CRC 1093 - Publications Project B5

Area B: Biological Targets

Publications by Prof. Dr. Shirley Knauer

Project B5:
Dissection and modulation of (patho)biological Survivin functions by supramolecular ligands

A. Höing, A. Zimmermann, L. Moews, M. Killa, M. Heimann, A. Hensel, J. Voskuhl*, S. K. Knauer*: A Bivalent Supramolecular GCP Ligand Enables Blocking of the Taspase1/Importin α Interaction. ChemMedChem 2021 Oct 8. doi: 10.1002/cmdc.202100640. *corresponding authors

A. Meiners, S. Bäcker, I. Hadrovic, C. Heid, C. Beuck, Y. B. Ruiz-Blanco, J. Mieres-Perez, M. Pörschke, J.-N. Grad, C. Vallet, D. Hoffmann, P. Bayer, E. Sanchez-Garcia *, T. Schrader*, S. K. Knauer*: Targeting a protein epitope: Specific inhibition of the Survivin-CRM1 interaction by peptide-modified molecular tweezers. *corresponding authors Nat. Comm. 2021, doi 10.1038/s41467-021-21753-9.

C. Vallet, D. Aschmann, C. Beuck C, M. Killa M, A. Meiners A, M. Mertel M, M. Ehlers M, P. Bayer, C. Schmuck, M. Giese, S. K. Knauer: Functional Disruption of the Cancer-Relevant Interaction between Survivin and Histone H3 with a Guanidiniocarbonyl Pyrrole Ligand. Angew Chem Int Ed Engl. 2020 Jan 8. doi: 10.1002/anie.201915400.

M. Li, M. Ehlers, S. Schlesiger, E. Zellermann, S. K. Knauer, C. Schmuck: Incorporation of a Non-Natural Arginine Analogue into a Cyclic Peptide Leads to Formation of Positively Charged Nanofibers Capable of Gene Transfection. Angew Chem Int Ed Engl . 2015, Nov 27. doi: 10.1002/anie.201508714.

M. Li, S. Schlesiger, S. K. Knauer, C. Schmuck: A Tailor-Made Specific Anion-Binding Motif in the Side Chain Transforms a Tetrapeptide into an Efficient Vector for Gene Delivery. Angew Chem Int Ed Engl . 2015, Jan 22.

J. van den Boom, M. Mamić, D. Baccelliere, S. Zweerink, F. Kaschani, S. Knauer, P. Bayer M. Kaiser: Peptidyl succinimidyl peptides as taspase 1 inhibitors. Chembiochem. 2014,Oct 13;15(15):2233-7.

G. Dördelmann, D. Kozlova, S. Karczewski, R. Lizio, S. Knauer, M. Epple: Calcium phosphate increases the encapsulation efficiency of hydrophilic drugs (proteins, nucleic acids) into poly (D,L-lactide-co-glycolide acid) nanoparticles for intracellular delivery. J. Mater. Chem. B. 2014, 2, 7250.

H. Y. Kuchelmeister, S. Karczewski, A. Gutschmidt, S. Knauer, C. Schmuck: Utilizing combinatorial chemistry and rational design: peptidic tweezers with nanomolar affinity to DNA can be transformed into efficient vectors for gene delivery by addition of a lipophilic tail. Angew Chem Int Ed Engl. 2013, Dec 23;52(52):14016-20.

S. K. Knauer, B. Unruhe, S. Karczewski, R. Hecht, V. Fetz, C. Bier, S. Friedl, B. Wollenberg, R. Pries, N. Habtemichael, U. R. Heinrich, R. H. Stauber. Functional Characterization of Novel Mutations Affecting Survivin (BIRC5)-Mediated Therapy Resistance in Head and Neck Cancer Patients. Hum. Mutat. 2013, 34, 395-404.

D. Wünsch, V. Fetz, D. Heider, S. Tenzer, C. Bier, L. Kunst, S. K. Knauer*, R. H. Stauber*. Chemico-genetic strategies to inhibit the leukemic potential of Threonine Aspartase-1.  Blood Cancer J. 2012, 2, e77, 1-3.

C. Bier, S. K. Knauer*, D. Wünsch, L. Kunst, S. Scheiding, M. Kaiser, C. Ottmann, O. H. Krämer, R. H. Stauber*. Allosteric inhibition of Taspase1's pathobiological activity by enforced dimerization in vivoFASEB J. 2012, 26, 3421-3429.

H. Y. Kuchelmeister, S. Tillmann, A. Gutschmidt, S. K. Knauer, C. Schmuck. Efficient Gene Delivery into Cells by a Surprisingly Small Three-Armed Peptide Ligand. Chem. Sci. 2012, 3, 996-1002.

C. Bier*, R. Hecht, L. Kunst, D. Wünsch, D. Gösswein, G. Schneider, O. H. Krämer, S.K. Knauer*, R. H. Stauber*. Overexpression of catalytically impaired Taspase1T234V or Taspase1D233A variants does not have a dominant negative effect in t(4;11) leukemia cells. PLOS One 2012, 7, e34142, 1-12.

N. Habtemichael, D. Wünsch, C. Bier, S. Tillmann, B. Unruhe, K. Frauenknecht, U. R. Heinrich, W.J. Mann, R. H. Stauber, S. K. Knauer*. Cloning and functional characterization of the guinea pig apoptosis inhibitor protein Survivin. Gene 2010, 469, 9-17.

R. H. Stauber, W. Mann, S. K. Knauer. Nuclear and Cytoplasmic Survivin: Molecular Mechanism, Prognostic and Therapeutic Potential. Cancer Res. 2007, 67, 5999-6002.

S. K. Knauer, O. H. Kramer, T. Knosel, K. Engels, F. Rodel, A. F. Kovacs, W. Dietmaier, L. Klein-Hitpass, N. Habtemichael, A. Schweitzer, J. Brieger, C. Rodel, W. Mann, I. Petersen, T. Heinzel, R. H. Stauber. Nuclear export is essential for the tumor-promoting activity of survivin. FASEB J. 2007, 21, 207-216.

S. K. Knauer, C. Bier, N. Habtemichael, R. H. Stauber. The survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function. EMBO Rep. 2006, 7, 1259-1265.

S. K. Knauer, W. Mann, R. H. Stauber. Survivin's dual role: an export's view. Cell Cycle 2007, 6, 518-521.

More Publications Area B

  • Project B1
    Supramolecular ligands modulate assembly and function of HtrA proteases (Michael Ehrmann)
  • Project B2
    Probing mechanisms of the Cdc48/p97 segregase with designed supramolecular ligands (Hemmo Meyer)
  • Project B3
    Supramolecular specific inhibitors of intestinal proteases against ischemia/reperfusion injury (Herbert de Groot)
  • Project B4
    Modulation of 14-3-3 protein-protein interactions by supramolecular chemistry (Christian Ottmann)
  • Project B5
  • Project B6
    Targeting centromer recruitment of mitotic regulators by supramolecular ligands (Andrea Musacchio)

Chemical Ligands and Methods Publications Area A

  • Project A1
    Protein-recognition by supramolecular ligands from focused combinatorial libraries (Carsten Schmuck)
  • Project A2
    Natural products as starting structures for the development of supramolecular ligands (Markus Kaiser)
  • Project A3
    Designed copolymers and molecular tweezers for protein surface recognition (Thomas Schrader)
  • Project A5
    Protein-specific nanoparticles for cellular uptake (Matthias Epple)
  • Project A6
    DNA-based nanocontainers for predesigned spatial confinement of proteins (Barbara Saccà)
  • Project A7
    Pareto-optimization of protein-surface targeting supramolecular binders with hetero-avidity (Daniel Hoffmann)
  • Project A8
    Exploring protein-recognition by supramolecular binders with MD and QM/MM methods (Elsa Sánchez-García)
  • Project A9
    Raman spectroscopic monitoring of protein recognition by supramolecular ligands (Sebastian Schlücker)