CRC 1093 - Principal Investigator Matthias Epple

Prof. Dr. Matthias Epple

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Phone: +49 201 183 2413


Inorganic Chemistry
Faculty of Chemistry
University of Duisburg-Essen

Project Area A A5: Protein-specific nanoparticles for cellular uptake

Since supramolecular ligands as well as certain proteins must ultimately be transported into cells, we will exploit large multishell CaP nanoparticles (100 nm) as transport vehicles across cell membranes. The pathway of the labeled cargo into and inside the cell can be monitored by confocal fluorescence microscopy. On the other hand, very small Au or SiO2 nanoparticles (2-5 nm) will be equipped with specific protein-binding peptides and receptor molecules provided by other partners from the CRC, which render the functionalized nanoparticles specific for central pores, flanks or interfaces of self-assembled protein machines.

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Curriculum Vitae

Professional career

Scientific education and degrees


Selected Publications

J. Helmlinger, C. Sengstock, C. Groß-Heitfeld, C. Mayer, T.A. Schildhauer, M. Köller, M. Epple: "Silver nanoparticles with different size and shape: Equal cytotoxicity, but different antibacterial effect", RSC Adv. 2016, 6, 18490-18501.

J. Helmlinger, O. Prymak, K. Loza, M. Gocyla, M. Heggen, M. Epple: "On the crystallography of silver nanoparticles with different shapes", Cryst. Growth & Design 2016, 16, 3677-3687.

K. Loza, I. Schremmer, J. Bünger, G.A. Westphal, M. Köller, M. Epple, C. Sengstock: "Barium sulfate micro- and nanoparticles as bioinert reference material in particle toxicology", Nanotoxicology 2016, 10, 1492-1502.

K. Haedicke, D. Kozlova, S. Gräfe, U. Teichgräber, M. Epple, I. Hilger: "Multi-functional calcium phosphate nanoparticles for combining near-infrared fluorescence optical imaging and photodynamic therapy", Acta Biomater. 2015, 14, 197-207.

S. Ristig, O. Prymak, K. Loza, M. Gocyla, W. Meyer-Zaika, M. Heggen, D. Raabe, M. Epple: "Nanostructure of wet-chemically prepared, polymer-stabilized silver-gold nanoalloys over the entire composition range", J. Mater. Chem. B 2015, 3, 4654-4662.

B. Neuhaus, A. Frede, A.M. Westendorf, M. Epple: "Gene silencing of the pro-inflammatory cytokine TNF-α with calcium phosphate nanoparticles", J. Mater. Chem. B 2015, 3, 7186-7193.

S. Banerjee, K. Loza, W. Meyer-Zaika, O. Prymak, M. Epple: Structural evolution of silver nanoparticles during wet-chemical synthesis. Chem. Mater. 2014, 26, 951-957.

J. Enax, O. Prymak, D. Raabe, M. Epple: Structure, composition, and mechanical properties of shark teeth. J. Struct. Biol. 2012, 178, 290-299.

D. Kozlova, S. Chernousova, T. Knuschke, J. Buer, A. M. Westendorf, M. Epple: Cell targeting by antibody-functionalized calcium phosphate nanoparticles. J. Mater. Chem. 2012, 22, 396-404.

S. Kittler, C. Greulich, J. Diendorf, M. Köller, M. Epple: Toxicity of silver nanoparticles increases during storage because of slow dissolution under release of silver ions. Chem. Mater. 2010, 22, 4548-45.