Supramolecular Chemistry on Proteins

Protein function is intimately connected with supramolecular chemistry: Substrate processing and various levels of regulation involve specific noncovalent interactions. Likewise, protein folding, assembly and protein-protein interactions are governed by intermolecular forces and their specific inhibition or support represents a very promising area for external interference, with profound mechanistic and therapeutic implications.

The CRC aims at applying recent knowledge and methods from supramolecular chemistry to achieve specific interaction with proteins by artificial ligands.

Overview
Michael Giese

5th International Symposium 2022

We invite you to celebrate with us the successes of 8 years joint CRC research!

This one day symposium will take place 19 October 2022 in Essen. Internationally renowned speakers and young scientists will present their latest research in the field of supramolecular chemistry and biology. In addition, selected PIs will present highlights from 8 years of joint SFB cooperation and give an outlook on future SFB-initiated research. Read more about confirmed speakers, the program and symposium dinner.

Molecular Basis of LifeGBM Herbstagung - Session Supramolecular Chemistry on Proteins

The Fall Conference of the German Society for Biochemistry and Molecular Biology (GBM) "Molecular Basis of Life" at the Heinrich Heine University Düsseldorf will take place in September 14th – 16th, 2022. This meeting is intended to promote lively discussions at the crossroads of various fields of biochemistry such as biophysics, structural biology, bioenergetics, cell biology, bioinformatics and others. The conference is organized by Prof. Dr. Claus Seidel (Heinrich Heine University) in collaboration with several GBM study groups. Our CRC 1093 is organizing one session about Supramolecular Chemistry On Proteins.

Recent PublicationAdvanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses

T. Weil, A. Kirupakaran, M.-H. Le, P. Rebmann, J. Mieres-Perez, L. Issmail, C. Conzelmann, J. A. Müller, L. Rauch, A. Gilg, L. Wettstein, R. Groß, C. Read, T. Bergner, S. Axberg Pålsson, N. Uhlig, V. Eberlein, H. Wöll, F.-G. Klärner, S. Stenger, B. M. Kümmerer, H. Streeck, G. Fois, M. Frick, P. Braubach, A.-L. Spetz, T. Grunwald, J. Shorter, E. Sanchez-Garcia*, T. Schrader*, and Jan Münch*; *corresponding authors, Journal of the American Chemical Society Au 2022, September 6, 2022 DOI: 10.1021/jacsau.2c00220;

Two awards for CRC 1093 members

Work on the dynamic hybrid AuNP origami platform for SERS by Michael Erkelenz and Richard Kosinski of Barbara Saccà's group (project A6) and Helene Giesler (Schlücker group, project A9, photo: middle) was presented at the International Conference on Raman Spectroscopy (ICORS) August 14-19, 2022 in Long Beach, California and awarded with one of the 7 prestigious poster prizes. "The Raman Award for the Most Innovative Technological Development" went to Sebastian Schlücker (photo:  left) for the development of a compact and fast Raman readout device for highly sensitive on-site diagnostics using nanotechnology and laser light. Congratulations to everyone involved in this collaborative work!

Recent publicationThe role of DNA nanostructures in the catalytic properties of an allosterically regulated protease

R. Kosinski, J. Mieres Perez, E.-C. Schöneweiß, Y. B. Ruiz-Blanco, I. Ponzo, K. Bravo-Rodriguez, M. Erkelenz, S. Schlücker, G. Uhlenbrock, E. Sanchez-Garcia , B. Saccà. Science Advances 2022 Jan 7; 8(1): eabk0425. doi: 10.1126/sciadv.abk0425.

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Recent publicationTargeted substrate loop insertion by VCP/p97 during PP1 complex disassembly.

J. van den Boom, A. F. Kueck, B. Kravic, H. Müschenborn, M. Giesing, D. Pan, F. Kaschani, M. Kaiser, A. Musacchio, H. Meyer. Nat Struct Mol Biol 2021 Nov 25. doi: 10.1038/s41594-021-00684-5.

Read press release and the original article

Recent PublicationSupramolecular Enhancement of a Natural 14-3-3 Protein Ligand

X. Guillory, I. Hadrović, P. J. de Vink, A. Sowislok, L. Brunsveld, T. Schrader, C. Ottmann.

J Am Chem Soc. 2021 Sep 1;143(34):13495-13500.

doi: 10.1021/jacs.1c07095.

Recent PublicationTargeting a protein epitope: Specific inhibition of the Survivin-CRM1 interaction by peptide-modified molecular tweezers

A. Meiners, S. Bäcker, I. Hadrovic, C. Heid, C. Beuck, Y. B. Ruiz-Blanco, J. Mieres-Perez, M. Pörschke, J.-N. Grad, C. Vallet, D. Hoffmann, P. Bayer, E. Sanchez-Garcia *, T. Schrader*, S. K. Knauer*, *corresponding authors

Nat Comm 2021, doi 10.1038/s41467-021-21753-9. Read More: press release (in German, in English)

The local newspaper WAZ (Westdeutsche Allgemeine Zeitung)  reported on March 23rd about this project and our consortium: "Mit Maßarbeit gegen Krebs".

Recent PublicationStructure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions.

E. Sijbesma , E. Visser , K. Plitzko, P. Thiel, L.-G. Milroy, M. Kaiser, L. Brunsveld, C. Ottmann

Nat Commun.  2020 Aug 7;11(1): 3954. doi: 10.1038/s41467-020-17741-0.

Read press release (in German)

Internal area for CRC1093 members

access the internal website here