CRC1093 People - Ulla Gerling-Driessen
Research within the CRC1093 Supramolecular ligands for modulating protein interactions of the cytosolic enzyme NGLY1
Research summary follows soon
Professional career
|
2021-today |
Postdoctoral Researcher / Junior group leader at the Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich-Heine-University Düsseldorf |
|
2019-2020 |
Postdoctoral Researcher / Project leader at the Department of Biochemistry, Julius-Maximilians-University Würzburg |
| 2016-2019 |
Postdoctoral Fellow with Prof. Dr. Carolyn Bertozzi (Department of Chemistry) at Stanford University, Palo Alto, CA, USA |
| 2014-2015 |
Postdoctoral Researcher with Prof. Dr. Beate Koksch (Institute of Organic Chemistry) at Freie Universität Berlin and Prof. Dr. Rainer Haag (Institute of Biomaterial Science) at Helmholtz-Zentrum Geesthacht, Berlin-Teltow |
Education
|
2009-2013 |
PhD in Chemistry, Freie Universität Berlin |
|
2006-2009 |
MSc in Chemistry, Freie Universität Berlin |
Selected Publications
M. Santos de Freitasa, R. Rezaei Araghi, E. Brandenburg, J. Leitererd, F. Emmerling, K. Folmert, U. I. M. Gerling-Driessen, B. Bardiaux, C. Böttcher, K. Pagel, A. Diehl, H. v. Berlepsch, H. Oschkinat, B. Koksch: The protofilament architecture of a de novo designed coiled coil-based amyloidogenic peptide. J. Struct. Biol. 2018;203:263–272. doi: 10.1016/j.jsb.2018.05.009.
F. M. Tomlin*, U. I. M. Gerling-Driessen*, Y-C. Liu, R. A. Flynn, J. R. Vangala, C. S. Lentz, S Clauder-Muenster, P. Jakob, W. F. Mueller, D. Ordonez, M. Paulsen, N. Matsui, D. Foley, A. Rafalko, T. Suzuki, M. Bogyo, L. M. Steinmetz, S. K. Radhakrishnan, C. R. Bertozzi: Inhibition of NGLY1 inactivates the transcription factor Nrf1 and potentiates proteasome inhibitor cytotoxicity. ACS Cent. Sci. 2017;3(11):1143-1155. doi: 10.1021/acscentsci.7b00224.
J-S. Völler, M. Dulic, U. I. M. Gerling-Driessen, H. Biava, T. Baumann, N. Budisa, I. Gruic-Sovulj, B. Koksch: Discovery and Investigation of Natural Editing Function against Artificial Amino Acids in Protein Translation. ACS Cent. Sci. 2017;3(1):73-80. doi: 10.1021/acscentsci.6b00339.
U. I. M. Gerling-Driessen, N. Mujkic-Ninnemann, D. Ponader, D. Schöne, L. Hartmann, B. Koksch: Exploiting Oligo(amido amine) Backbones for the Multivalent Presentation of Coiled-Coil Peptides. Biomacromolecules 2015; 16(8):2394-2402. doi: 10.1021/acs.biomac.5b00634.
U. I. M. Gerling*, M.S. Miettinen*, B. Koksch: Concluding the amyloid formation pathway from the size of the critical nucleus. ChemPhysChem 2015;16(1):108-114. doi: 10.1002/cphc.201402400.
U. I. M. Gerling, M. Salwiczek, C. D. Cadicamo, H. Erdbrink, C. Czekelius, S. L. Grage, P. Wadhwani, A. S. Ulrich, M. Behrends, G. Haufe, B. Koksch: Fluorinated amino acids in amyloid formation: a symphony of size, hydrophobicity, and α-helix propensity. Chem. Sci. 2014;5:819-830. doi: 10.1039/C3SC52932K.
J. Maity*, U. I. M. Gerling*, S. Vukelić, A. Schäfer, B. Koksch: Proline-glutamate chimera’s side chain conformation directs the type of β-hairpin structure. Amino Acids 2014;46(1):177-186. doi: 10.1007/s00726-013-1610-1.
M. Salwiczek, E. K. Nyakatura, U. I. M. Gerling, S. Ye, B. Koksch: Fluorinated Amino Acids: Compatibility with native protein structures and effects on protein-protein interactions. Chem. Soc Rev. 2012;41(6):2135-2171. doi: 10.1039/c1cs15241f Journal cover.
E. Brandenburg, H. v. Berlepsch, U. I. M. Gerling, C. Böttcher, B. Koksch: Inhibition of Amyloid Aggregation by Formation of Helical Assemblies. Chem. Eur. J. 2011;17(38):10651-10661. doi: 10.1002/chem.201100670.
U. I. M. Gerling, E. Brandenburg, H.v. Berlepsch, K. Pagel, B. Koksch: Structure Analysis of an Amyloid-Forming Model Peptide by a Systematic Glycine and Proline Scan. Biomacromolecules 2011;12(8):2988-96. doi: 10.1021/bm200587m.