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Funktionen
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Universitätsprofessor/in, Institut für Physiologische Chemie
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Stellvertreter/in, Institut für Physiologische Chemie
Aktuelle Veranstaltungen
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2023 SS
- Seminar Gestörte Organfunktionen (PV)
- Physiologische Chemie (Biochemie/Molekularbiologie) Teil I (WA)
- Praktikum der Physiologischen Chemie (Biochemie/Molekularbiologie) (PV)
- Praktikum der Biochemie für Chemiker (WP)
- Wahlfach Pathobiologie (WP)
- Physiologische Chemie (Biochemie/Molekularbiologie) Repetitorien (WA)
- Physiologische Chemie (Biochemie/Molekularbiologie) f. Med. Biologen Repetitorien (PV)
- Praktikum der Physiologischen Chemie (Biochemie/Molekularbiologie) f. Med. Biologen (PV)
- Seminar für Diplomanden und Doktoranden (*) (Naturwissenschaftler und Mediziner)
- Vertiefungspraktikum Biochemie für Chemiker (PV)
- Seminar Biochemie 2 für Medizintechniker (PV)
- Biochemie II für Chemiker
- BIOME Seminar „Basic Science in Transplantation"
- Anleitung zu wissenschaftlichem Arbeiten (*)
- Biochemie 1 für Medizintechniker (PV)
- Kolloquium über neuere Arbeiten auf dem Gebiet der Biochemie (*)
Vergangene Veranstaltungen (max. 10)
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2022 WS
- BIOME Seminar „Basic Science in Transplantation"
- Seminar Biochemie 2 für Medizintechniker (PV)
- Kolloquium über neuere Arbeiten auf dem Gebiet der Biochemie (*)
- Vertiefungspraktikum Biochemie für Chemiker (PV)
- Anleitung zu wissenschaftlichem Arbeiten (*)
- Seminar der Physiologischen Chemie (Biochemie/Molekularbiologie) Teil II (Drittsemester) (PV)
- Seminar für Diplomanden und Doktoranden (*) (Naturwissenschaftler und Mediziner)
- Biochemie I für Chemiker (WA)
- Vertiefungsseminar für Medizinische Biologen
- Vorlesung Biochemie/Molekularbiologie Teil II (WA)
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Human HepaRG liver spheroids : cold storage protocol and study on pyridinium oxime-induced hepatotoxicity in vitroIn: Chemico-Biological Interactions Jg. 369 (2023)ISSN: 0009-2797; 1872-7786Online Volltext: dx.doi.org/ (Open Access)
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Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungsIn: PLoS ONE Jg. 17 (2022)ISSN: 1932-6203Online Volltext: dx.doi.org/ (Open Access)
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Characterisation of cold-induced mitochondrial fission in porcine aortic endothelial cellsIn: Molecular Medicine Jg. 28 (2022) Nr. 1,ISSN: 1528-3658; 1076-1551Online Volltext: dx.doi.org/ (Open Access)
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Custodiol-MP for ex vivo lung perfusion : A comparison in a porcine model of donation after circulatory determination of deathIn: The International Journal of Artificial Organs (IJAO) Jg. 45 (2022) Nr. 2, S. 162 - 173ISSN: 0391-3988; 1724-6040Online Volltext: dx.doi.org/ (Open Access)
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HTK-N as a new preservation solution for human kidney preservation : Results of a pilot randomized controlled clinical phase II trial in living donor transplantationIn: Clinical Transplantation Jg. 36 (2022) Nr. 3,ISSN: 1399-0012; 0902-0063Online Volltext: dx.doi.org/ (Open Access)
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Recovery from cold-induced mitochondrial fission in endothelial cells requires reconditioning temperatures of ≥ 25◦CIn: Frontiers in Transplantation Jg. 1 (2022)ISSN: 2813-2440Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Inhaled sphingosine has no adverse side effects in isolated ventilated and perfused pig lungsIn: Scientific Reports Jg. 11 (2021) Nr. 1,ISSN: 2045-2322Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Optimization of long-term cold storage of rat precision-cut lung slices with a tissue preservation solutionIn: American Journal of Physiology: Lung Cellular and Molecular Physiology Jg. 321 (2021) Nr. 6, S. L1023 - L1035ISSN: 1522-1504; 1040-0605Online Volltext: dx.doi.org/ (Open Access)
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Use of the new preservation solution Custodiol-MP for ex vivo reconditioning of kidney graftsIn: Artificial Organs Jg. 45 (2021) Nr. 9, S. 1117 - 1123ISSN: 0160-564X; 1525-1594Online Volltext: dx.doi.org/ (Open Access)
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A novel histidine–tryptophan–ketoglutarate formulation ameliorates intestinal injury in a cold storage and ex vivo warm oxygenated reperfusion model in ratsIn: Bioscience Reports Jg. 40 (2020) Nr. 5, S. BSR20191989ISSN: 1573-4935; 0144-8463Online Volltext: dx.doi.org/ (Open Access)
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Inflammatory Response after Immediate versus Delayed Ex-Vivo Lung Perfusion in a Porcine Cardiac Arrest Donation ModelIn: The Journal of Heart and Lung Transplantation Jg. 39 (2020) Nr. 4, S. S200ISSN: 1557-3117Online Volltext: dx.doi.org/
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Effects of immediate versus delayed ex-vivo lung perfusion in a porcine cardiac arrest donation modelIn: The International Journal of Artificial Organs (IJAO) Jg. 42 (2019) Nr. 7, S. 362 - 369ISSN: 0391-3988; 1724-6040Online Volltext: dx.doi.org/
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Cold storage injury to rat small-bowel transplants - beneficial effect of a modified HTK solutionIn: Transplantation Jg. 102 (2018) Nr. 10, S. 1666 - 1673ISSN: 0041-1337; 1534-6080Online Volltext: dx.doi.org/
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Methylene Blue Treatment of Grafts During Cold Ischemia Time Reduces the Risk of Hepatitis C Virus TransmissionIn: The Journal of Infectious Diseases Jg. 218 (2018) Nr. 11, S. 1711 - 1721ISSN: 1537-6613; 0022-1899Online Volltext: dx.doi.org/ (Open Access)
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Preservation of Cell Structure, Metabolism, and Biotransformation Activity of Liver-On-Chip Organ Models by Hypothermic StorageIn: Advanced Healthcare Materials Jg. 7 (2018) Nr. 2, S. 1700616ISSN: 2192-2659; 2192-2640Online Volltext: dx.doi.org/
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Serum- and albumin-free cryopreservation of endothelial monolayers with a new solutionIn: Organogenesis Jg. 14 (2018) Nr. 2, S. 107 - 121ISSN: 1555-8592; 1547-6278Online Volltext: dx.doi.org/ (Open Access)
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Serum-Free Cryopreservation of Primary Rat Hepatocytes in a Modified Cold Storage Solution: Improvement of Cell Attachment and FunctionIn: Biopreservation and Biobanking Jg. 16 (2018) Nr. 4, S. 285 - 295ISSN: 1947-5543; 1947-5535Online Volltext: dx.doi.org/
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Characterization of injury in isolated rat proximal tubules during cold incubation and rewarmingIn: PLoS ONE Jg. 12 (2017) Nr. 7, S. e0180553ISSN: 1932-6203Online Volltext: dx.doi.org/ (Open Access)
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Mitochondrial Impairment as a Key Factor for the Lack of Attachment after Cold Storage of Hepatocyte SuspensionsIn: Cell Transplantation Jg. 26 (2017) Nr. 12, S. 1855 - 1867ISSN: 1555-3892; 0963-6897Online Volltext: dx.doi.org/ (Open Access)
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Resveratrol Does Not Protect from Ischemia-Induced Acute Kidney Injury in an in Vivo Rat ModelIn: Kidney & Blood Pressure Research Jg. 42 (2017) Nr. 6, S. 1090 - 1103ISSN: 1423-0143; 1420-4096Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Controlled Oxygenated Rewarming of Cold Stored Livers Prior to Transplantation : First Clinical Application of a New ConceptIn: Transplantation Jg. 100 (2016) Nr. 1, S. 147 - 152ISSN: 0041-1337; 1534-0608; 1534-6080Online Volltext: dx.doi.org/ (Open Access)
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Kidney transplantation after oxygenated machine perfusion preservation with Custodiol-N solutionIn: Transplant International Jg. 28 (2015) Nr. 9, S. 1102 - 1108ISSN: 1432-2277; 0934-0874Online Volltext: dx.doi.org/ (Open Access)
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Influence of oxygen concentration during hypothermic machine perfusion on porcine kidneys from donation after circulatory deathIn: Transplantation Jg. 98 (2014) Nr. 9, S. 944 - 950ISSN: 0041-1337Online Volltext: dx.doi.org/
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Subnormothermic machine perfusion for preservation of porcine kidneys in a donation after circulatory death modelIn: Transplant International Jg. 27 (2014) Nr. 10, S. 1097 - 1106ISSN: 0934-0874Online Volltext: dx.doi.org/
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Hepatic and Pancreatic Systems : Steatosis does not impair liver regeneration after partial hepatectomyIn: Laboratory Investigation Jg. 93 (2013) Nr. 1, S. 20 - 30ISSN: 1530-0307; 0023-6837Online Volltext: dx.doi.org/
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Use of the new preservation solution Custodiol-N supplemented with dextran for hypothermic machine perfusion of the kidneyIn: Cryobiology Jg. 66 (2013) Nr. 2, S. 131 - 135ISSN: 1090-2392; 0011-2240Online Volltext: dx.doi.org/
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„Transportschäden“ von Transplantaten : Zellulärer Energiemangel, „ranzige“ Membranen und zerstörte Zellkraftwerke – und was man dagegen tun kann…In: Unikate: Berichte aus Forschung und Lehre (2013) Nr. 44: Medizin : 50 Jahre Universitätsklinikum Essen, S. 92 - 105ISBN: 978-3-934359-44-4 ISSN: 0944-6060; 1869-3881Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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A new preservation solution for lung transplantation : Evaluation in a porcine transplantation modelIn: The Journal of Heart and Lung Transplantation Jg. 31 (2012) Nr. 3, S. 310 - 317ISSN: 1557-3117Online Volltext: dx.doi.org/
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Aggravation of cold-induced injury in Vero-B4 cells by RPMI 1640 medium – Identification of the responsible medium componentsIn: BMC Biotechnology Jg. 12 (2012)ISSN: 1472-6750Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Cold storage of rat hepatocyte suspensions for one week in a customized cold storage solution - preservation of cell attachment and metabolismIn: PLoS ONE Jg. 7 (2012) Nr. 7, S. e40444ISSN: 1932-6203Online Volltext: dx.doi.org/ (Open Access)
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FNOCT as a fluorescent probe for in vivo localization of nitric oxide distribution in tobacco rootsIn: Plant Physiology and Biochemistry Jg. 59 (2012) S. 80 - 89ISSN: 1873-2690; 0981-9428Online Volltext: dx.doi.org/
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HTK-N, a modified HTK solution, decreases preservation injury in a model of microsteatotic rat liver transplantationIn: Langenbeck's Archives of Surgery Jg. 397 (2012) Nr. 8, S. 1323 - 1331ISSN: 1435-2451Online Volltext: dx.doi.org/
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Improved Kidney Isograft Survival with a New Histidine-Tryptophan-Ketoglutarate (HTK)-Based Cold Preservation SolutionIn: Transplantation Jg. 94 (2012) Nr. Suppl.10, S. 1139ISSN: 0041-1337
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Improved kidney isograft survival with a new Histidine-Tryptophane-Ketoglutarate (HTK)-based cold preservation solutionIn: Nephrology Dialysis Transplantation Jg. 27 (2012) Nr. Suppl. 2, S. 519ISSN: 0931-0509; 1460-2385
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Improvement of the Cold Storage of Isolated Human HepatocytesIn: Cell Transplantation Jg. 21 (2012) Nr. 1, S. 23 - 37ISSN: 1555-3892; 0963-6897Online Volltext: dx.doi.org/ (Open Access)
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Reduction of chronic graft injury with a new HTK-based preservation solution in a murine heart transplantation modelIn: Cryobiology Jg. 64 (2012) Nr. 3, S. 273 - 278ISSN: 1090-2392; 0011-2240Online Volltext: dx.doi.org/
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Assessment of a chloride-poor versus a chloride-containing version of a modified histidine-tryptophan-ketoglutarate solution in a rat liver transplantation modelIn: Liver Transplantation Jg. 17 (2011) Nr. 6, S. 650 - 660ISSN: 1527-6465; 1527-6473Online Volltext: dx.doi.org/
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Cold-induced injury to lung epithelial cells can be inhibited by iron chelators - implications for lung preservationIn: European Journal of Cardio-Thoracic Surgery Jg. 40 (2011) Nr. 4, S. 948 - 955ISSN: 1873-734X; 1010-7940; 1567-4258; 1878-3309Online Volltext: dx.doi.org/
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Evaluation of Functional and Structural Alterations in Muscle Tissue after Short-Term Cold Storage in a New Tissue Preservation SolutionIn: Cells Tissues Organs Jg. 194 (2011) Nr. 6, S. 501 - 509ISSN: 1422-6421; 1422-6405Online Volltext: dx.doi.org/
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Preservation of human artery function following prolonged cold storage with a new solutionIn: Journal of Vascular Surgery Jg. 53 (2011) Nr. 4, S. 1063 - 1070ISSN: 1097-6809Online Volltext: dx.doi.org/ (Open Access)
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Prolonged cold storage using a new histidine-tryptophan-ketoglutarate-based preservation solution in isogeneic cardiac mouse graftsIn: European Heart Journal Jg. 32 (2011) Nr. 4, S. 509 - 516ISSN: 0195-668X; 1522-9645Online Volltext: dx.doi.org/
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Eine neue Lösung zur kalten Lagerung von BlutgefäßenIn: Gefäßchirurgie Jg. 15 (2010) Nr. 6, S. 442 - 447ISSN: 1434-3932; 0948-7034Online Volltext: dx.doi.org/
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Eine neue Lösung zur kalten Lagerung von BlutgefäßenIn: Zeitschrift für Herz-, Thorax- und Gefässchirurgie Jg. 24 (2010) Nr. 6, S. 341 - 346ISSN: 0930-9225; 1435-1277Online Volltext: dx.doi.org/
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Glycine pretreatment ameliorates liver injury after partial hepatectomy in the ratIn: Journal of Investigative Surgery Jg. 23 (2010) Nr. 1, S. 12 - 20ISSN: 0894-1939; 1521-0553Online Volltext: dx.doi.org/
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Pyrene-based fluorescent nitric oxide cheletropic traps (FNOCTs) for the detection of nitric oxide in cell cultures and tissuesIn: Chemistry - A European Journal Jg. 16 (2010) Nr. 36, S. 11121 - 11132ISSN: 0947-6539; 1521-3765Online Volltext: dx.doi.org/
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Use of a New Modified HTK Solution for Machine Preservation of Marginal Liver GraftsIn: Journal of Surgical Research Jg. 160 (2010) Nr. 1, S. 155 - 162ISSN: 0022-4804; 1095-8673Online Volltext: dx.doi.org/
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Evaluation of a modified HTK solution containing the new iron chelator LK 614 in an isolated rat liver perfusion modelIn: Journal of Investigative Surgery Jg. 22 (2009) Nr. 5, S. 340 - 347ISSN: 0894-1939; 1521-0553Online Volltext: dx.doi.org/
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Erythropoietin treatment improves liver regeneration and survival in rat models of extended liver resection and living donor liver transplantationIn: Transplantation Jg. 86 (2008) Nr. 11, S. 1578 - 1585ISSN: 0041-1337; 1534-0608Online Volltext: dx.doi.org/
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Preservation of pig liver allografts after warm ischemia : Normothermic perfusion versus cold storageIn: Langenbecks Archiv für Chirurgie Jg. 382 (1997) Nr. 4, S. 175 - 184ISSN: 0023-8236Online Volltext: dx.doi.org/
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Composition of Ex Vivo Lung Perfusion Solutions and Kinetics Define Differential Cytokine and Chemokine Secretion in a Porcine Cardiac Arrest Model of Lung PreservationIn: The Journal of Heart and Lung Transplantation Jg. 40 (2021) Nr. 4, S. S346ISSN: 1053-2498; 1557-3117Online Volltext: dx.doi.org/
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Composition of ex lung perfusion solutions and kinetics define differential cytokine/chemokine secretion in a porcine cardiac arrest model of lung preservationIn: Transplant International Jg. 33 (2020) Nr. S2, Special Issue: Abstracts of the 29th Annual Meeting of the German Transplantation Society, Cologne, Germany, 15–17 October 2020, S. 14 - 15ISSN: 0934-0874; 1432-2277Online Volltext: dx.doi.org/ (Open Access)
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Use of the new preservation solution Custodiol-MP for ex vivo reconditioning of kidney graftsIn: Transplant International Jg. 33 (2020) Nr. S2, Special Issue: Abstracts of the 29th Annual Meeting of the German Transplantation Society, Cologne, Germany, 15–17 October 2020, S. 34 - 35ISSN: 0934-0874; 1432-2277Online Volltext: dx.doi.org/ (Open Access)
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Charakterisierung der Zellschädigung von Lungenepithelzellen durch Kaltlagerung/Wiedererwärmung
Herbsttagung der Sektion Zellbiologie in der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V., Essen, 09.–10.11.2018,In: Pneumologie Jg. 73 (2019) Nr. 02, S. 114 - 115ISSN: 0934-8387; 1438-8790Online Volltext: dx.doi.org/ -
A Novel Histidine‐Tryptophan‐Ketoglutarate (HTK‐N) Formulation Ameliorates Ischemia‐reperfusion Injury in Intestinal Grafts
27th Annual Meeting of the German Transplantation Society, Berlin, Germany, 7–10 November 2018,In: Transplant International Jg. 31 (2018) Nr. S5, S. 42ISSN: 1432-2277; 0934-0874 -
Effects of Short and Long Term Cold Static Preservation Followed by Normothermic Ex Vivo Lung Perfusion in a Porcine ModelIn: The Journal of Heart and Lung Transplantation Jg. 37 (2018) Nr. 4, S. S224ISSN: 1053-2498Online Volltext: dx.doi.org/
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Use of Modified Custodiol‐N as Perfusion Solution in ex vivo Lung Perfusion (EVLP)
27th Annual Meeting of the German Transplantation Society, Berlin, Germany, 7–10 November 2018,In: Transplant International Jg. 31 (2018) Nr. S5, S. 39ISSN: 1432-2277; 0934-0874Online Volltext: dx.doi.org/ (Open Access) -
Controlled Oxygenated Rewarming and Subnormothermic Machine Perfusion of Steatotic Livers : First Clinical ResultsIn: American Journal of Transplantation Jg. 16 (2016) Nr. Suppl. 3, S. 377ISSN: 1600-6135; 1600-6143; 1602-1363; 1601-2577Online Volltext: dx.doi.org/
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Custodial-N attenuates the cold storage-induced development of graft vasculopathy in a rat aortic transplantation modelIn: Transplant International Jg. 29 (2016) Nr. Suppl. 3, S. 45ISSN: 0934-0874Online Volltext: dx.doi.org/ (Open Access)
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Hepatic steatosis induced by Western diet modulates expression of HGF and ERK signalling and improves liver regeneration in mice after 70% partial hepatectomyIn: Journal of Hepatology / International Liver Congress™ ; Annual meeting of the European Association for the Study of the Liver ; 18-22 April 2012, Barcelona Jg. 56 (2012) Nr. Supplement 2, S. S499ISSN: 0168-8278; 1600-0641Online Volltext: dx.doi.org/
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Liver Transplantation in Swine Using Modified Histidine-Tryptophan-Ketoglutarate Solution - Safety and Feasability StudyIn: Transplantation / 24th International Congress of the Transplantation Society; 15-19 July 2010; Berlin, Germany Jg. 94 (2012) Nr. 10S, S. 512ISSN: 0041-1337Online Volltext: dx.doi.org/
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Novel ex-vivo perfusion system : functional characteristics of human noncirrhotic and cirrhotic liver sections mirror patients' clinical parametersIn: Journal of Hepatology / International Liver Congress™ ; Annual meeting of the European Association for the Study of the Liver ; 18-22 April 2012, Barcelona Jg. 56 (2012) Nr. Supplement 2, S. S74ISSN: 0168-8278; 1600-0641Online Volltext: dx.doi.org/
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Safety study of modified HTK solution-first results after liver transplantation in swine
19th Annual Congress of the German Transplantation Society, Hamburg, Germany, 7‐9 October 2010,In: Transplant International Jg. 23 (2010) Nr. Suppl. 2, S. 25ISSN: 0934-0874; 1432-2277Online Volltext: dx.doi.org/ -
Morphological alterations in primary hepatocytes upon nanomaterial incubation assessed by digital holographic microscopy and holotomographyIn: Quantitative Phase Imaging VIII / Quantitative Phase Imaging VIII, 22-27 January 2022, San Francisco, California, United States & 20-24 February 2022, online / Liu, Yang; Popescu, Gabriel; Park, YongKeun (Hrsg.) 2022ISBN: 978-1-5106-4811-1; 978-1-5106-4812-8Online Volltext: dx.doi.org/