CRC 1093 - Publications Project A2

Area A: Chemical Ligands and Methods

Publications by Prof. Dr. Markus Kaiser

Project A2 (Markus Kaiser):
Natural products as starting structures for the development of supramolecular ligands

D. Krahn, G. Heilmann, F. C. E. Vogel, C. Papadopoulos, S. Zweerink, F. Kaschani, H. Meyer, A. Roesch, M. Kaiser: Zelkovamycin is an OXPHOS inhibitory member of the argyrin natural product family. Chemistry. 2020 Apr 6. doi: 10.1002/chem.202001577.

S. Köcher, S. Resch, T. Kessenbrock, L. Schrapp, M. Ehrmann, M. Kaiser: From dolastatin 13 to cyanopeptolins, micropeptins, and lyngbyastatins: the chemical biology of Ahp-cyclodepsipeptides. Nat Prod Rep. 2019 Aug 27. doi: 10.1039/c9np00033j.

J. Bongard, A. L. Schmitz, A. Wolf, G. Zischinsky, M. Pieren, B. Schellhorn, K. Bravo-Rodriguez, J. Schillinger, U. Koch, P. Nussbaumer, B. Klebl, J. Steinmann, J. Buer, E. Sanchez-Garcia, M. Ehrmann, M. Kaiser: Chemical validation of DegS as a target for the development of antibiotics with a novel mode of action. ChemMedChem 10.1002/cmdc.201900193.

V. Halder, J. Oeljeklaus, G. Heilmann, J.H. Krahn, Y. Liu, Y. Xiong, M. Schlicht, J. Schillinger, B. Kracher, M. Ehrmann, E. Kombrink, F. Kaschani, M. Kaiser: Identification of the Natural Product Rotihibin A as a TOR Kinase Signaling Inhibitor by Unbiased Transcriptional Profiling. Chemistry. 2018 Aug 27;24(48):12500-12504. doi: 10.1002/chem.201802647.

E. Yilmaz, D. Bier, X. Guillory, J. Briels, Y.B. Ruiz-Blanco, E. Sanchez-Garcia, C. Ottmann, M. Kaiser: Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry. 2018 Jun 20. doi: 10.1002/chem.201801074.

S. Koecher, J. Rey, J. Bongard, A. N. Tiaden, M. Meltzer, P. Richards, M. Ehrmann, M. Kaiser: Tailored Ahp-cyclodepsipeptides as potent non-covalent serine protease inhibitors. Angew. Chem. Int. Ed. 2017 May 17. doi: 10.1002/anie.201701771

J. van den Boom, M. Wolf, L. Weimann, N. Schulze, F. Li, F. Kaschani, A. Riemer, C. Zierhut, M. Kaiser, G. Iliakis, H. Funabiki, H. Meyer: VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair. Molecular Cell 2016 64, 189–198 October 6.

M. Ehrmann, F. Kaschani , M. Kaiser: Chemical proteomics versus Leishmaniasis. Chem. Biol. 2015, 22:309-310

J. van den Boom, M. Mamić, D. Baccelliere, S. Zweerink, F. Kaschani, S. Knauer, P. Bayer M. Kaiser: Peptidyl succinimidyl peptides as taspase 1 inhibitors. Chembiochem. 2014,Oct 13;15(15):2233-7.

C. Meesters, T. Mönig, J. Oeljeklaus, D. Krahn, C. S. Westfall, B. Hause, J. M. Jez, M. Kaiser, E. Kombrink: A chemical inhibitor of jasmonate signaling targets JAR1 in Arabidopsis thaliana. Nat Chem Biol. 2014 Aug 17.

S. C. Stolze, M. Meltzer, M. Ehrmann, M. Kaiser: Development of a solid-phase approach to the natural product class of Ahp containing cy-clodepsipeptides. Eur. J. Org. Chem. 2012, 1616-1625.

F. Kaschani, S. Nickel, B. Pandey, B. F. Cravatt, M. Kaiser, R. A. L. van der Hoorn: Selective inhibition of plant serine hydrolases by agrochemicals revealed by competitive ABPP. Bioorg. Med. Chem. 2012, 20, 597-600. 

F. Kaschani, J. Clerc, D. Krahn, D. Bier, T. N. Hong, C. Ottmann, S. Niessen, T. Colby, R. A. L. van der Hoorn, M. Kaiser: Identification of a selective, activity-based probe for GAPDHs. Angew. Chem. Int. Ed. 2012,51, 5230-5233.

L. Trübestein, A. Tennstaedt, T. Mönig, T. Krojer, F. Canellas, M. Kaiser, T. Clausen, M. Ehrmann: Substrate induced remodeling of the active site regulates HtrA1 activity. Nat. Struct. Mol. Biol. 2011, 18, 386-388.

I. Kolodziejek, J. C. Misas-Villamil, F. Kaschani, J. Clerc, C. Gu, D. Krahn, S. Nies-sen, M. Verdoes, L. I. Willems, H. S. Overkleeft, M. Kaiser, R. A.L. van der Hoorn: Proteasome activity imaging and profiling characterizes bacterial effector Syringolin A. Plant Physiol. 2011, 155, 477-489.

T. Clausen, M. Kaiser, R. Huber, M. Ehrmann: HTRA proteases: regulated proteolysis in protein quality control. Nat. Rev. Mol. Cell Biol. 2011, 12, 152-162.

M. Merdanovic, N. Mamant, M. Meltzer, S. Poepsel, A. Auckenthaler, R. Melgaard, P. Hauske, L. Nagel-Steger, A. R. Clarke, M. Kaiser, R. Huber, M. Ehrmann: Determinants of structural and functional plasticity of the widely conserved protease chaperone machine DegP. Nat. Struct. Mol. Biol. 2010, 17, 837-843.

S. C. Stolze, M. Meltzer, M. Ehrmann, M. Kaiser: Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A. Chem. Commun. 2010, 46, 8857–8859; 

P. Hauske, M. Meltzer, C. Ottmann, T. Krojer, T. Clausen, M. Ehrmann, M. Kaiser: Selectivity profiling of DegP sub-strates and inhibitors. Bioorg. Med. Chem. 2009, 17, 2920-2924. 

J. Clerc, B. I. Florea, M. Kraus, M. Groll, R. Huber, A. S. Bachmann, R. Dudler, C. Driessen, H. S. Overkleeft, M. Kaiser: Syringolin A selectively labels the 20S proteasome in murine EL4 and wildtype and bortezomib adapted leukemic cell lines. Chembiochem. 2009, 10, 2638-2643. 

J. Clerc, M. Groll, D. Nukic, A. S. Bachmann, R. Huber, B. Schellenberg, R. Dudler, M. Kaiser: Synthetic and structural studies on Syringolin A and B reveal critical determinants for se-lectivity and potency of proteasome inhibition. Proc. Natl. Acad. Sci. USA 2009, 106, 6507-6512.

Z. Wang, C. Gu, T. Colby, T. Shindo, R. Balamurugan, H. Waldmann, M. Kaiser, R. A. L. van der Hoorn: -lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana. Nat. Chem. Biol. 2008, 4, 557-563.

M. Meltzer, S. Hasenbein, P. Hauske, N. Kucz, M. Merdanovic, S. Grau, A. Beil, D. Jones, T. Krojer, T. Clausen, M. Ehrmann, M. Kaiser: Allosteric activation of HtrA protease DegP by stress signals during bacterial protein quality control. Angew. Chem. Int. Ed. 2008, 47, 1332-1334.

M. Groll, B. Schellenberg, A. S. Bachmann*, C. R. Archer, R. Huber, T. K. Powell, S. Lindow, M. Kaiser*, R. Dudler*: A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism. Nature 2008, 452, 755-758.

 A. Nören-Müller, W. Wilk, K. Saxena, H. Schwalbe, M. Kaiser*, H. Waldmann*: Discovery of a New Class of Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B by Biology-Oriented Synthesis. Angew. Chem. Int. Ed. 2008, 47, 5973-5977. 

More Publications Area A

  • Project A1
    Protein-recognition by supramolecular ligands from focused combinatorial libraries (Carsten Schmuck)
  • Project A2
  • Project A3
    Designed copolymers and molecular tweezers for protein surface recognition (Thomas Schrader)
  • Project A5
    Protein-specific nanoparticles for cellular uptake (Matthias Epple)
  • Project A6
    DNA-based nanocontainers for predesigned spatial confinement of proteins (Barbara Saccà)
  • Project A7
    Pareto-optimization of protein-surface targeting supramolecular binders with hetero-avidity (Daniel Hoffmann)
  • Project A8
    Exploring protein-recognition by supramolecular binders with MD and QM/MM methods (Elsa Sánchez-Garcia)
  • Project A9
    Raman spectroscopic monitoring of protein recognition by supramolecular ligands (Sebastian Schlücker)

Biological Targets Publications Area B

  • Project B1
    Supramolecular ligands modulate assembly and function of HtrA proteases (Michael Ehrmann)
  • Project B2
    Probing mechanisms of the Cdc48/p97 segregase with designed supramolecular ligands (Hemmo Meyer)
  • Project B3
    Supramolecular specific inhibitors of intestinal proteases against ischemia/reperfusion injury (Herbert de Groot)
  • Project B4
    Modulation of 14-3-3 protein-protein interactions by supramolecular chemistry (Christian Ottmann)
  • Project B5
    Dissection and modulation of (patho)biological Survivin functions by supramolecular ligands (Shirley Knauer)
  • Project B6
    Targeting centromer recruitment of mitotic regulators by supramolecular ligands (Andrea Musacchio)