Protein function is intimately connected with supramolecular chemistry: Substrate processing and various levels of regulation involve specific noncovalent interactions. Likewise, protein folding, assembly and protein-protein interactions are governed by intermolecular forces and their specific inhibition or support represents a very promising area for external interference, with profound mechanistic and therapeutic implications.
The CRC aims at applying recent knowledge and methods from supramolecular chemistry to achieve specific interaction with proteins by artificial ligands.
The group of Dr. Barbara Sacca, principle investigator of the CRC1093, has now succeeded with the help of supramolecular chemistry to construct tiny, tailor-made DNA-nanocontainers entrapping target proteins in a specific fashion. Read More
Congratulations to Jean-Pierre Sauvage, Fraser Stoddart und Ben Feringa for the Nobel prize in Chemistry!
From left to right:Jean-Pierre Sauvage, Fraser Stoddart und Bernard Feringa
The three researchers use Supramolecular Chemistry for the development of molecular machines. Jean-Pierre Sauvage became famous for his “molecular knots”, Fraser Stoddart for numerous molecular tools, and Ben Feringa for the first molecular motor. Supramolecular Chemistry is also one of the main research areas at the Faculty of Chemistry and unifying scheme of our CRC 1093 “Supramolecular Chemistry on Proteins”.
The Nobel prize 2016 was awarded “for the design and synthesis of molecular machines.” Read More: www.nobelprize.org
Pictures: Strasbourg University / Northwestern University / University of Groningen
Molecular Tweezers and Protein Aggregation
Frank-Gerrit Klärner and Thomas Schrader have designed and optimized molecular tweezers with a unique structure which makes them selective for lysine and arginine residues. Their fruitful collaboration with Gal Bitan from the David Geffen School of Medicine at the University of California, Los Angeles, revealed the ability of these tweezers to inhibit aberrant peptide and protein aggregation, which is a common pathogenic feature of neurodegenerative diseases like Alzheimer’s, Parkinson’s or Transthyretin (TTR)-related Amyloidosis. Latest promising results offer the prospect of developing molecular tweezers as suitable drug candidates. Thomas Schrader, Frank-Gerrit Klärner and Gal Bitan, who was also an invited guest professor of our CRC, have now summarized the properties and the potential of these molecular tweezers in the renowned journal Chemical Communications: “Molecular tweezers for lysine and arginine – powerful inhibitors of pathologic protein aggregation”. This Feature Article carries the issue’s front cover.
Our second Graduate Student Symposium took place from 31st of August to 2nd of Septemberat the GHotel in Hannover. 45 graduate students from the CRC1093 of Duisburg-Essen and the CRC765 of Berlin discussed latest results within the field of supramolecular chemistry. Read More
"PLUS3" Grant from the Boehringer Ingelheim Foundation
CRC1093 Principal Investigator Dr. Elsa Sánchez-García received the prestigious “PLUS3” grant from the Boehringer Ingelheim Foundation. This programme supports her project focusing on the computational design of molecules with therapeutic potential. Read more
Drug Discovery and its Challenges
The drug discovery workshop provides insight into applied research in the pharmaceutical industry from target identification to clinical studies and emphasises the challenges of classical and modern screening methods. The workshop is a full day seminar with some short introductory lectures given by Oliver von Ahsen and literature talks that should be prepared and presented by the students in teams of two.
Lecturer: Oliver von Ahsen (Global Drug Discovery - Bayer Pharma AG, Berlin)