Chemical Ligands and Methods A3: Designed copolymers and molecular tweezers for protein surface recognition

Prof. Dr. Thomas Schrader

In project A3, inspection of protein crystal structures and theoretical simulations result in the selection of distinct methacrylamide-based monomers from a modular set of specific binders for all classes of amino acids. These mixtures will be subjected to radical copolymerization and later also to molecular imprinting, to produce specific protein surface binders as inhibitors of isolated digestive enzymes and HtrA proteases. In an alternative approach, powerful molecular lysine and arginine tweezers will be equipped with additional peptidic binding sites for their immediate protein environment. These tailored molecular tweezers will be directed to hot spots on proteins of all CRC partners.