CRC1093 People - Doris Hellerschmied

Dr. Doris Hellerschmied

Associated member since July 2019

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Phone: +49 201 183 3120
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Mechanistic Cell Biology
Faculty of Biology
University of Duisburg-Essen

Research within the CRC1093 Modulating Chaperone-Client Protein Complexes

Proper folding of proteins is essential for their functionality. To this end chaperones perform protein quality control by surveying the folding state of their clients and supporting the folding process. Misfolded client proteins that cannot be rescued are eventually degraded. In the Hellerschmied lab, we study the role of chaperones during protein folding stress in the Golgi apparatus. As part of the CRC, we will study the molecular interactions between chaperones and their client proteins, and modulate these interactions with chemical probes. In vitro reconstitution of chaperone-client complexes will give molecular insight into chaperone function and provide assays for the evaluation and characterization of supramolecular ligands. Modulating chaperone-client complexes, eventually on a cellular level, will support influencing the equilibrium between protein folding and degradation.

Professional career

2019 – present

Group leader at the University of Duisburg-Essen

2015 – 2019

EMBO Fellow at Yale University, New Haven (USA), lab of Prof. Craig

2013 – 2015

Postdoctoral Associate at the Research Institute of Molecular Pathology (IMP), Vienna (Austria), lab of Dr. Tim Clausen

Education

2009 – 2013

PhD in Molecular Biology, University of Vienna, IMP Vienna (Austria), lab of Dr. Tim Clausen

2004 – 2009

Diploma in Molecular Biology, University of Vienna (Austria)