Supramolecular Chemistry on Proteins

Protein function is intimately connected with supramolecular chemistry: Substrate processing and various levels of regulation involve specific noncovalent interactions. Likewise, protein folding, assembly and protein-protein interactions are governed by intermolecular forces and their specific inhibition or support represents a very promising area for external interference, with profound mechanistic and therapeutic implications.

The CRC aims at applying recent knowledge and methods from supramolecular chemistry to achieve specific interaction with proteins by artificial ligands.


3rd International CRC1093 Symposium Supramolecular Principles in Biological Systems

10 – 12 September 2019
University of Duisburg-Essen, Essen, Germany

The third CRC 1093 International Symposium will focus on supramolecular principles in biological systems.


New Associated Member Doris Hellerschmied joins the CRC1093

Doris Hellerschmied has been appointed as a group leader at the Faculty of Biology recently and will start now to collaborate with several groups within the CRC as an associated member. She will study the molecular interactions between chaperones and their client proteins, and modulate these interactions with chemical probes (read more).

Sad News

We all grieve the loss of our dear colleague and friend Prof. Dr. Carsten Schmuck who passed away on August 1, 2019. Carsten was an excellent scientist, teacher and mentor. His excellent research within the field of supramolecular and combinatorial chemistry and his extraordinary commitment as a group leader and vice speaker was highly appreciated in our consortium. We sorely miss him. He will be in our thoughts.

Aspire Lecture and Autumn School Leadership and Diversity: The Key to Excellence

The keynote lecture of Dr. Gaby Schilling is the opening event for the 3-days autumn school for CRC PhD-students and Postdocs offering several workshops and individual coachings about leadership, project management, and career planning (view program).

The lecture starts on Monday, Sept 30 at 11:15 am in S07 S00 D07. Guests are most welcome.

Recent Publication Mol Cell 2018 Nov 15

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation. M. Weith, J. Seiler, J. van den Boom, M. Kracht, J. Hülsmann, I. Primorac, J. Del Pino Garcia, F. Kaschani, M. Kaiser, A. Musacchio, M. Bollen, H. Meyer.

Recent Publication ChemMedChem 2019 Jun

Chemical validation of DegS as a target for the development of antibiotics with a novel mode of action. J. Bongard, A. L. Schmitz, A. Wolf, G. Zischinsky, M. Pieren, B. Schellhorn, K. Bravo-Rodriguez, J. Schillinger, U. Koch, P. Nussbaumer, B. Klebl, J. Steinmann, J. Buer, E. Sanchez-Garcia, M. Ehrmann, M. Kaiser.

SFB1093 starts into the 2nd funding period


[28.10.2017] The SFB 1093 will start into its second round in 2018: the German Research Foundation (DFG) will fund 18 interdisciplinary projects for another 4 years with around 10 million Euro. The CRC “Supramolecular Chemistry on Proteins” aims at a deeper understanding of the underlying principles of protein recognition and functional modulation by supramolecular ligands.

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International Symposium 2017 Picture Gallery


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