CRC 1093 - Publications Project A6

Area A: Chemical Ligands and Method

Publications by Dr. B. Saccà

Project A6:
DNA-based nanocontainers for predesigned spatial confinement of proteins

R. Kosinski, A. Mukhortava, W. Pfeifer, A. Candelli, P. Rauch, B. Saccà: Sites of high local frustration in DNA origami. Nat Commun. 2019 Mar 5;10(1):1061. doi: 10.1038/s41467-019-09002-6.

W. Pfeifer, P. Lill, C. Gatsogiannis, B. Saccà: Hierarchical Assembly of DNA Filaments with Designer Elastic Properties. ACS Nano. 2017 Nov 21. doi: 10.1021/acsnano.7b06012.

A. Sprengel, P. Lill, P. Stegemann, K. Bravo-Rodriguez, E.-C. Schöneweiß, M. Merdanovic, D. Gudnason, M. Aznauryan, L. Gamrad, S. Barcikowski, E. Sanchez-Garcia , V. Birkedal, C. Gatsogiannis, M. Ehrmann , B. Saccà: Tailored protein encapsulation into a DNA host using geometrically organized supramolecular interactions. Nat. Comm. 2017. doi: 10.1038/ncomms14472

E.-C. Schöneweiß, B. Saccà: The collective behavior of spring-like motifs tethered to a DNA origami nanostructure. Nanoscale. 2017, 9, 4486

B. Saccà, Y. Ishitsuka, R. Meyer, A. Sprengel, E.C. Schöneweiß, G.U. Nienhaus, C.M. Niemeyer: Reversible Reconfiguration of DNA Origami Nanochambers Monitored by Single-Molecule FRET. Angew Chem Int Ed Engl. 2015 Jan 28.

R. Meyer, B. Saccà, C.M. Niemeyer: Site-directed, on-surface assembly of DNA nanostructures. Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12039-43. doi: 10.1002/anie.201505553.

B. Saccà: Nucleic acids nanotechnology Methods. 2014, May 15;67(2):103-4. doi: 10.1016/j.ymeth.2014.04.018.

M. Erkelenz, D.M. Bauer, R. Meyer, C. Gatsogiannis, S. Raunser, B. Saccà, C.M. Niemeyer: A Facile Method for Preparation of Tailored Scaffolds for DNA-Origami. Small 2013 Jul 17. doi: 10.1002/smll.201300701.

B. Saccà, B. Siebers, R. Meyer, M. Bayer, C. M. Niemeyer: Nanolattices of switchable DNA-based motors. Small, 2012, 8, 3000-3008. (Highlighted as cover picture)

B. Saccà, C. M. Niemeyer: Covalent tethering of protruding arms for addressable DNA nanostructures. Small 2011, 7, 2887-2898.

B. Saccà, B. Siebers, R. Meyer, M. Bayer, C. M. Niemeyer: Nanolattices of switchable DNA-based motors. Small, 2012, 8, 3000-3008. (Highlighted as cover picture)

B. Saccà, C. M. Niemeyer: Covalent tethering of protruding arms for addressable DNA nanostructures. Small 2011, 7, 2887-2898.

B. Saccà, C. M. Niemeyer: Functionalization of DNA nanostructures with proteins. Chemical Society Reviews, 2011, 40, 5910-5921.

B. Saccà, C. M. Niemeyer: DNA origami: the art of folding DNA. Angew. Chem. Int. Ed. 2011, 51, 58-66.

B. Saccà, R. Meyer, M. Erkelenz, K. S. Rabe, K. Kiko, A. Arndt, C. M. Niemeyer: Orthogonal protein decoration of DNA origami. Angew. Chem. Int. Ed. 2010, 49, 9378-9383.

B. Saccà, R. Meyer, C. M. Niemeyer: Analysis of the self-assembly of 4x4 DNA tiles by temperature-dependent FRET spectroscopy. ChemPhysChem 2009, 10, 3239-3248.

B. Saccà, R. Meyer, C. M. Niemeyer: Temperature-dependent FRET spectroscopy for the high-throughput analysis of self-assembled DNA nanostructures in real time. Nat. Protoc. 2009, 4, 271-285.

B. Saccà, R. Meyer, U. Feldkamp, H. Schroeder, C. M. Niemeyer: High-throughput, real-time monitoring of the self-assembly of DNA nanostructures by FRET spectroscopy. Angew. Chem. Int. Ed. 2008, 47, 2135-2137.

More Publications Area A

  • Project A1
    Protein-recognition by supramolecular ligands from focused combinatorial libraries (Carsten Schmuck)
  • Project A2
    Natural products as starting structures for the development of supramolecular ligands (Markus Kaiser)
  • Project A3
    Designed copolymers and molecular tweezers for protein surface recognition (Thomas Schrader)
  • Project A5
    Protein-specific nanoparticles for cellular uptake (Matthias Epple)
  • Project A6
  • Project A7
    Pareto-optimization of protein-surface targeting supramolecular binders with hetero-avidity (Daniel Hoffmann)
  • Project A8
    Exploring protein-recognition by supramolecular binders with MD and QM/MM methods (Elsa Sánchez-Garcia)
  • Project A9
    Raman spectroscopic monitoring of protein recognition by supramolecular ligands (Sebastian Schlücker)

Biological Targets Publications Area B

  • Project B1
    Supramolecular ligands modulate assembly and function of HtrA proteases (Michael Ehrmann)
  • Project B2
    Probing mechanisms of the Cdc48/p97 segregase with designed supramolecular ligands (Hemmo Meyer)
  • Project B3
    Supramolecular specific inhibitors of intestinal proteases against ischemia/reperfusion injury (Herbert de Groot)
  • Project B4
    Modulation of 14-3-3 protein-protein interactions by supramolecular chemistry (Christian Ottmann)
  • Project B5
    Dissection and modulation of (patho)biological Survivin functions by supramolecular ligands (Shirley Knauer)
  • Project B6
    Targeting centromer recruitment of mitotic regulators by supramolecular ligands (Andrea Musacchio)