Supramolecular Chemistry on Proteins

Protein function is intimately connected with supramolecular chemistry: Substrate processing and various levels of regulation involve specific noncovalent interactions. Likewise, protein folding, assembly and protein-protein interactions are governed by intermolecular forces and their specific inhibition or support represents a very promising area for external interference, with profound mechanistic and therapeutic implications.

The CRC aims at applying recent knowledge and methods from supramolecular chemistry to achieve specific interaction with proteins by artificial ligands.

Overview

Recent PublicationStructure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions.

E. Sijbesma , E. Visser , K. Plitzko, P. Thiel, L.-G. Milroy, M. Kaiser, L. Brunsveld, C. Ottmann

Nat Commun.  2020 Aug 7;11(1): 3954. doi: 10.1038/s41467-020-17741-0.

Read press release (in German)

Review Guanidiniocarbonyl‐Pyrroles (GCP) – 20 Years of the Schmuck Binding Motif

In this Minireview, an overview about the past 20 years of the guanidiniocarbonyl‐pyrrole (GCP) binding motif, which was designed, investigated and applied by Prof. Dr. Carsten Schmuck, is presented.

M. Giese,  J. Niemeyer, J. Voskuhl

Chem Plus Chem. 2020 May; 85(5):985-997.

Andrea Musacchio receives Leibniz Prize 2020

Andrea Musacchio receives the Leibniz Prize for his pioneering work in structural biology, specifically the mechanisms of chromosome segregation in cell division. Musacchio focuses on the structure and function of the kinetochore, an extremely complex structure that plays a key role in the distribution of chromosomes among the daughter cells when a cell divides. By combining structural analysis with biochemical and cell biology studies, he has obtained fundamental insights into the function and regulation of the kinetochore, making an outstanding contribution to our understanding of the critical phases of cell division. Read more about the Leibniz Prize of the DFG here.

Find information about the CRC1093 project B6 of Andrea Musacchio here.

Recent PublicationFunctional Disruption of the Cancer-Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole Ligand

C. Vallet, D. Aschmann, C. Beuck C, M. Killa M, A. Meiners A, M. Mertel M, M. Ehlers M, P. Bayer, C. Schmuck, M. Giese, S. K. Knauer

Angew Chem Int Ed Engl. 2020 Jan 8. doi: 10.1002/anie.201915400.

Recent PublicationActivation by substoichiometric inhibition

M. Merdanovic, S. G. Burston, A. L. Schmitz, S. Köcher, S. Knapp, T. Clausen, M. Kaiser, R. Huber, M. Ehrmann.

Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1414-1418. doi: 10.1073/pnas.1918721117. Epub 2020 Jan 6.

Sofja Kovalevskaja-Award for Doris HellerschmiedProtein Folding and Stress

August 2019
Dr. Doris Hellerschmied examines how cells react to molecular forms of stress. She is one of six winners of the Sofja Kovalevskaja-Award of the Alexander von Humboldt-Stiftung. She has received 1.65 million euros to establish an independent research group at the UDE. Read more

Find information about the CRC1093 project AM1 of Doris Hellerschmied here.

Internal area for CRC1093 members

access the internal website here