CRC 1093 - Publications

Joint publications of CRC members

2021

A. Dudziak, L. Engelhard, C. Bourque, B. U. Klink, P. Rombaut, N. Kornakov, K. Jänen, F. Herzog, C. Gatsogiannis, S. Westermann: Phospho-regulated Bim1/EB1 interactions trigger Dam1c ring assembly at the budding yeast outer kinetochore. EMBO J 2021 Jul 27:e108004. doi: 10.15252/embj.2021108004.

M. Böhm, K. Killinger, A. Dudziak, P. Pant, K. Jänen, S. Hohoff, K. Mechtler, M. Örd, M. Loog , E. Sanchez-Garcia , S. Westermann: Cdc4 phospho-degrons allow differential regulation of Ame1CENP-U protein stability across the cell cycle. Elife 2021 Jul 26;10:e67390. doi: 10.7554/eLife.67390.

O. Wetzel, S. Hosseini, K. Loza, Kateryna, M. Heggen, O. Prymak, P. Bayer, C. Beuck, T. Schaller, F. Niemeyer, C. Weidenthaler, M. Epple: Metal-ligand interface and internal structure of ultrasmall silver nanoparticles (2 nm). J Phys Chem B 2021; 125. doi: 10.1021/acs.jpcb.1c02512

K. Walstein, A. Petrovic, D. Pan, B. Hagemeier, D. Vogt, I. R. Vetter, A. Musacchio: Assembly principles and stoichiometry of a complete human kinetochore module. Sci Adv 2021 Jun 30;7(27):eabg1037. doi: 10.1126/sciadv.abg1037.

V. Sokolova, M. Epple: Biological and medical applications of calcium phosphate nanoparticles. Chem Eur J 2021 May 12; 27(27):7471-7488. doi: 10.1002/chem.202005257

P. Pasch, M. Killa, H. L. Junghans, M. Schmidt, S. Schmidt, J. Voskuhl, L. Hartmann: Take your Positions and Shine: Effects of Positioning Aggregation-Induced Emission Luminophores within Sequence-Defined Macromolecules. Chemistry 2021 Apr 20. doi: 10.1002/chem.202101086.

A. Meiners, S. Bäcker, I. Hadrovic, C. Heid, C. Beuck, Y. B. Ruiz-Blanco, J. Mieres-Perez, M. Pörschke, J.-N. Grad, C. Vallet, D. Hoffmann, P. Bayer, E. Sanchez-Garcia *, T. Schrader*, S. K. Knauer*: Targeting a protein epitope: Specific inhibition of the Survivin-CRM1 interaction by peptide-modified molecular tweezers. *corresponding authors Nature Commun 2021, doi 10.1038/s41467-021-21753-9.

P. Pasch, A. Höing, S. Ueclue, M. Killa, J. Voskuhl, S. K. Knauer , L. Hartmann: PEGylated sequence-controlled macromolecules using supramolecular binding to target the Taspase1/Importin α interaction. Chem Commun (Camb) 2021 Feb 24. doi: 10.1039/d0cc07139k.

T. Ruks, K. Loza, M. Heggen, O. Prymak, A. L. Sehnem, C. L. P. Oliveira, P. Bayer, C. Beuck, M. Epple: Peptide-conjugated ultrasmall gold nanoparticles (2 nm) for selective protein targeting. ACS Applied Bio Materials 2021; 4 (1): 945-965. doi: 10.1021/acsabm.0c01424

R. Malishev, N. Salinas, J. Gibson, A. B. Eden, J. Mieres-Perez, Y. B. Ruiz-Blanco, O. Malka, S. Kolusheva, F. G. Klärner, T. Schrader , E. Sanchez-Garcia, C. Wang, M. Landau, G. Bitan, R. Jelinek: Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers. Cell Chem Biol 2021 Apr 2:S2451-9456(21)00152-5. doi: 10.1016/j.chembiol.2021.03.013.

V. Kumar, T. Holtum, D. Sebena, M. Giese, J. Voskuhl , S. Schlücker : Ultraviolet resonance Raman spectroscopy with a continuously tunable picosecond laser: Application to the supramolecular ligand guanidiniocarbonyl pyrrole (GCP). Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 5;250:119359. doi: 10.1016/j.saa.2020.119359.

N. Tötsch, D. Hoffmann: Classifier uncertainty: evidence, potential impact, and probabilistic treatment. Peer J Computer Science 2021. 7:e398 https://doi.org/10.7717/peerj-cs.398

T. Ruks, K. Loza, M. Heggen, C. Ottmann, P. Bayer, C. Beuck, M. Epple: Targeting the surface of the protein 14-3-3 by ultrasmall gold nanoparticles (1.5 nm), carrying the specific peptide CRaf. Chem Bio Chem 2021 Apr 16;22(8):1456-1463. doi: 10.1002/cbic.202000761.

M. Erkelenz, R. Kosinski, O. Sritharan, H. Giesler, B. Saccà , S. Schlücker : Site-specific facet protection of gold nanoparticles inside a 3D DNA origami box: a tool for molecular plasmonics. Chem Commun (Camb) 2021 Feb 26. doi: 10.1039/d0cc07712g.

P. Singh, M. E. Pesenti, S. Maffini, S. Carmignani, M. Hedtfeld, A. Petrovic, A. Srinivasamani, T. Bange, A. Musacchio: BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis. Mol Cell 2021 Jan 7;81(1):67-87.e9. doi: 10.1016/j.molcel.2020.10.040

V. Piano, A. Alex, P. Stege, S. Maffini, G. A. Stoppiello, P. J. Huis in ‘t Veld, I. Vetter, A. Musacchio: CDC20 assists its catalytic incorporation in the mitotic checkpoint complex. Science 2021 Jan 1;371(6524):67-71. doi: 10.1126/science.abc1152

S. B. van der Meer, I. Hadrovic, A. Meiners, K. Loza, M. Heggen, S. Knauer, P. Bayer, T. Schrader, C. Beuck,M. Epple: New Tools to Probe the Protein Surface: Ultrasmall Gold Nanoparticles Carry Amino Acid Binders. J Phys Chem B 2021 Jan 14;125(1):115-127. doi: 10.1021/acs.jpcb.0c09846

S. B. van der Meer, T. Seiler, C. Buchmann, G. Partalidou, S. Boden, K. Loza, M. Heggen, J. Linders, O. Prymak, L. Hartmann, C. L. P. Oliveira, M. Epple: Controlling the surface functionalization of ultrasmall gold nanoparticles by sequence-defined macromolecules. Chem Eur J 2021 Jan 18; 27(4):1451-1464. doi: 10.1002/chem.202003804

2020

F. Jacobi, D. Wilms, T. Seiler, T. Queckbörner, M. Tabatabai, L. Hartmann, S. Schmidt: The effect of PEGylation on receptor anchoring and steric shielding at interfaces: an adhesion and surface plasmon resonance study with precision polymers. Biomacromolecules2020. 21:4850–4856. doi/10.1021/acs.biomac.0c01060

D. Schütz, Y. B. Ruiz-Blanco, J. Münch, F. Kirchhoff, E. Sanchez-Garcia, J. A. Müller: Peptide and peptide-based inhibitors of SARS-CoV-2 entry. Adv Drug Deliv Rev 2020 Dec;167:47-65. doi: 10.1016/j.addr.2020.11.007.

T. Holtum, V. Kumar, D. Sebena, J. Voskuhl , S. Schlücker : UV resonance Raman spectroscopy of the supramolecular ligand guanidiniocarbonyl indole (GCI) with 244 nm laser excitation. Beilstein J Org Chem 2020 Nov 27;16:2911-2919. doi: 10.3762/bjoc.16.240.

K. Wey, M. Epple: Ultrasmall gold and silver/gold nanoparticles (2 nm) as autofluorescent labels for poly(D,L-lactide-co-glycolide) nanoparticles (140 nm), J Mater Sci Mater Med 2020 Nov 28;31(12):117. doi 10.1007/s10856-020-06449-8.

N. Kornakov, B. Mollers, S. Westermann: The EB1-Kinesin-14 complex is required for efficient metaphase spindle assembly and kinetochore bi-orientation. J Cell Biol 2020 Oct 7, 219 (12): e202003072. doi: 10.1083/jcb.202003072

P. Bayer, A. Matena, C. Beuck: NMR Spectroscopy of supramolecular chemistry on protein surfaces. Beilstein J Org Chem 2020 Oct 9;16:2505-2522. doi: 10.3762/bjoc.16.203.

L. Rojas-Sánchez, K. Loza, M. Epple: Synthesis and intracellular tracing of surface-functionalized calcium phosphate nanoparticles by super-resolution microscopy (STORM), Materialia 2020; 12:100773. doi: 10.1016/j.mtla.2020.100773.

T. Lieblein, R. Zangl, J. Martin, J. Hoffmann, M. Hutchinson, T. Stark, T. Schrader, H. Schwalbe and N. Morgner: Structural rearrangement of Aβ42 upon inhibitor binding suppresses formation of toxic Alzheimer oligomers. eLife 2020 Oct 23;9:e59306. doi: 10.7554/eLife.59306.

M. Kracht, J. van den Boom, J. Seiler, A. Kröning, F. Kaschani, M. Kaiser, H. Meyer: Protein phosphatase-1 complex disassembly by p97 is initiated through multivalent recognition of catalytic and regulatory subunits by the p97 SEP-domain adapters. J Mol Biol 2020 Oct 12; S0022-2836(20)30576-3 doi: 10.1016/j.jmb.2020.10.001.

D. Smolin, N. Tötsch, J.-N. Grad, J. Linders, F. Kaschani, M. Kaiser, M. Kirsch, D. Hoffmann, T. Schrader: Accelerated Trypsin Autolysis by Affinity Polymer Templates. RSC Advances 2020, 10, 28711-28719. doi: 10.1039/D0RA05827K

V. Sokolova, G. Mekky, S. B. van der Meer, M. C. Seeds, A. J. Atala, M. Epple: Transport of ultrasmall gold nanoparticles (2 nm) across the blood-brain barrier in a six-cell brain spheroid model. Sci Rep 2020 Oct 22;10(1):18033. doi: 10.1038/s41598-020-75125-2.

T. Weil, R. Groß, A. Röcker, K. Bravo-Rodriguez, C. Heid, A. Sowislok, M.-H. Le, N. Erwin, M. Dwivedi, S. Bart, P. Bates, L. Wettstein, J. Müller, M. Harms, K. Sparrer, Y. B. Ruiz-Blanco, C. Stuerzel, J. von Einem, S. Lippold, C. Read, P. Walther, M. Hebel, F. Kreppel, F.-G. Klärner, G. Bitan, M. Ehrmann , T. Weil, R. Winter, T. Schrader* , J. Shorter*, E. Sanchez-Garcia*, J. Muench*: Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers. J Am Chem Soc 2020 Sep 14.doi: 10.1021/jacs.0c06400.*corresponding authors

N. Bengoa-Vergniory, E. Faggiani, P. Ramos, E. Kirkiz, N. Connor-Robson, S. Vingill, M. Cioroch, F. Cavaliere, S. Threlfell, B. Roberts, T. Schrader, F.-G. Klarner, S. Cragg, B. Dehay, G. Bitan, C. Matute-Almau, E. Bezard, R. Wade-Martins: CLR01 protects dopaminergic neurons in vitro and in vivo in human neurons and mouse models of Parkinson’s. Nature Commun 2020 Sep 28;11(1):4885. doi: 10.1038/s41467-020-18689-x.

E. Sijbesma , E. Visser , K. Plitzko, P. Thiel, L.-G. Milroy, M. Kaiser, L. Brunsveld, C. Ottmann: Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions. Nature Commun 2020 Aug 7;11(1): 3954.doi: 10.1038/s41467-020-17741-0.

E. Stepula, X. P. Wang, S. Srivastav, M. König, J. Levermann, S. Kasimir-Bauer, S. Schlücker : 6-Color/1-Target Immuno-SERS Microscopy on the Same Single Cancer Cell. ACS Appl Mater Interfaces 2020 Jul 10. doi: 10.1021/acsami.0c07269.

S. Kollenda, M. Kopp, J. Wens, J. Koch, N. Schulze, C. Papadopoulos, R. Pöhler, H. Meyer, M. Epple: A pH-sensitive fluorescent protein sensor to follow the pathway of calcium phosphate nanoparticles into cells. Acta Biomater 2020 Jul 15;111:406-417. doi: 10.1016/j.actbio.2020.05.014.

V. Sokolova, G. Nzou, S. B. van der Meer, T. Ruks, M. Heggen, K. Loza, N. Hagemann, F. Murke, B. Giebel, D. M. Hermann, A. J. Atala, M. Epple: Ultrasmall gold nanoparticles (2 nm) can penetrate and enter cell nuclei in an in vitro 3D brain spheroid model. Acta Biomater 2020 Jul 15;111:349-362. doi: 10.1016/j.actbio.2020.04.023.

N. Toetsch, D. Hoffmann: Bayesian Data Integration Questions Classic Study on Protease Self-Digest Kinetics. ACS Omega 2020 Jun22, https://dx.doi.org/10.1021/acsomega.0c01109

K. Killinger, M. Böhm, P. Steinbach, G. Hagemann, M. Blüggel, K. Jänen, S. Hohoff, P. Bayer, F. Herzog, S. Westermann: Auto-inhibition of Mif2/CENP-C Ensures Centromere-Dependent Kinetochore Assembly in Budding Yeast. EMBO J 2020 Jun 9;e102938, doi: 10.15252/embj.2019102938.

N. Sadeghi, A. Kirupakaran, F.-G. Klärner, T. Schrader: Molecular Clips and Tweezers modify Protein Function. Supramolecular Protein Chemistry. Chapter 6, Peter Cowley, Editor; Royal Society of Chemistry, London 2020, doi:10.1039/9781788019798-00161

M. Giese, J. Niemeyer , J. Voskuhl: Guanidiniocarbonyl-Pyrroles (GCP) – 20 Years of the Schmuck Binding Motif. Chem Plus Chem 2020,10.1002/cplu.202000142

A. Goehring, I. Michin, T. Gerdes, N. Schulze, M. Blueggel, E. Rehic, F. Kaschani, M. Kaiser, P. Bayer: Targeting of parvulin interactors by diazirine mediated cross-linking discloses a cellular role of human Par14/17 in actin polymerization. Biol Chem 2020, 401(8): 955–968. doi: 10.1515/hsz-2019-0423

A. Prabodh, D. Bauer, S. Kubik, P. Rebmann, F.-G. Klärner, T. Schrader, L. Delarue Bizzini, M. Mayor, F. Biedermann: Chirality Sensing of Terpenes, Steroids, Amino Acids, Peptides and Drugs with Acyclic Cucur-bit[n]urils and Molecular Tweezers. Chem Commun (Camb) 2020 Apr 7. doi: 10.1039/d0cc00707b.

D. Krahn, G. Heilmann, F. C. E. Vogel, C. Papadopoulos, S. Zweerink, F. Kaschani, H. Meyer, A. Roesch, M. Kaiser: Zelkovamycin is an OXPHOS inhibitory member of the argyrin natural product family. Chemistry 2020 Apr 6. doi: 10.1002/chem.202001577.

S. Riebe, C. Wölper, J. Baszuweit, M. Hayduk, M. Ezequiel Gutierrez Suburu, C. A. Strassert, N. L. Doltsinis, J. Voskuhl: Understanding the Role of Chalcogens in Ether-Based Luminophores with Aggregation-Induced Fluorescence and Phosphorescence". Chem Photo Chem 2020, 4, 1-10

Y. B. Ruiz-Blanco and E. Sanchez-Garcia: CL-FEP: An End-State Free Energy Perturbation Approach. J Chem Theory Comput 2020, Mar 10;16(3):1396-1410. doi: 10.1021/acs.jctc.9b00725.

C. Vallet, D. Aschmann, C. Beuck C, M. Killa M, A. Meiners A, M. Mertel M, M. Ehlers M, P. Bayer, C. Schmuck, M. Giese, S. K. Knauer: Functional Disruption of the Cancer-Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole Ligand. Angew Chem Int Ed 2020 Jan 8. doi: 10.1002/anie.201915400.

M. Merdanovic, S. G. Burston, A. L. Schmitz, S. Köcher, S. Knapp, T. Clausen, M. Kaiser, R. Huber, M. Ehrmann: Activation by substoichiometric inhibition. Proc Natl Acad Sci U S A 2020 Jan 21;117(3):1414-1418. doi: 10.1073/pnas.1918721117.

2019

A. Gigante, E. Sijbesma , P. A. Sánchez-Murcia, X. Hu, D. Bier, S. Bäcker, S. K. Knauer, Gago F, C. Ottmann, C. Schmuck : A Supramolecular Stabilizer of the 14-3-3ζ/ERα Protein-Protein Interaction with a Synergistic Mode of Action. Angew Chem Int Ed 2019 Dec 9. doi: 10.1002/anie.201914517.

A. Alex, V. Piano, S. Polley, M. Stuiver, S. Voss, G. Ciossani, K. Overlack, B. Voss, S. Wohlgemuth, A. Petrovic, Y. Wu, P. Selenko, A. Musacchio *, S. Maffini S*: Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology. Elife 2019 e48287. doi: 10.7554/eLife.48287. *co-corresponding authors.

M. Blueggel, J. van den Boom, H. Meyer, P. Bayer, C. Beuck: Structure of the PUB Domain from Ubiquitin Regulatory X Domain Protein 1 (UBXD1) and Its Interaction with the p97 AAA+ ATPase. Biomolecules 2019 Dec 14;9(12). pii: E876. doi: 10.3390/biom9120876.

A. Kuusk, J. F. Neves, K. Bravo Rodriguez, A. Gunnarsson, Y. B. Ruiz-Blanco, M. Ehrmann, H. Chen, I. Landrieu, E. Sanchez-Garcia , H. Boyd, C. Ottmann, R. G. Doveston: Adoption of a Turn Conformation Drives the Binding Affinity of p53 C-Terminal Domain Peptides to 14-3-3σ. ACS Chem Biol 2019 Nov doi 10.1021/acschembio.9b00893.

A. Jaekel, P. Stegemann, B. Saccà: Manipulating Enzymes Properties with DNA Nanostructures. Molecules 2019, 24(20), 3694; doi: 10.3390/molecules24203694

I. Hadrovic, P. Rebmann, F.-G. Klärner, G. Bitan, T. Schrader: Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. Frontiers in Chemistry, Mini Review, 01 October 2019. doi: 10.3389/fchem.2019.00657

D. Pan, K. Walstein, A. Take, D. Bier, N. Kaiser, A. Musacchio: Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing. Nature Commun 2019 Sep 6;10(1):4046. doi: 10.1038/s41467-019-12019-6.

S. Köcher, S. Resch, T. Kessenbrock, L. Schrapp, M. Ehrmann, M. Kaiser: From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides. Nat Prod Rep 2019 Aug 27. doi: 10.1039/c9np00033j.

J. Hatai and C. Schmuck : Artificial Peptide and Protein Receptors Supramolecular Chemistry in Water, Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim, 2019, 79-113, Doi: 10.1002/9783527814923.ch3.

N. Berger, L. J. B Wollny, P. Sokkar, S. Mittal, J. Mieres-Perez, R. Stoll, W. Sander, E. Sanchez-Garcia: Solvent-Enhanced Conformational Flexibility of Cyclic Tetrapeptides. Chem phys chem 2019 Jul 2;20(13):1664-1670. doi: 10.1002/cphc.201900345.

L. Li, N. Erwin, S. Möbitz, F. Niemeyer, T. Schrader, R. Winter: Dissociation of the Signaling Protein K-Ras4B from Lipid Membranes Induced by a Molecular Tweezer. Chem Eur J 2019, Jul 25;25(42):9827-9833. doi: 10.1002/chem.201901861.

G. Ertürk, M. Akhoundian, K. Kujawski ,S. Shinde, S. Yee Yeung, M. Hedström, T. Schrader, B. Mattiasson, B. Sellergren: Bisphosphonate Ligand Mediated Ultrasensitive Capacitive Protein Sensor: Complementary Match of Supramolecular and Dynamic Chemistry. New J Chem 2019, 43, 847-852. doi.org/10.1039/C8NJ05238G

L. Bartsch, M. Bartel, J. Iglesias Fernandez, Y. Ruiz Blanco, C. Beuck, J. Briels, A. Gigante, N. Toetsch, P. Bayer , E. Sanchez-Garcia , C. Ottmann, C. Schmuck : Multivalent ligands with tailor-made anion binding motif as stabilizers of protein-protein interactions. Chem bio chem 2019 Jun 6. doi: 10.1002/cbic.201900288.

D. Maity, A. Gigante, P. A. Sánchez-Murcia, E. Sijbesma, M. Li, D. Bier, S. Mosel, S. K. Knauer, C. Ottmann, C. Schmuck : Arginine mimetic appended peptide-based probes for fluorescence turn-on detection of 14-3-3 proteins, Org Biomol Chem 2019, 17, 4359-4363, Doi: 10.1039/C9OB00620F.

S. B. van der Meer, K. Loza, K. Wey, M. Heggen, C. Beuck, P. Bayer, M. Epple: Click chemistry on the surface of ultrasmall gold nanoparticles (2 nm) for covalent ligand attachment followed by NMR spectroscopy”, Langmuir 2019, 35, 6288-6296.

J. Bongard, A. L. Schmitz, A. Wolf, G. Zischinsky, M. Pieren, B. Schellhorn, K. Bravo-Rodriguez, J. Schillinger, U. Koch, P. Nussbaumer, B. Klebl, J. Steinmann, J. Buer, E. Sanchez-Garcia, M. Ehrmann, M. Kaiser: Chemical validation of DegS as a target for the development of antibiotics with a novel mode of action. Chem Med Chem 10.1002/cmdc.201900193.

L. Rojas-Sanchez, V. Sokolova, S. Riebe, J. Voskuhl, M. Epple: Covalent Surface Functionalization of Calcium Phosphate Nanoparticles with Fluorescent Dyes by Copper-Catalysed and by Strain-Promoted Azide-Alkyne Click Chemistry. ChemNanoMat 2019, 5, 436 –446, Doi: 10.1002/cnma.201800509

T. Ruks, C. Beuck, T. Schaller, F. C. Niemeyer, M. Zähres, K. Loza, M. Heggen, U. Hagemann, C. Mayer, P. Bayer, M. Epple: Solution NMR spectroscopy with isotope-labelled cysteine (13C, 15N) reveals the surface structure of L-cysteine-coated ultrasmall gold nanoparticles (1.8 nm). Langmuir 2019, 35 (3), 767-778 Doi: 10.1021/acs.langmuir.8b03840

V. Sokolova, L. Rojas-Sánchez, N. Białas, N. Schulze, M. Epple: Calcium phosphate nanoparticle-mediated transfection in 2D and 3D mono- and co-culture cell models. Acta Biomaterialia 2019, 84 391–401

A. Gigante, J. N. Grad, J. Briels, M. Bartel, D. Hoffmann, C. Ottmann, C. Schmuck : A new class of supramolecular ligands stabilizes 14-3-3 protein–protein interactions by up to two orders of magnitude. Chem Commun 2019, 55, 111-114, Doi: 10.1039/C8CC07946C.

2018

M. Weith, J. Seiler, J. van den Boom, M. Kracht, J. Hülsmann, I. Primorac, J. Del Pino Garcia, F. Kaschani, M. Kaiser, A. Musacchio, M. Bollen, H. Meyer: Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation. Mol Cell 2018 Nov 15;72(4):766-777.e6. doi: 10.1016/j.molcel.2018.09.020.

K. Kujawski, C. Heid, T. Schrader: Maßgeschneiderte Liganden für Protein-Protein-Interaktionen. BIOspektrum 2018, 24, 387-389, Springer. Doi: 10.1007/s12268-018-0934-5.

M. E. Pesenti, D. Prumbaum, P. Auckland, C. M. Smith, A. C. Faesen, A. Petrovic, M. Erent, S. Maffini, S. Pentakota, J. R. Weir, Y.-C. Lin, S. Raunser, A. D. McAinsh, A. Musacchio: Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80. Mol Cell 2018 Sep 20; 71(6):923–939.e10. doi:10.1016/j.molcel.2018.07.038.

S. A. Hill, C. Gerke, L. Hartmann: (2018) Recent Developments in Solid-Phase Strategies towards Synthetic, Sequence-Defined Macromolecules. Chem Asian J 13:3611-3622. doi/full/10.1002/asia.201801171

V. Halder, J. Oeljeklaus, G. Heilmann, J.H. Krahn, Y. Liu, Y. Xiong, M. Schlicht, J. Schillinger, B. Kracher, M. Ehrmann, E. Kombrink, F. Kaschani, M. Kaiser: Identification of the Natural Product Rotihibin A as a TOR Kinase Signaling Inhibitor by Unbiased Transcriptional Profiling. Chemistry 2018 Aug 27;24(48):12500-12504. doi: 10.1002/chem.201802647.

M. Hayduk , S. Riebe, J. Voskuhl: Phosphorescence Through Hindered Motion of Pure Organic Emitters. Chemistry 2018 Aug 22;24(47):12221-12230. doi: 10.1002/chem.201800521.

Schillinger J, Severin K, Kaschani F, M. Kaiser, M. Ehrmann: HTRA1-Dependent Cell Cycle Proteomics. J Proteome Res 2018 Aug 3;17(8):2679-2694. doi: 10.1021/acs.jproteome.8b00129.

C. Heid, A. Sowislok, T. Schaller, F. Niemeyer, F.G. Klärner, T. Schrader: Molecular Tweezers with Additional Recognition Sites. Chemistry 2018 Aug 6;24(44):11332-11343. doi: 10.1002/chem.201801508.

M. Nshanian, C. Lantz, P. Wongkongkathep, T. Schrader, F.-G. Klärner, A. Blümke, C. Despres, M. Ehrmann, C. Smet-Nocca, G. Bitan, J. A. Loo: Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator. J Am Soc Mass Spectrom 2018. DOI: 10.1007/s13361-018-2027-6

K. Bravo-Rodriguez, B. Hagemeier, L. Drescher, M. Lorenz, J. Rey, M. Meltzer, F. Kaschani, M. Kaiser, M. Ehrmann: Utilities for Mass Spectrometry Analysis of Proteins: Fast post processing of mass spectrometry data. Rapid Commun Mass Spectrom 2018 Jul 31. doi: 10.1002/rcm.8243.

E. Yilmaz, D. Bier, X. Guillory, J. Briels, Y. B. Ruiz-Blanco, E. Sanchez-Garcia, C. Ottmann, M. Kaiser: Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry 2018 Jun 20. doi: 10.1002/chem.201801074.

S. Wagner, A. Z. Politi, A. Ast, K. Bravo-Rodriguez, K. Baum, A. Buntru, N. U. Strempel, L. Brusendorf, C. Hänig, A. Boeddrich, S. Plassmann, K. Klockmeier, J. M. Ramirez-Anguita, E. Sanchez-Garcia, J. Wolf and E Wanker: Self -assembly of Mutant Huntingtin Exon-1 Fragments into Large Complex Fibrillar Structures Involves Nucleated Branching. J Mol Biol 2018. 430:1725-1744. doi: 10.1016/j.jmb.2018.03.017

M. Hayduk, S. Riebe, K. Rudolph, S. Schwarze, F. van der Vight, C. G. Daniliuc, G. Jansen, J. Voskuhl: Molecular Recognition of Spermine using Aggregation-Induced Emission. Israel Journal of Chemistry 2018 58(8) June 2018 Doi: 10.1002/ijch.201800037

F. Trusch, L. Loebach, S. Wawra, E. Durward, A. Wuensch, N. A. Iberahim, I. de Bruijn, K. MacKenzie, A. Willems, A. Toloczko, J. Diéguez-Uribeondo, T. Rasmussen, T. Schrader, P. Bayer, C. J. Secombes & P. van West: Cell entry of a host-targeting protein of oomycetes requires gp96. Nature Commun 2018, 9, 2347. doi: 10.1038/s41467-018-04796-3.

V. A. Volkov, P. J. Huis In 't Veld, M. Dogterom, A. Musacchio: Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces. Elife 2018 Apr 9;7. pii: e36764. doi: 10.7554/eLife.36764.

J.Bongard, M. Lorenz, I. R. Vetter , P. Stege, A. T. Porfetye, A. L. Schmitz, F. Kaschani, A. Wolf, U. Koch, P. Nussbaumer, B. Klebl, M. Kaiser, M. Ehrmann: Identification of Noncatalytic Lysine Residues from Allosteric Circuits via Covalent Probes. ACS Chem Biol 2018, 13, 5, 1307–1312 Doi: 10.1021/acschembio.8b00101

S. Mittal, K. Bravo-Rodriguez, E. Sanchez-Garcia: Mechanism of Inhibition of Beta Amyloid Toxicity by Supramolecular Tweezers. J Phys Chem B 2018 Apr 19;122(15):4196-4205. doi: 10.1021/acs.jpcb.7b10530.

M. Li, S. Mosel, S. K. Knauer, C. Schmuck: A dipeptide with enhanced anion binding affinity enables cell uptake and protein delivery. Org Biomol Chem 2018 Mar 28;16(13):2312-2317. doi: 10.1039/c7ob02721d.

R. Pöhler, J. H. Krahn, J. van den Boom, G. Dobrynin, F. Kaschani, H.-M. Eggenweiler, F. T. Zenke, M. Kaiser, H. Meyer: A Non-Competitive Inhibitor of VCP/p97 and VPS4 RevealsConserved Allosteric Circuits in Type I and II AAA ATPases. Angew Chem Int Ed 2018 Volume 57, Issue 6, February 5, DOI: 10.1002/anie.201711429

M. Ehlers, J. N. Grad, S. Mittal, D. Bier, M. Mertel, L. Ohl, M. Bartel, J. Briels, M. Heimann, C. Ottmann, E. Sanchez-Garcia, D. Hoffmann, C. Schmuck: Rational Design, Binding Studies, and Crystal-Structure Evaluation of the First Ligand Targeting the Dimerization Interface of the 14-3-3ζ Adapter Protein. Chembiochem 2018 Mar 16;19(6):591-595. doi: 10.1002/cbic.201700588.

J. Stelzer, C. Vallet, A. Sowa, D. Gonzalez‐Abradelo, S. Riebe, C. G. Daniliuc, M. Ehlers, C. A. Strassert, S. Knauer, J. Voskuhl: On the Influence of Substitution Patterns in Thioether‐Based Luminophores with Aggregation‐Induced Emission Properties. Chemistry Select 2018, 25 Jan. 2018, doi 10.1002/slct.201702900

B. Zakeri, S. Niebling, A. G. Martinéz, P. Sokkar, E. Sanchez-Garcia, C. Schmuck, S. Schlücker: Molecular recognition of carboxylates in the protein leucine zipper by a multivalent supramolecular ligand: residue-specific, sensitive and label-free probing by UV resonance Raman spectroscopy. Phys Chem Chem Phys 2018 Jan 17;20(3):1817-1820. doi: 10.1039/c7cp04971d.

J. N. Grad, A. Gigante, C. Wilms, J. N. Dybowski, L. Ohl, C. Ottmann, C. Schmuck, D. Hoffmann: Locating Large, Flexible Ligands on Proteins. J Chem Inf Model. 2018 Jan 11. doi: 10.1021/acs.jcim.7b00413.

J. Wissler, M. Wehmeyer, S. Bäcker, S. Knauer , S. Schlücker : Simultaneous Rayleigh/Mie and Raman/Fluorescence Characterization of Molecularly Functionalized Colloids by Correlative Single-Particle Real-Time Imaging in Suspension. Anal Chem 2018 Jan 2;90(1):723-728. doi: 10.1021/acs.analchem.7b02528

W. Pfeifer, P. Lill, C. Gatsogiannis, B. Saccà: Hierarchical Assembly of DNA Filaments with Designer Elastic Properties. ACS Nano 2018 Jan 23;12(1):44-55. doi: 10.1021/acsnano.7b06012

Publications 2014-2017 First Funding Period

Complete list of publications

Chemical Ligands and Methods Publications Area A

Sorted by project:

  • Project A1
    Protein-recognition by supramolecular ligands from focused combinatorial libraries (Carsten Schmuck)
  • Project A2
    Natural products as starting structures for the development of supramolecular ligands (Markus Kaiser)
  • Project A3
    Designed copolymers and molecular tweezers for protein surface recognition (Thomas Schrader)
  • Project A5
    Protein-specific nanoparticles for cellular uptake (Matthias Epple)
  • Project A6
    DNA-based nanocontainers for predesigned spatial confinement of proteins (Barbara Saccà)
  • Project A7
    Pareto-optimization of protein-surface targeting supramolecular binders with hetero-avidity (Daniel Hoffmann)
  • Project A8
    Exploring protein-recognition by supramolecular binders with MD and QM/MM methods (Elsa Sánchez-Garcia)
  • Project A9
    Raman spectroscopic monitoring of protein recognition by supramolecular ligands (Sebastian Schlücker)
  • Project A10
    Novel luminophores with aggregation induced emission properties for protein recognition (Jens Voskuhl)
  • Project A11
    Precision macromolecules for the sequence-controlled presentation of supramolecular ligands (Laura Hartmann)

Biological Targets Publications Area B

Sorted by project:

  • Project B1
    Supramolecular ligands modulate assembly and function of HtrA proteases (Michael Ehrmann)
  • Project B2
    Probing mechanisms of the Cdc48/p97 segregase with designed supramolecular ligands (Hemmo Meyer)
  • Project B4
    Modulation of 14-3-3 protein-protein interactions by supramolecular chemistry (Christian Ottmann)
  • Project B5
    Dissection and modulation of (patho)biological Survivin functions by supramolecular ligands (Shirley Knauer)
  • Project B6
    Targeting centromer recruitment of mitotic regulators by supramolecular ligands (Andrea Musacchio)
  • Project B7
    Manipulation of the kinetochore-microtubule interface by supramoleular ligands (Stefan Westermann)

Central Service Projects Publications Area Z

Sorted by project: