Supramolecular Chemistry on Proteins

Protein function is intimately connected with supramolecular chemistry: Substrate processing and various levels of regulation involve specific noncovalent interactions. Likewise, protein folding, assembly and protein-protein interactions are governed by intermolecular forces and their specific inhibition or support represents a very promising area for external interference, with profound mechanistic and therapeutic implications.

The CRC aims at applying recent knowledge and methods from supramolecular chemistry to achieve specific interaction with proteins by artificial ligands.


War in UkraineSolidarity with the people of Ukraine

We are all appalled by the attack on Ukraine. Two members of our research consortium come from Ukraine and have family there. They gave a radio interview on 25th of February at Radio Essen:

Recent publicationThe role of DNA nanostructures in the catalytic properties of an allosterically regulated protease

R. Kosinski, J. Mieres Perez, E.-C. Schöneweiß, Y. B. Ruiz-Blanco, I. Ponzo, K. Bravo-Rodriguez, M. Erkelenz, S. Schlücker, G. Uhlenbrock, E. Sanchez-Garcia , B. Saccà. Science Advances 2022 Jan 7; 8(1): eabk0425. doi: 10.1126/sciadv.abk0425.

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Recent publicationTargeted substrate loop insertion by VCP/p97 during PP1 complex disassembly.

J. van den Boom, A. F. Kueck, B. Kravic, H. Müschenborn, M. Giesing, D. Pan, F. Kaschani, M. Kaiser, A. Musacchio, H. Meyer. Nat Struct Mol Biol 2021 Nov 25. doi: 10.1038/s41594-021-00684-5.

Read press release and the original article

Recent PublicationSupramolecular Enhancement of a Natural 14-3-3 Protein Ligand

X. Guillory, I. Hadrović, P. J. de Vink, A. Sowislok, L. Brunsveld, T. Schrader, C. Ottmann.

J Am Chem Soc. 2021 Sep 1;143(34):13495-13500.

doi: 10.1021/jacs.1c07095.

Public OutreachThe next Generation

The new issue of Unikate focuses on a series of "Junge Wilde", exemplary for the many young researchers at our university.  Doris Hellerschmied-Jelinek, Michael Giese, Jens Voskuhl and Jochen Niemeyer who are young researchers of our CRC report on their research topics and make them accessible to readers from outside the field and to the public. Read more

Recent PublicationTargeting a protein epitope: Specific inhibition of the Survivin-CRM1 interaction by peptide-modified molecular tweezers

A. Meiners, S. Bäcker, I. Hadrovic, C. Heid, C. Beuck, Y. B. Ruiz-Blanco, J. Mieres-Perez, M. Pörschke, J.-N. Grad, C. Vallet, D. Hoffmann, P. Bayer, E. Sanchez-Garcia *, T. Schrader*, S. K. Knauer*, *corresponding authors

Nat Comm 2021, doi 10.1038/s41467-021-21753-9. Read More: press release (in German, in English)

The local newspaper WAZ (Westdeutsche Allgemeine Zeitung)  reported on March 23rd about this project and our consortium: "Mit Maßarbeit gegen Krebs".

Recent PublicationProtein phosphatase-1 complex disassembly by p97 is initiated through multivalent recognition of catalytic and regulatory subunits by the p97 SEP-domain adapters.

M. Kracht, J. van den Boom, J. Seiler, A. Kröning, F. Kaschani, M. Kaiser, H. Meyer

J Mol Biol. 2020 Oct 12, doi: 10.1016/j.jmb.2020.10.001.

Recent PublicationTransport of ultrasmall gold nanoparticles (2 nm) across the blood-brain barrier in a six-cell brain spheroid model.

V. Sokolova, G. Mekky, S. B. van der Meer, M. C. Seeds, A. J. Atala, M. Epple

Sci Rep 2020 Oct 22;10(1):18033. doi: 10.1038/s41598-020-75125-2.

Recent PublicationStructure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions.

E. Sijbesma , E. Visser , K. Plitzko, P. Thiel, L.-G. Milroy, M. Kaiser, L. Brunsveld, C. Ottmann

Nat Commun.  2020 Aug 7;11(1): 3954. doi: 10.1038/s41467-020-17741-0.

Read press release (in German)

Andrea Musacchio receives Leibniz Prize 2020

Andrea Musacchio receives the Leibniz Prize for his pioneering work in structural biology, specifically the mechanisms of chromosome segregation in cell division. Musacchio focuses on the structure and function of the kinetochore, an extremely complex structure that plays a key role in the distribution of chromosomes among the daughter cells when a cell divides. By combining structural analysis with biochemical and cell biology studies, he has obtained fundamental insights into the function and regulation of the kinetochore, making an outstanding contribution to our understanding of the critical phases of cell division. Read more about the Leibniz Prize of the DFG here.

Find information about the CRC1093 project B6 of Andrea Musacchio here.

Internal area for CRC1093 members

access the internal website here