Personensuche
Personensuche
Es wurde 1 Person gefunden.
Fakultät Biologie, Molekularbiologie I
Anschrift
Universitätsstr. 2
45141 Essen
45141 Essen
Raum
S03 V04 F44
Telefon
Telefax
E-Mail
Funktionen
-
Professor/in, Molekularbiologie I
-
Vorsitzender, Prüfungsausschuss für Medizinische Biologie
Aktuelle Veranstaltungen
-
2023 SS
- Zell- und Molekularbiologie
- (Einführung in die) Molekularbiologie
- Übung Molekulare Zellbiologie für Molekularbiologen
- (Einführung in die) Molekularbiologie (LA Ba und Bio B.Sc.); Einführung in die molekulare Zellbiologie (MolBio Bachelor)
- Applied Molecular Biology
- Struktur und Funktion (LA Ba) - Anmeldung mit mehreren Prioritäten
- Group/Lab Meeting
- Protein Engineering und Funktionalisierung
Vergangene Veranstaltungen (max. 10)
-
2022 WS
- Allgemeine Methoden (Bachelor Bio)
- Allgemeine Methoden Praktikum (Bachelor Bio); Priorität für G1 oder G2
- Group/Lab Meeting
- Molecular Cell Biology
- Anleitung zum wissenschaftlichen Arbeiten
- Grundlagen der Biotechnologie (LA Ba); Platzvergabe: 3 Präferenzen angeben
- Molekulare Zellbiologie
- ZJA91051 Molekulare Zellbiologie
- Zell- und Molekularbiologie
-
2022 SS
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
-
Targeting of client proteins to the VCP/p97/Cdc48 unfolding machineIn: Frontiers in Molecular Biosciences Jg. 10 (2023)ISSN: 2296-889XOnline Volltext: dx.doi.org/ (Open Access)
-
MAGED2 Is Required under Hypoxia for cAMP Signaling by Inhibiting MDM2-Dependent Endocytosis of G-Alpha-SIn: Cells Jg. 11 (2022) Nr. 16,ISSN: 2073-4409Online Volltext: dx.doi.org/ (Open Access)
-
Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1In: Molecular Cell Jg. 82 (2022) Nr. 14, S. 2633 - 2649.e7ISSN: 1097-2765; 1097-4164Online Volltext: dx.doi.org/
-
Ubiquitin-directed AAA+ ATPase p97/VCP unfolds stable proteins crosslinked to DNA for proteolysis by SPRTNIn: The Journal of Biological Chemistry (JBC) Jg. 298 (2022) Nr. 6,ISSN: 0021-9258; 1083-351XOnline Volltext: dx.doi.org/ (Open Access)
-
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)In: Autophagy Jg. 17 (2021) Nr. 1, S. 1 - 382ISSN: 1554-8635; 1554-8627Online Volltext: dx.doi.org/ (Open Access)
-
Targeted substrate loop insertion by VCP/p97 during PP1 complex disassemblyIn: Nature Structural & Molecular Biology Jg. 28 (2021) Nr. 12, S. 964 - 971ISSN: 1545-9993; 1545-9985Online Volltext: dx.doi.org/
-
A pH-sensitive fluorescent protein sensor to follow the pathway of calcium phosphate nanoparticles into cellsIn: Acta Biomaterialia Jg. 111 (2020) S. 406 - 417ISSN: 1878-7568; 1742-7061Online Volltext: dx.doi.org/
-
Protein Phosphatase-1 Complex Disassembly by p97 is Initiated through Multivalent Recognition of Catalytic and Regulatory Subunits by the p97 SEP-domain AdaptersIn: Journal of Molecular Biology (JMB) Jg. 432 (2020) Nr. 23, S. 6061 - 6074ISSN: 1089-8638; 0022-2836Online Volltext: dx.doi.org/
-
Regulation of lysosome integrity and lysophagy by the ubiquitin-conjugating enzyme UBE2QL1In: Autophagy Jg. 16 (2020) Nr. 1, S. 179 - 180ISSN: 1554-8635; 1554-8627Online Volltext: dx.doi.org/ Online Volltext (Open Access)
-
Repair or Lysophagy : Dealing with Damaged LysosomesIn: Journal of Molecular Biology (JMB) Jg. 432 (2020) Nr. 1, S. 231 - 239ISSN: 1089-8638; 0022-2836Online Volltext: dx.doi.org/
-
Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product FamilyIn: Chemistry - A European Journal Jg. 26 (2020) Nr. 39, S. 8524 - 8531ISSN: 0947-6539; 1521-3765Online Volltext: dx.doi.org/ (Open Access)
-
Structure of the PUB Domain from Ubiquitin Regulatory X Domain Protein 1 (UBXD1) and Its Interaction with the p97 AAA+ ATPaseIn: Biomolecules Jg. 9 (2019) Nr. 12,ISSN: 2218-273XOnline Volltext: dx.doi.org/ Online Volltext (Open Access)
-
The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damageIn: EMBO Reports (2019) S. e48014ISSN: 1469-3178; 1469-221XOnline Volltext: dx.doi.org/ (Open Access)
-
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscleIn: Autophagy Jg. 15 (2019) Nr. 6, S. 1082 - 1099ISSN: 1554-8635; 1554-8627Online Volltext: dx.doi.org/ (Open Access)
-
A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPasesIn: Angewandte Chemie International Edition Jg. 57 (2018) Nr. 6, S. 1576 - 1580ISSN: 1521-3773; 1433-7851; 0570-0833Online Volltext: dx.doi.org/
-
AP-SWATH reveals direct involvement of VCP/ p97 in integrated stress response signaling through facilitating CReP/PPP1R15B degradationIn: Molecular and Cellular Proteomics Jg. 17 (2018) Nr. 7, S. 1295 - 1307ISSN: 1535-9484; 1535-9476Online Volltext: dx.doi.org/ Online Volltext (Open Access)
-
Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme FormationIn: Molecular Cell Jg. 72 (2018) Nr. 4, S. 766 - 777ISSN: 1097-2765; 1097-4164Online Volltext: dx.doi.org/ (Open Access)
-
VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and SignalingIn: Molecular Cell Jg. 69 (2018) Nr. 2, S. 182 - 194ISSN: 1097-2765; 1097-4164Online Volltext: dx.doi.org/ (Open Access)
-
Delivery of the autofluorescent protein R-phycoerythrin by calcium phosphate nanoparticles into four different eukaryotic cell lines (HeLa, HEK293T, MG-63, MC3T3) : Highly efficient, but leading to endolysosomal proteolysis in HeLa and MC3T3 cellsIn: PLoS ONE Jg. 12 (2017) Nr. 6, S. e0178260ISSN: 1932-6203Online Volltext: dx.doi.org/ Online Volltext (Open Access)
-
Detection and Clearance of Damaged Lysosomes by the Endo-Lysosomal Damage Response and LysophagyIn: Current Biology Jg. 27 (2017) Nr. 24, S. R1330 - R1341ISSN: 1879-0445; 0960-9822Online Volltext: dx.doi.org/
-
VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagyIn: The EMBO Journal Jg. 36 (2017) Nr. 2, S. 135 - 150ISSN: 0261-4189; 1460-2075Online Volltext: dx.doi.org/ (Open Access)
-
Molecular tweezers target a protein-protein interface and thereby modulate complex formationIn: Chemical Communications: ChemComm Jg. 52 (2016) Nr. 98, S. 14141 - 14144ISSN: 1364-548X; 0009-241X; 0022-4936; 1359-7345Online Volltext: dx.doi.org/ (Open Access)
-
VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break RepairIn: Molecular Cell Jg. 64 (2016) Nr. 1, S. 189 - 198ISSN: 1097-2765; 1097-4164Online Volltext: dx.doi.org/ (Open Access)
-
The N-terminal region of the ubiquitin regulatory X (UBX) domain-containing protein 1 (UBXD1) modulates interdomain communication within the valosin-containing protein p97In: The Journal of Biological Chemistry (JBC) Jg. 290 (2015) Nr. 49, S. 29414 - 29427ISSN: 0021-9258; 1083-351XOnline Volltext: dx.doi.org/ (Open Access)
-
Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1In: The EMBO Journal Jg. 33 (2014) Nr. 22, S. 2704 - 2720ISSN: 0261-4189; 1460-2075Online Volltext: dx.doi.org/ Online Volltext (Open Access)
-
The VCP/p97 system at a glance : connecting cellular function to disease pathogenesisIn: Journal of Cell Science Jg. 127 (2014) Nr. 18, S. 3877 - 3883ISSN: 0021-9533; 1477-9137Online Volltext: dx.doi.org/
-
The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradationIn: Cell Cycle Jg. 13 (2014) Nr. 6, S. 919 - 927ISSN: 1551-4005Online Volltext: dx.doi.org/ Online Volltext (Open Access)
-
The p97-Ufd1-Npl4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradationIn: The FEBS Journal Jg. 281 (2014) Nr. Suppl. 1, S. 82ISSN: 1742-4658; 1742-464XOnline Volltext: dx.doi.org/
-
Coal mining meets chromatin research: Digging for mechanisms in epigenetic control of gene expression : Report from the 43rd Annual Meeting of the German Genetics Society on "Chromatin and Epigenetics" in Essen, GermanyIn: BioEssays Jg. 35 (2013) Nr. 2, S. 141 - 144ISSN: 0265-9247; 1521-1878Online Volltext: dx.doi.org/
-
The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora AIn: The Journal of Cell Biology (JCB) Jg. 201 (2013) Nr. 4, S. 559 - 575ISSN: 1540-8140; 0021-9525Online Volltext: dx.doi.org/
-
Ubiquitination of the n-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPaseIn: The Journal of Biological Chemistry (JBC) Jg. 288 (2013) Nr. 10, S. 7363 - 7372ISSN: 0021-9258; 1083-351XOnline Volltext: dx.doi.org/
-
Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopyIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 109 (2012) S. 1098 - 1103.ISSN: 1091-6490; 0027-8424Online Volltext: dx.doi.org/ (Open Access)
-
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin systemIn: Nature Cell Biology Jg. 14 (2012) Nr. 2, S. 117 - 123ISSN: 1465-7392Online Volltext: dx.doi.org/
-
Expanding into new markets – VCP/p97 in endocytosis and autophagyIn: Journal of Structural Biology Jg. 179 (2012) Nr. 2, S. 78 - 82ISSN: 1095-8657; 1047-8477Online Volltext: dx.doi.org/
-
p97 complexes as signal integration hubsIn: BMC Biology (incorporating Journal of Biology) Jg. 10 (2012) S. 48ISSN: 1741-7007Online Volltext: dx.doi.org/ Online Volltext (Open Access)
-
Cdc48/p97-Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells.In: Journal of Cell Science Jg. 124 (2011) Nr. 9, S. 1571 - 1580ISSN: 0021-9533; 1477-9137Online Volltext: dx.doi.org/
-
Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutationsIn: Nature Cell Biology Jg. 13 (2011) Nr. 9, S. 1116 - 1123ISSN: 1465-7392Online Volltext: dx.doi.org/
-
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaksIn: Nature Cell Biology Jg. 13 (2011) Nr. 11, S. 1376 - 1382ISSN: 1465-7392Online Volltext: dx.doi.org/
-
A role for Cdc48/p97 and Aurora B in controlling chromatin condensation during exit from mitosisIn: Biochemistry and cell biology Jg. 88 (2010) Nr. 1, S. 23 - 28ISSN: 0829-8211; 0714-7511; 0008-4018; 1208-6002Online Volltext: dx.doi.org/
-
Caveolin-1 is ubiquitinated and targeted to intralumenal vesicles in endolysosomes for degradationIn: The Journal of Cell Biology (JCB) Jg. 191 (2010) Nr. 3, S. 615 - 629ISSN: 1540-8140; 0021-9525Online Volltext: dx.doi.org/
-
Role(s) of Cdc48/p97 in mitosisIn: Biochemical Society Transactions Jg. 36 (2008) Nr. 1, S. 126 - 130ISSN: 0300-5127; 1470-8752
-
Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatinIn: Nature Jg. 450 (2007) Nr. 7173, S. 1258ISSN: 0028-0836; 1476-4687
-
Detailed structural insights into the p97-Npl4-Ufd1 interfaceIn: The Journal of Biological Chemistry (JBC) Jg. 282 (2007) Nr. 29, S. 21361 - 21369ISSN: 0021-9258; 1083-351X
-
NSF- and SNARE-mediated membrane fusion is required for nuclear envelope formation and completion of nuclear pore complex assembly in Xenopus laevis egg extractsIn: Journal of Cell Science Jg. 120 (2007) Nr. 16, S. 2895 - 2903ISSN: 0021-9533; 1477-9137
-
Structural insights into the p97-Ufd1-NpI4 complexIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 104 (2007) Nr. 2, S. 467 - 472ISSN: 1091-6490; 0027-8424
-
Golgi reassembly after mitosis : The AAA family meets the ubiquitin familyIn: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Jg. 1744 (2005) Nr. 2, S. 108 - 119ISSN: 1879-2596; 0167-4889Online Volltext: dx.doi.org/ (Open Access)
-
The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanismIn: The Journal of Biological Chemistry (JBC) Jg. 279 (2004) Nr. 48, S. 49609 - 49616ISSN: 0021-9258; 1083-351X
-
Ubiquitin Interactions of NZF Zinc FingersIn: The EMBO Journal Jg. 23 (2004) Nr. 7, S. 1411 - 1421ISSN: 0261-4189; 1460-2075
-
VCIP135 acts as a deubiquitinating enzyme during p97–p47-mediated reassembly of mitotic Golgi fragmentsIn: The Journal of Cell Biology (JCB) Jg. 164 (2004) Nr. 7, S. 973 - 978ISSN: 1540-8140; 0021-9525
-
Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosol : dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chainsIn: The Journal of Cell Biology (JCB) Jg. 162 (2003) Nr. 1, S. 71 - 84ISSN: 0021-9525; 1540-8140Online Volltext: dx.doi.org/
-
Structure and Ubiquitin Interactions of the Conserved Zinc Finger Domain of Npl4In: The Journal of Biological Chemistry (JBC) Jg. 278 (2003) S. 20225 - 20234ISSN: 0021-9258; 1083-351X
-
The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosisIn: Cell Jg. 115 (2003) Nr. 3, S. 355 - 367ISSN: 0092-8674
-
Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1–Npl4In: The EMBO Journal Jg. 21 (2002) Nr. 21, S. 5645 - 5652.ISSN: 0261-4189; 1460-2075
-
Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assemblyIn: Nature Cell Biology Jg. 3 (2001) Nr. 12, S. 1086 - 1091ISSN: 1465-7392
-
The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosolIn: Nature Jg. 414 (2001) S. 652 - 656ISSN: 0028-0836; 1476-4687
-
A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathwaysIn: The EMBO Journal Jg. 19 (2000) Nr. 10, S. 2181 - 2192ISSN: 0261-4189; 1460-2075
-
Structure of the AAA ATPase p97In: Molecular Cell Jg. 6 (2000) Nr. 6, S. 1473 - 1484ISSN: 1097-2765; 1097-4164Online Volltext: dx.doi.org/
-
The mouse p97 (CDC48) gene. Genomic structure, definition of transcriptional regulatory sequences, gene expression, and characterization of a pseudogene.In: The Journal of Biological Chemistry (JBC) Jg. 274 (1999) Nr. 15, S. 10154 - 10162ISSN: 0021-9258; 1083-351X
-
The p47 co-factor regulates the ATPase activity of the membrane fusion protein, p97In: FEBS Letters Jg. 437 (1998) Nr. 3, S. 255 - 257ISSN: 0014-5793; 1873-3468