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Universitätsprofessor/in, Institut für Zellbiologie (Tumorforschung)
Aktuelle Veranstaltungen
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2023 SS
- Praktikum Zell- und Molekularbiologie für med. Biologen (Bachelor) (PV)
- Vorlesung Immunologie für medizinische Biologen (Masters)
- Seminar Molekulare Immunologie für medizinische Biologen (Master)
- Seminar Neue Literatur der Zell- und Molekularbiologie für med. Biologen (Bachelor) Gruppe I
- Seminar Neue Literatur der Zell- und Molekularbiologie für med. Biologen (Bachelor) Gruppe II
- Neue Literatur der Zell- und Molekularbiologie für Med. Biologen
- Mitarbeiterseminar in englischer Sprache (Lymphome)
- Seminar für Zellbiologie und experimentelle Krebsforschung (mit Gastsprechern) (*)
- Neue Literatur (Zellbiologie, experimentelle Krebsforschung) (*)
- Anleitung zu selbständigen wissenschaftlichen Arbeiten (*)
- Mitarbeiterseminar in englischer Sprache (Immunologie)
- Mitarbeiterseminar zur Besprechung aktueller Arbeiten
Vergangene Veranstaltungen (max. 10)
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2022 WS
- Seminar für Zellbiologie und experimentelle Krebsforschung (mit Gastsprechern) (*)
- Mitarbeiterseminar zur Besprechung aktueller Arbeiten
- Mitarbeiterseminar in englischer Sprache (Immunologie)
- Anleitung zu selbständigen wissenschaftlichen Arbeiten (*)
- Neue Literatur (Zellbiologie, experimentelle Krebsforschung) (*)
- Mitarbeiterseminar in englischer Sprache (Lymphome)
- Laborpraktikum I für Masterstudenten der medizinischen Biologie (WP)
- Modern Biomedicine/Beispiele biologischer Forschung (Teil 1)
- Laborpraktikum II für Masterstudenten der medizinischen Biologie (WP)
- Molekular- und Zellbiologie für Biomediziner
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Author Correction: Pan-cancer analysis of whole genomesIn: Nature Jg. 614 (2023) Nr. 7948, S. E39ISSN: 0028-0836; 1476-4687Online Volltext: dx.doi.org/ (Open Access)
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Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomasIn: Haematologica / The Hematology Journal Jg. 108 (2023) Nr. 2, S. 543 - 554ISSN: 1592-8721; 0390-6078Online Volltext: dx.doi.org/ (Open Access)
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Publisher Correction: Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarkerIn: Clinical Epigenetics Jg. 15 (2023) Nr. 1,ISSN: 1868-7083; 1868-7075Online Volltext: dx.doi.org/ (Open Access)
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Author Correction : Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSigIn: Nature Communications Jg. 13 (2022)ISSN: 2041-1723Online Volltext: dx.doi.org/
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Author Correction : A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patternsIn: Nature Communications Jg. 13 (2022)ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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Author Correction : Divergent mutational processes distinguish hypoxic and normoxic tumoursIn: Nature Communications Jg. 13 (2022)ISSN: 2041-1723Online Volltext: dx.doi.org/
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Author Correction : Integrative pathway enrichment analysis of multivariate omics dataIn: Nature Communications Jg. 13 (2022)ISSN: 2041-1723Online Volltext: dx.doi.org/
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Author Correction : High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterationsIn: Nature Communications Jg. 13 (2022)ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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Author Correction : Pathway and network analysis of more than 2500 whole cancer genomesIn: Nature Communications Jg. 13 (2022)ISSN: 2041-1723Online Volltext: dx.doi.org/
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Author Correction : Inferring structural variant cancer cell fractionIn: Nature Communications Jg. 13 (2022)ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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Author Correction : Combined burden and functional impact tests for cancer driver discovery using DriverPowerIn: Nature Communications Jg. 13 (2022)ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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Author Correction : Genomic footprints of activated telomere maintenance mechanisms in cancerIn: Nature Communications Jg. 13 (2022)ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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Distinct Chemokine Receptor Expression Profiles in De Novo DLBCL, Transformed Follicular Lymphoma, Richter's Trans-Formed DLBCL and Germinal Center B-CellsIn: International Journal of Molecular Sciences (IJMS) Jg. 23 (2022) Nr. 14,ISSN: 1422-0067; 1661-6596Online Volltext: dx.doi.org/ (Open Access)
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Epigenome-wide analysis of T-cell large granular lymphocytic leukemia identifies BCL11B as a potential biomarkerIn: Clinical Epigenetics Jg. 14 (2022) Nr. 1,ISSN: 1868-7083; 1868-7075Online Volltext: dx.doi.org/ (Open Access)
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Loss of function mutations of BCOR in classical Hodgkin lymphomaIn: Leukemia and Lymphoma Jg. 63 (2022) Nr. 5, S. 1080 - 1090ISSN: 1042-8194; 1029-2403Online Volltext: dx.doi.org/
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The Biology of Ocular Adnexal Marginal Zone LymphomasIn: Cancers Jg. 14 (2022) Nr. 5,ISSN: 2072-6694Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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The Splenic Marginal Zone in Children Is Characterized by a Subpopulation of CD27-Negative, Lowly IGHV-Mutated B CellsIn: Frontiers in Immunology Jg. 13 (2022)ISSN: 1664-3224Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Context-dependent regulation of immunoglobulin mutagenesis by p53In: Molecular Immunology Jg. 138 (2021) S. 128 - 136ISSN: 1872-9142; 0161-5890Online Volltext: dx.doi.org/
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Human cord blood b cells differ from the adult counterpart by conserved ig repertoires and accelerated response dynamicsIn: Journal of Immunology Jg. 206 (2021) Nr. 12, S. 2839 - 2851ISSN: 1550-6606; 0022-1767Online Volltext: dx.doi.org/ (Open Access)
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Impact of a faulty germinal center reaction on the pathogenesis of primary diffuse large b cell lymphoma of the central nervous systemIn: Cancers Jg. 13 (2021) Nr. 24,ISSN: 2072-6694Online Volltext: dx.doi.org/ (Open Access)
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Molecular biology of Hodgkin lymphomaIn: Leukemia Jg. 35 (2021) Nr. 4, S. 968 - 981ISSN: 1476-5551; 0887-6924Online Volltext: dx.doi.org/ (Open Access)
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Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomasIn: Leukemia Jg. 35 (2021) S. 2002 - 2016ISSN: 0887-6924; 1476-5551Online Volltext: dx.doi.org/ (Open Access)
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PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected miceIn: EMBO Reports (2021)ISSN: 1469-3178; 1469-221XOnline Volltext: dx.doi.org/ (Open Access)
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Sugar-modified B-cell receptors in DLBCLIn: Blood Jg. 138 (2021) Nr. 17, S. 1512 - 1514ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/ (Open Access)
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Systematic memory B cell archiving and random display shape the human splenic marginal zone throughout lifeIn: Journal of Experimental Medicine (JEM) Jg. 218 (2021) Nr. 4, S. e20201952ISSN: 1540-9538; 0022-1007Online Volltext: dx.doi.org/ (Open Access)
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The life of B cells according to JEMIn: Journal of Experimental Medicine (JEM) Jg. 218 (2021) Nr. 5, S. e20210647ISSN: 1540-9538; 0022-1007Online Volltext: dx.doi.org/ (Open Access)
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The process of somatic hypermutation increases polyreactivity for central nervous system antigens in primary central nervous system lymphomaIn: Haematologica / The Hematology Journal Jg. 106 (2021) Nr. 3, S. 708 - 717ISSN: 1592-8721; 0390-6078Online Volltext: dx.doi.org/ (Open Access)
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UMI or not UMI, that is the question for scRNA-seq zero-inflationIn: Nature Biotechnology Jg. 39 (2021) Nr. 2, S. 158 - 159ISSN: 1087-0156; 1546-1696; 0733-222XOnline Volltext: dx.doi.org/
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A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patternsIn: Nature Communications Jg. 11 (2020)ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samplesIn: Nature Communications Jg. 11 (2020) Nr. 1, S. 6232ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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Combined burden and functional impact tests for cancer driver discovery using DriverPowerIn: Nature Communications Jg. 11 (2020)ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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Divergent mutational processes distinguish hypoxic and normoxic tumoursIn: Nature Communications Jg. 11 (2020)ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypesIn: Blood Jg. 136 (2020) Nr. 12, S. 1419 - 1432ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Genomic footprints of activated telomere maintenance mechanisms in cancerIn: Nature Communications Jg. 11 (2020)ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterationsIn: Nature Communications Jg. 11 (2020)ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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Identifying genetic lesions in ocular adnexal extranodal marginal zone lymphomas of the malt subtype by whole genome, whole exome and targeted sequencingIn: Cancers Jg. 12 (2020) Nr. 4, S. 986ISSN: 2072-6694Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Inferring structural variant cancer cell fractionIn: Nature Communications Jg. 11 (2020)ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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Integrative pathway enrichment analysis of multivariate omics dataIn: Nature Communications Jg. 11 (2020)ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphomaIn: Nature Communications Jg. 11 (2020) Nr. 1, S. 2465ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLLIn: Genome Medicine Jg. 12 (2020) Nr. 1,ISSN: 1756-994XOnline Volltext: dx.doi.org/ (Open Access)
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Molecular Mechanisms in the Pathogenesis of Composite LymphomasIn: Klinische Pädiatrie Jg. 232 (2020) Nr. 02, S. 80ISSN: 1439-3824; 0300-8630Online Volltext: dx.doi.org/
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Pan-cancer analysis of whole genomesIn: Nature Jg. 578 (2020) Nr. 7793, S. 82 - 93ISSN: 0028-0836; 1476-4687Online Volltext: dx.doi.org/ (Open Access)
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Pathway and network analysis of more than 2500 whole cancer genomesIn: Nature Communications Jg. 11 (2020)ISSN: 2041-1723Online Volltext: dx.doi.org/
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Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSigIn: Nature Communications Jg. 11 (2020)ISSN: 2041-1723Online Volltext: dx.doi.org/
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Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samplesIn: Nature Communications Jg. 11 (2020) Nr. 1, S. 4748ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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Role of Specific B-Cell Receptor Antigens in LymphomagenesisIn: Frontiers in Oncology Jg. 10 (2020) S. 604685ISSN: 2234-943XOnline Volltext: dx.doi.org/ (Open Access)
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Sex differences in oncogenic mutational processesIn: Nature Communications Jg. 11 (2020) Nr. 1, S. 4330ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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The Genomic Landscape of HIV-Associated Plasmablastic LymphomaIn: Blood Cancer Discovery Jg. 1 (2020) Nr. 1, S. 23 - 25ISSN: 2643-3230; 2643-3249Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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γδ T-cell receptors derived from breast cancer-infiltrating T lymphocytes mediate antitumor reactivityIn: Cancer Immunology Research Jg. 8 (2020) Nr. 4, S. 530 - 543ISSN: 2326-6074; 2326-6066Online Volltext: dx.doi.org/
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CD30 expression in neoplastic T cells of follicular T cell lymphoma is a helpful diagnostic tool in the differential diagnosis of Hodgkin lymphomaIn: Modern Pathology Jg. 32 (2019) Nr. 1, S. 37 - 47ISSN: 1530-0285; 0893-3952Online Volltext: dx.doi.org/ (Open Access)
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CD81 as target for B cell lymphomasIn: Journal of Experimental Medicine (JEM) Jg. 216 (2019) Nr. 7, S. 1469 - 1470ISSN: 1540-9538; 0022-1007Online Volltext: dx.doi.org/ (Open Access)
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Fibroblasts in nodular sclerosing classical Hodgkin lymphoma are defined by a specific phenotype and protect tumor cells from brentuximab-Vedotin induced injuryIn: Cancers Jg. 11 (2019) Nr. 11, Article-No: 1687ISSN: 2072-6694Online Volltext: dx.doi.org/ (Open Access)
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Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphomaIn: Nature Communications Jg. 10 (2019) Nr. 1, S. 1459ISSN: 2041-1723Online Volltext: dx.doi.org/ (Open Access)
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JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte-rich large B-cell lymphomaIn: Haematologica Jg. 104 (2019) Nr. 2, S. 330 - 337ISSN: 1592-8721Online Volltext: dx.doi.org/ (Open Access)
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MDM4 Is Targeted by 1q Gain and Drives Disease in Burkitt LymphomaIn: Cancer Research Jg. 79 (2019) Nr. 12, S. 3125 - 3138ISSN: 1538-7445; 0008-5472Online Volltext: dx.doi.org/
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Migration properties distinguish tumor cells of classical hodgkin lymphoma from anaplastic large cell lymphoma cellsIn: Cancers Jg. 11 (2019) Nr. 10, S. 1484ISSN: 2072-6694Online Volltext: dx.doi.org/ (Open Access)
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An oncogenic axis of STAT-mediated BATF3 upregulation causing MYC activity in classical Hodgkin lymphoma and anaplastic large cell lymphomaIn: Leukemia Jg. 32 (2018) Nr. 1, S. 92 - 101ISSN: 0887-6924; 1476-5551Online Volltext: dx.doi.org/
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Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus–infected individualsIn: Blood Jg. 131 (2018) Nr. 5, S. 546 - 557ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/ (Open Access)
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CD83 in Hodgkin lymphomaIn: Haematologica Jg. 103 (2018) Nr. 4, S. 561 - 562ISSN: 1592-8721; 0390-6078Online Volltext: dx.doi.org/ (Open Access)
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Critical influences on the pathogenesis of follicular lymphomaIn: Blood Jg. 131 (2018) Nr. 21, S. 2297 - 2306ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/ (Open Access)
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Ectopic expression of transcription factor BATF3 induces B-cell lymphomas in a murine B-cell transplantation modelIn: OncoTarget Jg. 9 (2018) Nr. 22, S. 15942 - 15951ISSN: 1949-2553Online Volltext: dx.doi.org/ (Open Access)
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Expression profile of translation initiation factor eIF2B5 in diffuse large B-cell lymphoma and its correlation to clinical outcome.In: Blood Cancer Journal Jg. 8 (2018) Nr. 9, S. 79ISSN: 2044-5385Online Volltext: dx.doi.org/ (Open Access)
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Human CD30⁺ B cells represent a unique subset related to Hodgkin lymphoma cellsIn: The Journal of Clinical Investigation (JCI) Jg. 128 (2018) Nr. 7, S. 2996 - 3007ISSN: 1558-8238; 0021-9738Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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IG-MYC⁺ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomasIn: Blood Jg. 132 (2018) Nr. 21, S. 2280 - 2285ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/ (Open Access)
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SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemiaIn: Blood Cancer Journal Jg. 8 (2018) Nr. 1, S. 11ISSN: 2044-5385Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Complex Immune Evasion Strategies in Classical Hodgkin LymphomaIn: Cancer Immunology Research Jg. 5 (2017) Nr. 12, S. 1122 - 1132ISSN: 2326-6074; 2326-6066Online Volltext: dx.doi.org/
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Concepts in mature T-cell lymphomas – highlights from an international joint symposium on T-cell immunology and oncologyIn: Leukemia and Lymphoma Jg. 58 (2017) Nr. 4, S. 788 - 796ISSN: 1029-2403; 1042-8194Online Volltext: dx.doi.org/
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Quantitative Comparison of Abundance Structures of Generalized Communities : from B-Cell Receptor Repertoires to MicrobiomesIn: PLoS Computational Biology Jg. 13 (2017) Nr. 1,ISSN: 1553-734X; 1553-7358Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Structure and diversification of immunoglobulin genes in African Burkitt lymphomaIn: Blood Advances Jg. 1 (2017) Nr. 16, S. 1259 - 1260ISSN: 2473-9537; 2473-9529Online Volltext: dx.doi.org/ (Open Access)
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TET2 mutations in B cells of patients affected by angioimmunoblastic T-cell lymphomaIn: The Journal of Pathology Jg. 242 (2017) Nr. 2, S. 129 - 133ISSN: 1096-9896; 0022-3417; 0368-3494Online Volltext: dx.doi.org/
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A strong host response and lack of MYC expression are characteristic for diffuse large B cell lymphoma transformed from nodular lymphocyte predominant Hodgkin lymphomaIn: OncoTarget Jg. 7 (2016) Nr. 44, S. 72197 - 72210ISSN: 1949-2553Online Volltext: dx.doi.org/ (Open Access)
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Alterations of microRNA and microRNA-regulated messenger RNA expression in germinal center B-cell lymphomas determined by integrative sequencing analysisIn: Haematologica Jg. 101 (2016) Nr. 11, S. 1380 - 1389ISSN: 0390-6078; 1592-8721Online Volltext: dx.doi.org/ (Open Access)
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DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemiaIn: Nature Genetics Jg. 48 (2016) Nr. 3, S. 253 - 264ISSN: 1061-4036; 1546-1718Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphomaIn: Blood Jg. 128 (2016) Nr. 23, S. 2666 - 2670ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/ (Open Access)
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Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphomaIn: Leukemia Jg. 30 (2016) Nr. 4, S. 844 - 853ISSN: 0887-6924; 1476-5551Online Volltext: dx.doi.org/
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Hodgkin lymphoma : Pathology and biologyIn: Seminars in Hematology Jg. 53 (2016) Nr. 3, S. 139 - 147ISSN: 0037-1963Online Volltext: dx.doi.org/
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Human memory B cellsIn: Leukemia Jg. 30 (2016) Nr. 12, S. 2283 - 2292ISSN: 0887-6924; 1476-5551Online Volltext: dx.doi.org/
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Mikrofluidik-Chip-Architekturen für eine Zell-Sortieranlage basierend auf der Elektrowetting-TechnologieIn: Technisches Messen: tm Jg. 83 (2016) Nr. 5, S. 274 - 288ISSN: 2196-7113; 0171-8096Online Volltext: dx.doi.org/
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NF-κB deregulation in Hodgkin lymphomaIn: Seminars in Cancer Biology Jg. 39 (2016) S. 32 - 39ISSN: 1044-579X; 1096-3650Online Volltext: dx.doi.org/
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Novel IGH and MYC Translocation Partners in Diffuse Large B-Cell LymphomasIn: Genes, Chromosomes and Cancer Jg. 55 (2016) Nr. 12, S. 932 - 943ISSN: 1098-2264; 1045-2257Online Volltext: dx.doi.org/
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Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemiaIn: International Journal of Cancer Jg. 138 (2016) Nr. 1, S. 121 - 124ISSN: 0020-7136; 1097-0215Online Volltext: dx.doi.org/ (Open Access)
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Recurrent mutations in NF-κB pathway components, KMT2D, and NOTCH1/2 in ocular adnexal MALT-type marginal zone lymphomasIn: OncoTarget Jg. 7 (2016) Nr. 38, S. 62627 - 62639ISSN: 1949-2553Online Volltext: dx.doi.org/ (Open Access)
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The International Human Epigenome Consortium : A Blueprint for Scientific Collaboration and DiscoveryIn: Cell Jg. 167 (2016) Nr. 5, S. 1145 - 1149ISSN: 0092-8674Online Volltext: dx.doi.org/ (Open Access)
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The role of t cells in the microenvironment of hodgkin lymphomaIn: Journal of Leukocyte Biology Jg. 99 (2016) Nr. 1, S. 45 - 50ISSN: 1938-3673; 0741-5400Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Tumor-infiltrating HLA-matched CD4(+) T cells retargeted against Hodgkin and Reed-Sternberg cellsIn: OncoImmunology Jg. 5 (2016) Nr. 6,ISSN: 2162-402X; 2162-4011Online Volltext: dx.doi.org/ (Open Access)
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A large fraction of human tonsillar B cells expressing CD27 are germinal center B cellsIn: Immunology and Cell Biology Jg. 93 (2015) Nr. 5, S. 429 - 430ISSN: 0818-9641; 1440-1711; 0004-945XOnline Volltext: dx.doi.org/
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Alterations of the CD58 gene in classical Hodgkin lymphomaIn: Genes, Chromosomes and Cancer Jg. 54 (2015) Nr. 10, S. 638 - 645ISSN: 1098-2264; 1045-2257Online Volltext: dx.doi.org/
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Analysis of mechanisms of malignant transformation in TP53 wild-type burkitts lymphoma by integration of molecular and functional genomics dataIn: Haematologica Jg. 100 (2015) Nr. Suppl. 1, S. 105ISSN: 1592-8721; 0390-6078Online Volltext (Open Access)
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Characterization of genomic imbalances in diffuse large B-cell lymphoma by detailed SNP-chip analysisIn: International Journal of Cancer Jg. 136 (2015) Nr. 5, S. 1033 - 1042ISSN: 0020-7136; 1097-0215Online Volltext: dx.doi.org/ (Open Access)
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Complexity of the human memory B-cell compartment is determined by the versatility of clonal diversification in germinal centersIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 112 (2015) Nr. 38, S. E5281 - E5289ISSN: 1091-6490; 0027-8424Online Volltext: dx.doi.org/ (Open Access)
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DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional controlIn: Nature Genetics Jg. 47 (2015) Nr. 11, S. 1316 - 1325ISSN: 1061-4036; 1546-1718Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Functional capacities of human igm memory b cells in early inflammatory responses and secondary germinal center reactionsIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 112 (2015) Nr. 6, S. E546 - E555ISSN: 1091-6490; 0027-8424Online Volltext: dx.doi.org/ (Open Access)
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Genomic and epigenomic co-evolution in follicular lymphomasIn: Leukemia Jg. 29 (2015) Nr. 2, S. 456 - 463ISSN: 1476-5551Online Volltext: dx.doi.org/
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IRAK4 inhibition to shut down TLR signaling in autoimmunity and MyD88-dependent lymphomasIn: Journal of Experimental Medicine (JEM) Jg. 212 (2015) Nr. 13, S. 2184ISSN: 1540-9538; 0022-1007Online Volltext: dx.doi.org/ (Open Access)
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MINCR is a MYC-induced lncRNA able to modulate MYC's transcriptional network in Burkitt lymphoma cellsIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 112 (2015) Nr. 38, S. E5261 - E5270ISSN: 1091-6490; 0027-8424Online Volltext: dx.doi.org/ (Open Access)
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Moraxella Catarrhalis-A bacterial involvement in the origin of nodular lymphocyte predominant Hodgkin Lymphoma of IGD type?In: Haematologica Jg. 100 (2015) Nr. Suppl.1, S. 106 - 107ISSN: 0390-6078; 1592-8721(Open Access)
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Potential role of hypoxia in early stages of Hodgkin lymphoma pathogenesisIn: Haematologica Jg. 100 (2015) Nr. 10, S. 1320 - 1326ISSN: 1592-8721; 0390-6078Online Volltext: dx.doi.org/ (Open Access)
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Progressive Epigenetic Programming during B Cell Maturation Is Reflected in a Continuum of Epigenetic Disease Phenotypes in Chronic Lymphocytic LeukemiaIn: Blood Jg. 126 (2015) Nr. 23, S. 2436ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/
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Progressive epigenetic programming during B cell maturation yields a continuum of clonal disease phenotypes with distinct etiologies in chronic lymphocytic leukemiaIn: Clinical Cancer Research Jg. 21 (2015) Nr. 17 Suppl., S. B25 - B25ISSN: 1078-0432Online Volltext: dx.doi.org/
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Whole exome sequencing of microdissected splenic marginal zone lymphoma : A study to discover novel tumor-specific mutationsIn: BMC Cancer Jg. 15 (2015) Nr. 1, S. 773ISSN: 1471-2407Online Volltext: dx.doi.org/ (Open Access)
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Whole-genome fingerprint of the DNA methylome during human B cell differentiationIn: Nature Genetics Jg. 47 (2015) Nr. 7, S. 746 - 756ISSN: 1061-4036; 1546-1718Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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A microRNA involved in the germinal center reactionIn: Blood Jg. 124 (2014) Nr. 2, S. 158 - 159ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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A novel immunohistochemical classifier to distinguish Hodgkin lymphoma from ALK anaplastic large cell lymphomaIn: Modern Pathology Jg. 27 (2014) Nr. 10, S. 1345 - 1354ISSN: 1530-0285; 0893-3952Online Volltext: dx.doi.org/
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A recurrent 11q aberration pattern characterizes a subset of MYC-negative high-grade B-cell lymphomas resembling Burkitt lymphomaIn: Blood Jg. 123 (2014) Nr. 8, S. 1187 - 1198ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/
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Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphomaIn: Haematologica Jg. 99 (2014) Nr. 4, S. 726 - 735ISSN: 1592-8721Online Volltext: dx.doi.org/ (Open Access)
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Characterization of the DNA Methylome during Human B-Cell DifferentiationIn: Blood Jg. 124 (2014) Nr. 21, S. 4346ISSN: 1528-0020; 0006-4971
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Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphomaIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 111 (2014) Nr. 42, S. E4513 - E4522ISSN: 1091-6490; 0027-8424Online Volltext: dx.doi.org/
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Subclonal evolution of a classical Hodgkin lymphoma from a germinal center B-cell-derived mantle cell lymphomaIn: International Journal of Cancer Jg. 134 (2014) Nr. 4, S. 832 - 843ISSN: 0020-7136; 1097-0215Online Volltext: dx.doi.org/
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The PRDX2 gene is transcriptionally silenced and de novo methylated in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphomaIn: Blood Jg. 123 (2014) Nr. 23, S. 3672 - 3674ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/
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B Cells in Chronically Hepatitis C Virus-Infected Individuals Lack a Virus-Induced Mutation Signature in the TP53, CTNNB1, and BCL6 GenesIn: Journal of Virology Jg. 87 (2013) Nr. 5, S. 2956 - 2962ISSN: 1098-5514; 0022-538XOnline Volltext: dx.doi.org/
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Hodgkin-Reed-Sternberg cells in classical Hodgkin lymphoma show alterations of genes encoding the NADPH oxidase complex and impaired reactive oxygen species synthesis capacityIn: PLoS ONE Jg. 8 (2013) Nr. 12, S. e84928ISSN: 1932-6203Online Volltext: dx.doi.org/ (Open Access)
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Macrophages in T cell/histiocyte rich large B cell lymphoma strongly express metal-binding proteins and show a bi-activated phenotypeIn: International Journal of Cancer Jg. 133 (2013) Nr. 11, S. 2609 - 2618ISSN: 0020-7136; 1097-0215Online Volltext: dx.doi.org/
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Next generation transcriptome sequencing confirms the presence of somatic STAT3 mutations and identifies novel TNFAIP3 mutations in T Large Granular Lymphocytic Leukemia (T-LGL)In: Onkologie Jg. 36 (2013) Nr. Suppl. 7, S. 196ISSN: 0378-584X; 1423-0240
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Nodular lymphocyte predominant hodgkin lymphoma and T cell/histiocyte rich large B cell lymphoma : Endpoints of a spectrum of one disease?In: PLoS ONE Jg. 8 (2013) Nr. 11,ISSN: 1932-6203Online Volltext: dx.doi.org/ (Open Access)
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Role of early B-cell factor 1 (EBF1) in Hodgkin lymphomaIn: Leukemia Jg. 27 (2013) Nr. 3, S. 671 - 679ISSN: 1476-5551; 0887-6924Online Volltext: dx.doi.org/
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Whole exome massive parallel sequencing of splenic marginal zone lymphoma reveals novel somatic mutations in NOTCH2 and SMYD1 genesIn: European Journal of Cancer Jg. 49 (2013) Nr. Suppl. 2, S. 837ISSN: 0959-8049
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Analyzing primary Hodgkin and Reed-Sternberg cells to capture the molecular and cellular pathogenesis of classical Hodgkin lymphomaIn: Blood Jg. 120 (2012) Nr. 23, S. 4609 - 4620ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/
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Array-based DNA methylation analysis in classical Hodgkin lymphoma reveals new insights into the mechanisms underlying silencing of B cell-specific genesIn: Leukemia Jg. 26 (2012) Nr. 1, S. 185 - 188ISSN: 0887-6924; 1476-5551Online Volltext: dx.doi.org/
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BLUEPRINT to decode the epigenetic signature written in bloodIn: Nature Biotechnology Jg. 30 (2012) Nr. 3, S. 224 - 226ISSN: 1087-0156; 1546-1696Online Volltext: dx.doi.org/
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Cellular origin and pathophysiology of chronic lymphocytic leukemiaIn: Journal of Experimental Medicine (JEM) Jg. 209 (2012) Nr. 12, S. 2183 - 2198ISSN: 1540-9538; 0022-1007Online Volltext: dx.doi.org/ (Open Access)
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Combined SNP Microarray Based Genomic Mapping and Next Generation Transcriptome Sequencing Confirms the Presence of Somatic STAT3 Mutations and Identifies Novel Chromosomal Imbalances and Candidate Genes in T Large Granular Lymphocytic Leukemia (T-LGL)In: Blood Jg. 120 (2012) Nr. 21, S. 3512ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/
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Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion VariantsIn: Clinical Cancer Research Jg. 18 (2012) Nr. 17, S. 4682 - 4690ISSN: 1557-3265; 1078-0432Online Volltext: dx.doi.org/ (Open Access)
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Dysregulation of global microRNA expression in splenic marginal zone lymphoma and influence of chronic hepatitis C virus infectionIn: Leukemia Jg. 26 (2012) Nr. 7, S. 1654 - 1662ISSN: 0887-6924; 1476-5551Online Volltext: dx.doi.org/
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Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphomaIn: British Journal of Haematology Jg. 157 (2012) Nr. 6, S. 702 - 708ISSN: 1365-2141; 0007-1048Online Volltext: dx.doi.org/ (Open Access)
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New insights in the biology of Hodgkin lymphomaIn: Hematology: The American Society of Hematology Education Program Book (2012) Nr. 1, S. 328 - 334ISSN: 1520-4383; 1520-4391Online Volltext: dx.doi.org/ (Open Access)
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Recurrent deletions of the TNFSF7 and TNFSF9 genes in 19p13.3 in diffuse large B-cell and Burkitt lymphomasIn: International Journal of Cancer Jg. 131 (2012) Nr. 5, S. E830 - E835ISSN: 0020-7136; 1097-0215Online Volltext: dx.doi.org/
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Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencingIn: Nature Genetics Jg. 44 (2012) Nr. 12, S. 1316 - 1320ISSN: 1061-4036; 1546-1718Online Volltext: dx.doi.org/
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Von Genchips, Antikörpern und leuchtenden Krebszellen : Translationale Forschung bei LymphomenIn: Unikate: Berichte aus Forschung und Lehre (2012) Nr. 42: Translationale Krebsforschung: Auf dem Weg zu neuen Therapien, S. 70 - 79ISBN: 978-3-934359-42-0 ISSN: 0944-6060; 1869-3881Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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CCR7 & lymphotoxin in lymphoma nicheIn: Blood Jg. 118 (2011) Nr. 4, S. 831 - 832ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/
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GCSF reduces mutated (CD27+) B-cells but increases unmutated naive (CD27-) B-cells in stem cell donorsIn: Bone Marrow Transplantation Jg. 46 (2011) Nr. Suppl. 1, S. S344 - S345ISSN: 1476-5365; 0268-3369
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Mutation analysis of the TNFAIP3 (A20) tumor suppressor gene in CLLIn: International Journal of Cancer Jg. 128 (2011) Nr. 7, S. 1747 - 1750ISSN: 0020-7136; 1097-0215Online Volltext: dx.doi.org/
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Translocations activating IRF4 identify a subtype of germinal center-derived B-cell lymphoma affecting predominantly children and young adultsIn: Blood Jg. 118 (2011) Nr. 1, S. 139 - 147ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/
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Detection of genomic aberrations in molecularly defined Burkitt’s lymphoma by array-based, high resolution, single nucleotide polymorphism analysisIn: Haematologica Jg. 95 (2010) Nr. 12, S. 2047 - 2055ISSN: 1592-8721; 0390-6078Online Volltext: dx.doi.org/
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High resolution SNP array genomic profiling of peripheral T cell lymphomas, not otherwise specified, identifies a subgroup with chromosomal aberrations affecting the REL locusIn: British Journal of Haematology Jg. 148 (2010) Nr. 3, S. 402 - 412ISSN: 1365-2141; 0007-1048Online Volltext: dx.doi.org/
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Mechanisms of aberrant GATA3 expression in classical Hodgkin lymphoma and its consequences for the cytokine profile of Hodgkin and Reed/Sternberg cellsIn: Blood Jg. 116 (2010) Nr. 20, S. 4202 - 4211ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/ (Open Access)
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Mutations in the genes coding for the NF-κB regulating factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin’s lymphomaIn: Haematologica Jg. 95 (2010) Nr. 1, S. 153 - 157ISSN: 1592-8721Online Volltext: dx.doi.org/ (Open Access)
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Mutations of CARD11 but not TNFAIP3 may activate the NF-κB pathway in primary CNS lymphomaIn: Acta Neuropathologica Jg. 120 (2010) Nr. 4, S. 529 - 535ISSN: 0001-6322; 1432-0533Online Volltext: dx.doi.org/
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Side population cells in Hodgkin lymphomaIn: Leukemia and Lymphoma Jg. 51 (2010) Nr. 5, S. 741 - 742ISSN: 1042-8194; 1029-2403Online Volltext: dx.doi.org/
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Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B-chronic lymphocytic leukaemiaIn: British Journal of Haematology Jg. 138 (2007) Nr. 2, S. 217 - 220ISSN: 1365-2141; 0007-1048Online Volltext: dx.doi.org/
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OBF1 and OCT1/2 regulate the germinal center B-cell programIn: Blood Jg. 137 (2021) Nr. 21, S. 2862 - 2863ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/ (Open Access)
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PrefaceIn: Lymphoma: Methods and Protocols / Küppers, Ralf (Hrsg.) (2019) S. vISBN: 978-1-4939-9150-1; 978-1-4939-9151-8 ISSN: 1064-3745; 1940-6029
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Hodgkin lymphomaIn: The Journal of Clinical Investigation (JCI) Jg. 122 (2012) Nr. 10, S. 3439 - 3447ISSN: 1558-8238; 0021-9738Online Volltext: dx.doi.org/
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New insights into the molecular pathogenesis of Hodgkin lymphoma
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Dysregulated eukaryotic initiation factors may impact on the pathogenesis of primary central nervous system lymphomas
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Genomic Analysis of Hodgkin Lymphoma
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IG‐MYC ‐positive leukemia and lymphoma with precursor B‐cell phenotype are genetically and epigenetically distinct from Burkitt lymphomas
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Low NR4A1 expression is associated with an up-regulation of immune checkpoints and their ligands in DLBCL
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Modeling of the Epigenome of the Cell-of-Origin Identifies Cancer-Specific DNA Methylation Patterns in CLL
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Reduced NR4A1 levels are associated with high expression of miR-15a and miR-15a*in DLBCL
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The DNA-methylation status of BCL11B in T-Cell-Large Granular Lymphocytic Leukemia - a diagnostic target
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Translation initiation factors are over-expressed in aggressive lymphomas and influence their clinical course
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CD30+ Germinal Center (GC) B cells are transciptionally related to light zone GC B cells reentering the dark zone, and to tumor cells of Classical Hodkin Lymphoma (CHL)In: Haematologica Jg. 102 (2017) Nr. Suppl. 3, S. 30ISSN: 0390-6078; 1592-8721
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CDK9 Inhibition with LDC526 Is an Effective Treatment for T-Cell Prolymphocytic Leukemia (T-PLL) in VitroIn: Blood Jg. 130 (2017) Nr. Suppl. 1, S. 1262ISSN: 1528-0020; 0006-4971Online Volltext: dx.doi.org/
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Epigenetic analyses of T-cell large granular lymphocytic leukemia identify differentially methylated enhancer regions leading to deregulation of gene interactionsIn: Oncology Research and Treatment Jg. 40 (2017) Nr. Suppl. 3, Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, Stuttgart, 29. September-3. Oktober 2017: Abstracts, S. 109 - 110ISSN: 2296-5270Online Volltext: dx.doi.org/
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Efficient chip architectures for a microfluidic cell sorter actuated by electrowetting and its electro-hydrodynamic analysisIn: 1st YRA MedTech Symposium 2016: April 8th / 2016 / University of Duisburg-Essen / 1st YRA MedTech Symposium (YRA-MedTech 2016), April 8th 2016 University of Duisburg-Essen, Duisburg, Germany / Erni, Daniel (Hrsg.) (2016) S. 31 - 32ISBN: 978-3-940402-06-6Online Volltext (Open Access)
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Genomic profiling of T-cell Prolymphocytic Leukemia (T-PLL) identifies novel recurrent mutations in SAMHD1 and PTPRC
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The AP-1 transcription factor BATF3 regulates MYC expression and is required for tumor cell survival in classical Hodgkin lymphoma and anaplastic large cell lymphomaIn: Haematologica Jg. 101 (2016) Nr. S 5: You have access 10th International Symposium on Hodgkin Lymphoma, Cologne, Germany, October 22–25, 2016, Abstract Book, S. 2ISSN: 0390-6078; 1592-8721(Open Access)
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Cellular origin of CLL
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Moraxella catarrhalis - the infectious origin of nodular lymphocyte predominant Hodgkin lymphoma of IgD type?
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Aspects of Hodgkin lymphoma pathogenesis
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Autoreactivity of B cell receptors of nodular lymphocyte predominant Hodgkin lymphoma
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Functional Characterization and Clonal Composition of Human Post-germinal Center Memory B CellsIn: Scandinavian Journal of Immunology Jg. 80 (2014) Nr. 3: The 18th germinal centre conferenceUddevalla, SwedenSeptember 11–14, 2014, Abstracts, S. 233ISSN: 0300-9475; 1365-3083Online Volltext: dx.doi.org/
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Dysregulation of micro-RNA expression in splenic marginal zone lymphoma in patients with and without chronic hepatitis C virus infectionIn: Journal of Hepatology / The International Liver Congress™ 2011 ; 46th annual meeting of the European Association for the Study of the Liver ; Berlin, 30 March-3 April 2011 Jg. 54 (2011) Nr. Suppl. 1, S. S324 - S325ISSN: 0168-8278; 1600-0641Online Volltext: dx.doi.org/
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Pathology and molecular pathology of hodgkin lymphomaIn: Hodgkin Lymphoma: A Comprehensive Overview / Engert, Andreas; Younes, Anas (Hrsg.) 2020, S. 47 - 68ISBN: 978-3-030-32481-0; 978-3-030-32482-7 ISSN: 2197-9774; 2197-9766Online Volltext: dx.doi.org/
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Laser-Based Microdissection of Single Cells from Tissue Sections and PCR Analysis of Rearranged Immunoglobulin Genes from Isolated Normal and Malignant Human B CellsIn: Lymphoma: Methods and Protocols 2019, S. 61 - 75ISBN: 978-1-4939-9150-1; 978-1-4939-9151-8Online Volltext: dx.doi.org/
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Origin and Pathogenesis of B Cell LymphomasIn: Lymphoma: Methods and Protocols / Küppers, Ralf (Hrsg.) 2019, S. 1 - 33ISBN: 978-1-4939-9150-1; 978-1-4939-9151-8Online Volltext: dx.doi.org/
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Origin of Hodgkin LymphomaIn: Hematology: Basic Principles and Practice / Hoffman, Ronald; Benz, Edward J.; Silberstein, Leslie E.; et al. (Hrsg.) 2018, S. 1204 - 1211ISBN: 978-0-323-35762-3Online Volltext: dx.doi.org/
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Determining the Origin of Human Germinal Center B Cell-Derived MalignanciesIn: Germinal Centers: Methods and Protocols / Calado, Dinis Pedro (Hrsg.) 2017, S. 253 - 279ISBN: 978-1-4939-7094-0; 978-1-4939-7095-7Online Volltext: dx.doi.org/
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Digital microfluidics for microchip-based cell sortingIn: Micro-Nano-Integration: 6. GMM-Workshop : 5-6 Oct. 2016 / GMM-Workshop Mikro-Nano-Integration ; 5. - 6. Oktober 2016, Duisburg 2016, S. 17 - 21ISBN: 978-3-8007-4278-3
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Entwicklung einer Mikrochip navigierten ZellsortieranlageIn: MEMS, Mikroelemente, Systeme: MikroSystemTechnik Kongress 2015 ; 26. - 28. Oktober 2015 in Karlsruhe ; proceedings / MikroSystemTechnik Kongress ; 26. - 28. Oktober 2015, Karlsruhe / Saile, Volker (Hrsg.) 2015, S. 463 - 466ISBN: 978-3-8007-4100-7
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Lymphoma : Methods and ProtocolsNew York, NY (2019) XII, 439 p. 66 illus., 48 illus. in color
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An efficient on-chip electrowetting cell sorter architecture based on smart diffusion
Microfluidics 2014 - EMBL Conference, 23 - 25.07.2014, Heidelberg,(2014)