CRC 1093 - Principal Investigator Hemmo Meyer

Prof. Dr. Hemmo Meyer

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Phone: +49 201 183 4217

Molecular Biology I

Centre for Medical Biotechnology (ZMB)
Faculty of Biology
University of Duisburg-Essen

Area B: Biological Targets B2: Probing mechanisms of the Cdc48/p97 segregase with designed supramolecular ligands

B2 will probe three prominent structural elements of the segregrase p97 with customized supramolecular compounds to explore their biological function: the central pore, adapter binding and the N-D1 communication will be examined in biochemical and cell-based assays to understand their relevance in p97 function. In addition, supramolecular p97 ligands and p97 itself will be delivered into mammalian cells using CaP nanoparticles to study uptake and targeting of intracellular p97 in different subcellular localizations.

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Curriculum Vitae

Professional career

Scientific education and degrees


Selected Publications

C. Papadopoulos, P. Kirchner, M. Bug, D. Grum, L. Koerver, N. Schulze, R. Poehler, A. Dressler, S. Fengler, K. Arhzaouy, V. Lux, M. Ehrmann, C. C. Weihl, H. Meyer:  VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. EMBO J. 2017, 36:135-150.

J. van den Boom, M. Wolf, L. Weimann, N. Schulze, F. Li, F. Kaschani, A. Riemer, C. Zierhut, M. Kaiser, G. Iliakis, H. Funabiki, H. Meyer: VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. Molecular Cell 2016 64, 189–198 October 6.

H. Meyer, Bug M, Bremer S. Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system. Nat. Cell Biol. 2012, 14:117-23.

Meerang M, Ritz D, Paliwal S, Garajova Z, Bosshard M, Mailand N, Janscak P, Hüscher U, H. Meyer, Ramadan K. The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double strand breaks. Nat. Cell Biol. 2011, 13, 1376-82.

Ritz D., Vuk M., Kirchner P., Bug M, Schütz S, Hayer A, Bremer S., Lusk C., Baloh RH, Lee H, Glatter T., Gstaiger M., Aebersold R., Weihl C.C., H. Meyer: Endolysosomal sorting of ubiquitinated caveolin-1 is regulated by VCP/p97 and UBXD1 and impaired by VCP disease mutations. Nat. Cell Biol. 2011, 13, 1116-23.

Dobrynin G, Popp O, Romer T, Bremer S, Schmitz MHA, Gerlich DW and H. Meyer: Cdc48/p97(Ufd1-Npl4) antagonizes Aurora B during chromosome segregation in HeLa cells. J Cell Sci. 2011, 124, 1571-80.

Ramadan K, Bruderer R, Spiga F, Popp O, Baur T, Gotta M, and H. Meyer: Cdc48/p97 promotes reformation of the nucleus by extracting Aurora B kinase from chromatin. Nature, 2007, 450, 1258-62.