CRC 1093 - Publications Project B2

Area B: Biological Targets

Publications by Prof. Dr. Hemmo Meyer

Project B2 (Hemmo Meyer):
Probing mechanisms of the Cdc48/p97 segregase with designed supramolecular ligands

J. van den Boom, A. F. Kueck, B. Kravic, H. Müschenborn, M. Giesing, D. Pan, F. Kaschani, M. Kaiser, A. Musacchio, H. Meyer: Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly. Nat Struct Mol Biol 2021 Nov 25. doi: 10.1038/s41594-021-00684-5.

M. Kracht, J. van den Boom, J. Seiler, A. Kröning, F. Kaschani, M. Kaiser, H. Meyer: Protein phosphatase-1 complex disassembly by p97 is initiated through multivalent recognition of catalytic and regulatory subunits by the p97 SEP-domain adapters. J Mol Biol. 2020 Oct 12; S0022-2836(20)30576-3. doi: 10.1016/j.jmb.2020.10.001.

M. Weith, J. Seiler, J. van den Boom, M. Kracht, J. Hülsmann, I. Primorac, J. Del Pino Garcia, F. Kaschani, M. Kaiser, A. Musacchio, M. Bollen, H. Meyer: Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation. Mol Cell. 2018 Nov 15;72(4):766-777.e6. doi: 10.1016/j.molcel.2018.09.020.

R. Pöhler, J. H. Krahn, J. van den Boom, G. Dobrynin, F. Kaschani, H.-M. Eggenweiler, F. T. Zenke, M.Kaiser, H. Meyer: A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases. Angew Chem Int Ed Engl. 2018 Volume 57, Issue 6, February 5, DOI: 10.1002/anie.201711429

C. Papadopoulos, P. Kirchner, M. Bug, D. Grum, L. Koerver, N. Schulze, R. Poehler, A. Dressler, S. Fengler, K. Arhzaouy, V. Lux, M. Ehrmann, C. C. Weihl , H. Meyer: VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. EMBO J. 2017, 36:135-150

J. van den Boom, M. Wolf, L. Weimann, N. Schulze, F. Li, F. Kaschani, A. Riemer, C. Zierhut, M. Kaiser, G. Iliakis, H. Funabiki, H. Meyer: VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. Molecular Cell 2016 64, 189–198 October 6.

A. Eiteneuer, J. Seiler, M. Weith, M. Beullens, B. Lesage, V. Krenn, A. Musacchio, M. Bollen, H. Meyer: Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 to kinetochore-bound protein phosphatase-1. EMBO J.. 2014, Nov 18;33(22):2704-20.

Dobrynin G, Popp O, Romer T, Bremer S, Schmitz MHA, Gerlich  DW and Meyer H.: Cdc48/p97Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells.  J. Cell Sci. 2011, 124:1571-80.

Ritz D., Vuk M.,Kirchner P., Bug M, Schütz S, Hayer A, Bremer S., Lusk C., Baloh RH, Lee H, Glatter T., Gstaiger M., Aebersold R., Weihl C.C., Meyer H.: Endolysosomal sorting of ubiquitinated caveolin-1 is regulated by VCP/p97 and UBXD1 and impaired by VCP disease mutations. Nat. Cell Biol. 2011, 13:1116-23.

Meerang M, Ritz D, Paliwal S, Garajova Z, Bosshard M, Mailand N, Janscak P, Hüscher U, Meyer H, Ramadan K.: The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double strand breaks.. Nat. Cell Biol., 2011, 13:1376-82.

Ramadan K, Bruderer R, Spiga F, Popp O, Baur T, Gotta M, and Meyer H.: Cdc48/p97 promotes reformation of the nucleus by extracting Aurora B kinase from chromatin. Nature, 2007, 450, 1258-62.

Wang Y, Satoh A, Warren G, and Meyer H.: VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments. J. Cell Biol. 2004, 164: 973-978.

Bruderer RM, Brasseur C, and Meyer HH: The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism. J Biol Chem. 2004, 279:49609-16.

 Zhang X, Shaw A, Bates PA, Newman RH, Gowen B, Orlova E, Gorman MA, Kondo H, Dokurno P, Lally J, Leonard G, Meyer HH, van Heel M, Freemont PS.: Structure of the AAA ATPase p97. Mol Cell. 2000, 6:1473-84.

More Publications Area B

  • Project B1
    Supramolecular ligands modulate assembly and function of HtrA proteases (Michael Ehrmann)
  • Project B2
  • Project B3
    Supramolecular specific inhibitors of intestinal proteases against ischemia/reperfusion injury (Herbert de Groot)
  • Project B4
    Modulation of 14-3-3 protein-protein interactions by supramolecular chemistry (Christian Ottmann)
  • Project B5
    Dissection and modulation of (patho)biological Survivin functions by supramolecular ligands (Shirley Knauer)
  • Project B6
    Targeting centromer recruitment of mitotic regulators by supramolecular ligands (Andrea Musacchio)

Chemical Ligands and Methods Publications Area A

  • Project A1
    Protein-recognition by supramolecular ligands from focused combinatorial libraries (Carsten Schmuck)
  • Project A2
    Natural products as starting structures for the development of supramolecular ligands (Markus Kaiser)
  • Project A3
    Designed copolymers and molecular tweezers for protein surface recognition (Thomas Schrader)
  • Project A5
    Protein-specific nanoparticles for cellular uptake (Matthias Epple)
  • Project A6
    DNA-based nanocontainers for predesigned spatial confinement of proteins (Barbara Saccà)
  • Project A7
    Pareto-optimization of protein-surface targeting supramolecular binders with hetero-avidity (Daniel Hoffmann)
  • Project A8
    Exploring protein-recognition by supramolecular binders with MD and QM/MM methods (Elsa Sánchez-García)
  • Project A9
    Raman spectroscopic monitoring of protein recognition by supramolecular ligands (Sebastian Schlücker)