Principal Investigators

Area A - Chemical Ligands and Methods

A1: Protein-recognition by supramolecular ligands from focused combinatorial libraries


Since August 2019 the project is supervised by
Prof. Dr. Jens Voskuhl and Prof. Dr. Thomas Schrader

Group of Prof. Dr. Carsten Schmuck †

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Organic Chemistry
Faculty of Chemistry, University of Duisburg-Essen

A2: Natural products as starting structures for the development of supramolecular ligands

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Prof. Dr. Markus Kaiser

Phone: +49 201 183 4980
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Chemical Biology

Centre for Medical Biotechnology (ZMB)
Faculty of Biology, University of Duisburg-Essen

A3: Designed copolymers and molecular tweezers for protein surface recognition

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Prof. Dr. Thomas Schrader

Phone: +49 201 183 3081
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Organic Chemistry
Faculty of Chemistry, University of Duisburg-Essen

A5: Protein-specific nanoparticles for cellular uptake

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Prof. Dr. Matthias Epple

Phone: +49 201 183 2413
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Inorganic Chemistry
Faculty of Chemistry, University of Duisburg-Essen

A6: DNA-based nanocontainers for predesigned spatial confinement of proteins

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Prof. Dr. Barbara Saccà

Phone: +49 201 183 3097
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Bionanotechnology

Centre for Medical Biotechnology (ZMB)
Faculty of Biology, University of Duisburg-Essen

A7: Pareto-optimization of protein-surface targeting supramolecular binders with hetero-avidity

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Prof. Dr. Daniel Hoffmann

Phone: +49 201 183 4391
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Bioinformatics

Centre for Medical Biotechnology (ZMB)
Faculty of Biology, University of Duisburg-Essen

A8: Exploring protein-recognition by supramolecular binders with MD an QM/MM methods

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Prof. Dr. Elsa Sánchez-Garcia

Phone: +49 201 183 3839
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Computational Biochemistry

Centre for Medical Biotechnology (ZMB)
Faculty of Biology, University of Duisburg-Essen

A9: Raman spectroscopic monitoring of protein recognition by supramolecular ligands

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Prof. Dr. Sebastian Schlücker

Phone: +49 201 183 6843
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Physical Chemistry

Faculty of Chemistry, University of Duisburg-Essen

A10: Novel luminophores with aggregation induced emission properties for protein recognition

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Prof. Dr. Jens Voskuhl

Phone: +49 201 183 2404
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Biosupramolecular Chemistry, University of Duisburg-Essen

A11: Precision macromolecules for the sequence-controlled presentation of supramolecular ligands

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Prof. Dr. Laura Hartmann

Phone: +49 211 811 0360
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Macromolecular Chemistry, HHU Düsseldorf

Area B - Biological Targets

B1: Supramolecular ligand modulate assembly and function of HtrA proteases

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Prof. Dr. Michael Ehrmann

Phone: +49 201 183 2949
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Microbiology II

Centre for Medical Biotechnology (ZMB)
Faculty of Biology, University of Duisburg-Essen

B2: Probing mechanisms of the Cdo48/p97 segregase with designed supramolecular ligands

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Prof. Dr. Hemmo Meyer

Phone: +49 201 183 4217
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Molecular Biology I

Centre for Medical Biotechnology (ZMB)
Faculty of Biology, University of Duisburg-Essen

B4: Modulation of 14-3-3 protein-protein interactions by supramolecular chemistry

This project has been finished in 2020.

B5: Dissection and modulation of (patho)biological Survivin functions by supramolecular ligands

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Prof. Dr. Shirley Knauer

Phone: +49 201 183 4987
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Molecular Biology II

Centre for Medical Biotechnology (ZMB)
Faculty of Biology, University of Duisburg-Essen

B6: Targeting centromer recuitment of mitotic regulators by supramolecular ligands

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Hon. Prof. Dr. Andrea Musacchio

Phone: +49 231 133-2101
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Department of Mechanistic Cell Biology

Max-Planck-Institut für molekulare Physiologie, Dortmund

B7: Manipulation of the kinetochore-microtubule interface by supramoleular ligands

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Prof. Dr. Stefan Westermann

Phone: +49 201 183 2404
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Molecular Genetics, ZMB, Faculty of Biology, University of Duisburg-Essen

Area Z - Central Service

Z2: X-Ray Crystallography

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Dr. Ingrid Vetter

Phone: +49 231 133-2737
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Max-Planck-Institut für molekulare Physiologie, Dortmund

Z3: NMR Spectroscopy

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Prof. Dr. Peter Bayer

Phone: +49 201 183 4677
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Structural and Medicinal Biochemistry

Centre for Medical Biotechnology (ZMB)
Faculty of Biology, University of Duisburg-Essen

Associated Members

AM1: Modulating chaperone-client protein complexes

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Jun.-Prof. Doris Hellerschmied

Phone: +49 201 183 3120
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Mechanistic Cell Biology

AM2: Phosphoric acid based supramolecular ligands

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Priv.-Doz. Dr. Jochen Niemeyer

Phone: +49 201 183 3148
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Supramolecular Organocatalysis and Chemosensing

AM3: Molecular Design of Photoswitches for Dynamic Supramolecular Modulation of Proteins

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Prof. Dr. Bart Jan Ravoo

Phone: +49 201 183 3120
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Synthesis of Nanoscale Systems

AM4: A modular ligand design for protein surfaces – addressing the conformational dynamics of proteins via adaptive GCP-ligands

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Prof. Dr. Michael Giese

Phone: +49 201 183 2087
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Supramolekulare Materialien

AM5: Supramolecular ligands for modulating protein interactions of the cytosolic enzyme NGLY1

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Dr. Ulla Gerling-Driessen

Phone: +49 211 81-14788
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Subgroup Gerling-Driessen - Macromolecular Chemistry, HHU Düsseldorf