Mechanistic Cell Biology


Portrait of Doris Hellerschmied
© D. Hellerschmied

Prof. Dr. Doris Hellerschmied-Jelinek

Group Leader Mechanistic Cell Biology
  • +49 (0)201 183-3120
  • S05 T04 B30

Faculty of Biology

Universität Duisburg-Essen
45141 Essen

ResearchChemical Biology to Unravel Protein Homeostasis

Understanding how cells maintain homeostasis is critical to understanding cell survival during stress. Cells have to withstand stress from changing environmental conditions, such as temperature, pH, nutrient or oxygen supply, but also during cell differentiation and aging. Eukaryotic cells have evolved to use distinct cellular compartments, known as organelles, which maintain homeostatic mechanisms to ensure their distinct functionalities and overall cellular homeostasis. Within the secretory pathway, these stress response mechanisms have been extensively studied at the level of the endoplasmic reticulum (ER). In contrast, the mechanism(s) by which the Golgi apparatus deals with unfolded proteins and how it reacts to stress are only beginning to be unraveled.

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