Collaborative Research Centre 1093: Supramolecular Chemistry on Proteins

Protein function is intimately connected with supramolecular chemistry: Substrate processing and various levels of regulation involve specific noncovalent interactions. Likewise, protein folding, assembly and protein-protein interactions are governed by intermolecular forces and their specific inhibition or support represents a very promising area for external interference, with profound mechanistic and therapeutic implications.

The CRC aims at applying recent knowledge and methods from supramolecular chemistry to achieve specific interaction with proteins by artificial ligands.

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Recent Publication Chemical validation of DegS as a target for the development of antibiotics with a novel mode of action

J. Bongard, A. L. Schmitz, A. Wolf, G. Zischinsky, M. Pieren, B. Schellhorn, K. Bravo-Rodriguez, J. Schillinger, U. Koch, P. Nussbaumer, B. Klebl, J. Steinmann, J. Buer, E. Sanchez-Garcia, M. Ehrmann, M. Kaiser.

ChemMedChem 10.1002/cmdc.201900193.

Recent Publication Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation

M. Weith, J. Seiler, J. van den Boom, M. Kracht, J. Hülsmann, I. Primorac, J. Del Pino Garcia, F. Kaschani, M. Kaiser, A. Musacchio, M. Bollen, H. Meyer.

Mol Cell. 2018 Nov 15;72(4):766-777.e6.

Recent Publication Covalent Surface Functionalization of Calcium Phosphate Nanoparticles with Fluorescent Dyes by Copper-Catalysed and by Strain-Promoted Azide-Alkyne Click Chemistry

Leonardo Rojas-Sanchez, Viktoriya Sokolova, Steffen Riebe, Jens Voskuhl and Matthias Epple

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SFB1093 starts into the 2nd funding period

 

[28.10.2017] The SFB 1093 will start into its second round in 2018: the German Research Foundation (DFG) will fund 18 interdisciplinary projects for another 4 years with around 10 million Euro. The CRC “Supramolecular Chemistry on Proteins” aims at a deeper understanding of the underlying principles of protein recognition and functional modulation by supramolecular ligands.

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3rd International Symposium 2019

Supramolecular Principles in Biological Systems

10 – 12 September 2019
University of Duisburg-Essen, Essen, Germany

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International Symposium 2017 Picture Gallery

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