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Prof. Dr. rer. nat. Bertram Opalka

E-Mail
bertram.opalka@uni-due.de

Funktionen

  • Universitätsprofessor/in, Innere Klinik (Tumorforschung)

Aktuelle Veranstaltungen

Keine aktuellen Veranstaltungen.

Vergangene Veranstaltungen (max. 10)

Keine vergangenen Veranstaltungen.

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Vorwerk, Jan; Liu, Longlong; Stadler, Theresa Helene; Frank, Daria; Ahmed, Helal Mohammed Mohammed; Patnana, Pradeep Kumar; Kebenko, Maxim; Dazert, Eva; Opalka, Bertram; von Bubnoff, Nikolas; Khandanpour, Cyrus
    Germline Single-Nucleotide Polymorphism GFI1-36N Causes Alterations in Mitochondrial Metabolism and Leads to Increased ROS-Mediated DNA Damage in a Murine Model of Human Acute Myeloid Leukemia
    In: Biomedicines, Jg. 13, 2025, Nr. 1, 107
    DOI (Open Access)
  • Ahmed, Helal; Patnana, Pradeep Kumar; Al-Matary, Yahya S.; Fiori, Maren; Vorwerk, Jan; Ahmad, Marah H.; Dazert, Eva; Oelschläger, Lorenz; Künstner, Axel; Opalka, Bertram; von Bubnoff, Nikolas; Khandanpour, Cyrus
    Impact of Acute Myeloid Leukemia Cells on the Metabolic Function of Bone Marrow Mesenchymal Stem Cells
    In: International Journal of Molecular Sciences (IJMS), Jg. 26, 2025, Nr. 17, 8301
    DOI (Open Access)
  • Sun, Kaiyan; Jin, Ling; Karolová, Jana; Vorwerk, Jan; Hailfinger, Stephan; Opalka, Bertram; Zapukhlyak, Myroslav; Lenz, Georg; Khandanpour, Cyrus
    Combination Treatment Targeting mTOR and MAPK Pathways Has Synergistic Activity in Multiple Myeloma
    In: Cancers, Jg. 15, 2023, Nr. 8, 2373
    DOI (Open Access)
  • Patnana, Pradeep Kumar; Liu, Longlong; Frank, Daria; Nimmagadda, Subbaiah Chary; Behrens, Matthias; Ahmed, Helal; Xie, Xiaoqing; Liebmann, Marie; Wei, Lanying; Gerdemann, Andrea; Thivakaran, Aniththa; Humpf, Hans-Ulrich; Klotz, Luisa; Dugas, Martin; Varghese, Julian; Trajkovic-Arsic, Marija; Siveke, Jens T.; Hanenberg, Helmut; Opalka, Bertram; Dührsen, Ulrich; Reinhardt, Hans Christian; Guenther, Ulrich; von Bubnoff, Nikolas; Khandanpour, Cyrus
    Dose-dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9-induced leukaemic cells
    In: British Journal of Haematology, Jg. 202, 2023, Nr. 5, S. 1033 – 1048
    DOI (Open Access)
  • Frank, Daria; Patnana, Pradeep Kumar; Vorwerk, Jan; Mao, Lianghao; Gopal, Lavanya Mokada; Jung, Noelle; Hennig, Thorben; Ruhnke, Leo; Frenz, Joris Maximillian; Kuppusamy, Maithreyan; Autry, Robert; Wei, Lanying; Sun, Kaiyan; Mohammed Ahmed, Helal Mohammed; Künstner, Axel; Busch, Hauke; Müller, Heiko; Hutter, Stephan; Hoermann, Gregor; Liu, Longlong; Xie, Xiaoqing; Al-Matary, Yahya; Nimmagadda, Subbaiah Chary; Charles Cano, Fiorella; Heuser, Michael; Thol, Felicitas; Göhring, Gudrun; Steinemann, Doris; Thomale, Jürgen; Leitner, Theo; Fischer, Anja; Rad, Roland; Röllig, Christoph; Altmann, Heidi; Kunadt, Desiree; Berdel, Wolfgang E.; Hüve, Jana; Neumann, Felix; Klingauf, Jürgen; Calderon, Virginie; Opalka, Bertram; Dührsen, Ulrich; Rosenbauer, Frank; Dugas, Martin; Varghese, Julian; Reinhardt, Hans Christian; von Bubnoff, Nikolas; Möröy, Tarik; Lenz, Georg; Batcha, Aarif M. N.; Giorgi, Marianna; Selvam, Murugan; Wang, Eunice; McWeeney, Shannon K.; Tyner, Jeffrey W.; Stölzel, Friedrich; Mann, Matthias; Jayavelu, Ashok Kumar; Khandanpour, Cyrus
    Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy
    In: Blood, Jg. 142, 2023, Nr. 25, S. 2175 – 2191
    DOI (Open Access)
  • Ahmed, Helal Mohammed Mohammed; Nimmagadda, Subbaiah Chary; Al-Matary, Yahya S.; Fiori, Maren; May, Tobias; Frank, Daria; Patnana, Pradeep Kumar; Récher, Christian; Schliemann, Christoph; Mikesch, Jan-Henrik; Koenig, Thorsten; Rosenbauer, Frank; Hartmann, Wolfgang; Tuckermann, Jan; Dührsen, Ulrich; Lanying, Wei; Dugas, Martin; Opalka, Bertram; Lenz, Georg; Khandanpour, Cyrus
    Dexamethasone-mediated inhibition of Notch signalling blocks the interaction of leukaemia and mesenchymal stromal cells
    In: British Journal of Haematology, Jg. 196, 2022, Nr. 4, S. 995 – 1006
    DOI (Open Access)
  • Liu, Longlong; Patnana, Pradeep Kumar; Xie, Xiaoqing; Frank, Daria; Nimmagadda, Subbaiah Chary; Su, Minhua; Zhang, Donghua; Koenig, Thorsten; Rosenbauer, Frank; Liebmann, Marie; Klotz, Luisa; Xu, Wendan; Vorwerk, Jan; Neumann, Felix; Hüve, Jana; Unger, Andreas; Okun, Jürgen Günther; Opalka, Bertram; Khandanpour, Cyrus
    GFI1B acts as a metabolic regulator in hematopoiesis and acute myeloid leukemia
    In: Leukemia, Jg. 36, 2022, Nr. 9, S. 2196 – 2207
    DOI (Open Access)
  • Liu, Longlong; Patnana, Pradeep Kumar; Xie, Xiaoqing; Frank, Daria; Nimmagadda, Subbaiah Chary; Rosemann, Annegret; Liebmann, Marie; Klotz, Luisa; Opalka, Bertram; Khandanpour, Cyrus
    High Metabolic Dependence on Oxidative Phosphorylation Drives Sensitivity to Metformin Treatment in MLL/AF9 Acute Myeloid Leukemia
    In: Cancers, Jg. 14, 2022, Nr. 3, 486
    DOI, Online Volltext (Open Access)
  • Vorwerk, Jan; Sun, Kaiyan; Frank, Daria; Neumann, Felix; Hüve, Jana; Budde, Paulina Marie; Liu, Longlong; Xie, Xiaoqing; Patnana, Pradeep Kumar; Ahmed, Helal Mohammed Mohammed; Opalka, Bertram; Lenz, Georg; Jayavelu, Ashok Kumar; Khandanpour, Cyrus
    Presence of the GFI1-36N single nucleotide polymorphism enhances the response of MLL-AF9 leukemic cells to CDK4/6 inhibition
    In: Frontiers in Oncology, Jg. 12, 2022, 903691
    DOI (Open Access)
  • Lipps, Christoph; Klein, Franziska; Wahlicht, Tom; Seiffert, Virginia; Butueva, Milada; Zauers, Jeannette; Truschel, Theresa; Luckner, Martin; Köster, Mario; MacLeod, Roderick; Pezoldt, Jörn; Hühn, Jochen; Yuan, Qinggong; Müller, Peter Paul; Kempf, Henning; Zweigerdt, Robert; Dittrich-Breiholz, Oliver; Pufe, Thomas; Beckmann, Rainer; Drescher, Wolf; Riancho, Jose; Sañudo, Carolina; Korff, Thomas; Opalka, Bertram; Rebmann, Vera; Göthert, Joachim Rudolf; Alves, Paula M; Ott, Michael; Schucht, Roland; Hauser, Hansjörg; Wirth, Dagmar; May, Tobias
    Expansion of functional personalized cells with specific transgene combinations.
    In: Nature Communications, Jg. 9, 2018, Nr. 1, S. 994
    DOI (Open Access)
  • Thivakaran, Aniththa; Botezatu, Lacramioara; Hönes, Judith M.; Schütte, Judith; Vassen, Lothar; Al-Matary, Yahya S.; Patnana, Pradeep; Zeller, Amos; Heuser, Michael; Thol, Felicitas; Gabdoulline, Razif; Olberding, Nadine; Frank, Daria; Suslo, Marina; Köster, Renata; Lennartz, Klaus; Görgens, Andre; Giebel, Bernd; Opalka, Bertram; Dührsen, Ulrich; Khandanpour, Cyrus
    Gfi1b : A key player in the genesis and maintenance of acute myeloid leukemia and myelodysplastic syndrome
    In: Haematologica / The Hematology Journal, Jg. 103, 2018, Nr. 4, S. 614 – 625
    DOI (Open Access)
  • Ludwig, Anna-Kristin; De Miroschedji, Kyra; Döppner, Thorsten R.; Börger, Verena; Ruesing, Johannes; Rebmann, Vera; Durst, Stephan; Jansen, Sören; Bremer, Michel; Behrmann, Elmar; Singer, Bernhard B.; Jastrow, Holger; Kuhlmann, Jan Dominik; El Magraoui, Fouzi; Meyer, Helmut E.; Hermann, Dirk M.; Opalka, Bertram; Raunser, Stefan; Epple, Matthias; Horn, Peter; Giebel, Bernd
    Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales
    In: Journal of Extracellular Vesicles (JEV), Jg. 7, 2018, Nr. 1, S. 1528109
    DOI (Open Access)
  • Thivakaran, A.; Botezatu, L.; Hönes, J.; Al-Matary, Y.; Schütte, Jochen; Patnana, P. K.; Koester, R.; Opalka, Bertram; Dührsen, Ulrich; Khandanpour, Cyrus
    GFI1B-A novel oncosuppressor which restricts number of leukemic stem stells
    In: Haematologica / The Hematology Journal, Jg. 102, 2017, Nr. Suppl. 2, S. 204 – 204
  • Al-Matary, Y.; Botezatu, L.; Thivakaran, A.; Köster, R.; Schütte, Jochen; Göthert, Joachim Rudolf; Dührsen, Ulrich; Opalka, Bertram; Khandanpour, Cyrus
    Growth factor independence 1 (GFI !) regulates the AML supporting function of mesenchymal stromal cells
    In: Haematologica / The Hematology Journal, Jg. 102, 2017, Nr. Suppl. 2, S. 459 – 459
  • Al-Matary, Yahya S; Botezatu, Lacramioara; Opalka, Bertram; Hönes, Judith M; Lams, Robert F; Thivakaran, Aniththa; Schütte, Judith; Köster, Renata; Lennartz, Klaus; Schroeder, Thomas; Haas, Rainer; Dührsen, Ulrich; Khandanpour, Cyrus
    Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner
    In: Haematologica / The Hematology Journal, Jg. 101, 2016, Nr. 10, S. 1216 – 1227
    DOI (Open Access)
  • Botezatu, Lacramioara; Michel, Lars; Makishima, Hideki; Schroeder, Thomas; Germing, Ulrich; Haas, Rainer; Van der Reijden, Bert; Marneth, Anne E.; Bergevoet, Saskia M.; Jansen, Joop H.; Przychodzen, Bartlomiej; Wlodarski, Marcin; Niemeyer, Charlotte; Platzbecker, Uwe; Ehninger, Gerhard; Unnikrishnan, Ashwin; Beck, Dominik; Pimanda, John; Hellström-Lindberg, Eva; Malcovati, Luca; Boultwood, Jacqueline; Pellagatti, Andrea; Papaemmanuil, Elli; Le Coutre, Philipp; Kaeda, Jaspal; Opalka, Bertram; Möröy, Tarik; Dührsen, Ulrich; Maciejewski, Jaroslaw; Khandanpour, Cyrus
    GFI136N as a therapeutic and prognostic marker for myelodysplastic syndrome
    In: Experimental Hematology, Jg. 44, 2016, Nr. 7, S. 590 – 595.e1
    DOI (Open Access)
  • Koldehoff, Michael; Lindemann, Monika; Opalka, Bertram; Bauer, Sebastian; Roß, Rudolf Stefan; Elmaagacli, Ahmet Hayri
    Cytomegalovirus induces apoptosis in acute leukemia cells as a virus-versus-leukemia function
    In: Leukemia and Lymphoma, Jg. 56, 2015, Nr. 11, S. 3189 – 3197
    DOI
  • Kehrmann, Angela; Truong, Ha; Repenning, Antje; Boger, Regina; Klein-Hitpaß, Ludger; Pascheberg, Ulrich; Beckmann, Alf; Opalka, Bertram; Kleine-Lowinski, Kerstin
    Complementation of non-tumorigenicity of HPV18-positive cervical carcinoma cells involves differential mRNA expression of cellular genes including potential tumor suppressor genes on chromosome 11q13
    In: Cancer Genetics, Jg. 206, 2013, Nr. 7-8, S. 279 – 292
    DOI
  • Rebmann, Vera; Gauler, Thomas; Schott, B.; Schott, P.; Bauer, Sebastian; Opalka, Bertram; Stamatis, Georgios; Eberhardt, Wilfried; Schuler, Martin; Horn, Peter
    Free soluble HLA-G molecules but not exosome-derived soluble HLA-G molecules are of prognostic relevance in lung cancer patients
    In: Tissue Antigens, Jg. 81, 2013, Nr. 5, S. 282 – 283
    DOI
  • Hones, J.; Botezatu, L.; Thiede, C.; Reijden, B.; Ehninger, G.; Opalka, Bertram; Valk, P.; Lowenberg, B.; Dührsen, Ulrich; Khandanpour, Cyrus
    Gfi1 as a novel prognostic marker and tumor suppressor in acute myeloid leukemia
    In: Onkologie, Jg. 36 7, 2013, S. 193 – 193
  • Wagner, B.; Gothert, J. R.; Dührsen, Ulrich; May, T.; Horn, Peter; Rebmann, Vera; Opalka, Bertram
    Immuno-modulatory properties of primary-like immortalized stroma cell lines from leukemia patients
    In: Onkologie, Jg. 36, 2013, Nr. Suppl. 7, S. 270 – 271
  • Koch, Carmen M.; Reck, Kristina; Shao, Kaifeng; Lin, Qiong; Joussen, Sylvia; Ziegler, Patrick; Walenda, Gudrun; Drescher, Wolf; Opalka, Bertram; May, Tobias; Brummendorf, Tim; Zenke, Martin; Saric, Tomo; Wagner, Wolfgang
    Pluripotent stem cells escape from senescenceassociated DNA methylation changes
    In: Genome Research, Jg. 23, 2013, Nr. 2, S. 248 – 259
    DOI (Open Access)
  • Rost, S.; Necke, M.; Weber, S.; Mollmann, M.; Gobel, M.; Opalka, Bertram; Dührsen, Ulrich; Dürig, Jan; Gothert, J. R.
    Abundance of a NOTCH1 mutated clone affects clinical outcome of patients with chronic lymphocytic leukemia
    In: Onkologie, Jg. 35, 2012, Nr. Suppl. 6, S. 97 – 97
  • Hollenbeck, A.; Handschke, K.; Weber, Stefanie; Necke, M.; Opalka, Bertram; Dührsen, Ulrich; Göthert, Joachim Rudolf
    Genetic modification of the oxygen-sensing pathway alters the develoment of early thymic progenitors
    In: Experimental Hematology, Jg. 40, 2012, Nr. 8, Suppl. 1, S. 21 – 22
  • Opalka, Bertram; Wagner, Bettina; Rebmann, Vera; May, T.; Horn, Peter; Dührsen, Ulrich; Göthert, Joachim Rudolf
    Immunomodulatory activity in the supernatants of novel human bone marrow stroma cell lines from a normal donor and leukemia patients
    In: Onkologie, Jg. 35, 2012, Nr. Suppl. 6, S. 120 – 121
  • May, T.; Schucht, R.; Zauers, J.; Dürig, Jan; Horn, Peter; Rebmann, Vera; Dührsen, Ulrich; Göthert, Joachim Rudolf; Opalka, Bertram
    Novel human bone marrow stroma cell lines from a normal donor and leukemia and lymphoma patients
    Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie. Basel, 30.09.–04.10. 2011,
    In: Onkologie, Jg. 34, 2011, Nr. Suppl. 6, S. 260
    DOI
  • Sellmann, Ludger; Röth, Alexander; Baerlocher, Gabriela M.; Küppers, Ralf; Siemer, Dörte; Seifert, Marc; Dürig, Jan; Dührsen, Ulrich; Nückel, Holger; Opalka, Bertram; Bartels, Marius; de Beer, Dirk
    Telomeres and prognosis in patients with chronic lymphocytic leukaemia
    In: International Journal of Hematology, Jg. 93, 2011, Nr. 1, S. 74 – 82
    DOI
  • Schütt, Philipp; Schütt, Birgit; Switala, Magdalena; Bauer, Sebastian; Stamatis, Georgios; Opalka, Bertram; Eberhardt, Wilfried; Schuler, Martin; Horn, Peter; Rebmann, Vera
    Prognostic relevance of soluble human leukocyte antigen-G and total human leukocyte antigen class I molecules in lung cancer patients
    In: Human Immunology, Jg. 71, 2010, Nr. 5, S. 489 – 495
    DOI
  • Koehler-Hansner, Karin; Flore, Ornella; Opalka, Bertram; Hengge, Ulrich R.
    Interaction of Adenovirus E1A with the HHV8 Promoter of Latent Genes : E1A Proteins are Able to Activate the HHV-8 LANAp in MV3 Reporter Cells
    In: The Open Virology Journal, Jg. 12, 2008, S. 61 – 68
    DOI (Open Access)
  • Opalka, Bertram; Schütt, Philipp; Nowrousian, Mohammad Resa; Moritz, Thomas
    Impfung gegen Krebs : Tumorvakzinen
    In: Essener Unikate: Berichte aus Forschung und Lehre, 2006, Nr. 27 : Medizin – Immunologie, S. 100 – 109
    Online Volltext, Online Volltext (Open Access)
  • Schütt, Philipp; Ebeling, Peter; Buttkereit, U.; Brandhorst, D.; Opalka, Bertram; Hoiczyk, M.; Flaßhove, Michael; Hense, Jörg; Bojko, P.; Metz, Klaus; Moritz, Thomas; Seeber, S.; Nowrousian, Mohammad Resa
    Thalidomide in combination with vincristine, epirubicin and dexamethasone (VED) for previously untreated patients with multiple myeloma
    In: European Journal of Haematology, Jg. 74, 2005, Nr. 1, S. 40 – 46
    DOI

    • Abstracts

  • Fiori, M. N.; Al-Matary, Y.; Fraszczak, J.; Heinrichs, D.; Opalka, Bertram; Dührsen, U.; Möröy, T.; Khandanpour, Cyrus
    The bone marrow niche as a potential target to improve the outcome of acute myeoloid leukemia using dexamethasone
    Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie ; 28. September - 2. Oktober 2018, Wien,
    In: Oncology Research and Treatment. Basel: Karger, Jg. 41, 2018, Nr. Suppl. 4, S. 73 – 74
    DOI (Open Access)
  • Rost, S.; Mollmann, M.; Eisele, Lewin; Weber, S.; Opalka, Bertram; Dührsen, Ulrich; Dürig, Jan; Göthert, Joachim Rudolf
    Establishment of a real-time PCR assay to quantify the size of a NOTCH1 mutated subclone in chronic lymphocytic leukemia
    Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Onkologie, 18.-22. Oktober 2013, Wien, Österreich,
    In: Onkologie. Basel: Karger, Jg. 36, 2013, Nr. Suppl. 7, S. 60
    DOI
  • Hollenbeck, Anita; Handschke, Kathrin; Necke, Mandy; Weber, Stefanie; Opalka, Bertram; Dührsen, Ulrich; Göthert, Joachim Rudolf
    Mice with thymic epithelial deletion of the von Hippel-Lindau gene are lacking a functioning thymus
    In: Onkologie. Basel: Karger, Jg. 36, 2013, Nr. Suppl. 7, S. 276
  • Handschke, Kathrin; Weber, Stefanie; Necke, Mandy; Hollenbeck, Anita; Grabellus, Florian; Dührsen, Ulrich; Opalka, Bertram; Gothert, Joachim
    Vav-iCre mediated deletion of the von hippel lindau gene does not alter the cell cycle status of hematopoietic stem cells in vivo
    In: Experimental Hematology. New York: Elsevier, Jg. 40, 2012, Nr. 8, Suppl. 1, S. 101
  • Elmaagacli, Ahmet Hayri; Lindemann, Monika; Opalka, Bertram; Koldehoff, Michael; Gromke, Tanja; Ottinger, Hellmut; Roß, Rudolf Stefan; Bauer, Sebastian; Hilgendorf, I.; Beelen, Dietrich
    Cytomegalovirus increases incidence of acute GvHD and reduces the relapse risk for acute leukaemia after transplant : there is a virus-versus-leukaemia effect
    EBMT (European Group for Blood and Bone Marrow Transplantation) 2010. March 21-14, 2010. Vienna, Austria,
    In: Bone Marrow Transplantation. London: Springer Nature, Jg. 45, 2010, Nr. Suppl. 2, S. S79
    DOI
  • Buttkereit, Ulrike; Mohamad, Sana; Lindemann, Monika; Göthert, Joachim Rudolf; Opalka, Bertram; Dürig, Jan; Dührsen, Ulrich
    Heterogeneous Interactions of Leukemic and Control Bone Marrow Stroma Cells with an AML Cell Line and AML Leukemic Blasts
    In: Blood. Washington; New York, NY [u.a.]; Philadelphia, Pa.: American Society of Hematology, Jg. 116, 2010, Nr. 21, S. 460
    DOI
  • Buttkereit, U.; Mohamad, Sana; Lindemann, Monika; Göthert, Joachim Rudolf; Opalka, Bertram; Dürig, Jan; Dührsen, Ulrich
    Heterogeneous interactions of leukemic and control bone marrow stroma cells with an AML cell line and AML leukemic blasts
    Deutsche, Österreichische und Schweizerische Gesellschaften für Hämatologie und Onkologie Jahrestagung, Berlin, Oktober 2010,
    In: Onkologie. Basel: Karger, Jg. 33, 2010, Nr. Suppl. 6, S. 235
    DOI