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Image caption: Principle of action: The target protein (pink) binds the orange BacPROTAC, is then unfolded by the green enzyme and degraded by the blue enzyme.

2022Development of novel antibiotic class in cooperation with the group of Prof. Markus Kaiser

In a publication in the highly respected journal Cell, scientists from the Research Institute of Molecular Pathology in Vienna together with the group of Professor Dr. Markus Kaiser (Faculty of Biology) present novel drugs, so-called BacPROTACs. Since these BacPROTACs can specifically degrade exclusively bacterial proteins, they thus represent a completely novel class of antibiotics. Due to their special properties, they are effective against infections with various classes of bacteria, including, for example, the mycobacteria that cause tuberculosis.

"Since this is a novel approach to fighting bacterial infections to which resistance does not yet exist, BacPROTACs could be used especially when conventional antibiotics are no longer effective," Kaiser said.

For more on this exciting topic, see the original publication, "BacPROTACs mediate targeted protein degradation in bacteria": https://doi.org/10.1016/j.cell.2022.05.009

The Biology Department congratulates Prof. M. Kaiser on his research and publication in Cell.

Collaborative Research Centre (CRC) 1439Multilevel response to stressor increase and release in stream ecosystems (RESIST)

Rivers and streams are centres of biodiversity and vital to humans. Human activities impair water bodies and their communities in many ways, and a wide range of measures are in place to reverse these stressors. However, the effects of degradation and recovery are only partially understood, especially when many stressors act simultaneously. RESIST investigates the underlying mechanisms by combining field studies and mesocosm experiments with statistical and mechanistic modelling and synthesis. This broad range of methods is used to investigate the effects of multiple stressors on all components of the stream food web (from viruses to fish) and on four ecosystem functions. The focus of the studies is on the effects of three globally relevant stressors: temperature increase, salinization, and hydromorphological degradation, and the combination of these forms of stress. The goal is to understand and predict the effects of degradation and recovery on stream biodiversity and functions.

In addition to 15 researchers from the UDE, teams from the universities of Bochum, Cologne, Kiel and Koblenz-Landau as well as the Leibniz-Institute of Freshwater Ecology and Inland Fisheries (Berlin) and the Helmholtz-Centre for Environmental Research Halle-Leipzig are involved in the CRC RESIST.

Click here for the website SFB-RESIST

Information for students of the Faculty of BiologyChanges in lectures and exams due to the Covid-19 crisis

Last updated, April, 30th

 

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