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Collaborative Research Centre 1093: Supramolecular Chemistry on Proteins

Protein function is intimately connected with supramolecular chemistry: Substrate processing and various levels of regulation involve specific noncovalent interactions. Likewise, protein folding, assembly and protein-protein interactions are governed by intermolecular forces and their specific inhibition or support represents a very promising area for external interference, with profound mechanistic and therapeutic implications.

The CRC aims at applying recent knowledge and methods from supramolecular chemistry to achieve specific interaction with proteins by artificial ligands.

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Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation

M. Weith, J. Seiler, J. van den Boom, M. Kracht, J. Hülsmann, I. Primorac, J. Del Pino Garcia, F. Kaschani, M. Kaiser, A. Musacchio, M. Bollen, H. Meyer.

Mol Cell. 2018 Nov 15;72(4):766-777.e6.

SFB1093 starts into the 2nd funding period

 

[28.10.2017] The SFB 1093 will start into its second round in 2018: the German Research Foundation (DFG) will fund 18 interdisciplinary projects for another 4 years with around 10 million Euro. The CRC “Supramolecular Chemistry on Proteins” aims at a deeper understanding of the underlying principles of protein recognition and functional modulation by supramolecular ligands.

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