AG Sutter

Forschungsbereich

Während den meisten Virusinfektionen ist die erste Immunantwort charakterisiert durch die Induktion von Typ I Interferon (IFN). IFN gehört zu einer Genfamilie, welche bis zu 13 verschiedene IFN-α Subtypen und IFN-β mit einschließt. Diese Interferone weisen alle unterschiedliche biologische Aktivitäten auf wie z.B. antivirale, anti-proliferative und immunmodulatorische Eigenschaften. Nach ihrer Induktion, binden alle Interferone an den gleichen Rezeptor, was zu der Expression zahlreicher verschiedener IFN-stimulierter Gene führt, welche für antivirale Proteine kodieren, die direkt die virale Replikation inhibieren wie auch die Funktion von Immunzellen modulieren. Daher ist die Induktion von Typ I IFN ein wirkungsvolles Mittel gegen Virusinfektionen anzukämpfen. Viele Viren haben Wege gefunden der IFN-Antwort zu entgehen. Deshalb sollte die therapeutische Gabe von exogenem Typ I IFN ein großes Potential für zukünftige Immuntherapien gegen Virusinfektionen besitzen. Die Arbeitsgruppe ist hauptsächlich interessiert an den verschiedenen antiviralen und immunmodulatorischen Eigenschaften aller humanen und murinen IFN-α Subtypen in akuten und chronischen Virusinfektionen. Ein besonderer Augenmerk liegt auf der Induktion der verschiedenen Subtypen, deren Regulation und ihren erschiedenen biologischen Eigenschaften besonders die Modulation von Immunantworten. 

PD Dr. rer. nat. Kathrin Sutter

IG1, Raum 2.045

Tel. 0201/723-83250

Fax 0201/723-5543

kathrin.sutter@uk-essen.de

Mitglieder der Arbeitsgruppe

​ZehraZehra Karaköse, M.Sc.

Doktorandin

Raum 2.051

Tel. 02101/723-4224

zehra.karakoese@uk-essen.de

​MaraMara Schwerdtfeger, M.Sc.

Doktorandin

Raum 2.051

Tel. 0201/723-4050

mara.schwerdtfeger@uk-essen.de

​Sandra FrancoisSandra Francois

Technische Angestellte

Raum 2.061

Tel. 0201/723-83737

sandra.francois@uk-essen.de

​Thea​​Ann Therese Paraguya

SHK

Raum 2.061

Tel. 0201/723-4055

AnnTherese.Paraguya@uk-essen.de

​random face​​​Julia Boesner

Bachelor-Studentin

Raum 2.051

Tel. 0201/723-4050

 

Publikationsliste

    2024

  • Steinbach, Philine; Pastille, Eva; Kaumanns, Lara; Adamczyk, Alexandra; Sutter, Kathrin; Hansen, Wiebke; Dittmer, Ulf; Buer, Jan; Westendorf, Astrid M.; Knuschke, Torben
    Influenza virus infection enhances tumour-specific CD8+ T-cell immunity, facilitating tumour control
    In: PLoS Pathogens Jg. 20 (2024) Nr. 1, e1011982
    Online Volltext: dx.doi.org/ (Open Access)
  • Albanese, Manuel; Chen, Hong-Ru; Gapp, Madeleine; Muenchhoff, Maximilian; Yang, Hsiu-Hui; Peterhoff, David; Hoffmann, Katja; Xiao, Qianhao; Ruhle, Adrian; Ambiel, Ina; Schneider, Stephanie; Mejías-Pérez, Ernesto; Stern, Marcel; Wratil, Paul R.; Hofmann, Katharina; Amann, Laura; Jocham, Linda; Fuchs, Thimo; Ulivi, Alessandro F.; Besson-Girard, Simon; Weidlich, Simon; Schneider, Jochen; Spinner, Christoph D.; Sutter, Kathrin; Dittmer, Ulf; Humpe, Andreas; Baumeister, Philipp; Wieser, Andreas; Rothenfusser, Simon; Bogner, Johannes; Roider, Julia; Knolle, Percy; Hengel, Hartmut; Wagner, Ralf; Laketa, Vibor; Fackler, Oliver T.; Keppler, Oliver T.
    Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells
    In: Cell Reports Medicine Jg. 5 (2024) Nr. 4, 101483
    Online Volltext: dx.doi.org/ (Open Access)
  • Karakoese, Zehra; Ingola, Martha; Sitek, Barbara; Dittmer, Ulf; Sutter, Kathrin
    IFNα Subtypes in HIV Infection and Immunity
    In: Viruses Jg. 16 (2024) Nr. 3, 364
    Online Volltext: dx.doi.org/ (Open Access)

    • 2023

  • Wang, Qin; Liu, Yanan; Luo, Jinzhuo; Yang, Shangqing; Wang, Lu; Lu, Yinping; Feng, Xuemei; Yang, Xuecheng; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Zheng, Xin; Yang, Dongliang; Liu, Jia
    A systematic comparison reveals dynamic differences in early adaptive immune responses of acute-resolving versus chronic HBV replication
    In: Journal of Medical Virology Jg. 95 (2023) Nr. 3, e28670
    Online Volltext: dx.doi.org/ (Open Access)
  • Malyshkina, Anna; Bayer, Wibke; Podschwadt, Philip; Otto, Lucas; Karakoese, Zehra; Sutter, Kathrin; Bruderek, Kirsten; Wang, Baoxiao; Lavender, Kerry J.; Santiago, Mario L.; Leipe, Pia Madeleine; Elsner, Carina; Esser, Stefan; Brandau, Sven; Gunzer, Matthias; Dittmer, Ulf
    Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell follicles
    In: PLoS Pathogens Jg. 19 (2023) Nr. 10, e1011725
    Online Volltext: dx.doi.org/ (Open Access)
  • Westmeier, Jaana; Brochtrup, Annika; Paniskaki, Krystallenia; Karakoese, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Limmer, Andreas; Mittermüller, Daniela; Liu, Jia; Zheng, Xin; Koval, Tetiana; Kaidashev, Igor; Berger, Marc Moritz; Herbstreit, Frank; Brenner, Thorsten; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Macrophage migration inhibitory factor receptor CD74 expression is associated with expansion and differentiation of effector T cells in COVID-19 patients
    In: Frontiers in Immunology Jg. 14 (2023) 1236374
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Liu, Jing; Deng, Hui; Yang, Xuecheng; Wang, Hua; Feng, Xuemei; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Wang, Baoju; Yang, Dongliang; Zheng, Xin; Liu, Jia
    SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection
    In: Virologica Sinica (2023) in press
    Online Volltext: dx.doi.org/ (Open Access)
  • Karakoese, Zehra; Le-Trilling, Vu Thuy Khanh; Schuhenn, Jonas; Francois, Sandra; Lu, Mengji; Liu, Jia; Trilling, Mirko; Hoffmann, Daniel; Dittmer, Ulf; Sutter, Kathrin
    Targeted mutations in IFNα2 improve its antiviral activity against various viruses
    In: mBio Jg. 14 (2023) Nr. 6, e02357-23
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Schefczyk, Stefan; Luo, Xufeng; Liang, Yaojie; Hasenberg, Mike; Walkenfort, Bernd; Trippler, Martin; Schuhenn, Jonas; Sutter, Kathrin; Lu, Mengji; Wedemeyer, Heiner; Schmidt, Hartmut H.; Broering, Ruth
    Tg1.4HBV-s-rec mice, a crossbred hepatitis B virus-transgenic model, develop mild hepatitis
    In: Scientific Reports Jg. 13 (2023) Nr. 1, 22829
    Online Volltext: dx.doi.org/ (Open Access)

    • 2022

  • Xie, Xiaohong; Karakoese, Zehra; Ablikim, Dilhumare; Ickler, Julia; Schuhenn, Jonas; Zeng, Xiaoqing; Feng, Xuemei; Yang, Xuecheng; Dittmer, Ulf; Yang, Dongliang; Sutter, Kathrin; Liu, Jia
    IFNα subtype-specific susceptibility of HBV in the course of chronic infection
    In: Frontiers in Immunology Jg. 13 (2022) 1017753
    Online Volltext: dx.doi.org/ (Open Access)
  • Karakoese, Zehra; Schwerdtfeger, Mara; Karsten, Christina; Esser, Stefan; Dittmer, Ulf; Sutter, Kathrin
    Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected Individuals
    In: Frontiers in Immunology Jg. 13 (2022) 936918
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Meister, Toni Luise; Brüggemann, Yannick; Nocke, Maximilian K.; Ulrich, Rainer G.; Schuhenn, Jonas; Sutter, Kathrin; Gömer, André; Bader, Verian; Winklhofer, Konstanze F.; Bröring, Ruth; Verhoye, Lieven; Meuleman, Philip; Vondran, Florian W. R.; Camuzet, Charline; Cocquerel, Laurence; Todt, Daniel; Steinmann, Eike
    A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 119 (2022) Nr. 34, e2202653119
    Online Volltext: dx.doi.org/ (Open Access)
  • Sertznig, Helene; Roesmann, Fabian; Wilhelm, Alexander; Heininger, Delia; Bleekmann, Barbara; Elsner, Carina; Santiago, Mario; Schuhenn, Jonas; Karakoese, Zehra; Benatzy, Yvonne; Snodgrass, Ryan; Esser, Stefan; Sutter, Kathrin; Dittmer, Ulf; Widera, Marek
    SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps
    In: Frontiers in Immunology Jg. 13 (2022) 935800
    Online Volltext: dx.doi.org/ (Open Access)
  • Schwerdtfeger, Mara; Dickow, Julia; Schmitz, Yasmin; Francois, Sandra; Karakoese, Zehra; Malyshkina, Anna; Knuschke, Torben; Dittmer, Ulf; Sutter, Kathrin
    Immunotherapy With Interferon α11, But Not Interferon Beta, Controls Persistent Retroviral Infection
    In: Frontiers in Immunology Jg. 12 (2022) 809774
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Schmitz, Yasmin; Schwerdtfeger, Mara; Westmeier, Jaana; Littwitz-Salomon, Elisabeth; Alt, Mira; Brochhagen, Leonie; Krawczyk, Adalbert; Sutter, Kathrin
    Superior antiviral activity of IFNβ in genital HSV-1 infection
    In: Frontiers in Cellular and Infection Microbiology Jg. 12 (2022) 949036
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Wenzek, Christina; Steinbach, Philine; Wirsdörfer, Florian; Sutter, Kathrin; Boehme, Julia D.; Geffers, Robert; Klopfleisch, Robert; Bruder, Dunja; Jendrossek, Verena; Buer, Jan; Westendorf, Astrid; Knuschke, Torben
    CD47 restricts antiviral function of alveolar macrophages during influenza virus infection
    In: iScience Jg. 25 (2022) Nr. 12, 105540
    Online Volltext: dx.doi.org/
  • Hussain, Timon; Domnich, Maksim; Bordbari, Sharareh; Pylaeva, Ekaterina; Siakaeva, Elena; Spyra, Ilona; Ozel, Irem; Droege, Freya; Squire, Anthony; Lienenklaus, Stefan; Sutter, Kathrin; Hasenberg, Anja; Gunzer, Matthias; Lang, Stephan; Jablonska, Jadwiga
    IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph Nodes
    In: Frontiers in Immunology Jg. 13 (2022)
    Online Volltext: dx.doi.org/ (Open Access)
  • David, Paul; Westmeier, Jaana; Drabczyk-Pluta, Malgorzata; Werner, Tanja; Ickler, Julia; Francois, Sandra; Bayer, Wibke; Sutter, Kathrin; Del Rio, Maria Luisa; Rodriguez-Barbosa, Jose-Ignacio; Dittmer, Ulf; Zelinskyy, Gennadiy
    The Role of the Inhibitory Ligand HVEM and Its Receptors CD160 and BTLA in the Regulation of Anti-retroviral T Cell Responses
    In: Frontiers in Virology Jg. 2 (2022) 836291
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Schuhenn, Jonas; Meister, Toni Luise; Todt, Daniel; Bracht, Thilo; Schork, Karin; Billaud, Jean-Noel; Elsner, Carina; Heinen, Natalie; Karakoese, Zehra; Haid, Sibylle; Kumar, Sriram; Brunotte, Linda; Eisenacher, Martin; Di, Yunyun; Lew, Jocelyne; Falzarano, Darryl; Chen, Jieliang; Yuan, Zhenghong; Pietschmann, Thomas; Wiegmann, Bettina; Uebner, Hendrik; Taube, Christian; Le-Trilling, Vu Thuy Khanh; Trilling, Mirko; Krawczyk, Adalbert; Ludwig, Stephan; Sitek, Barbara; Steinmann, Eike; Dittmer, Ulf; Lavender, Kerry J.; Sutter, Kathrin; Pfaender, Stephanie
    Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 119 (2022) Nr. 8, e2111600119
    Online Volltext: dx.doi.org/ (Open Access)
  • Sperber, Hannah Sabeth; Sutter, Kathrin; Müller, Karin; Müller, Peter; Schwarzer, Roland
    The Bovine Seminal Plasma Protein PDC-109 Possesses Pan-Antiviral Activity
    In: Viruses Jg. 14 (2022) Nr. 9, 2031
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Rout, Saurav S.; Di, Yunyun; Dittmer, Ulf; Sutter, Kathrin; Lavender, Kerry J.
    Distinct effects of treatment with two different interferon-alpha subtypes on HIV-1-associated T-cell activation and dysfunction in humanized mice
    In: AIDS Jg. 36 (2022) Nr. 3, S. 325 - 336
    Online Volltext: dx.doi.org/

    • 2021

  • Chen, Jieliang; Li, Yaming; Lai, Fritz; Wang, Yang; Sutter, Kathrin; Dittmer, Ulf; Ye, Jianyu; Zai, Wenjing; Liu, Min; Shen, Fang; Wu, Min; Hu, Kongying; Li, Baocun; Lu, Mengji; Zhang, Xiaonan; Zhang, Jiming; Li, Jianhua; Chen, Qingfeng; Yuan, Zhenghong
    Functional Comparison of Interferon-α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon-α and Interferon-γ Signaling
    In: Hepatology Jg. 73 (2021) Nr. 2, S. 486 - 502
    Online Volltext: dx.doi.org/
  • Wienhöfer, Lisa; Marker, Max; Antoni, Anne-Charlotte; Sutter, Kathrin; Sander, André; Dudda, Marcel; Flohe, Stefanie
    TLR4 Transactivates CD8⁺ T Lymphocytes upon Acute Sterile Tissue Injury
    In: ImmunoHorizons Jg. 5 (2021) Nr. 5, S. 298 - 306
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Liu, Jia; Yang, Xuecheng; Wang, Hua; Li, Ziwei; Deng, Hui; Liu, Jing; Xiong, Shue; He, Junyi; Feng, Xuemei; Guo, Chunxia; Wang, Weixian; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Senff, Tina; Menne, Christopher; Timm, Jörg; Zhang, Yanfang; Deng, Fei; Lu, Yinping; Wu, Jun; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Wang, Baoju; Zheng, Xin
    Analysis of the long-term impact on cellular immunity in COVID-19-recovered individuals reveals a profound nkt cell impairment
    In: mBio Jg. 12 (2021) Nr. 2, S. e00085 - 21
    Online Volltext: dx.doi.org/ (Open Access)
  • Li, Ziwei; Xiang, Tiandan; Liang, Boyun; Deng, Hui; Wang, Hua; Feng, Xuemei; Quan, Xufeng; Wang, Xiaoyan; Li, Sumeng; Lu, Sihong; Yang, Xuecheng; Wang, Baoju; Zelinskyy, Gennadiy; Trilling, Mirko; Sutter, Kathrin; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang; Zheng, Xin; Liu, Jia
    Characterization of SARS-CoV-2-Specific Humoral and Cellular Immune Responses Induced by Inactivated COVID-19 Vaccines in a Real-World Setting
    In: Frontiers in Immunology Jg. 12 (2021) 802858
    Online Volltext: dx.doi.org/ (Open Access)
  • Xiong, Shue; Zhu, Dan; Liang, Boyun; Li, Mingyue; Pan, Wen; He, Junyi; Wang, Hua; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Liu, Di; Yang, Dongliang; Liu, Jia; Zheng, Xin
    Longitudinal characterization of phenotypic profile of T cells in chronic hepatitis B identifies immune markers associated with HBsAg loss
    In: EBioMedicine Jg. 69 (2021) 103464
    Online Volltext: dx.doi.org/ (Open Access)

    • 2020

  • Wang, Shichuan; Trilling, Mirko; Sutter, Kathrin; Dittmer, Ulf; Lu, Mengji; Zheng, Xin; Yang, Dongliang; Liu, Jia
    A Crowned Killer’s Résumé : Genome, Structure, Receptors, and Origin of SARS-CoV-2
    In: Virologica Sinica (2020)
    Online Volltext: dx.doi.org/ (Open Access)
  • Sutter, Kathrin
    Die Einmischer: Interferone : Wie sie die Immunantwort beeinflussen, um Viren effektiv zu bekämpfen
    In: Unikate: Berichte aus Forschung und Lehre (2020) Nr. 54: Medizin: Infektionskrankheiten - ein globales Problem, S. 18 - 27
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Erratum for Westmeier et al., "Impaired Cytotoxic CD8⁺ T Cell Response in Elderly COVID-19 Patients"
    In: mBio Jg. 11 (2020) Nr. 5, S. 02243 - 02220
    Online Volltext: dx.doi.org/ (Open Access)
  • Westmeier, Jaana; Paniskaki, Krystallenia; Karaköse, Zehra; Werner, Tanja; Sutter, Kathrin; Dolff, Sebastian; Overbeck, Marvin; Limmer, Andreas; Liu, Jia; Zheng, Xin; Brenner, Thorsten; Berger, Marc; Witzke, Oliver; Trilling, Mirko; Lu, Mengji; Yang, Dongliang; Babel, Nina; Westhoff, Timm; Dittmer, Ulf; Zelinskyy, Gennadiy
    Impaired cytotoxic CD8⁺ T cell response in elderly COVID-19 patients
    In: mBio Jg. 11 (2020) Nr. 5, S. e02243 - 20
    Online Volltext: dx.doi.org/ (Open Access)
  • Liu, Jia; Zheng, Xin; Tong, Qiaoxia; Li, Wei; Wang, Baoju; Sutter, Kathrin; Trilling, Mirko; Lu, Mengji; Dittmer, Ulf; Yang, Dongliang
    Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV
    In: Journal of Medical Virology Jg. 92 (2020) Nr. 5, S. 491 - 494
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Ickler, Julia; Francois, Sandra; Widera, Marek; Santiago, Mario L.; Dittmer, Ulf; Sutter, Kathrin
    HIV infection does not alter interferon α/β receptor 2 expression on mucosal immune cells
    In: PLoS ONE Jg. 15 (2020) Nr. 1, S. e0218905
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Guo, Kejun; Shen, Guannan; Kibbie, Jon; Gonzalez, Tania; Dillon, Stephanie M.; Smith, Harry A.; Cooper, Emily H.; Lavender, Kerry; Hasenkrug, Kim J.; Sutter, Kathrin; Dittmer, Ulf; Kroehl, Miranda; Kechris, Katerina; Wilson, Cara C.; Santiago, Mario L.
    Qualitative differences between the IFNα subtypes and IFNβ influence chronic mucosal HIV-1 pathogenesis
    In: PLoS Pathogens Jg. 16 (2020) Nr. 10, S. 1008986
    Online Volltext: dx.doi.org/ (Open Access)
  • Heilingloh, Christiane Silke; Aufderhorst, Ulrich Wilhelm; Schipper, Leonie; Dittmer, Ulf; Witzke, Oliver; Yang, Dongliang; Zheng, Xin; Sutter, Kathrin; Trilling, Mirko; Alt, Mira; Steinmann, Eike; Krawczyk, Adalbert
    Susceptibility of SARS-CoV-2 to UV irradiation
    In: American Journal of Infection Control Jg. 48 (2020) Nr. 10, S. 1273 - 1275
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Zutz, Ariane; Schölz, Christian; Schneider, Stephanie; Pierini, Virginia; Münchhoff, Maximilian; Sutter, Kathrin; Wittmann, Georg; Dittmer, Ulf; Draenert, Rika; Bogner, Johannes R.; Fackler, Oliver T.; Keppler, Oliver T.
    SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation
    In: Journal of Innate Immunity Jg. 12 (2020) Nr. 5, S. 399 - 409
    Online Volltext: dx.doi.org/ (Open Access)

    • 2019

  • Dickow, Julia; Francois, Sandra; Kaiserling, Rouven-Luca; Malyshkina, Anna; Drexler, Ingo; Westendorf, Astrid Maria; Lang, Karl Sebastian; Santiago, Mario L.; Dittmer, Ulf; Sutter, Kathrin
    Diverse immunomodulatory effects of individual IFNα subtypes on virus-specific CD8⁺ T cell responses
    In: Frontiers in Immunology Jg. 10 (2019) 2255
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Matos, Aline da Rocha; Wunderlich, Katharina; Schloer, Sebastian; Schughart, Klaus; Geffers, Robert; Seders, Martine; Witt, Marlous de; Christersson, Anmari; Wiewrodt, Rainer; Wiebe, Karsten; Barth, Peter; Hocke, Andreas; Hippenstiel, Stefan; Hönzke, Katja; Dittmer, Ulf; Sutter, Kathrin; Rescher, Ursula; Rodionycheva, Svetlana; Matera, Nicoletta; Ludwig, Stephan; Brunotte, Linda
    Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities
    In: Emerging Microbes & Infections Jg. 8 (2019) Nr. 1, S. 1763 - 1776
    Online Volltext: dx.doi.org/ (Open Access)
  • Passos, Vânia; Zillinger, Thomas; Casartelli, Nicoletta; Wachs, Amelie S.; Xu, Shuting; Malassa, Angelina; Steppich, Katja; Schilling, Hildegard; Franz, Sergej; Todt, Daniel; Steinmann, Eike; Sutter, Kathrin; Dittmer, Ulf; Bohne, Jens; Schwartz, Olivier; Barchet, Winfried; Goffinet, Christine
    Characterization of Endogenous SERINC5 Protein as Anti-HIV-1 Factor
    In: Journal of Virology Jg. 93 (2019) Nr. 24, S. e01221 - 19
    Online Volltext: dx.doi.org/ (Open Access)
  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Ross, Jean Alexander; Paschen, Annette; Windmann, Sonja; Schimmer, Simone; Dittmer, Ulf
    Chronic retroviral infection of mice promotes tumor development, but CD137 agonist therapy restores effective tumor immune surveillance
    In: Cancer Immunology, Immunotherapy Jg. 68 (2019) Nr. 3, S. 479 - 488
    Online Volltext: dx.doi.org/
  • Sutter, Kathrin; Lavender, Kerry J.; Messer, Ronald J.; Widera, Marek; Williams, Katie; Race, Brent; Hasenkrug, Kim J.; Dittmer, Ulf
    Concurrent administration of IFNα14 and cART in TKO-BLT mice enhances suppression of HIV-1 viremia but does not eliminate the latent reservoir
    In: Scientific Reports Jg. 9 (2019) S. 18089
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Dittmer, Ulf; Sutter, Kathrin; Kassiotis, George; Zelinskyy, Gennadiy; Bánki, Zoltán; Stoiber, Heribert; Santiago, Mario L.; Hasenkrug, Kim J.
    Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity
    In: FEMS Microbiology Reviews Jg. 43 (2019) Nr. 5, S. 435 - 456
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Hasenkrug, Kim J.; Lavender, Kerry J.; Santiago, Mario L.; Sutter, Kathrin; Dittmer, Ulf
    Different Biological Activities of Specific Interferon Alpha Subtypes
    In: mSphere Jg. 4 (2019) Nr. 4, e00127 - 19
    Online Volltext: dx.doi.org/ (Open Access)
  • Gujer, Cornelia; Murer, Anita; Müller, Anne; Vanoaica, Danusia; Sutter, Kathrin; Jacque, Emilie; Fournier, Nathalie; Kalchschmidt, Jens; Zbinden, Andrea; Capaul, Riccarda; Dzionek, Andrzej; Mondon, Philippe; Dittmer, Ulf; Münz, Christian
    Plasmacytoid dendritic cells respond to Epstein-Barr virus infection with a distinct type I interferon subtype profile
    In: Blood Advances Jg. 3 (2019) Nr. 7, S. 1129 - 1144
    Online Volltext: dx.doi.org/ (Open Access)
  • Braun, Elisabeth; Hotter, Dominik; Koepke, Lennart; Zech, Fabian; Groß, Rüdiger; Sparrer, Konstantin M.J.; Müller, Janis A.; Pfaller, Christian K.; Heusinger, Elena; Wombacher, Rebecka; Sutter, Kathrin; Dittmer, Ulf; Winkler, Michael; Simmons, Graham; Jakobsen, Martin R.; Conzelmann, Karl-Klaus; Pöhlmann, Stefan; Münch, Jan; Fackler, Oliver T.; Kirchhoff, Frank; Sauter, Daniel
    Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins
    In: Cell Reports Jg. 27 (2019) Nr. 7, S. 2092 - 2104.e10
    Online Volltext: dx.doi.org/ (Open Access)
  • Xia, Yuchen; Schlapschy, Martin; Morath, Volker; Roeder, Natalie; Vogt, Elisabeth I.; Stadler, Daniela; Cheng, Xiaoming; Dittmer, Ulf; Sutter, Kathrin; Heikenwalder, Mathias; Skerra, Arne; Protzer, Ulrike
    PASylated interferon α efficiently suppresses hepatitis B virus and induces anti-HBs seroconversion in HBV-transgenic mice
    In: Antiviral Research Jg. 161 (2019) S. 134 - 143
    Online Volltext: dx.doi.org/

    • 2018

  • Shen, Fang; Li, Yaming; Wang, Yang; Sozzi, Vitina; Revill, Peter A.; Liu, Jiangxia; Gao, Lu; Yang, Guang; Lu, Mengji; Sutter, Kathrin; Dittmer, Ulf; Chen, Jieliang; Yuan, Zhenghong
    Hepatitis B virus sensitivity to interferon-α in hepatocytes is more associated with cellular interferon response than with viral genotype
    In: Hepatology Jg. 67 (2018) Nr. 4, S. 1237 - 1252
    Online Volltext: dx.doi.org/ (Open Access)
  • Korth, Johannes; Anastasiou, Olympia E.; Verheyen, Jens; Dickow, Julia; Sertznig, Helene; Frericks, Nicola; Bleekmann, Barbara; Kribben, Andreas; Brinkhoff, Alexandra; Wilde, Benjamin; Sutter, Kathrin; Dittmer, Ulf; Ciesek, Sandra; Witzke, Oliver; Widera, Marek
    Impact of immune suppressive agents on the BK-Polyomavirus non coding control region
    In: Antiviral Research Jg. 159 (2018) S. 68 - 76
    Online Volltext: dx.doi.org/
  • Lavender, Kerry J.; Pace, Craig; Sutter, Kathrin; Messer, Ronald J.; Pouncey, Dakota L.; Cummins, Nathan W.; Natesampillai, Sekar; Zheng, Jim; Goldsmith, Joshua; Widera, Marek; Van Dis, Erik S.; Phillips, Katie; Race, Brent; Dittmer, Ulf; Kukolj, George; Hasenkrug, Kim J.
    An advanced BLT-humanized mouse model for extended HIV-1 cure studies
    In: AIDS Jg. 32 (2018) Nr. 1, S. 1 - 10
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)
  • Sutter, Kathrin; Dickow, Julia; Dittmer, Ulf
    Interferon α subtypes in HIV infection
    In: Cytokine & Growth Factor Reviews Jg. 40 (2018) S. 13 - 18
    Online Volltext: dx.doi.org/
  • Knuschke, Torben; Rotan, Olga; Bayer, Wibke; Kollenda, Sebastian; Dickow, Julia; Sutter, Kathrin; Hansen, Wiebke; Dittmer, Ulf; Lang, Karl S.; Epple, Matthias; Buer, Jan; Westendorf, Astrid
    Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8+ T Cell Responses During Chronic Retroviral Infection
    In: Frontiers in Immunology Jg. 9 (2018) 614
    Online Volltext: dx.doi.org/ (Open Access)

    • 2017

  • Malyshkina, Anna; Littwitz-Salomon, Elisabeth; Sutter, Kathrin; Zelinskyy, Gennadiy; Windmann, Sonja; Schimmer, Simone; Paschen, Annette; Streeck, Hendrik; Hasenkrug, Kim J; Dittmer, Ulf
    Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection
    In: Scientific Reports Jg. 7 (2017) S. 7785
    Online Volltext: dx.doi.org/ (Open Access)
  • Schreiber, Timm; Quinting, Theresa; Dittmer, Ulf; Fandrey, Joachim; Sutter, Kathrin
    Hypoxia-inducible factor 1α is essential for macrophage-mediated erythroblast proliferation in acute friend retrovirus infection
    In: Scientific Reports Jg. 7 (2017) art. no. 17236
    Online Volltext: dx.doi.org/ (Open Access)
  • M. Ziegler, Susanne; Beisel, Claudia; Sutter, Kathrin; Griesbeck, Morgane; Hildebrandt, Heike; H. Hagen, Sven; Dittmer, Ulf; Altfeld, Marcus
    Human pDCs display sex-specific differences in type I interferon subtypes and interferon α/β receptor expression
    In: European Journal of Immunology Jg. 47 (2017) Nr. 2, S. 251 - 256
    Online Volltext: dx.doi.org/
  • Zhou, Yun; Li, Sheng; Tang, Zongsheng; Xu, Chunli; Huang, Shunmei; Wu, Jun; Dittmer, Ulf; Dickow, Julia; Sutter, Kathrin; Lu, Mengji; Yang, Dongliang; Song, Jingjiao
    Different antiviral effects of IFNα and IFNβ in an HBV mouse model
    In: Immunobiology Jg. 222 (2017) Nr. 3, S. 562 - 570
    Online Volltext: dx.doi.org/
  • Li, Yanpeng; Sun, Binlian; Esser, Stefan; Jessen, Heiko; Streeck, Hendrik; Widera, Marek; Yang, Rongge; Dittmer, Ulf; Sutter, Kathrin
    Expression pattern of individual IFNA subtypes in chronic HIV infection
    In: Journal of Interferon & Cytokine Research Jg. 37 (2017) Nr. 12, S. 541 - 549
    Online Volltext: dx.doi.org/
  • Song, Jingjiao; Li, Sheng; Zhou, Yun; Liu, Jia; Francois, Sandra; Lu, Mengji; Yang, Dongliang; Dittmer, Ulf; Sutter, Kathrin
    Different antiviral effects of IFNα subtypes in a mouse model of HBV infection
    In: Scientific Reports Jg. 7 (2017) Nr. 1, S. 334
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)

    • 2016

  • Blömker, Dominique; Mollérus, Sina; Gibbert, Kathrin; Dittmer, Ulf; Del Rey, Adriana E.; Schedlowski, Manfred; Engler, Harald
    Inhibition of catecholamine degradation ameliorates while chemical sympathectomy aggravates the severity of acute Friend retrovirus infection in mice
    In: Brain, Behavior and Immunity Jg. 54 (2016) S. 252 - 259
    Online Volltext: dx.doi.org/
  • Littwitz-Salomon, Elisabeth; Dittmer, Ulf; Sutter, Kathrin
    Insufficient natural killer cell responses against retroviruses : How to improve NK cell killing of retrovirus-infected cells
    In: Retrovirology Jg. 13 (2016) Nr. 1, 77
    Online Volltext: dx.doi.org/ (Open Access)
  • Lavender, Kerry J.; Gibbert, Kathrin; Peterson, Karin E.; Van Dis, Erik; Francois, Sandra; Woods, Tyson; Messer, Ronald J.; Gawanbacht, Ali; Müller, Janis A.; Münch, Jan; Phillips, Katie; Race, Brent; Harper, Michael S.; Guo, Kejun; Lee, Eric J.; Trilling, Mirko; Hengel, Hartmut; Piehler, Jacob; Verheyen, Jens; Wilson, Cara C.; Santiago, Mario L.; Hasenkrug, Kim J.; Dittmer, Ulf
    Interferon alpha subtype-specific suppression of HIV-1 infection in vivo
    In: Journal of Virology Jg. 90 (2016) Nr. 13, S. 6001 - 6013
    Online Volltext: dx.doi.org/ (Open Access)

    • 2015

  • Harper, Michael S.; Guo, Kejun; Gibbert, Kathrin; Lee, Eric J.; Dillon, Stephanie M.; Barrett, Bradley S.; McCarter, Martin D.; Hasenkrug, Kim J.; Dittmer, Ulf; Wilson, Cara C.; Santiago, Mario L.
    Interferon-α subtypes in an ex vivo model of acute HIV-1 infection : expression, potency and effector mechanisms
    In: PLoS Pathogens Jg. 11 (2015) Nr. 11, S. e1005254
    Online Volltext: dx.doi.org/ (Open Access)
  • Littwitz-Salomon, Elisabeth; Akhmetzyanova, Ilseyar; Vallet, Cecilia; Francois, Sandra; Dittmer, Ulf; Gibbert, Kathrin
    Activated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection
    In: Retrovirology Jg. 12 (2015) Nr. 1, 66
    Online Volltext: dx.doi.org/ (Open Access)
  • Wu, Weimin; Dietze, Kirsten; Gibbert, Kathrin; Lang, Karl S.; Trilling, Mirko; Yan, Huimin; Wu, Jun; Yang, Dongliang; Lu, Mengji; Roggendorf, Michael; Dittmer, Ulf; Liu, Jia
    TLR ligand induced IL-6 counter-regulates the anti-viral CD8+ T cell response during an acute retrovirus infection
    In: Scientific Reports Jg. 5 (2015) S. 10501
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)

    • 2014

  • Bröring, Ruth; Real, Catherine; John, Matthias J.; Jahn-Hofmann, Kerstin; Ickenstein, Ludger M.; Kleinehr, Kathrin; Paul, Andreas; Sutter, Kathrin; Dittmer, Ulf; Gerken, Guido; Schlaak, Jörg Friedrich
    Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro
    In: International Immunology Jg. 26 (2014) Nr. 1, S. 35 - 46
    Online Volltext: dx.doi.org/

    • 2013

  • Gibbert, K.; Schlaak, Jörg Friedrich; Yang, D.; Dittmer, Ulf; Schlaak, JF
    IFN-α subtypes : Distinct biological activities in anti-viral therapy
    In: British Journal of Pharmacology (BJP) Jg. 168 (2013) Nr. 5, S. 1048 - 1058
    Online Volltext: dx.doi.org/ (Open Access)
  • Harper, Michael S.; Barrett, Bradley S.; Smith, Diana S.; Li, Sam X.; Gibbert, Kathrin; Dittmer, Ulf; Hasenkrug, Kim J.; Santiago, Mario L.
    IFN-α treatment inhibits acute friend retrovirus replication primarily through the antiviral effector molecule Apobec3
    In: The Journal of Immunology (JI) Jg. 190 (2013) Nr. 4, S. 1583 - 1590
    Online Volltext: dx.doi.org/
  • Behrendt, Rayk; Schumann, Tina; Gerbaulet, Alexander; Nguyen, Laura A.; Schubert, Nadja; Alexopoulou, Dimitra; Berka, Ursula; Lienenklaus, Stefan; Peschke, Katrin; Gibbert, Kathrin; Wittmann, Sabine; Lindemann, Dirk; Weiss, Siegfried; Dahl, Andreas; Naumann, Ronald; Dittmer, Ulf; Kim, Baek; Mueller, Werner; Gramberg, Thomas; Roers, Axel
    Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response
    In: Cell Reports Jg. 4 (2013) Nr. 4, S. 689 - 696
    Online Volltext: dx.doi.org/ (Open Access)
  • Wobben, Regina; Hüsecken, Yvonne; Lodewick, Claudia; Gibbert, Kathrin; Fandrey, Joachim; Winning, Sandra
    Role of hypoxia inducible factor-1 α for interferon synthesis in mouse dendritic cells
    In: Biological Chemistry Jg. 394 (2013) Nr. 4, S. 495 - 505
    Online Volltext: dx.doi.org/
  • Littwitz-Salomon, Elisabeth; Francois, Sandra; Dittmer, Ulf; Gibbert, Kathrin
    Distinct roles of NK cells in viral immunity during different phases of acute Friend retrovirus infection
    In: Retrovirology Jg. 10 (2013) Nr. 1, 127
    Online Volltext: dx.doi.org/ (Open Access)

    • 2012

  • Gibbert, Kathrin; Joedicke, Jara J.; Meryk, Andreas; Trilling, Mirko; Francois, Sandra; Duppach, Janine; Kraft, Anke; Lang, Karl S.; Dittmer, Ulf
    Interferon-alpha Subtype 11 Activates NK Cells and Enables Control of Retroviral Infection
    In: PLoS Pathogens Jg. 8 (2012) Nr. 8, S. e1002868
    Online Volltext: dx.doi.org/ Online Volltext (Open Access)

    • 2011

  • Gibbert, Kathrin; Dittmer, Ulf
    Distinct antiviral activities of IFN-α subtypes
    In: Immunotherapy Jg. 3 (2011) Nr. 7, S. 813 - 816
    Online Volltext: dx.doi.org/
  • Dietze, Kirsten; Zelinskyy, Gennadiy; Gibbert, Kathrin; Schimmer, Simone; Francois, Sandra; Myers, Lara; Sparwasser, Tim; Hasenkrug, Kim J.; Dittmer, Ulf
    Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8⁺ T cells and reduces chronic retroviral set points
    In: Proceedings of the National Academy of Sciences of the United States of America (PNAS) Jg. 108 (2011) Nr. 6, S. 2420 - 2425
    Online Volltext: dx.doi.org/ (Open Access)
  • Zelinskyy, Gennadiy; Myers, Lara; Dietze, Kirsten; Gibbert, Kathrin; Roggendorf, Michael; Liu, Jia; Lu, Mengji; Kraft, Anke R.; Teichgräber, Volker; Hasenkrug, Kim J.; Dittmer, Ulf
    Virus-Specific CD8+ T Cells Upregulate Programmed Death-1 Expression during Acute Friend Retrovirus Infection but Are Highly Cytotoxic and Control Virus Replication
    In: The Journal of Immunology (JI) Jg. 187 (2011) Nr. 7, S. 3730 - 3737
    Online Volltext: dx.doi.org/

    • 2010

  • Sender, Linda Y.; Gibbert, Kathrin; Suezer, Yasemin; Radeke, Heinfried H.; Kalinke, Ulrich; Waibler, Zoe
    CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals
    In: Molecular Immunology Jg. 47 (2010) Nr. 6, S. 1255 - 1261
    Online Volltext: dx.doi.org/
  • Gibbert, Kathrin; Dietze, Kirsten; Zelinskyy, Gennadiy; Lang, Karl S.; Barchet, Winfried; Kirschning, Carsten Jürgen; Dittmer, Ulf
    Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease
    In: The Journal of Immunology (JI) Jg. 185 (2010) Nr. 10, S. 6179 - 6189
    Online Volltext: dx.doi.org/ (Open Access)