CRC 1093 - Principal Investigator Peter Bayer

Prof. Dr. Peter Bayer

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Phone: +49 201 183 4677

Structural and Medicinal Biochemistry

Centre for Medical Biotechnology (ZMB)
Faculty of Biology
University of Duisburg-Essen

Area Z: Central Service Z3: NMR Spectroscopy

In project Z3 NMR spectroscopic methods will be offered for ligand optimization (STD), epitope identification (chemical shift perturbation) and structural characterization of protein-ligand complexes. Transferred NOE experiments will be employed in the case of weak interactions, while full structure determination of strong protein-ligand complexes will be attempted by a combination of classical 3D, 4D heteronuclear experiments and half-filtered NOESY experiments as well as by the use of residual dipolar coupling measurements and computational docking.

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Curriculum Vitae

Professional career

Scientific education and degrees


Selected Publications

F. Trusch, K. Kowski, K. Bravo-Rodriguez, C. Beuck, A. Sowislok, B. Wettig, A. Matena, E. Sanchez-Garcia, H. Meyer, T. Schrader and P. Bayer: Molecular tweezers target a protein–protein interface and thereby modulate complex formation. Chem. Comm. 2016, 52, 14141 - 14144.

A. Matena, C. Sinnen, J. van den Boom, C. Wilms, J. N.j Dybowski, R. Maltaner, J. W. Mueller, N. M. Link, D. Hoffmann, and P. Bayer: Transient domain interactions enhance the affinity of the mitotic regulator Pin1 towards phosphorylated peptide ligands. Structure. 2013, 21, 1769-1777.

SpHtp1 from the oomycete Saprolegnia parasitica translocates specifically into fish cells in a tyrosine-O-sulphate–dependent manner. Stephan Wawra, Judith Bain, Elaine Durward, Irene de Bruijn, Kirsty L. Minor, Anja Matena, Lars Löbach, Stephen C. Whisson, Peter Bayer, Andrew J. Porter, Paul R. J. Birch, Chris J. Secombes, and Pieter van West.  PNAS 2012, 109, 2096-2101.

Crystallographic Proof for an Extended Hydrogen Bonding Network in Small Prolyl Isomerases. Jonathan W Mueller, Nina M. Link, Anja Matena, Lukas Hoppstock, Alma Rüppel, Peter Bayer, and Wulf Blankenfeldt. J. Am. Chem. Soc. 2011, 133 (50), 20096–20099.

Structure and Dynamics of the First Archaeal Parvulin Reveal a New Functionally Important Loop in Parvulin-type Prolyl Isomerases. Ɓukasz Jaremko, Mariusz Jaremko, Imadeldin Elfaki, Jonathan W. Mueller, Andrzej Ejchart, Peter Bayer and Igor Zhukov J.Biol.Chem., 2011, 286, 6554–6565

The solution structure of pGolemi, a high affinity Mena EVH1 binding miniature protein, explains paralog-specific binding to Ena/VASP homology (EVH) 1 domains. Nina M Link; Hunke Cornelia, Jonathan W Mueller, Jutta Eichler,  Peter Bayer. Biol. Chem. 2009, 390, pp. 417–426..

Harjes, E., Harjes, S., Wohlgemuth, S., Mueller, K.-H., Krieger, E., Herrmann, C. and Bayer, P. GTP-Ras disrupts the intramolecular complex of C1 and RA domains of Nore1. Structure 2006, 14, 881-888.