CRC 1093 - Publications Project B2

Area B: Biological Targets

Publications by Prof. Dr. Hemmo Meyer

Project B2 (Hemmo Meyer):
Probing mechanisms of the Cdc48/p97 segregase with designed supramolecular ligands

M. Weith, J. Seiler, J. van den Boom, M. Kracht, J. Hülsmann, I. Primorac, J. Del Pino Garcia, F. Kaschani, M. Kaiser, A. Musacchio, M. Bollen, H. Meyer: Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation. Mol Cell. 2018 Nov 15;72(4):766-777.e6. doi: 10.1016/j.molcel.2018.09.020.

R. Pöhler, J. H. Krahn, J. van den Boom, G. Dobrynin, F. Kaschani, H.-M. Eggenweiler, F. T. Zenke, M.Kaiser, H. Meyer: A Non-Competitive Inhibitor of VCP/p97 and VPS4 Reveals Conserved Allosteric Circuits in Type I and II AAA ATPases. Angew Chem Int Ed Engl. 2018 Volume 57, Issue 6, February 5, DOI: 10.1002/anie.201711429

C. Papadopoulos, P. Kirchner, M. Bug, D. Grum, L. Koerver, N. Schulze, R. Poehler, A. Dressler, S. Fengler, K. Arhzaouy, V. Lux, M. Ehrmann, C. C. Weihl , H. Meyer: VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy. EMBO J. 2017, 36:135-150

J. van den Boom, M. Wolf, L. Weimann, N. Schulze, F. Li, F. Kaschani, A. Riemer, C. Zierhut, M. Kaiser, G. Iliakis, H. Funabiki, H. Meyer: VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. Molecular Cell 2016 64, 189–198 October 6.

A. Eiteneuer, J. Seiler, M. Weith, M. Beullens, B. Lesage, V. Krenn, A. Musacchio, M. Bollen, H. Meyer: Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 to kinetochore-bound protein phosphatase-1. EMBO J.. 2014, Nov 18;33(22):2704-20.

Dobrynin G, Popp O, Romer T, Bremer S, Schmitz MHA, Gerlich  DW and Meyer H.: Cdc48/p97Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells.  J. Cell Sci. 2011, 124:1571-80.

Ritz D., Vuk M.,Kirchner P., Bug M, Schütz S, Hayer A, Bremer S., Lusk C., Baloh RH, Lee H, Glatter T., Gstaiger M., Aebersold R., Weihl C.C., Meyer H.: Endolysosomal sorting of ubiquitinated caveolin-1 is regulated by VCP/p97 and UBXD1 and impaired by VCP disease mutations. Nat. Cell Biol. 2011, 13:1116-23.

Meerang M, Ritz D, Paliwal S, Garajova Z, Bosshard M, Mailand N, Janscak P, Hüscher U, Meyer H, Ramadan K.: The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double strand breaks.. Nat. Cell Biol., 2011, 13:1376-82.

Ramadan K, Bruderer R, Spiga F, Popp O, Baur T, Gotta M, and Meyer H.: Cdc48/p97 promotes reformation of the nucleus by extracting Aurora B kinase from chromatin. Nature, 2007, 450, 1258-62.

Wang Y, Satoh A, Warren G, and Meyer H.: VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments. J. Cell Biol. 2004, 164: 973-978.

Bruderer RM, Brasseur C, and Meyer HH: The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism. J Biol Chem. 2004, 279:49609-16.

 Zhang X, Shaw A, Bates PA, Newman RH, Gowen B, Orlova E, Gorman MA, Kondo H, Dokurno P, Lally J, Leonard G, Meyer HH, van Heel M, Freemont PS.: Structure of the AAA ATPase p97. Mol Cell. 2000, 6:1473-84.

More Publications Area B

  • Project B1
    Supramolecular ligands modulate assembly and function of HtrA proteases (Michael Ehrmann)
  • Project B2
  • Project B3
    Supramolecular specific inhibitors of intestinal proteases against ischemia/reperfusion injury (Herbert de Groot)
  • Project B4
    Modulation of 14-3-3 protein-protein interactions by supramolecular chemistry (Christian Ottmann)
  • Project B5
    Dissection and modulation of (patho)biological Survivin functions by supramolecular ligands (Shirley Knauer)
  • Project B6
    Targeting centromer recruitment of mitotic regulators by supramolecular ligands (Andrea Musacchio)

Chemical Ligands and Methods Publications Area A

  • Project A1
    Protein-recognition by supramolecular ligands from focused combinatorial libraries (Carsten Schmuck)
  • Project A2
    Natural products as starting structures for the development of supramolecular ligands (Markus Kaiser)
  • Project A3
    Designed copolymers and molecular tweezers for protein surface recognition (Thomas Schrader)
  • Project A5
    Protein-specific nanoparticles for cellular uptake (Matthias Epple)
  • Project A6
    DNA-based nanocontainers for predesigned spatial confinement of proteins (Barbara Saccà)
  • Project A7
    Pareto-optimization of protein-surface targeting supramolecular binders with hetero-avidity (Daniel Hoffmann)
  • Project A8
    Exploring protein-recognition by supramolecular binders with MD and QM/MM methods (Elsa Sánchez-García)
  • Project A9
    Raman spectroscopic monitoring of protein recognition by supramolecular ligands (Sebastian Schlücker)