Welcome to CRC 1093


Collaborative Research Centre 1093:

Supramolecular Chemistry on Proteins

Protein function is intimately connected with supramolecular chemistry: Substrate processing and various levels of regulation involve specific noncovalent interactions. Likewise, protein folding, assembly and protein-protein interactions are governed by intermolecular forces and their specific inhibition or support represents a very promising area for external interference, with profound mechanistic and therapeutic implications.

The CRC aims at applying recent knowledge and methods from supramolecular chemistry to achieve specific interaction with proteins by artificial ligands.

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Congratulations to Jean-Pierre Sauvage, Fraser Stoddart und Ben Feringa for the Nobel prize in Chemistry!

Foto Nobelpreistraeger

From left to right:Jean-Pierre Sauvage, Fraser Stoddart und Bernard Feringa

The three researchers use Supramolecular Chemistry for the development of molecular machines. Jean-Pierre Sauvage became famous for his “molecular knots”, Fraser Stoddart for numerous molecular tools, and Ben Feringa for the first molecular motor. Supramolecular Chemistry is also one of the main research areas at the Faculty of Chemistry and unifying scheme of our CRC 1093 “Supramolecular Chemistry on Proteins”.

The Nobel prize 2016 was awarded “for the design and synthesis of molecular machines.” Read More: www.nobelprize.org

Pictures: Strasbourg University / Northwestern University / University of Groningen

New CRC1093 Associated Member

Professor Jens Voskuhl joins the CRC1093

Jens Voskuhl has been appointed as a Juniorprofessor at the Faculty of Chemistry recently and will start now to collaborate with several groups within the CRC as an associated member.

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Determinants of amyloid fibril degradation by the PDZ protease HTRA1

S. Poepsel, A. Sprengel, B. Sacca, F. Kaschani , M. Kaiser, C. Gatsogiannis, S. Raunser, T. Clausen and M. Ehrmann: Determinants of amyloid fibril degradation by the PDZ protease HTRA1.

Nature Chemical Biology. 2015, doi:10.1038/nchembio.1931


Molecular Tweezers and Protein Aggregation

Chem Comm Review Erste Seite120pxFrank-Gerrit Klärner and Thomas Schrader have designed and optimized molecular tweezers with a unique structure which makes them selective for lysine and arginine residues. Their fruitful collaboration with Gal Bitan from the David Geffen School of Medicine at the University of California, Los Angeles, revealed the ability of these tweezers to inhibit aberrant peptide and protein aggregation, which is a common pathogenic feature of neurodegenerative diseases like Alzheimer’s, Parkinson’s or Transthyretin (TTR)-related Amyloidosis. Latest promising results offer the prospect of developing molecular tweezers as suitable drug candidates. Thomas Schrader, Frank-Gerrit Klärner and Gal Bitan, who was also an invited guest professor of our CRC, have now summarized the properties and the potential of these molecular tweezers in the renowned journal Chemical Communications: “Molecular tweezers for lysine and arginine – powerful inhibitors of pathologic protein aggregation”. This Feature Article carries the issue’s front cover.

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Protein Ligand Interactions

CRC1093 / CRC765 Graduate Student Symposium 2016


Our second Graduate Student Symposium took place from 31st of August to 2nd of September at the GHotel in Hannover. 45 graduate students from the CRC1093 of Duisburg-Essen and the CRC765 of Berlin discussed latest results within the field of supramolecular chemistry. Read More

"PLUS3" Grant from the Boehringer Ingelheim Foundation

CRC1093 Principal Investigator Dr. Elsa Sánchez-García received the prestigious “PLUS3” grant from the Boehringer Ingelheim Foundation. This programme supports her project focusing on the computational design of molecules with therapeutic potential. Read more

CRC1093 Workshop

Drug Discovery and its Challenges

The drug discovery workshop provides insight into applied research in the pharmaceutical industry from target identification to clinical studies and emphasises the challenges of classical and modern screening methods. The workshop is a full day seminar with some short introductory lectures given by Oliver von Ahsen and literature talks that should be prepared and presented by the students in teams of two.

Lecturer: Oliver von Ahsen (Global Drug Discovery - Bayer Pharma AG, Berlin)

Saturday, 12th of March 2016  Programme

1st International Symposium 2015

Supramolecular Chemistry on Proteins

Crc1093 International Symposium 2015 1500 X 700

We thank all speakers and participants for this successful and inspiring symposium!