CRC 1093 - Publications Project B6

Area B: Biological Targets

Publications by Hon. Prof. Dr. Andrea Mussachio

Project B6:
Targeting centromere recruitment of mitotic regulators by supramolecular ligands

A. Petrovic, J. Keller, Y. Liu, K. Overlack, J. John, Y. Dimitrova, S. Jenni, S. van Gerwen, P. Stege, S. Wohlgemuth,P. Rombaut, F. Herzog, S.C. Harrison, I. Vetter, A. Musacchio: Structure of the MIS12 complex and molecular basis of its interaction with CENP-C at human kinetochores. Cell 2016 167:1020-1040.

J.R. Weir, A.C. Faesen, K. Klare, A. Petrovic, F. Basilico, J. Fischböck, S. Pentakota, J. Keller, M.E. Pesenti, D. Pan, D. Vogt, S. Wohlgemuth, F. Herzog, A. Musacchio: Insights from biochemical reconstitution into the architecture of human kinetochores. Nature. 2016 Aug 31;537(7619):249-253. doi: 10.1038/nature19333. Epub ahead of print

A. Friese, A.C. Faesen, P. J. Huis In 't Veld, J. Fischböck, D. Prumbaum, A. Petrovic, S. Raunser, F. Herzog, A. Musacchio: Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin. Nat Commun. 2016 7:11407. doi: 10.1038/ncomms11407.

V. Krenn, A. Musacchio: The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling. Front Oncol. 2015, 5:225. doi: 10.3389/fonc.2015.00225.

A. Musacchio: The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics. Curr Biol. 2015, 25:R1002-18. doi: 10.1016/j.cub.2015.08.051.

A. Altenfeld, S. Wohlgemuth, A. Wehenkel, I.R. Vetter, A. Musacchio: Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the human Rod-Zwilch-ZW10 (RZZ) complex. Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):438-42. doi: 10.1107/S2053230X15004343. Epub 2015 Mar 20.

A. Eiteneuer, J. Seiler, M. Weith, M. Beullens, B. Lesage, V. Krenn, A. Musacchio, M. Bollen, H. Meyer: Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 to kinetochore-bound protein phosphatase-1. EMBO J.. 2014, Nov 18;33(22):2704-20.

V. Krenn, A. Wehenkel, X. Li, S. Santaguida & A. Musacchio: Structural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interaction. J. Cell Biol. 2012, 196, 451-467.

A. De Antoni, S. Maffini, S. Knapp, A. Musacchio* & S. Santaguida: A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B. J. Cell Biol. 2012, 199, 269-284. (* co-corresponding author)

S. Santaguida, C. Vernieri, F. Villa, A. Ciliberto & A. Musacchio: Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction. EMBO J. 2011, 30, 1508-1519.

A. Petrovic, S. Pasqualato, P. Dube, V. Krenn, S. Santaguida, D. Cittaro, S. Monzani, L. Massimiliano, J. Keller, A. Tarricone, A. Maiolica, H. Stark & A. Musacchio: The MIS12 complex is a protein interaction hub for outer kinetochore assembly. J. Cell Biol. 2010, 190, 835-852.

S. Santaguida, A. Tighe, A. M. D'Alise, S. S. Taylor & A. Musacchio: Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J. Cell Biol. 2010, 190, 73-87.

G. M. Alushin, V. H. Ramey, S. Pasqualato, D. A. Ball, N. Grigorieff, A. Musacchio & E. Nogales: The Ndc80 kinetochore complex forms oligomeric arrays along microtubules. Nature 2010, 467, 805-10. 

F. Villa et al.: Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 20204-20209.

S. Santaguida & A. Musacchio: The life and miracles of kinetochores. EMBO J. 2009, 28, 2511–2531.

C. Ciferri, S. Pasqualato, E. Screpanti & A. Musacchio: Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. Cell 2008, 133, 427-439.

More Publications Area B

  • Project B1
    Supramolecular ligands modulate assembly and function of HtrA proteases (Michael Ehrmann)
  • Project B2
    Probing mechanisms of the Cdc48/p97 segregase with designed supramolecular ligands (Hemmo Meyer)
  • Project B3
    Supramolecular specific inhibitors of intestinal proteases against ischemia/reperfusion injury (Herbert de Groot)
  • Project B4
    Modulation of 14-3-3 protein-protein interactions by supramolecular chemistry (Christian Ottmann)
  • Project B5
    Dissection and modulation of (patho)biological Survivin functions by supramolecular ligands (Shirley Knauer)
  • Project B6

Chemical Ligands and Methods Publications Area A

  • Project A1
    Protein-recognition by supramolecular ligands from focused combinatorial libraries (Carsten Schmuck)
  • Project A2
    Natural products as starting structures for the development of supramolecular ligands (Markus Kaiser)
  • Project A3
    Designed copolymers and molecular tweezers for protein surface recognition (Thomas Schrader)
  • Project A5
    Protein-specific nanoparticles for cellular uptake (Matthias Epple)
  • Project A6
    DNA-based nanocontainers for predesigned spatial confinement of proteins (Barbara Saccà)
  • Project A7
    Pareto-optimization of protein-surface targeting supramolecular binders with hetero-avidity (Daniel Hoffmann)
  • Project A8
    Exploring protein-recognition by supramolecular binders with MD and QM/MM methods (Elsa Sánchez-García)
  • Project A9
    Raman spectroscopic monitoring of protein recognition by supramolecular ligands (Sebastian Schlücker)