.org/ -
Transcriptional networks controlling chondrocyte proliferation and differentiation during endochondral ossification.In: Pediatric Nephrology Jg. 25 (2010) Nr. 4, S. 625 - 631
ISSN: 0931-041XOnline Volltext: dx.doi.org/ -
Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60In: Chromosoma Jg. 119 (2010) Nr. 1, S. 99 - 113
ISSN: 0009-5915; 1432-0886Online Volltext: dx.doi.org/ -
Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3In: Developmental Biology Jg. 328 (2009) Nr. 1, S. 40 - 53
ISSN: 0012-1606Online Volltext: dx.doi.org/ -
Follistatin antagonizes transforming growth factor-beta3-induced epithelial-mesenchymal transition in vitro: implications for murine palatal development supported by microarray analysis.In: Differentiation Jg. 76 (2008) Nr. 4, S. 404 - 416
ISSN: 0301-4681 -
Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal developmentIn: Developmental Dynamics Jg. 2 (2008) Nr. 237, S. 339 - 353
ISSN: 1097-0177; 0002-9106 -
Tricho-rhino-phalangeal syndrome with supernumerary teethIn: Journal of Dental Research: JDR Online Jg. 87 (2008) Nr. 11, S. 1027 - 1031
ISSN: 1544-0591; 0022-0345Online Volltext: dx.doi.org/ -
Ucma - A novel secreted factor represents a highly specific marker for distal chondrocytesIn: Matrix Biology Jg. 27 (2008) Nr. 1, S. 3 - 11
ISSN: 1569-1802; 0945-053XOnline Volltext: dx.doi.org/ -
The rodent Four-jointed ortholog Fjx1 regulates dendrite extensionIn: Developmental Biology Jg. 312 (2007) Nr. 1, S. 461 - 470
ISSN: 0012-1606Online Volltext: dx.doi.org/ -
Hedgehog signaling in skeletal developmentIn: Birth Defects Research Part C: Embryo Today, Reviews Jg. 78 (2006) Nr. 3, S. 267 - 279
ISSN: 1542-9768; 1542-975XOnline Volltext: dx.doi.org/ -
The role of growth factors in chondrogenesis and osteogenesisIn: Current Opinion in Orthopaedics Jg. 17 (2006) S. 405 - 411
ISSN: 1531-7005; 1041-9918Online Volltext: dx.doi.org/ -
Expression of Fgf and Tgfβ signaling related genes during embryonic endochondral ossificationIn: Gene Expression Patterns Jg. 6 (2005) Nr. 1, S. 102 - 109
ISSN: 1872-7298; 1567-133XOnline Volltext: dx.doi.org/ -
Gli3 has repressing and activating functions downstream of Ihh in regulating two distinct steps of chondrocyte differentiationIn: Development Jg. 132 (2005) S. 5249 - 5260
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Essential role for ADAM19 in cardiovascular morphogenesisIn: Molecular and Cellular Biology Jg. 24 (2004) Nr. 1, S. 96 - 104
ISSN: 1098-5549; 0270-7306Online Volltext: dx.doi.org/ -
Ext1 dependent heparan sulfates regulate the range of Ihh signaling during endochondral ossificationIn: Developmental Cell Jg. 6 (2004) S. 801 - 813
ISSN: 1534-5807; 1878-1551Online Volltext: dx.doi.org/ (Open Access) -
Model systems for human muscoskeletal diseasesIn: Drug Discovery Today: Disease Models Jg. 1 (2004) Nr. 3, S. 359 - 364
ISSN: 1740-6757Online Volltext: dx.doi.org/ -
Targeted expression of SHH affects chondrocyte differentiation, growth plate organization, and Sox9 expressionIn: Journal of Bone and Mineral Research (JBMR) Jg. 19 (2004) S. 1678 - 1688
ISSN: 0884-0431; 1523-4681 -
Expression of Trps1 during mouse embryonic development.In: (Mech Dev) Jg. 119 Suppl 1 (2002) S. 117 - 120
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Interaction of FGF, Ihh/Pthlh and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation.In: (Dev Cell) Jg. 3 (2002) S. 439 - 449
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Role of Runx genes in chondrocyte differentiation.In: (Dev Biol) Jg. 245 (2002) S. 95 - 108
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BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation.In: Development Jg. 128 (2001) S. 4523 - 4534
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Interaction of growth factors regulating chondrocyte differentiation in the developing embryo.In: Osteoarthritis and Cartilage Jg. 9 (2001) S. 109 - 117
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Sex-specific expression of an evolutionarily conserved male regulatory gene, DMRT1, in birds.In: Cytogenetics and Cell Genetics Jg. 89 (2000) Nr. 3-4, S. 252 - 257
ISSN: 0301-0171 -
Interaction of Ihh and BMP/Noggin signaling during cartilage differentiation.In: (Dev Biol) Jg. 209 (1999) S. 239 - 253
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Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair.In: (Mech Dev) Jg. 71 (1998) S. 65 - 76
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Defining the skeletal elements.In: (Curr Biol) Jg. 7 (1997) S. 104 - 107
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Point mutations in human GLI3 cause Greig syndrome.In: (Hum Mol Genet) Jg. 6 (1997) S. 1979 - 1984
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PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth.In: Science Jg. 273 (1996) S. 663 - 666
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Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.In: Science Jg. 273 (1996) S. 613 - 622
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Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development.In: (Dev Biol) Jg. 180 (1996) S. 273 - 283
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The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse.In: (J Immunol) Jg. 156 (1996) S. 585 - 592
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Identification of optimized target sequences for the GLI3 zinc finger protein.In: (DNA Cell Biol) Jg. 14 (1995) S. 629 - 634
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Isolation and characterization of a cosmid contig for the GCPS gene region.In: (Hum Genet) Jg. 95 (1995) S. 82 - 88
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Isolation of a yeast artificial chromosome contig spanning the Greig cephalopolysyndactyly syndrome (GCPS) gene region.In: (Genomics) Jg. 22 (1994) S. 563 - 568
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Molecular linkage of the morphogenetic mutation add and the zinc finger gene Gli3.In: (Mamm Genome) Jg. 4 (1993) S. 276 - 277
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Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt).In: (Mamm Genome) Jg. 3 (1992) S. 461 - 463
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Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt).In: Development Jg. 116 (1992) S. 799 - 804
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A somatic cell hybrid panel and DNA probes for physical mapping of human chromosome 7p.In: Genomics Jg. 11 (1991) Nr. 3, S. 737 - 743
ISSN: 1089-8646; 0888-7543 -
GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families.In: Nature Jg. 352 (1991) Nr. 8. August, S. 535 - 540
ISSN: 0028-0836; 1476-4687 -
Untersuchung des Bmp-Signalweges während der MuskelregenerationDuisburg, Essen (2010) VIII, 93 Bl.
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Epigenetic profiling of articular chondrocytesIn: Osteoarthritis and Cartilage Jg. 29 (2021) Nr. Suppl. 1, S. 309
ISSN: 1063-4584; 1522-9653Online Volltext: dx.doi.org/ -
Heparan sulfate proteoglycans and integrin signaling in articular cartilage homeostasisIn: Osteoarthritis and Cartilage Jg. 29 (2021) Nr. Suppl. 1, S. 125 - S126
ISSN: 1063-4584; 1522-9653Online Volltext: dx.doi.org/ -
The role of heparan sulfate in the mechano-response of chondrocytesIn: Osteoarthritis and Cartilage Jg. 29 (2021) Nr. Suppl. 1, S. S131
ISSN: 1063-4584; 1522-9653Online Volltext: dx.doi.org/ -
Murine Limb Explant Cultures to Assess Cartilage DevelopmentIn: Skeletal Development and Repair: Methods and Protocols / Hilton, Matthew J. (Hrsg.) 2021, S. 139 - 149
ISBN: 978-1-0716-1027-5; 978-1-0716-1028-2Online Volltext: dx.doi.org/ -
Molecular control of cartilage differentiationIn: Cartilage: Volume 1: Physiology and Development / Grässel, Susanne; Aszódi, Attila (Hrsg.) 2016, S. 191 - 213
ISBN: 978-3-319-29568-8; 9783319295664Online Volltext: dx.doi.org/ -
Cartilage explant culturesIn: Skeletal Development and Repair: Methods and Protocols 2014, S. 89 - 97
ISBN: 978-1-62703-988-8; 978-1-62703-989-5Online Volltext: dx.doi.org/ -
Chondrocyte proliferation and differentiationIn: Cartilage and bone development and its disorders: 3 Tables / Camacho-Hübner, Cecilia; Nilsson, Ola G.; Sävendahl, Lars; 4th ESPE Advanced Seminar in Developmental Endocrinology, Stockholm, June 30 - July 1, 2010 2011, S. 1 - 11
ISBN: 978-3-8055-9792-0; 9783805597920 -
Regulation der Chondrozytendifferenzierung in der Wachstumsfuge: parakrine Signalsysteme.In: Molekularmedizinische Grundlagen von para- und autokrinen Regulationsstoerungen. 2006, S. 461 - 478
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The Indian hedgehog-PTHrP system in bone development.In: Ernst Schering Res Found Workshop 2000, S. 191 - 209