CRC1093 Project A11

Chemical Ligands and Methods A11: Precision macromolecules for the sequence-controlled presentation of supramolecular ligands

Prof. Dr. Laura Hartmann

In project A11 we will apply sequence-controlled oligo(amidoamines) as a new platform for the multivalent presentation of non-natural supramolecular binding motifs such as the molecular tweezer from the Schrader group or guanidiniocarbonylpyrrole cations from the Schmuck group in combination with biological ligands as well as sensor molecules e.g. from the Voskuhl group. The resulting macromolecular ligands will be analyzed for their modulation of different proteins under investigation within the CRC and we will try to derive new insights into the design and applications of supramolecular ligands based on multivalent macromolecules.