CRC 1093 - Principal Investigator Carsten Schmuck

Prof. Dr. Carsten Schmuck

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Since August 2019 the project is supervised by Prof. Dr. Jens Voskuhl and Prof. Dr. Thomas Schrader

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Organic Chemistry
Faculty of Chemistry
University of Duisburg-Essen

Project Area A A1: Protein-recognition by supramolecular ligands from focused combinatorial libraries

Project A1 generates and examines relatively small focussed combinatorial libraries of linear, multiarmed and branched peptidic dendrimers in two alternative approaches. With the “split-and-mix” method screening and determination of protein affinities as well as inhibitory properties will be performed “on-bead” using solid-phase bound libraries. Hit candidates will be synthesized in larger amounts for subsequent mechanistic studies as well as structural elucidation. In dynamic combinatorial libraries two or more building blocks are covalently connected by reversible transformations such as imine or hydrazone formation. Suitable screening and deconvolution strategies will allow to identify potent protein ligands.

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Curriculum Vitae

Professional career

Scientific education and degrees

 

Selected Publications

M. Li, M. Radic Stojkovoic, M. Ehlers, E. Zellermann, I. Piantanida, C. Schmuck: Use of an octapeptide - guanidiniocarbonylpyrrol conjugate for the formation of a supramolecular beta-helix which further self-assembles into pH responsive fibers. Angew. Chem. Int. Ed. 2016, 55, 1301.

M. Li, M. Ehlers, S. Schlesiger, E. Zellermann, S. Knauer, C. Schmuck: Incorporation of a Non-Natural Arginine Analogue into a Cyclic Peptide Leads to Formation of Positively Charged Nanofibers Capable of Gene Transfection. Angew. Chem. Int. Ed. 2016, 55, 598.

Q.-Q. Jiang, W. Sicking, M. Ehlers, C. Schmuck: Discovery of potent inhibitors of human β-tryptase from pre-equilibrated dynamic combinatorial libraries. Chem. Sci. 2015, 6, 1792.

H. Y. Kuchelmeister, S. Karczewski, A. Gutschmidt, S. Knauer, C. Schmuck: Utilizing Combinatorial Chemistry and Rational Design: Peptidic Tweezers with Nanomolar Affinity to DNA can be transformed into Efficient Vectors for Gene Delivery by Addition of a Lipophilic Tail. Angew. Chem. 2013, 125, 14266.

H. Y. Kuchelmeister, A. Gutschmidt, S. Knauer, C. Schmuck: Efficient Gene Delivery into Cells by a Surprisingly Small Three-Armed Peptide Ligand. Chem. Sci. 2012, 3, 996.

J. Wu, Y. Zou, W. Sicking, I. Piantanida, T. Yi, C. Schmuck: A Molecular Peptide Beacon for the Ratiometric Sensing of Nucleic Acids. J. Am. Chem. Soc. 2012, 134, 1958.

S. Niebling, H. Y. Kuchelmeister, C. Schmuck, S. Schlücker: Quantitative label-free monitoring of peptide recognition by artificial receptors: A comparative FT-IR and UV resonance Raman spectroscopic study. Chem. Sci. 2012, 3, 3371.

 J. Wu, A. Zawistowski, M. Ehrmann, T. Yi, C. Schmuck: Peptide functionalized Polydiacetylene Liposomes act as a Fluorescent Turn-On Sensor for Bacterial Lipopolysaccharide. J. Am. Chem. Soc. 2011, 133, 9720–9723

P. R. Wich, C. Schmuck: Reversible and Non-Competitive Inhibition of β-Tryptase by Protein Surface Binding of Tetravalent Peptide Ligands Identified from a Combinatorial Split-Mix-Library. Angew. Chem. Int. Ed. 2010, 49, 4113 –4116.

N. J. V. Lindgren, L. Geiger, J. Razkin, C. Schmuck, Lars Baltzer: Downsizing Enzymatic Function by Chemical Methods – Arginine Mimics with Low pKa Values Increase Rates of Hydrolysis of RNA Model Compounds. Angew. Chem. Int. Ed. 2009, 48, 6722.