Welcome to CRC 1093
Supramolecular Chemistry on Proteins
Protein function is intimately connected with supramolecular chemistry: Substrate processing and various levels of regulation involve specific noncovalent interactions. Likewise, protein folding, assembly and protein-protein interactions are governed by intermolecular forces and their specific inhibition or support represents a very promising area for external interference, with profound mechanistic and therapeutic implications.
The CRC aims at applying recent knowledge and methods from supramolecular chemistry to achieve specific interaction with proteins by artificial ligands.Overview
Recent PublicationTargeting a protein epitope: Specific inhibition of the Survivin-CRM1 interaction by peptide-modified molecular tweezers
A. Meiners, S. Bäcker, I. Hadrovic, C. Heid, C. Beuck, Y. B. Ruiz-Blanco, J. Mieres-Perez, M. Pörschke, J.-N. Grad, C. Vallet, D. Hoffmann, P. Bayer, E. Sanchez-Garcia *, T. Schrader*, S. K. Knauer*, *corresponding authors
Recent PublicationProtein phosphatase-1 complex disassembly by p97 is initiated through multivalent recognition of catalytic and regulatory subunits by the p97 SEP-domain adapters.
Recent PublicationStructure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions.
Review Guanidiniocarbonyl‐Pyrroles (GCP) – 20 Years of the Schmuck Binding Motif
In this Minireview, an overview about the past 20 years of the guanidiniocarbonyl‐pyrrole (GCP) binding motif, which was designed, investigated and applied by Prof. Dr. Carsten Schmuck, is presented.
Chem Plus Chem. 2020 May; 85(5):985-997.
Andrea Musacchio receives the Leibniz Prize for his pioneering work in structural biology, specifically the mechanisms of chromosome segregation in cell division. Musacchio focuses on the structure and function of the kinetochore, an extremely complex structure that plays a key role in the distribution of chromosomes among the daughter cells when a cell divides. By combining structural analysis with biochemical and cell biology studies, he has obtained fundamental insights into the function and regulation of the kinetochore, making an outstanding contribution to our understanding of the critical phases of cell division. Read more about the Leibniz Prize of the DFG here.
Find information about the CRC1093 project B6 of Andrea Musacchio here.
Sofja Kovalevskaja-Award for Doris HellerschmiedProtein Folding and Stress
Dr. Doris Hellerschmied examines how cells react to molecular forms of stress. She is one of six winners of the Sofja Kovalevskaja-Award of the Alexander von Humboldt-Stiftung. She has received 1.65 million euros to establish an independent research group at the UDE. Read more
Find information about the CRC1093 project AM1 of Doris Hellerschmied here.