AG Sutter

Forschungsbereich

Während den meisten Virusinfektionen ist die erste Immunantwort charakterisiert durch die Induktion von Typ I Interferon (IFN). IFN gehört zu einer Genfamilie, welche bis zu 13 verschiedene IFN-α Subtypen und IFN-β mit einschließt. Diese Interferone weisen alle unterschiedliche biologische Aktivitäten auf wie z.B. antivirale, anti-proliferative und immunmodulatorische Eigenschaften. Nach ihrer Induktion, binden alle Interferone an den gleichen Rezeptor, was zu der Expression zahlreicher verschiedener IFN-stimulierter Gene führt, welche für antivirale Proteine kodieren, die direkt die virale Replikation inhibieren wie auch die Funktion von Immunzellen modulieren. Daher ist die Induktion von Typ I IFN ein wirkungsvolles Mittel gegen Virusinfektionen anzukämpfen. Viele Viren haben Wege gefunden der IFN-Antwort zu entgehen. Deshalb sollte die therapeutische Gabe von exogenem Typ I IFN ein großes Potential für zukünftige Immuntherapien gegen Virusinfektionen besitzen. Die Arbeitsgruppe ist hauptsächlich interessiert an den verschiedenen antiviralen und immunmodulatorischen Eigenschaften aller humanen und murinen IFN-α Subtypen in akuten und chronischen Virusinfektionen. Ein besonderer Augenmerk liegt auf der Induktion der verschiedenen Subtypen, deren Regulation und ihren erschiedenen biologischen Eigenschaften besonders die Modulation von Immunantworten. 

PD Dr. rer. nat. Kathrin Sutter

IG1, Raum 2.045

Tel. 0201/723-83250

Fax 0201/723-5543

kathrin.sutter@uk-essen.de

Mitglieder der Arbeitsgruppe

​ZehraZehra Karaköse, M.Sc.

Doktorandin

Raum 2.051

Tel. 02101/723-4224

zehra.karakoese@uk-essen.de

​MaraMara Schwerdtfeger, M.Sc.

Doktorandin

Raum 2.051

Tel. 0201/723-4050

mara.schwerdtfeger@uk-essen.de

​Sandra FrancoisSandra Francois

Technische Angestellte

Raum 2.061

Tel. 0201/723-83737

sandra.francois@uk-essen.de

​Thea​​Ann Therese Paraguya

SHK

Raum 2.061

Tel. 0201/723-4055

AnnTherese.Paraguya@uk-essen.de

​random face​​​Julia Boesner

Bachelor-Studentin

Raum 2.051

Tel. 0201/723-4050

 

Publikationsliste

    2025

  • Schimmer, Simone; Kerkmann, Leonie; Kahlert, Nele; al Jubeh, Shahd; Werner, Tanja; Corkish, Carrie; Prendeville, Hannah; Finlay, David K.; Sutter, Kathrin; Dittmer, Ulf; Littwitz-Salomon, Elisabeth
    Dietary lipid overload creates a suppressive environment that impedes the antiviral functions of NK cells
    In: iScience, Jg. 28, 2025, Nr. 5, 112396
    DOI (Open Access)
  • Schlienkamp, Sarah; Veiga, Olinda Pinto; Gömer, André; Nörthemann, Luca; Sirkinti, Leyla; Frericks, Nicola; Sutter, Kathrin; Vondran, Florian W. R.; Hamprecht, Axel; Todt, Daniel; Steinmann, Eike; Kinast, Volker
    Interferon-induced immune signatures are associated with suppression of HEV infection in porcine cell culture models
    In: Emerging Microbes & Infections, Jg. 14, 2025, Nr. 1, 2525269
    DOI (Open Access)
  • Shahhamzehei, Nasim; Abdelfatah, Sara; Omer, Ejlal A.; Riedl, Max; Meesters, Christian; Schwarzer-Sperber, Hannah S.; Sutter, Kathrin; Bringmann, Gerhard; Schwarzer, Roland; Efferth, Thomas
    Diketopiperazine/piperidine alkaloid as a potential broad-spectrum coronaviral entry inhibitor identified by supercomputer-based virtual screening from a large natural product-based library
    In: Biomedicine & Pharmacotherapy, Jg. 183, 2025, 117841
    DOI (Open Access)
  • Omer, Ejlal A.; Abdelfatah, Sara; Shahhamzehei, Nasim; Guthart, Axel; Sutter, Kathrin; Schwarzer-Sperber, Hannah S.; Schwarzer, Roland; Efferth, Thomas
    Identification of nsp16 inhibitors of SARS -CoV-2, SARS -CoV-1 and MERS-CoV from FDA-approved drugs using in silico and in vitro methods
    In: Biomedicine & Pharmacotherapy, Jg. 189, 2025, 118246
    DOI (Open Access)
  • Schimmer, Simone; Sridhar, Vaasudevan; Satan, Zelal; Grebe, Anton; Saad, Mohamed; Wagner, Bernd; Kahlert, Nele; Werner, Tanja; Richter, Dana; Dittmer, Ulf; Sutter, Kathrin; Littwitz-Salomon, Elisabeth
    Iron improves the antiviral activity of NK cells
    In: Frontiers in Immunology, Jg. 15, 2025, 1526197
    DOI, Online Volltext (Open Access)
  • Zhu, Dan; Du, Yanqin; Zhao, Mengxiao; Ablikim, Dilhumare; Huang, Hongming; Pan, Wen; Zeng, Xiaoqing; Xu, Chunli; Lu, Mengji; Sutter, Kathrin; Dittmer, Ulf; Zheng, Xin; Yang, Dongliang; Liu, Jia
    Functional B cell deficiency promotes intrahepatic HBV replication and impairs the development of anti-HBV T cell responses
    In: Hepatology International, Jg. 19, 2025, Nr. 1, S. 93 – 105
    DOI
  • Du, Yanqin; Zhao, Mengxiao; Zeng, Xiaoqing; Wang, Shichuan; Wang, Qin; Chen, Liwei; Yang, Xuecheng; Feng, Xuemei; Lu, Mengji; Dittmer, Ulf; Sutter, Kathrin; Zheng, Xin; Yang, Dongliang; Xu, Chunli; Liu, Jia
    Regulatory T cells suppress TLR9-induced formation of intrahepatic myeloid-cell aggregates for T cell population expansion in liver
    In: Medical Microbiology and Immunology, Jg. 214, 2025, Nr. 1, 24
    DOI

    • 2024

  • Shahhamzehei, Nasim; Abdelfatah, Sara; Schwarzer-Sperber, Hannah S.; Sutter, Kathrin; Yücer, Rümeysa; Bringmann, Gerhard; Schwarzer, Roland; Efferth, Thomas
    Identification of nitrile-containing isoquinoline-related natural product derivatives as coronavirus entry inhibitors in silico and in vitro
    In: Biomedicine & Pharmacotherapy, Jg. 180, 2024, 117517
    DOI (Open Access)
  • Kühn, Daniel; Heinen, Natalie; Sutter, Kathrin; Herrmann, Simon T.; Nocke, Maximilian K.; Todt, Daniel; Burbelo, Peter D.; Steinmann, Eike; Ziehe, Dominik; Koos, Björn; Adamzik, Michael; Putensen, Christian; Zarbock, Alexander; Gravemann, Ute; Jork, Christine; Pfaender, Stephanie
    Divergent autoantibody and cytokine levels in COVID-19 sepsis patients influence survival
    In: Journal of Medical Virology, Jg. 96, 2024, Nr. 10, e29935
    DOI (Open Access)
  • Schreiber, Timm; Koll, Nora; Padberg, Claudia; de los Reyes, Buena; Quinting, Theresa; Malyshkina, Anna; Metzen, Eric; Sutter, Kathrin; Fandrey, Joachim; Winning, Sandra
    Reduced vacuolar ATPase protects mice from Friend virus infection : An unintended but instructive effect in Hif-2afl mice
    In: Journal of Cell Science, Jg. 137, 2024, Nr. 12, jcs261893
    DOI, Online Volltext (Open Access)
  • Albanese, Manuel; Chen, Hong-Ru; Gapp, Madeleine; Muenchhoff, Maximilian; Yang, Hsiu-Hui; Peterhoff, David; Hoffmann, Katja; Xiao, Qianhao; Ruhle, Adrian; Ambiel, Ina; Schneider, Stephanie; Mejías-Pérez, Ernesto; Stern, Marcel; Wratil, Paul R.; Hofmann, Katharina; Amann, Laura; Jocham, Linda; Fuchs, Thimo; Ulivi, Alessandro F.; Besson-Girard, Simon; Weidlich, Simon; Schneider, Jochen; Spinner, Christoph D.; Sutter, Kathrin; Dittmer, Ulf; Humpe, Andreas; Baumeister, Philipp; Wieser, Andreas; Rothenfusser, Simon; Bogner, Johannes; Roider, Julia; Knolle, Percy; Hengel, Hartmut; Wagner, Ralf; Laketa, Vibor; Fackler, Oliver T.; Keppler, Oliver T.
    Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells
    In: Cell Reports Medicine, Jg. 5, 2024, Nr. 4, 101483
    DOI (Open Access)
  • Roesmann, Fabian; Sertznig, Helene; Klaassen, Katleen; Wilhelm, Alexander; Heininger, Delia; Heß, Stefanie; Elsner, Carina; Marschalek, Rolf; Santiago, Mario L.; Esser, Stefan; Sutter, Kathrin; Dittmer, Ulf; Widera, Marek
    The interferon-regulated host factor hnRNPA0 modulates HIV-1 production by interference with LTR activity, mRNA trafficking, and programmed ribosomal frameshifting
    In: Journal of Virology, Jg. 98, 2024, Nr. 7, e0053424
    DOI
  • Karakoese, Zehra; Ingola, Martha; Sitek, Barbara; Dittmer, Ulf; Sutter, Kathrin
    IFNα Subtypes in HIV Infection and Immunity
    In: Viruses, Jg. 16, 2024, Nr. 3, 364
    DOI, Online Volltext (Open Access)
  • Steinbach, Philine; Pastille, Eva; Kaumanns, Lara; Adamczyk, Alexandra; Sutter, Kathrin; Hansen, Wiebke; Dittmer, Ulf; Buer, Jan; Westendorf, Astrid M.; Knuschke, Torben
    Influenza virus infection enhances tumour-specific CD8+ T-cell immunity, facilitating tumour control
    In: PLoS Pathogens, Jg. 20, 2024, Nr. 1, e1011982
    DOI (Open Access)

    • 2023

  • Schefczyk, Stefan; Luo, Xufeng; Liang, Yaojie; Hasenberg, Mike; Walkenfort, Bernd; Trippler, Martin; Schuhenn, Jonas; Sutter, Kathrin; Lu, Mengji; Wedemeyer, Heiner; Schmidt, Hartmut H.; Broering, Ruth
    Tg1.4HBV-s-rec mice, a crossbred hepatitis B virus-transgenic model, develop mild hepatitis
    In: Scientific Reports, Jg. 13, 2023, Nr. 1, 22829
    DOI, Online Volltext (Open Access)
  • Malyshkina, Anna; Bayer, Wibke; Podschwadt, Philip; Otto, Lucas; Karakoese, Zehra; Sutter, Kathrin; Bruderek, Kirsten; Wang, Baoxiao; Lavender, Kerry J.; Santiago, Mario L.; Leipe, Pia Madeleine; Elsner, Carina; Esser, Stefan; Brandau, Sven; Gunzer, Matthias; Dittmer, Ulf
    Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell follicles
    In: PLoS Pathogens, Jg. 19, 2023, Nr. 10, e1011725
    DOI (Open Access)
  • Wang, Qin; Liu, Yanan; Luo, Jinzhuo; Yang, Shangqing; Wang, Lu; Lu, Yinping; Feng, Xuemei; Yang, Xuecheng; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Zheng, Xin; Yang, Dongliang; Liu, Jia
    A systematic comparison reveals dynamic differences in early adaptive immune responses of acute-resolving versus chronic HBV replication
    In: Journal of Medical Virology, Jg. 95, 2023, Nr. 3, e28670
    DOI (Open Access)
  • Westmeier, Jaana; Brochtrup, Annika; Paniskaki, Krystallenia; Karakoese, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Limmer, Andreas; Mittermüller, Daniela; Liu, Jia; Zheng, Xin; Koval, Tetiana; Kaidashev, Igor; Berger, Marc Moritz; Herbstreit, Frank; Brenner, Thorsten; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patients
    In: Frontiers in Immunology, Jg. 14, 2023, 1236374
    DOI, Online Volltext (Open Access)
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Liu, Jing; Deng, Hui; Yang, Xuecheng; Wang, Hua; Feng, Xuemei; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Wang, Baoju; Yang, Dongliang; Zheng, Xin; Liu, Jia
    SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
    In: Virologica Sinica, Jg. 38, 2023, Nr. 4, S. 606 – 619
    DOI (Open Access)
  • Karakoese, Zehra; Le-Trilling, Vu Thuy Khanh; Schuhenn, Jonas; Francois, Sandra; Lu, Mengji; Liu, Jia; Trilling, Mirko; Hoffmann, Daniel; Dittmer, Ulf; Sutter, Kathrin
    Targeted mutations in IFNα2 improve its antiviral activity against various viruses
    In: mBio, Jg. 14, 2023, Nr. 6, e02357-23
    DOI, Online Volltext (Open Access)

    • 2022

  • Meister, Toni Luise; Brüggemann, Yannick; Nocke, Maximilian K.; Ulrich, Rainer G.; Schuhenn, Jonas; Sutter, Kathrin; Gömer, André; Bader, Verian; Winklhofer, Konstanze F.; Bröring, Ruth; Verhoye, Lieven; Meuleman, Philip; Vondran, Florian W. R.; Camuzet, Charline; Cocquerel, Laurence; Todt, Daniel; Steinmann, Eike
    A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Jg. 119, 2022, Nr. 34, e2202653119
    DOI (Open Access)
  • Wenzek, Christina; Steinbach, Philine; Wirsdörfer, Florian; Sutter, Kathrin; Boehme, Julia D.; Geffers, Robert; Klopfleisch, Robert; Bruder, Dunja; Jendrossek, Verena; Buer, Jan; Westendorf, Astrid; Knuschke, Torben
    CD47 restricts antiviral function of alveolar macrophages during influenza virus infection
    In: iScience, Jg. 25, 2022, Nr. 12, 105540
    DOI (Open Access)
  • Sertznig, Helene; Roesmann, Fabian; Wilhelm, Alexander; Heininger, Delia; Bleekmann, Barbara; Elsner, Carina; Santiago, Mario; Schuhenn, Jonas; Karakoese, Zehra; Benatzy, Yvonne; Snodgrass, Ryan; Esser, Stefan; Sutter, Kathrin; Dittmer, Ulf; Widera, Marek
    SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps
    In: Frontiers in Immunology, Jg. 13, 2022, 935800
    DOI (Open Access)
  • Schmitz, Yasmin; Schwerdtfeger, Mara; Westmeier, Jaana; Littwitz-Salomon, Elisabeth; Alt, Mira; Brochhagen, Leonie; Krawczyk, Adalbert; Sutter, Kathrin
    Superior antiviral activity of IFNβ in genital HSV-1 infection
    In: Frontiers in Cellular and Infection Microbiology, Jg. 12, 2022, 949036
    DOI, Online Volltext (Open Access)
  • Sperber, Hannah Sabeth; Sutter, Kathrin; Müller, Karin; Müller, Peter; Schwarzer, Roland
    The Bovine Seminal Plasma Protein PDC-109 Possesses Pan-Antiviral Activity
    In: Viruses, Jg. 14, 2022, Nr. 9, 2031
    DOI, Online Volltext (Open Access)
  • Schuhenn, Jonas; Meister, Toni Luise; Todt, Daniel; Bracht, Thilo; Schork, Karin; Billaud, Jean-Noel; Elsner, Carina; Heinen, Natalie; Karakoese, Zehra; Haid, Sibylle; Kumar, Sriram; Brunotte, Linda; Eisenacher, Martin; Di, Yunyun; Lew, Jocelyne; Falzarano, Darryl; Chen, Jieliang; Yuan, Zhenghong; Pietschmann, Thomas; Wiegmann, Bettina; Uebner, Hendrik; Taube, Christian; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Krawczyk, Adalbert; Ludwig, Stephan; Sitek, Barbara; Steinmann, Eike; Dittmer, Ulf; Lavender, Kerry J.; Sutter, Kathrin; Pfaender, Stephanie
    Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Jg. 119, 2022, Nr. 8, e2111600119
    DOI (Open Access)
  • Karakoese, Zehra; Schwerdtfeger, Mara; Karsten, Christina; Esser, Stefan; Dittmer, Ulf; Sutter, Kathrin
    Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected Individuals
    In: Frontiers in Immunology, Jg. 13, 2022, 936918
    DOI, Online Volltext (Open Access)
  • Xie, Xiaohong; Karakoese, Zehra; Ablikim, Dilhumare; Ickler, Julia; Schuhenn, Jonas; Zeng, Xiaoqing; Feng, Xuemei; Yang, Xuecheng; Dittmer, Ulf; Yang, Dongliang; Sutter, Kathrin; Liu, Jia
    IFNα subtype-specific susceptibility of HBV in the course of chronic infection
    In: Frontiers in Immunology, Jg. 13, 2022, 1017753
    DOI (Open Access)
  • Hussain, Timon; Domnich, Maksim; Bordbari, Sharareh; Pylaeva, Ekaterina; Siakaeva, Elena; Spyra, Ilona; Ozel, Irem; Droege, Freya; Squire, Anthony; Lienenklaus, Stefan; Sutter, Kathrin; Hasenberg, Anja; Gunzer, Matthias; Lang, Stephan; Jablonska, Jadwiga
    IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph Nodes
    In: Frontiers in Immunology, Jg. 13, 2022
    DOI (Open Access)
  • Rout, Saurav S.; Di, Yunyun; Dittmer, Ulf; Sutter, Kathrin; Lavender, Kerry J.
    Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice
    In: AIDS, Jg. 36, 2022, Nr. 3, S. 325 – 336
    DOI
  • Schwerdtfeger, Mara; Dickow, Julia; Schmitz, Yasmin; Francois, Sandra; Karakoese, Zehra; Malyshkina, Anna; Knuschke, Torben; Dittmer, Ulf; Sutter, Kathrin
    Immunotherapy With Interferon α11, But Not Interferon Beta, Controls Persistent Retroviral Infection
    In: Frontiers in Immunology, Jg. 12, 2022, 809774
    DOI, Online Volltext (Open Access)
  • David, Paul; Westmeier, Jaana; Drabczyk-Pluta, Malgorzata; Werner, Tanja; Ickler, Julia; Francois, Sandra; Bayer, Wibke; Sutter, Kathrin; Del Rio, Maria Luisa; Rodriguez-Barbosa, Jose-Ignacio; Dittmer, Ulf; Zelinskyy, Gennadiy
    The Role of the Inhibitory Ligand HVEM and Its Receptors CD160 and BTLA in the Regulation of Anti-retroviral T Cell Responses
    In: Frontiers in Virology, Jg. 2, 2022, 836291
    DOI, Online Volltext (Open Access)

    • 2021

  • Xiong, Shue; Zhu, Dan; Liang, Boyun; Li, Mingyue; Pan, Wen; He, Junyi; Wang, Hua; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Liu, Di; Yang, Dongliang; Liu, Jia; Zheng, Xin
    Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers associated with HBsAg loss
    In: eBioMedicine, Jg. 69, 2021, 103464
    DOI (Open Access)
  • Liu, Jia; Yang, Xuecheng; Wang, Hua; Li, Ziwei; Deng, Hui; Liu, Jing; Xiong, Shue; He, Junyi; Feng, Xuemei; Guo, Chunxia; Wang, Weixian; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Senff, Tina; Menne, Christopher; Timm, Jörg; Zhang, Yanfang; Deng, Fei; Lu, Yinping; Wu, Jun; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Wang, Baoju; Zheng, Xin
    Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound nkt cell impairment
    In: mBio, Jg. 12, 2021, Nr. 2, S. e00085 – 21
    DOI (Open Access)
  • Wienhöfer, Lisa; Marker, Max; Antoni, Anne-Charlotte; Sutter, Kathrin; Sander, André; Dudda, Marcel; Flohe, Stefanie
    TLR4 Transactivates CD8⁺ T Lymphocytes upon Acute Sterile Tissue Injury
    In: ImmunoHorizons, Jg. 5, 2021, Nr. 5, S. 298 – 306
    DOI, Online Volltext (Open Access)
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Deng, Hui; Wang, Hua; Feng, Xuemei; Quan, Xufeng; Wang, Xiaoyan; Li, Sumeng; Lu, Sihong; Yang, Xuecheng; Wang, Baoju; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang; Zheng, Xin; Liu, Jia
    Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting
    In: Frontiers in Immunology, Jg. 12, 2021, 802858
    DOI (Open Access)
  • Chen, Jieliang; Li, Yaming; Lai, Fritz; Wang, Yang; Sutter, Kathrin; Dittmer, Ulf; Ye, Jianyu; Zai, Wenjing; Liu, Min; Shen, Fang; Wu, Min; Hu, Kongying; Li, Baocun; Lu, Mengji; Zhang, Xiaonan; Zhang, Jiming; Li, Jianhua; Chen, Qingfeng; Yuan, Zhenghong
    Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ Signaling
    In: Hepatology, Jg. 73, 2021, Nr. 2, S. 486 – 502
    DOI

    • 2020

  • Sutter, Kathrin
    Die Einmischer: Interferone : Wie sie die Immunantwort beeinflussen, um Viren effektiv zu bekämpfen
    In: Unikate: Berichte aus Forschung und Lehre, 2020, Nr. 54: Medizin: Infektionskrankheiten - ein globales Problem, S. 18 – 27
    DOI, Online Volltext (Open Access)
  • Heilingloh, Christiane Silke; Aufderhorst, Ulrich Wilhelm; Schipper, Leonie; Dittmer, Ulf; Witzke, Oliver; Yang, Dongliang; Zheng, Xin; Sutter, Kathrin; Trilling, Mirko; Alt, Mira; Steinmann, Eike; Krawczyk, Adalbert
    Susceptibility of SARS-CoV-2 to UV irradiation
    In: American Journal of Infection Control, Jg. 48, 2020, Nr. 10, S. 1273 – 1275
    DOI, Online Volltext (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Erratum for Westmeier et al., "Impaired Cytotoxic CD8⁺ T Cell Response in Elderly COVID-19 Patients"
    In: mBio, Jg. 11, 2020, Nr. 5, S. 02243 – 02220
    DOI (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Impaired cytotoxic CD8⁺ T cell response in elderly COVID-19 patients
    In: mBio, Jg. 11, 2020, Nr. 5, S. e02243 – 20
    DOI (Open Access)
  • Wang, Shichuan; Trilling, Mirko; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Zheng, Xin; Yang, Dongliang; Liu, Jia
    A Crowned Killer’s Résumé : Genome, Structure, Receptors, and Origin of SARS-CoV-2
    In: Virologica Sinica, 2020
    DOI (Open Access)
  • Ickler, Julia; Francois, Sandra; Widera, Marek; Santiago, Mario L.; Dittmer, Ulf; Sutter, Kathrin
    HIV infection does not alter interferon α/β receptor 2 expression on mucosal immune cells
    In: PLoS ONE, Jg. 15, 2020, Nr. 1, S. e0218905
    DOI, Online Volltext (Open Access)
  • Zutz, Ariane; Schölz, Christian; Schneider, Stephanie; Pierini, Virginia; Münchhoff, Maximilian; Sutter, Kathrin; Wittmann, Georg; Dittmer, Ulf; Draenert, Rika; Bogner, Johannes R.; Fackler, Oliver T.; Keppler, Oliver T.
    SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation
    In: Journal of Innate Immunity, Jg. 12, 2020, Nr. 5, S. 399 – 409
    DOI (Open Access)
  • Liu, Jia; Zheng, Xin; Tong, Qiaoxia; Li, Wei; Wang, Baoju; Sutter, Kathrin; Trilling, Mirko; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang
    Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV
    In: Journal of Medical Virology, Jg. 92, 2020, Nr. 5, S. 491 – 494
    DOI, Online Volltext (Open Access)
  • Guo, Kejun; Shen, Guannan; Kibbie, Jon; Gonzalez, Tania; Dillon, Stephanie M.; Smith, Harry A.; Cooper, Emily H.; Lavender, Kerry; Hasenkrug, Kim J.; Sutter, Kathrin; Dittmer, Ulf; Kroehl, Miranda; Kechris, Katerina; Wilson, Cara C.; Santiago, Mario L.
    Qualitative differences between the IFNα subtypes and IFNβ influence chronic mucosal HIV-1 pathogenesis
    In: PLoS Pathogens, Jg. 16, 2020, Nr. 10, S. 1008986
    DOI (Open Access)

    • 2019

  • Dickow, Julia; Francois, Sandra; Kaiserling, Rouven-Luca; Malyshkina, Anna; Drexler, Ingo; Westendorf, Astrid Maria; Lang, Karl Sebastian; Santiago, Mario L.; Dittmer, Ulf; Sutter, Kathrin
    Diverse immunomodulatory effects of individual IFNα subtypes on virus-specific CD8⁺ T cell responses
    In: Frontiers in Immunology, Jg. 10, 2019, 2255
    DOI, Online Volltext (Open Access)
  • Sutter, Kathrin; Lavender, Kerry J.; Messer, Ronald J.; Widera, Marek; Williams, Katie; Race, Brent; Hasenkrug, Kim J.; Dittmer, Ulf
    Concurrent administration of IFNα14 and cART in TKO-BLT mice enhances suppression of HIV-1 viremia but does not eliminate the latent reservoir
    In: Scientific Reports, Jg. 9, 2019, S. 18089
    DOI, Online Volltext (Open Access)
  • Matos, Aline da Rocha; Wunderlich, Katharina; Schloer, Sebastian; Schughart, Klaus; Geffers, Robert; Seders, Martine; Witt, Marlous de; Christersson, Anmari; Wiewrodt, Rainer; Wiebe, Karsten; Barth, Peter; Hocke, Andreas; Hippenstiel, Stefan; Hönzke, Katja; Dittmer, Ulf; Sutter, Kathrin; Rescher, Ursula; Rodionycheva, Svetlana; Matera, Nicoletta; Ludwig, Stephan; Brunotte, Linda
    Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities
    In: Emerging Microbes & Infections, Jg. 8, 2019, Nr. 1, S. 1763 – 1776
    DOI (Open Access)
  • Passos, Vânia; Zillinger, Thomas; Casartelli, Nicoletta; Wachs, Amelie S.; Xu, Shuting; Malassa, Angelina; Steppich, Katja; Schilling, Hildegard; Franz, Sergej; Todt, Daniel; Steinmann, Eike; Sutter, Kathrin; Dittmer, Ulf; Bohne, Jens; Schwartz, Olivier; Barchet, Winfried; Goffinet, Christine
    Characterization of Endogenous SERINC5 Protein as Anti-HIV-1 Factor
    In: Journal of Virology, Jg. 93, 2019, Nr. 24, S. e01221 – 19
    DOI (Open Access)
  • Hasenkrug, Kim J.; Lavender, Kerry J.; Santiago, Mario L.; Sutter, Kathrin; Dittmer, Ulf
    Different Biological Activities of Specific Interferon Alpha Subtypes
    In: mSphere, Jg. 4, 2019, Nr. 4, e00127 - 19
    DOI (Open Access)
  • Braun, Elisabeth; Hotter, Dominik; Koepke, Lennart; Zech, Fabian; Groß, Rüdiger; Sparrer, Konstantin M.J.; Müller, Janis A.; Pfaller, Christian K.; Heusinger, Elena; Wombacher, Rebecka; Sutter, Kathrin; Dittmer, Ulf; Winkler, Michael; Simmons, Graham; Jakobsen, Martin R.; Conzelmann, Karl-Klaus; Pöhlmann, Stefan; Münch, Jan; Fackler, Oliver T.; Kirchhoff, Frank; Sauter, Daniel
    Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins
    In: Cell Reports, Jg. 27, 2019, Nr. 7, S. 2092 – 2104.e10
    DOI (Open Access)
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Ross, Jean Alexander; Paschen, Annette; Windmann, Sonja; Schimmer, Simone; Dittmer, Ulf
    Chronic retroviral infection of mice promotes tumor development, but CD137 agonist therapy restores effective tumor immune surveillance
    In: Cancer Immunology, Immunotherapy, Jg. 68, 2019, Nr. 3, S. 479 – 488
    DOI, Online Volltext (Open Access)
  • Dittmer, Ulf; Sutter, Kathrin; Kassiotis, George; Zelinskyy, Gennadiy; Bánki, Zoltán; Stoiber, Heribert; Santiago, Mario L.; Hasenkrug, Kim J.
    Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity
    In: FEMS Microbiology Reviews, Jg. 43, 2019, Nr. 5, S. 435 – 456
    DOI, Online Volltext (Open Access)
  • Xia, Yuchen; Schlapschy, Martin; Morath, Volker; Roeder, Natalie; Vogt, Elisabeth I.; Stadler, Daniela; Cheng, Xiaoming; Dittmer, Ulf; Sutter, Kathrin; Heikenwalder, Mathias; Skerra, Arne; Protzer, Ulrike
    PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice
    In: Antiviral Research, Jg. 161, 2019, S. 134 – 143
    DOI
  • Gujer, Cornelia; Murer, Anita; Müller, Anne; Vanoaica, Danusia; Sutter, Kathrin; Jacque, Emilie; Fournier, Nathalie; Kalchschmidt, Jens; Zbinden, Andrea; Capaul, Riccarda; Dzionek, Andrzej; Mondon, Philippe; Dittmer, Ulf; Münz, Christian
    Plasmacytoid dendritic cells respond to Epstein-Barr virus infection with a distinct type I interferon subtype profile
    In: Blood Advances, Jg. 3, 2019, Nr. 7, S. 1129 – 1144
    DOI (Open Access)

    • 2018

  • Korth, Johannes; Anastasiou, Olympia E.; Verheyen, Jens; Dickow, Julia; Sertznig, Helene; Frericks, Nicola; Bleekmann, Barbara; Kribben, Andreas; Brinkhoff, Alexandra; Wilde, Benjamin; Sutter, Kathrin; Dittmer, Ulf; Ciesek, Sandra; Witzke, Oliver; Widera, Marek
    Impact of immune suppressive agents on the BK-Polyomavirus non coding control region
    In: Antiviral Research, Jg. 159, 2018, S. 68 – 76
    DOI
  • Shen, Fang; Li, Yaming; Wang, Yang; Sozzi, Vitina; Revill, Peter A.; Liu, Jiangxia; Gao, Lu; Yang, Guang; Lu, Mengji; Sutter, Kathrin; Dittmer, Ulf; Chen, Jieliang; Yuan, Zhenghong
    Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotype
    In: Hepatology, Jg. 67, 2018, Nr. 4, S. 1237 – 1252
    DOI (Open Access)
  • Lavender, Kerry J.; Pace, Craig; Sutter, Kathrin; Messer, Ronald J.; Pouncey, Dakota L.; Cummins, Nathan W.; Natesampillai, Sekar; Zheng, Jim; Goldsmith, Joshua; Widera, Marek; Van Dis, Erik S.; Phillips, Katie; Race, Brent; Dittmer, Ulf; Kukolj, George; Hasenkrug, Kim J.
    An advanced BLT-humanized mouse model for extended HIV-1 cure studies
    In: AIDS, Jg. 32, 2018, Nr. 1, S. 1 – 10
    DOI, Online Volltext (Open Access)
  • Sutter, Kathrin; Dickow, Julia; Dittmer, Ulf
    Interferon α subtypes in HIV infection
    In: Cytokine & Growth Factor Reviews, Jg. 40, 2018, S. 13 – 18
    DOI
  • Knuschke, Torben; Rotan, Olga; Bayer, Wibke; Kollenda, Sebastian; Dickow, Julia; Sutter, Kathrin; Hansen, Wiebke; Dittmer, Ulf; Lang, Karl S.; Epple, Matthias; Buer, Jan; Westendorf, Astrid
    Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral Infection
    In: Frontiers in Immunology, Jg. 9, 2018, 614
    DOI (Open Access)

    • 2017

  • Song, Jingjiao; Li, Sheng; Zhou, Yun; Liu, Jia; Francois, Sandra; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Sutter, Kathrin
    Different antiviral effects of IFNα subtypes in a mouse model of HBV infection
    In: Scientific Reports, Jg. 7, 2017, Nr. 1, S. 334
    DOI, Online Volltext (Open Access)
  • Schreiber, Timm; Quinting, Theresa; Dittmer, Ulf; Fandrey, Joachim; Sutter, Kathrin
    Hypoxia-inducible factor 1α is essential for macrophage-mediated erythroblast proliferation in acute friend retrovirus infection
    In: Scientific Reports, Jg. 7, 2017, art. no. 17236
    DOI (Open Access)
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Zelinskyy, Gennadiy; Windmann, Sonja; Schimmer, Simone; Paschen, Annette; Streeck, Hendrik; Hasenkrug, Kim J; Dittmer, Ulf
    Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection
    In: Scientific Reports, Jg. 7, 2017, S. 7785
    DOI (Open Access)
  • Li, Yanpeng; Sun, Binlian; Esser, Stefan; Jessen, Heiko; Streeck, Hendrik; Widera, Marek; Yang, Rongge; Dittmer, Ulf; Sutter, Kathrin
    Expression pattern of individual IFNA subtypes in chronic HIV infection
    In: Journal of Interferon & Cytokine Research, Jg. 37, 2017, Nr. 12, S. 541 – 549
    DOI
  • Zhou, Yun; Li, Sheng; Tang, Zongsheng; Xu, Chunli; Huang, Shunmei; Wu, Jun; Dittmer, Ulf; Dickow, Julia; Sutter, Kathrin; Lu, Mengji; Yang, Dongliang; Song, Jingjiao
    Different antiviral effects of IFNα and IFNβ in an HBV mouse model
    In: Immunobiology, Jg. 222, 2017, Nr. 3, S. 562 – 570
    DOI
  • Ziegler, Susanne M.; Beisel, Claudia; Sutter, Kathrin; Griesbeck, Morgane; Hildebrandt, Heike; Hagen, Sven H.; Dittmer, Ulf; Altfeld, Marcus
    Human pDCs display sex-specific differences in type I interferon subtypes and interferon α/β receptor expression
    In: European Journal of Immunology, Jg. 47, 2017, Nr. 2, S. 251 – 256
    DOI

    • 2016

  • Littwitz-Salomon, Elisabeth; Dittmer, Ulf; Sutter, Kathrin
    Insufficient natural killer cell responses against retroviruses : How to improve NK cell killing of retrovirus-infected cells
    In: Retrovirology, Jg. 13, 2016, Nr. 1, 77
    DOI (Open Access)
  • Blömker, Dominique; Mollérus, Sina; Gibbert, Kathrin; Dittmer, Ulf; Del Rey, Adriana E.; Schedlowski, Manfred; Engler, Harald
    Inhibition of catecholamine degradation ameliorates while chemical sympathectomy aggravates the severity of acute Friend retrovirus infection in mice
    In: Brain, Behavior and Immunity, Jg. 54, 2016, S. 252 – 259
    DOI
  • Lavender, Kerry J.; Gibbert, Kathrin; Peterson, Karin E.; Van Dis, Erik; Francois, Sandra; Woods, Tyson; Messer, Ronald J.; Gawanbacht, Ali; Müller, Janis A.; Münch, Jan; Phillips, Katie; Race, Brent; Harper, Michael S.; Guo, Kejun; Lee, Eric J.; Trilling, Mirko; Hengel, Hartmut; Piehler, Jacob; Verheyen, Jens; Wilson, Cara C.; Santiago, Mario L.; Hasenkrug, Kim J.; Dittmer, Ulf
    Interferon alpha subtype-specific suppression of HIV-1 infection in vivo
    In: Journal of Virology, Jg. 90, 2016, Nr. 13, S. 6001 – 6013
    DOI (Open Access)

    • 2015

  • Littwitz-Salomon, Elisabeth; Akhmetzyanova, Ilseyar; Vallet, Cecilia; Francois, Sandra; Dittmer, Ulf; Gibbert, Kathrin
    Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection
    In: Retrovirology, Jg. 12, 2015, Nr. 1, 66
    DOI (Open Access)
  • Harper, Michael S.; Guo, Kejun; Gibbert, Kathrin; Lee, Eric J.; Dillon, Stephanie M.; Barrett, Bradley S.; McCarter, Martin D.; Hasenkrug, Kim J.; Dittmer, Ulf; Wilson, Cara C.; Santiago, Mario L.
    Interferon-α subtypes in an ex vivo model of acute HIV-1 infection : expression, potency and effector mechanisms
    In: PLoS Pathogens, Jg. 11, 2015, Nr. 11, S. e1005254
    DOI (Open Access)
  • Wu, Weimin; Dietze, Kirsten; Gibbert, Kathrin; Lang, Karl S.; Trilling, Mirko; Yan, Huimin; Wu, Jun; Yang, Dongliang; Lu, Mengji; Roggendorf, Michael; Dittmer, Ulf; Liu, Jia
    TLR ligand induced IL-6 counter-regulates the anti-viral CD8+ T cell response during an acute retrovirus infection
    In: Scientific Reports, Jg. 5, 2015, 10501
    DOI, Online Volltext (Open Access)

    • 2014

  • Bröring, Ruth; Real, Catherine; John, Matthias J.; Jahn-Hofmann, Kerstin; Ickenstein, Ludger M.; Kleinehr, Kathrin; Paul, Andreas; Sutter, Kathrin; Dittmer, Ulf; Gerken, Guido; Schlaak, Jörg Friedrich
    Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro
    In: International Immunology, Jg. 26, 2014, Nr. 1, S. 35 – 46
    DOI

    • 2013

  • Gibbert, K.; Schlaak, Jörg Friedrich; Yang, D.; Dittmer, Ulf; Schlaak, JF
    IFN-α subtypes : Distinct biological activities in anti-viral therapy
    In: British Journal of Pharmacology (BJP), Jg. 168, 2013, Nr. 5, S. 1048 – 1058
    DOI (Open Access)
  • Harper, Michael S.; Barrett, Bradley S.; Smith, Diana S.; Li, Sam X.; Gibbert, Kathrin; Dittmer, Ulf; Hasenkrug, Kim J.; Santiago, Mario L.
    IFN-α treatment inhibits acute friend retrovirus replication primarily through the antiviral effector molecule Apobec3
    In: The Journal of Immunology (JI), Jg. 190, 2013, Nr. 4, S. 1583 – 1590
    DOI
  • Wobben, Regina; Hüsecken, Yvonne; Lodewick, Claudia; Gibbert, Kathrin; Fandrey, Joachim; Winning, Sandra
    Role of hypoxia inducible factor-1 α for interferon synthesis in mouse dendritic cells
    In: Biological Chemistry, Jg. 394, 2013, Nr. 4, S. 495 – 505
    DOI
  • Behrendt, Rayk; Schumann, Tina; Gerbaulet, Alexander; Nguyen, Laura A.; Schubert, Nadja; Alexopoulou, Dimitra; Berka, Ursula; Lienenklaus, Stefan; Peschke, Katrin; Gibbert, Kathrin; Wittmann, Sabine; Lindemann, Dirk; Weiss, Siegfried; Dahl, Andreas; Naumann, Ronald; Dittmer, Ulf; Kim, Baek; Mueller, Werner; Gramberg, Thomas; Roers, Axel
    Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response
    In: Cell Reports, Jg. 4, 2013, Nr. 4, S. 689 – 696
    DOI (Open Access)
  • Littwitz-Salomon, Elisabeth; Francois, Sandra; Dittmer, Ulf; Gibbert, Kathrin
    Distinct roles of NK cells in viral immunity during different phases of acute Friend retrovirus infection
    In: Retrovirology, Jg. 10, 2013, Nr. 1, 127
    DOI (Open Access)

    • 2012

  • Gibbert, Kathrin; Joedicke, Jara J.; Meryk, Andreas; Trilling, Mirko; Francois, Sandra; Duppach, Janine; Kraft, Anke; Lang, Karl S.; Dittmer, Ulf
    Interferon-alpha Subtype 11 Activates NK Cells and Enables Control of Retroviral Infection
    In: PLoS Pathogens, Jg. 8, 2012, Nr. 8, S. e1002868
    DOI, Online Volltext (Open Access)

    • 2011

  • Gibbert, Kathrin; Dittmer, Ulf
    Distinct antiviral activities of IFN-α subtypes
    In: Immunotherapy, Jg. 3, 2011, Nr. 7, S. 813 – 816
    DOI
  • Dietze, Kirsten; Zelinskyy, Gennadiy; Gibbert, Kathrin; Schimmer, Simone; Francois, Sandra; Myers, Lara; Sparwasser, Tim; Hasenkrug, Kim J.; Dittmer, Ulf
    Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8⁺ T cells and reduces chronic retroviral set points
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS), Jg. 108, 2011, Nr. 6, S. 2420 – 2425
    DOI (Open Access)
  • Zelinskyy, Gennadiy; Myers, Lara; Dietze, Kirsten; Gibbert, Kathrin; Roggendorf, Michael; Liu, Jia; Lu, Mengji; Kraft, Anke R.; Teichgräber, Volker; Hasenkrug, Kim J.; Dittmer, Ulf
    Virus-Specific CD8+ T Cells Upregulate Programmed Death-1 Expression during Acute Friend Retrovirus Infection but Are Highly Cytotoxic and Control Virus Replication
    In: The Journal of Immunology (JI), Jg. 187, 2011, Nr. 7, S. 3730 – 3737
    DOI

    • 2010

  • Sender, Linda Y.; Gibbert, Kathrin; Suezer, Yasemin; Radeke, Heinfried H.; Kalinke, Ulrich; Waibler, Zoe
    CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals
    In: Molecular Immunology, Jg. 47, 2010, Nr. 6, S. 1255 – 1261
    DOI
  • Gibbert, Kathrin; Dietze, Kirsten; Zelinskyy, Gennadiy; Lang, Karl S.; Barchet, Winfried; Kirschning, Carsten Jürgen; Dittmer, Ulf
    Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease
    In: The Journal of Immunology (JI), Jg. 185, 2010, Nr. 10, S. 6179 – 6189
    DOI (Open Access)