Biological Targets B5: Dissection and modulation of (patho)biological Survivin functions by supramolecular ligands

Prof. Dr. Shirley Knauer

Project B5 will develop specific supramolecular binders to Survivin’s nuclear export signal to prevent interaction with its cognate receptor Crm1. Molecular recognition by combinatorial peptide ligands and modified molecular tweezers will be directed against essential unpolar amino acids and functionally characterized by comprehensive biochemical interaction assays.