Klinische Studien
Forschungsbereich
HIV
Schwerpunkte in der klinischen HIV-Forschung der HPSTD-Ambulanz (HIV/AIDS, Proktologie, Geschlechtskrankheiten (STD)) sind das Altern mit HIV, chronische Inflammation, Komorbiditäten und Langzeittoxizitäten der antiretroviralen Therapie (ART) in Menschen, die mit einer HIV-Infektion leben, Weiterentwicklungen der ART, Heilungsversuche bei HIV-Infizierten mit Indikation zur Knochenmarkstransplantation, schwer ART-Vorbehandelte mit Resistenzen und HIV-Infizierte mit antiretroviralem Therapieversagen. Neben kardiovaskulären Erkrankungen werden besonders HIV-assoziierte Neoplasien wie das Kaposi Sarkom und das Analkarzinom wissenschaftlich untersucht.
Unser Zentrum nimmt an nationalen und internationalen Studien teil, z. B. an der START Studie von der INSIGHT-Gruppe, der ClinSurv Kohorte des Robert-Koch-Instituts, über das DZIF an einer Studie zu neutralisierenden Antikörpern und an einer HIV-Inzidenz-Studie bei Männern, die Sex mit Männern haben (MSM), im Rahmen des US Military HIV Research Programms (USMHRP) zur Erhebung der Durchführbarkeit einer HIV-Impfstudie. Alle Fälle von SARS-CoV-2 Infektionen bei HIV-Infizierten werden prospektiv systematisch erfasst und Proben asserviert.
STI und Proktologie
Prävention, Screening, Diagnostik und Behandlung von sexuell übertragbaren Infektionen einschließlich Hepatitis A, B und C werden im Rahmen wissenschaftlicher Projekte erforscht.
Als eines der ersten Zentren in Europa haben wir am Universitätsklinikum Essen die High Resolution Anoscopy zur Früherkennung HPV-assoziierter Läsionen und das Analkarzinom-Screening bei Menschen, die mit einer HIV-Infektion leben, eingeführt. Die Behandlung von Feigwarzen und analen intraepitehlialen Neoplasien gehört ebenso wie die Teilnahme an Impfstudien gegen HPV zu den Forschungsschwerpunkten.
Prof. Dr. med. Stefan Esser
stellvertretener Institutsleiter
Hautklinik, Raum 2.016
Tel. 0201/723-3878
Fax 0201/723-3845
Laufende Studien
Eigene Studien
HIV HEART Aging
Mit der HIV HEART Aging Studie findet unter Leitung des Essener Zentrums seit mehr als 15 Jahren die größte prospektive deutsche Kohortenstudie zum Altern mit HIV-Infektion und zu kardiovaskulären Erkrankungen bei Menschen, die mit einer HIV-Infektion leben, im Ruhrgebiet statt (unterstützt von ViiV, MSD, Janssen, Gilead und BMBF).
TECAIN
Die TECAIN Studie untersucht multizentrisch, prospektiv, randomisiert die Effektivität einer topischen Behandlung mit Trichloressigsäure (T) im Vergleich zur lokalen elektrokaustischen Abtragung (EC) von histologisch gesicherten, analen, intraepithelialen Neoplasien (AIN) bei Menschen, die mit einer HIV-Infektion leben (gefördert durch das BMBF).
PrEP und Impfung
Verschiedene Studien untersuchen Personen, die eine Präexpositions-Prophylaxe gegen HIV bekommen, in Bezug auf Effektivität, STI-Screening, Inzidenz und Prävalenz von STI, Veränderungen im Risikoverhalten sowie Eignung und Bereitschaft zur Teilnahme an Impfstudien.
Low Level Virämie, virologisches Versagen und Resistenzen
Trotz auf der Basis von Resistenztestungen, Nebenwirkungsmanagement, Compliance-Erhebungen und Medikamentenspiegelmessungen optimierter antiretroviraler Therapie besteht bei einigen HIV-Infizierten nach Ausschluss eines virologischen Versagens eine Low-Level-Virämie, deren klinische und immunologische Auswirkungen wir wissenschaftlich untersuchen (unterstützt von Janssen).
Auftragsforschung
In der Auftragsforschung beteiligen wir uns für Menschen, die mit einer HIV-Infektion leben, an der Weiterentwicklung der antiretroviralen Therapie (Injectables, Long-acting Substanzen, neue Substanzklassen besonders für schwer Vorbehandelte mit Resistenzen) und an Studien zu Impfstoffen gegen HIV, HSV, HPV und anderen STI.
Klinische Proben anfragen
Mitglieder des Forschungsbereichs
HPSTD-Ambulanz
Tel. 0201/723-3696, Fax 0201/723-3631, Webseite
Ärzteteam:
Dr. med. Stefanie Sammet (Fachärztin für Dermatovenerologie, Infektiologin), E-Mail
Felix Maischack (Facharzt für Innere Medizin), E-Mail
Theodora Kanaki (Fachärztin für Dermatovenerologie), E-Mail
Nina Giese (Assistenzärztin), E-Mail
Pflegeteam:
Heidi Wiehler (Teamleitung, Study Nurse, Krankenschwester), E-Mail
Anja Bunk (Krankenschwester), E-Mail
Pia Schenk-Westkamp (Medizinische Dokumentarin), E-Mail
Kornelia Krupok (Medizinische Fachangestellte), E-Mail
Aylin Yavuz (Medizinische Fachangestellte), E-Mail
Kimberly Solis-Sanchez (Medizinische Fachangestellte), E-Mail
HIV HEART Aging Studien-Team
Sarah Albayrak-Rena (Study Nurse), E-Mail
Franziska Kaiser (Study Nurse), E-Mail
Dr. rer. nat. Laven Maravani (Biometrikerin vom IMIBE (Institut für Medizinische Informatik, Biometrie und Epidemiologie)), E-Mail
PD Dr. rer. medic. Börge Schmidt (Biometriker vom IMIBE), E-Mail
Konstantinos Bilbilis (Dipl.-Biologe vom IMIBE), E-Mail
Assoziierte Ärzte und Psychologen
PD Dr. med. Nico Reinsch (Kardiologe am Alfried Krupp Krankenhaus Essen und Dozent an der Universität Witten/Herdecke), E-Mail
PD Dr. med. Sebastian Dolff (Infektiologe, Nephrologe, Klinik für Infektionsmedizin UK Essen), E-Mail
PD Dr. med. Mark Stettner (Neurologe, Klinik für Neurologie UK Essen), E-Mail
Dr. rer. medic. Henrike Schecke (Psychologische Psychotherapeutin, Leiterin Suchtforschung, LVR-Klinikum, Universität Duisburg Essen), E-Mail
PD Dr. rer. pol. Anja Neumann (Stiftungslehrstuhl für Medizinmanagement Universität Duisburg Essen), E-Mail
Prof. Dr. med. Hendrik Streeck (Institutsdirektor Virologie, UK Bonn), E-Mail
Publikationsliste (Auswahl)
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Characterising HIV-Indicator conditions among two nationwide long-term cohorts of people living with HIV in Germany (1999–2023)In: Infection - A Journal of Infectious Disease (2024) in pressOnline Volltext: dx.doi.org/ (Open Access)
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Characterising HIV-Indicator conditions among two nationwide long-term cohorts of people living with HIV in Germany (1999-2023)In: Infection - A Journal of Infectious Disease (2024) in pressOnline Volltext: dx.doi.org/ (Open Access)
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Establishment of a non-Westernized gut microbiota in men who have sex with men is associated with sexual practicesIn: Cell Reports Medicine Jg. 5 (2024) Nr. 3, 101426Online Volltext: dx.doi.org/ (Open Access)
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High cure rates of Mycoplasma genitalium following empiric treatment with azithromycin alongside frequent detection of macrolide resistance in AustriaIn: Infection - A Journal of Infectious Disease Jg. 52 (2024) Nr. 5, S. 1921 - 1930Online Volltext: dx.doi.org/ (Open Access)
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Hypercalcemia as a rare manifestation of immune reconstitution inflammatory syndrome (IRIS) in a person living with Human Immunodeficiency Virus (HIV) with disseminated nontuberculous mycobacteriosisIn: Infection - A Journal of Infectious Disease Jg. 52 (2024) Nr. 4, S. 1627 - 1631Online Volltext: dx.doi.org/ (Open Access)
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Immunogenicity of the Monovalent Omicron XBB.1.5-Adapted BNT162b2 COVID-19 Vaccine in People Living with HIV (PLWH)In: Vaccines Jg. 12 (2024) Nr. 7, 785Online Volltext: dx.doi.org/ (Open Access)
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Combined bictegravir, emtricitabine and tenofovir alafenamide for treating people with HIV : A plain language summary of the BICSTaR study up to 1 yearIn: Future Microbiology (2024) in pressOnline Volltext: dx.doi.org/ (Open Access)
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The interferon-regulated host factor hnRNPA0 modulates HIV-1 production by interference with LTR activity, mRNA trafficking, and programmed ribosomal frameshiftingIn: Journal of Virology Jg. 98 (2024) Nr. 7, e0053424Online Volltext: dx.doi.org/
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Prevalence of sarcopenia among people living with HIV defined by the revised European working group on sarcopenia in older peopleIn: International Journal of STD and AIDS (2024) in pressOnline Volltext: dx.doi.org/
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Prevalence of HIV in people with potential HIV-indicator conditions in Germany : an analysis of data from statutory health insurancesIn: eClinicalMedicine Jg. 73 (2024) 102694Online Volltext: dx.doi.org/ (Open Access)
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T Cell Responses against Orthopoxviruses in HIV-Positive PatientsIn: Vaccines Jg. 12 (2024) Nr. 2, 131Online Volltext: dx.doi.org/ (Open Access)
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Torque Teno Virus Load Is Associated With Centers for Disease Control and Prevention Stage and CD4+ Cell Count in People Living With Human Immunodeficiency Virus but Seems Unrelated to AIDS-Defining Events and Human Pegivirus LoadIn: The Journal of Infectious Diseases (JID) Jg. 230 (2024) Nr. 2, S. e437 - e446Online Volltext: dx.doi.org/ (Open Access)
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The Association of HIV-Specific Risk Factors with Cardiovascular Events in Addition to Traditional Risk Factors in People Living with HIVIn: AIDS Research and Human Retroviruses Jg. 40 (2024) Nr. 4, S. 235 - 245Online Volltext: dx.doi.org/
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Twelve-month effectiveness and safety of bictegravir/emtricitabine/tenofovir alafenamide in people with HIV : Real-world insights from BICSTaR cohortsIn: HIV Medicine Jg. 25 (2024) Nr. 4, S. 440 - 453Online Volltext: dx.doi.org/ (Open Access)
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Dynamics and durability of HIV-1 neutralization are determined by viral replicationIn: Nature Medicine Jg. 29 (2023) Nr. 11, S. 2763 - 2774Online Volltext: dx.doi.org/ (Open Access)
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Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell folliclesIn: PLoS Pathogens Jg. 19 (2023) Nr. 10, e1011725Online Volltext: dx.doi.org/ (Open Access)
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Changes in body mass index, weight, and waist-to-hip ratio over five years in HIV-positive individuals in the HIV Heart Aging Study compared to the general populationIn: Infection - A Journal of Infectious Disease Jg. 51 (2023) Nr. 4, S. 1081 - 1091Online Volltext: dx.doi.org/ (Open Access)
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Long-term effects on subclinical cardiovascular disease of switching from boosted protease inhibitors to dolutegravirIn: Journal of Antimicrobial Chemotherapy Jg. 78 (2023) Nr. 9, S. 2361 - 2365Online Volltext: dx.doi.org/
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Incidence of Hypertension and Blood Pressure Changes in Persons With Human Immunodeficiency Virus (HIV) at High Risk for Cardiovascular Disease Switching From Boosted Protease Inhibitors to Dolutegravir : A Post-hoc Analysis of the 96-week Randomised NEAT-022 TrialIn: Clinical Infectious Diseases (CID) Jg. 77 (2023) Nr. 7, S. 991 - 1009Online Volltext: dx.doi.org/
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Optimization of HIV testing services in Germany using HIV indicator diseases : study protocol of the HeLP studyIn: Archives of Public Health Jg. 81 (2023) Nr. 1, 159Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Clinical characteristics of monkeypox virus infections among men with and without HIV : A large outbreak cohort in GermanyIn: HIV Medicine Jg. 24 (2023) Nr. 4, S. 389 - 397Online Volltext: dx.doi.org/ (Open Access)
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The "Intimarzt" (intimate doctor) Model Project : Anonymous Remote Diagnosis of Sexually Transmitted DiseasesIn: Deutsches Ärzteblatt international Jg. 120 (2023) Nr. 6, S. 94 - 95Online Volltext: dx.doi.org/ (Open Access)
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False-Positive Screening and Confirmatory HIV Diagnostic Test in a Patient with Cured SARS-CoV-2 Infection Is Not Mediated by Env/Spike Cross-Reactive AntibodiesIn: Viruses Jg. 15 (2023) Nr. 5, 1161Online Volltext: dx.doi.org/ (Open Access)
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Limited Weight Impact After Switching From Boosted Protease Inhibitors to Dolutegravir in Persons With Human Immunodeficiency Virus With High Cardiovascular Risk : A Post Hoc Analysis of the 96-Week NEAT-022 Randomized TrialIn: Clinical Infectious Diseases (CID) Jg. 76 (2023) Nr. 5, S. 861 - 870Online Volltext: dx.doi.org/ (Open Access)
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Sexually Transmitted Dermatophytes Can Cause Severe Infection Among Men who Have Sex With Men as Tinea GenitalisIn: Open Forum Infectious Diseases Jg. 10 (2023) Nr. 11, ofad519Online Volltext: dx.doi.org/ (Open Access)
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S1-Leitlinie: Kaposi-SarkomIn: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 20 (2022) Nr. 6, S. 892 - 905Online Volltext: dx.doi.org/; Online Volltext: dx.doi.org/ (Open Access)
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Antiretrovirale Therapie-Strategien: eine aktuelle Leitlinien-fokussierte ÜbersichtIn: Haut: Dermatologie, Allergologie, Kosmetologie (2022) Nr. 4, S. 194 - 197
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HIV pre-exposure prophylaxis was associated with no impact on sexually transmitted infection prevalence in a high-prevalence population of predominantly men who have sex with men, Germany, 2018 to 2019In: Eurosurveillance Jg. 27 (2022) Nr. 14, 2100591Online Volltext: dx.doi.org/ (Open Access)
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SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration stepsIn: Frontiers in Immunology Jg. 13 (2022) 935800Online Volltext: dx.doi.org/ (Open Access)
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Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected IndividualsIn: Frontiers in Immunology Jg. 13 (2022) 936918Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Reduction of CD8 T Cell Functionality but Not Inhibitory Capacity by Integrase InhibitorsIn: Journal of Virology Jg. 96 (2022) Nr. 5, e01730-21Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Infektionen mit Herpes-simplex-Viren : Diagnosestellung und TherapieIn: MMW - Fortschritte der Medizin Jg. 163 (2021) Nr. 12, S. 46 - 55Online Volltext: dx.doi.org/
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S1-Leitlinie kutane Angiosarkome : Update 2021In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 19 (2021) Nr. 12, S. 1801 - 1813Online Volltext: dx.doi.org/ (Open Access)
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Prediction of future cardiovascular events by Framingham, SCORE and asCVD risk scores is less accurate in HIV-positive individuals from the HIV-HEART Study compared with the general populationIn: HIV Medicine Jg. 22 (2021) Nr. 8, S. 732 - 741Online Volltext: dx.doi.org/ (Open Access)
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S1‐Guideline Cutaneous Angiosarcomas : Update 2021In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 19 (2021) Nr. 12, S. 1801 - 1812Online Volltext: dx.doi.org/ (Open Access)
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Evolution of drug resistance mutation archive in patients infected with multi-class resistant HIV-1 and with viral suppressionIn: Infection - A Journal of Infectious Disease Jg. 49 (2021) Nr. Suppl. 1, S. 17 - S18Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Weight Change Following Antiretroviral Therapy Switch in People With Viral Suppression : Pooled Data from Randomized Clinical TrialsIn: Clinical Infectious Diseases (CID) Jg. 73 (2021) Nr. 8, S. 1440 - 1451Online Volltext: dx.doi.org/
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Eosinophilic pustular folliculitis (EPF) in a patient with HIV infectionIn: Infection - A Journal of Infectious Disease Jg. 49 (2021) Nr. 4, S. 799 - 801Online Volltext: dx.doi.org/ (Open Access)
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Switching from boosted PIs to dolutegravir decreases soluble CD14 and adiponectin in high cardiovascular risk people living with HIVIn: Journal of Antimicrobial Chemotherapy Jg. 76 (2021) Nr. 9, S. 2380 - 2393Online Volltext: dx.doi.org/
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Factors associated with testing for HIV and hepatitis C among behaviorally vulnerable men in Germany : A cross-sectional analysis upon enrollment into an observational cohortIn: AIDS Research and Therapy Jg. 18 (2021) Nr. 1, 52Online Volltext: dx.doi.org/ (Open Access)
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GNA14, GNA11, and GNAQ Mutations Are Frequent in Benign but Not Malignant Cutaneous Vascular TumorsIn: Frontiers in Genetics Jg. 12 (2021) 663272Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Analkarzinom : die neue LeitlinieIn: Best Practice Onkologie Jg. 16 (2021) S. 228 - 237Online Volltext: dx.doi.org/
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HIV-Medizin in der Dermatologie und VenerologieIn: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 19 (2021) Nr. 1, S. 82 - 97Online Volltext: dx.doi.org/ (Open Access)
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Production of HIV-1 env-specific antibodies mediating innate immune functions depends on cognate interleukin-21-secreting CD4⁺T cellsIn: Journal of Virology Jg. 95 (2021) Nr. 8, S. e02097Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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HIV medicine for dermatologists and venereologistsIn: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 19 (2021) Nr. 1, S. 82 - 96Online Volltext: dx.doi.org/ (Open Access)
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High prevalence of recreational and illicit drug use in German people living with HIV with a potential for drug : Drug interactions with antiretroviral therapyIn: International Journal of STD and AIDS Jg. 32 (2021) Nr. 1, S. 75 - 82Online Volltext: dx.doi.org/
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Rare TERT Promoter Mutations Present in Benign and Malignant Cutaneous Vascular TumorsIn: Dermato Jg. 1 (2021) Nr. 1, S. 18 - 25Online Volltext: dx.doi.org/ (Open Access)
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Switching to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide in Adults With HIV and M184V/I MutationIn: JAIDS - Journal of Acquired Immune Deficiency Syndromes Jg. 86 (2021) Nr. 4, S. 490 - 495Online Volltext: dx.doi.org/ (Open Access)
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Erratum zu : Diagnostik und Therapie der Syphilis. Aktualisierung der S2k-Leitlinie 2020 der Deutsche STI-Gesellschaft (DSTIG) in Kooperation mit folgenden Fachgesellschaften: DAIG, dagnä, DDG, DGA, DGGG, DGHM, DGI, DGN, DGPI, DGU, RKIIn: Der Hautarzt Jg. 71 (2020) S. 898Online Volltext: dx.doi.org/ (Open Access)
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Denken Sie bei HIV-Infizierten auch ans Herz! : Kardiovaskuläre ErkrankungenIn: MMW - Fortschritte der Medizin Jg. 162 (2020) S. 20 - 23Online Volltext: dx.doi.org/
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Diagnostik und Therapie der Syphilis : Aktualisierung der S2k-Leitlinie 2020 der Deutsche STI-Gesellschaft (DSTIG) in Kooperation mit folgenden Fachgesellschaften: DAIG, dagnä, DDG, DGA, DGGG, DGHM, DGI, DGN, DGPI, DGU, RKIIn: Der Hautarzt (2020)Online Volltext: dx.doi.org/
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Klassische sexuell übertragbare Infektionen im AnalbereichIn: Der Hautarzt Jg. 71 (2020) Nr. 4, S. 275 - 283Online Volltext: dx.doi.org/
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High effectiveness of recommended first-line antiretroviral therapies in Germany : a nationwide, prospective cohort studyIn: Infection - A Journal of Infectious Disease Jg. 48 (2020) Nr. 3, S. 453 - 461Online Volltext: dx.doi.org/
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Externe wissenschaftliche Evaluation der ersten Teledermatologie-App ohne direkten Patientenkontakt in Deutschland („Online Hautarzt – AppDoc“)In: Der Hautarzt Jg. 71 (2020) Nr. 11, S. 887 - 897Online Volltext: dx.doi.org/ (Open Access)
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Treatment modification after starting cART in people living with HIV : retrospective analysis of the German ClinSurv HIV Cohort 2005–2017In: Infection - A Journal of Infectious Disease Jg. 48 (2020) Nr. 5, S. 723 - 733Online Volltext: dx.doi.org/ (Open Access)
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Rapid uptake of pre-exposure prophylaxis (PrEP) after significant price reduction in Germany highlights importance of PrEP accessibilityIn: AIDS Research and Human Retroviruses (2020)Online Volltext: dx.doi.org/
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Weight gain following initiation of antiretroviral therapy : Risk factors in randomized comparative clinical trialsIn: Clinical Infectious Diseases (CID) Jg. 71 (2020) Nr. 6, S. 1379 - 1389Online Volltext: dx.doi.org/ (Open Access)
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Week 96 results of a phase 3 trial of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-naive HIV-1 patientsIn: AIDS Jg. 34 (2020) Nr. 5, S. 707 - 718Online Volltext: dx.doi.org/ (Open Access)
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SARS-CoV-2-specific antibody detection in healthcare workers in Germany with direct contact to COVID-19 patientsIn: Journal of Clinical Virology Jg. 128 (2020) 104437Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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Disseminated emergomycosis in a person with HIV infection, UgandaIn: Emerging Infectious Diseases (EID) Jg. 25 (2019) Nr. 9, S. 1750 - 1751Online Volltext: dx.doi.org/ (Open Access)
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Higher Prevalence of CKD in HIV plus individuals compared to the general populationIn: HIV Medicine Jg. 20 (2019) Nr. Suppl. 9, S. 140
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Antiretroviral therapy suppresses rectal HIV-RNA shedding despite inflammation in MSM with rectal C. trachomatis and N. gonorrhoeae infections - A cross-sectional, single-center studyIn: Sexually Transmitted Infections Jg. 95 (2019) Nr. 2, S. 95 - 98Online Volltext: dx.doi.org/ (Open Access)
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Planning HIV therapy to prevent future comorbidities : patient years for tenofovir alafenamideIn: HIV Medicine Jg. 20 (2019) Nr. S7, S. 1 - 16Online Volltext: dx.doi.org/ (Open Access)
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Renal safety of tenofovir alafenamide vs. tenofovir disoproxil fumarate : A pooled analysis of 26 clinical trialsIn: AIDS Jg. 33 (2019) Nr. 9, S. 1455 - 1465Online Volltext: dx.doi.org/ (Open Access)
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B-type natriuretic peptides for the prediction of cardiovascular events and mortality in patients living with HIV : Results from the HIV-HEART studyIn: International Journal of Cardiology Jg. 281 (2019) S. 127 - 132Online Volltext: dx.doi.org/
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Effect of HIV infection and antiretroviral therapy on immune cellular functionsIn: JCI Insight Jg. 4 (2019) Nr. 12, :e126675Online Volltext: dx.doi.org/ (Open Access)
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Determinants of blood telomere length in antiretroviral treatment-naïve HIV-positive participants enrolled in the NEAT 001/ANRS 143 clinical trialIn: HIV Medicine Jg. 20 (2019) Nr. 10, S. 691 - 698Online Volltext: dx.doi.org/ (Open Access)
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Rapid rebound of a preexisting CXCR4-tropic human immunodeficiency virus variant after allogeneic transplantation with CCR5 Δ32 homozygous stem cellsIn: Clinical Infectious Diseases (CID) Jg. 68 (2019) Nr. 4, S. 684 - 687Online Volltext: dx.doi.org/ (Open Access)
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Gut Microbiota in Human Immunodeficiency Virus-Infected Individuals Linked to Coronary Heart DiseaseIn: The Journal of Infectious Diseases (JID) Jg. 219 (2019) Nr. 3, S. 497 - 508Online Volltext: dx.doi.org/ (Open Access)
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Immediate versus deferred switching from a boosted protease inhibitor-based regimen to a dolutegravir-based regimen in virologically suppressed patients with high cardiovascular risk or age ≥50 years : Final 96-week results of the NEAT022 studyIn: Clinical Infectious Diseases (CID) Jg. 68 (2019) Nr. 4, S. 597 - 606Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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A skin cancer prevention facial-aging mobile app for secondary schools in Brazil : Appearance-focused interventional studyIn: JMIR mhealth and uhealth Jg. 6 (2018) Nr. 3, e60Online Volltext: dx.doi.org/ (Open Access)
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Facial-aging app availability in waiting rooms as a potential opportunity for skin cancer preventionIn: JAMA Dermatology Jg. 154 (2018) Nr. 9, S. 1085 - 1086Online Volltext: dx.doi.org/ (Open Access)
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Incidence and risk factors for relapses in hiv-associated non-hodgkin lymphoma as observed in the german HIV-related lymphoma cohort studyIn: Haematologica / The Hematology Journal Jg. 103 (2018) Nr. 5, S. 857 - 864Online Volltext: dx.doi.org/ (Open Access)
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Nosokomiale Scabies : Ausbruch bei Personal einer UniversitätsklinikIn: Deutsche Medizinische Wochenschrift - DMW Jg. 143 (2018) Nr. 12, S. e95 - e98Online Volltext: dx.doi.org/
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Modulation of Vaccine-Induced CD4 T Cell Functional Profiles by Changes in Components of HIV Vaccine Regimens in HumansIn: Journal of Virology Jg. 92 (2018) Nr. 23, S. e01143 - 18Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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A Face-Aging App for Smoking Cessation in a Waiting Room Setting : Pilot Study in an HIV Outpatient ClinicIn: Journal of Medical Internet Research (JMIR) Jg. 20 (2018) Nr. 8, S. e10976Online Volltext: dx.doi.org/ (Open Access)
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Profil der Kaposi-Sarkom-Patienten im Kompetenznetz HIV/AIDSIn: Der Hautarzt Jg. 69 (2018) Nr. 2, S. 143 - 148Online Volltext: dx.doi.org/
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S2k guideline : HPV‐associated lesions of the external genital region and the anus – anogenital warts and precancerous lesions of the vulva, the penis, and the peri‐ and intra‐anal skin (short version)In: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 16 (2018) Nr. 2, S. 242 - 255Online Volltext: dx.doi.org/
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Nekrotisierendes Exanthem, Schleimhautveränderungen und atypische Pneumonie bei einem indonesischen PfarrerIn: Der Hautarzt Jg. 69 (2018) Nr. 6, S. 516 - 518Online Volltext: dx.doi.org/
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Teledermatology : Comparison of Store-and-Forward Versus Live Interactive Video ConferencingIn: Journal of Medical Internet Research (JMIR) Jg. 20 (2018) Nr. 10, e11871Online Volltext: dx.doi.org/ (Open Access)
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HIV-Associated Kaposi's SarcomaIn: Oncology Research and Treatment Jg. 40 (2017) Nr. 3, S. 94 - 98Online Volltext: dx.doi.org/
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Dramatic changes over time of methamphetamine intake in a German, HIV-positive, sample of men who have sex with men (MSM)In: Pharmacopsychiatry Jg. 50 (2017) Nr. 3, S. 123 - 124Online Volltext: dx.doi.org/
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HIV-1 persistent viremia is frequently followed by episodes of low-level viremiaIn: Medical Microbiology and Immunology Jg. 206 (2017) Nr. 3, S. 203 - 215Online Volltext: dx.doi.org/ Online Volltext (Open Access)
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More and earlier cardiovascular events (CVEs) and shorter overall survival (OS) in HIV-positive patients (HIV positive) compared to the general population differ by sexIn: Journal of the International AIDS Society Jg. 20 (2017) Nr. Suppl. 5, S. 70 - 71
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Prolongation of the QTc interval in HIV-infected individuals compared to the general populationIn: Infection - A Journal of Infectious Disease Jg. 45 (2017) Nr. 5, S. 659 - 667Online Volltext: dx.doi.org/
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Sexual risk behavior, sexually transmitted infections, and HIV transmission risks in HIV-positive men who have sex with men (MSM) – approaches for medical preventionIn: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 15 (2017) Nr. 4, S. 421 - 428Online Volltext: dx.doi.org/
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Switching from a ritonavir-boosted protease inhibitor to a dolutegravir-based regimen for maintenance of HIV viral suppression in patients with high cardiovascular riskIn: AIDS Jg. 31 (2017) Nr. 18, S. 2503 - 2514Online Volltext: dx.doi.org/ (Open Access)
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Ulcerating Herpes Simplex InfectionIn: Deutsches Ärzteblatt international Jg. 114 (2017) Nr. 35-36, S. 604Online Volltext: dx.doi.org/ (Open Access)
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Expression pattern of individual IFNA subtypes in chronic HIV infectionIn: Journal of Interferon & Cytokine Research Jg. 37 (2017) Nr. 12, S. 541 - 549Online Volltext: dx.doi.org/
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HIV-Associated Anal Dysplasia and Anal CarcinomaIn: Oncology Research and Treatment Jg. 40 (2017) Nr. 3, S. 100 - 105Online Volltext: dx.doi.org/
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Preexposure prophylaxis failure with tenofovir disoproxilIn: AIDS Jg. 31 (2017) Nr. 9, S. 1344Online Volltext: dx.doi.org/
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Pre-exposure prophylaxis failure with tenofovir disoproxilIn: AIDS Jg. 31 (2017) Nr. 1, S. 176 - 177Online Volltext: dx.doi.org/
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Immunological recovery in tuberculosis/HIV co-infected patients on antiretroviral therapy : Implication for tuberculosis preventive therapyIn: BMC Infectious Diseases Jg. 17 (2017) Nr. 1, S. 517Online Volltext: dx.doi.org/ (Open Access)
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Accelerated CD4 + cell count decline in untreated HIV-1 patients points toward increasing virulence over the course of the epidemicIn: AIDS Jg. 30 (2016) Nr. 12, S. 1995 - 1997Online Volltext: dx.doi.org/
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CD4-cell counts and presence of AIDS in HIV-positive patients entering specialized care-a comparison of migrant groups in the German ClinSurv HIV Cohort Study, 1999-2013In: BMC Infectious Diseases Jg. 16 (2016) Nr. 1, S. 739Online Volltext: dx.doi.org/ (Open Access)
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Switching regimens in virologically suppressed HIV-1-infected patients : evidence base and rationale for integrase strand transfer inhibitor (INSTI)-containing regimensIn: HIV Medicine Jg. 17 (2016) Nr. S 5, S. 3 - 16Online Volltext: dx.doi.org/
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A simple self-reported adherence tool as a predictor of viral rebound in people with viral suppression on antiretroviral therapyIn: HIV Medicine Jg. 17 (2016) Nr. 2, S. 124 - 132Online Volltext: dx.doi.org/
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Gezielte ärztliche Präventionsangebote für HIV-positive Männer, die Sex mit Männern habenIn: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 14 (2016) Nr. Suppl. 3, S. 48Online Volltext: dx.doi.org/
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Development of a phenotypic susceptibility assay for HIV-1 integrase inhibitorsIn: Journal of Virological Methods Jg. 238 (2016) S. 29 - 37Online Volltext: dx.doi.org/ (Open Access)
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Reduced Frequencies and Activation of Regulatory T Cells After the Treatment of HIV-1-Infected Individuals with the CCR5 Antagonist Maraviroc Are Associated with a Reduction in Viral Loads Rather Than a Direct Effect of the Drug on Regulatory T CellsIn: Viral Immunology Jg. 29 (2016) Nr. 3, S. 192 - 196Online Volltext: dx.doi.org/
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HIV pre-exposure prophylaxis (PrEP) : a review of current knowledge of oral systemic HIV PrEP in humansIn: Infection - A Journal of Infectious Disease Jg. 44 (2016) Nr. 2, S. 151 - 158Online Volltext: dx.doi.org/
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Sexuell übertragbare Erkrankungen der AnalregionIn: Coloproctology Jg. 38 (2016) Nr. 4, S. 220 - 228Online Volltext: dx.doi.org/
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The F4/AS01B HIV-1 Vaccine Candidate Is Safe and Immunogenic, But Does Not Show Viral Efficacy in Antiretroviral Therapy-Naive, HIV-1-Infected Adults : A Randomized Controlled TrialIn: Medicine Jg. 95 (2016) Nr. 6, S. e2673Online Volltext: dx.doi.org/ (Open Access)
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Patient-reported outcomes in the single-tablet regimen (STaR) trial of rilpivirine/emtricitabine/tenofovir disoproxil fumarate versus efavirenz/emtricitabine/tenofovir disoproxil fumarate in antiretroviral treatment-naive adults infected with HIV-1 through 48 weeks of treatmentIn: AIDS Care: Psychological and Socio-Medical Aspects of AIDS/HIV Jg. 28 (2016) Nr. 3, S. 401 - 408Online Volltext: dx.doi.org/
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Viral load strategy : impact on risk behaviour and serocommunication of men who have sex with men in specialized careIn: Journal of the European Academy of Dermatology and Venereology Jg. 30 (2016) Nr. 9, S. 1561 - 1566Online Volltext: dx.doi.org/
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Anal cancer screeningIn: Journal of the American Academy of Dermatology: JAAD Jg. 72 (2015) Nr. 2, S. 367 - 368Online Volltext: dx.doi.org/
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Hodgkin lymphoma is as common as non-Hodgkin lymphoma in HIV-positive patients with sustained viral suppression and limited immune deficiency : a prospective cohort studyIn: HIV Medicine Jg. 16 (2015) Nr. 4, S. 261 - 264Online Volltext: dx.doi.org/ (Open Access)
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Prolongation of QTc interval in HIV-infected individuals compared to the general population is not caused by antiretroviral therapyIn: Journal of the International AIDS Society Jg. 18 (2015) Nr. Suppl. 4, S. 20479Online Volltext: dx.doi.org/ (Open Access)
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Parameters influencing baseline HIV-1 genotypic tropism testing related to clinical outcome in patients on maravirocIn: PLoS ONE Jg. 10 (2015) Nr. 5, S. e0125502Online Volltext: dx.doi.org/ (Open Access)
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From pills to patients : an evaluation of data sources to determine the number of people living with HIV who are receiving antiretroviral therapy in GermanyIn: BMC Public Health Jg. 15 (2015) Nr. 1, S. 252Online Volltext: dx.doi.org/ (Open Access)
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Sexuell übertragbare Erkrankungen der AnalregionIn: Der Hautarzt Jg. 66 (2015) Nr. 6, S. 430 - 438Online Volltext: dx.doi.org/
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German-Austrian guidelines on anal dysplasia and anal cancer in HIV-positive individuals : Prevention, diagnosis, and treatmentIn: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 13 (2015) Nr. 12, S. 1302 - 1319Online Volltext: dx.doi.org/
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Prevention of anal carcinomaIn: Deutsches Ärzteblatt international Jg. 112 (2015) Nr. 43, S. 739Online Volltext: dx.doi.org/ (Open Access)
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S2k guideline* "Diagnosis and therapy of syphilis" : short versionIn: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 13 (2015) Nr. 5, S. 472 - 480Online Volltext: dx.doi.org/
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Survival of AIDS-related diffuse large B-cell lymphoma, Burkitt lymphoma, and plasmablastic lymphoma in the German HIV Lymphoma CohortIn: British Journal of Haematology Jg. 168 (2015) Nr. 6, S. 806 - 810Online Volltext: dx.doi.org/
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35-jähriger Patient mit unklarem HautbefundIn: Deutsche Medizinische Wochenschrift - DMW Jg. 139 (2014) Nr. 46, S. 2339 - 2340Online Volltext: dx.doi.org/
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More on Shift of HIV Tropism in Stem-Cell Transplantation with CCR5 Delta32/Delta32 MutationIn: The New England Journal of Medicine Jg. 371 (2014) Nr. 25, S. 2438Online Volltext: dx.doi.org/
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Angioplasmacellular hyperplasia - a new histopathologic clue for anogenital herpes simplex recidivans in immunocompromised patients?In: American Journal of Dermatopathology Jg. 36 (2014) Nr. 10, S. 822 - 826Online Volltext: dx.doi.org/
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Shift of HIV tropism in stem-cell transplantation with CCR5 Delta32 mutationIn: The New England Journal of Medicine Jg. 371 (2014) Nr. 9, S. 880 - 882Online Volltext: dx.doi.org/
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Spontaneous reactivation of hepatitis B virus replication in an HIV coinfected patient with isolated anti-Hepatitis B core antibodiesIn: Virology Journal Jg. 11 (2014) 9Online Volltext: dx.doi.org/ (Open Access)
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Tuberculosis among people living with HIV/AIDS in the German ClinSurv HIV Cohort: Long-term incidence and risk factorsIn: BMC Infectious Diseases Jg. 14 (2014) Nr. 1, S. 148Online Volltext: dx.doi.org/ (Open Access)
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HIV-Infizierte erkranken immer häufiger an Analkarzinomen und Vorläuferläsionen - Neu: Analabstriche runden Screening ab : Anal cytology--a new recommended method for anal cancer screening in HIV-positive patientsIn: MMW - Fortschritte der Medizin Jg. 156 (2014) Nr. SUPPL. 1, S. 54 - 56
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Neu: Analabstriche runden Screening ab : HIV-Infizierte erkranken immer häufiger an Analkarzinomen und VorläuferläsionenIn: MMW - Fortschritte der Medizin Jg. 156 (2014) Nr. Suppl. 24, S. 54 - 57Online Volltext: dx.doi.org/
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Impfprävention HPV-assoziierter Neoplasien : Empfehlungen aus der aktuellen S3-Leitlinie des HPV-Management-Forums der Paul-Ehrlich-Gesellschaft für Chemotherapie e. V. – AWMF Leitlinien-Register Nr. 082-002 (Kurzfassung), gültig bis 31.12.2018In: Laryngo-Rhino-Otologie Jg. 93 (2014) Nr. 12, S. 848 - 856Online Volltext: dx.doi.org/
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Rates of cardiovascular events and deaths are associated with advanced stages of HIV-infection : results of the HIV HEART study 7, 5 year follow-upIn: Journal of the International AIDS Society Jg. 17 (2014) Nr. Suppl. 3, S. 36 - 37Online Volltext: dx.doi.org/ (Open Access)
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Vaccination against HPV-Associated NeoplasiasIn: Geburtshilfe und Frauenheilkunde Jg. 74 (2014) Nr. 3, S. 233 - 241Online Volltext: dx.doi.org/
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B-type natriuretic peptide elevation is more frequent in HIV plus patients compared to the general populationIn: Antiviral Therapy Jg. 18 (2013) Nr. Suppl. 3, S. A41 - A42
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Feasibility and Effectiveness of Indicator Condition-Guided Testing for HIV : results from HIDES I (HIV Indicator Diseases across Europe Study)In: PLoS ONE Jg. 8 (2013) Nr. 1, S. e52845Online Volltext: dx.doi.org/ (Open Access)
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Psychotropic drugs are prescribed more frequently in HIV-positive patients compared to the general population. Data from two German prospective cohorts : Heinz Nixdorf Recall Study and HIV HEART StudyIn: Antiviral Therapy Jg. 18 (2013) Nr. Suppl. 3, S. A77 - A78
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Factors associated with adherence amongst 5295 people receiving antiretroviral therapy as part of an international trialIn: The Journal of Infectious Diseases (JID) Jg. 208 (2013) Nr. 1, S. 40 - 49Online Volltext: dx.doi.org/
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Framingham risk score and cardiovascular risk profiles in HIV+ patients and HIV- controls differ by sexIn: European Heart Journal Jg. 34 (2013) Nr. Suppl. 1, S. P5164Online Volltext: dx.doi.org/
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Incidence and risk factors of herpes zoster among hiv-positive patients in the german competence network for HIV/AIDS (KompNet) : A cohort study analysisIn: BMC Infectious Diseases Jg. 13 (2013) Nr. 1, S. 372Online Volltext: dx.doi.org/ (Open Access)
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Kaposi´S Sarcoma Patient Profile in the Cohort of the German Competence Netzwork HIV/AIDSIn: Sexually Transmitted Infections Jg. 89 (2013) Nr. Suppl. 1, S. A126.3 - A127Online Volltext: dx.doi.org/ Online Volltext
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Therapy and prophylaxis of opportunistic infections in HIV-infected patients : a guideline by the German and Austrian AIDS societies (DAIG/ÖAG) (AWMF 055/066)In: Infection - A Journal of Infectious Disease Jg. 41 (2013) Nr. Supp. 2, S. 91 - 115Online Volltext: dx.doi.org/ (Open Access)
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Long-term gender-based outcomes for atazanavir/ritonavir (ATV/r)- containing regimens in treatment-experienced patients with HIVIn: Current HIV Research Jg. 11 (2013) Nr. 4, S. 333 - 341Online Volltext: dx.doi.org/
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P2.120Cohort of the German Competence Network For HIV/AIDS (KompNet)In: Sexually Transmitted Infections Jg. 89 (2013) Nr. Suppl. 1, S. A124.4 - A125Online Volltext: dx.doi.org/ Online Volltext
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Prevalence of cardiovascular diseases in HIV-infected outpatients: Results from a prospective, multicenter cohort studyIn: Clinical Research in Cardiology Jg. 102 (2013) Nr. 3, S. 203 - 213Online Volltext: dx.doi.org/
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The Pepsi Project : HVC resistance screening and prediction of pi-containing therapy outcomeIn: Journal of Hepatology Jg. 58 (2013) Nr. Suppl. 1, S. S489 - S490Online Volltext: dx.doi.org/
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Valvular manifestations of human immunodeficiency virus infection - Results from the prospective, multicenter HIV-HEART studyIn: Journal of Cardiovascular Medicine Jg. 14 (2013) Nr. 10, S. 733 - 739Online Volltext: dx.doi.org/
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Are HIV patients undertreated? : Cardiovascular risk factors in HIV: Results of the HIV-HEART studyIn: European Journal of Preventive Cardiology Jg. 19 (2012) Nr. 2, S. 267 - 274Online Volltext: dx.doi.org/
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Brain natriuretic peptide (BNP) : A general mortality predictor in HIV-infected patients? - Results from the 5 year follow-up of the HIV-HEART trialIn: European Heart Journal Jg. 33 (2012) Nr. Suppl. 1, S. 337
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Substance use and sexual risk behaviour among HIV-positive men who have sex with men in specialized out-patient clinicsIn: HIV Medicine Jg. 13 (2012) Nr. 9, S. 533 - 540Online Volltext: dx.doi.org/
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Detection of abacavir hypersensitivity by ELISpot methodIn: Inflammation & Allergy - Drug Targets Jg. 11 (2012) Nr. 3, S. 227 - 234Online Volltext: dx.doi.org/
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How individual can personalized antiretroviral treatment be? Deep salvage in an HIV-1-infected patientIn: Intervirology Jg. 55 (2012) Nr. 2, S. 167 - 171Online Volltext: dx.doi.org/
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Suchtmittelkonsum bei homo- und bisexuellen männernIn: Sucht Jg. 58 (2012) Nr. 4, S. 237 - 246Online Volltext: dx.doi.org/
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Bessere Compliance durch Fixkombinationen und einmal tägliche Gabe : Mehr Auswahl für die komplette TherapieIn: MMW - Fortschritte der Medizin Jg. 154 (2012) Nr. Suppl 1, S. 17 - 19
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Syphilis und Gonorrhoe - sexuell übertragbare Infektionen (STI) der Vergangenheit?In: Deutsche Medizinische Wochenschrift - DMW Jg. 137 (2012) Nr. 31-32, S. 1560 - 1564Online Volltext: dx.doi.org/
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Interleukin 21 augments the hepatitis B virus-specific CD8+ T-cell response in vitro in patients coinfected with HIV-1In: AIDS Jg. 26 (2012) Nr. 17, S. 2145 - 2153Online Volltext: dx.doi.org/
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Treatment of AIDS-related lymphomas : Rituximab is beneficial even in severely immunosuppressed patientsIn: AIDS Jg. 26 (2012) Nr. 4, S. 457 - 464Online Volltext: dx.doi.org/
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Oral health and the heart - Does HIV infection open a pathophysiological gateway?In: International Journal of Cardiology Jg. 151 (2011) Nr. 2, S. 254 - 257Online Volltext: dx.doi.org/
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Infektionen mit nichttuberkulösen Mykobakterien bei HIV-infizierten PatientenIn: Hautarzt Jg. 62 (2011) Nr. 4, S. 272 - 279Online Volltext: dx.doi.org/
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Structural gray and white matter changes in patients with HIVIn: Journal of Neurology Jg. 258 (2011) Nr. 6, S. 1066 - 1075Online Volltext: dx.doi.org/
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"One-stop-shop" staging : should we prefer FDG-PET/CT or MRI for the detection of bone metastases?In: European Journal of Radiology Jg. 78 (2011) Nr. 3, S. 430 - 435Online Volltext: dx.doi.org/
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Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic ApproachIn: Journal of Visualized Experiments (2011) Nr. 58,Online Volltext: dx.doi.org/
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Long-term outcomes of liver transplant patients with human immunodeficiency virus infection and end-stage-liver-disease : single center experienceIn: European Journal of Medical Research Jg. 16 (2011) Nr. 8, S. 342 - 348Online Volltext: dx.doi.org/ (Open Access)
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Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimensIn: Journal of Antimicrobial Chemotherapy Jg. 66 (2011) Nr. 9, S. 2092 - 2098Online Volltext: dx.doi.org/
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Efficacy, adherence and tolerability of once daily tenofovir DF-containing antiretroviral therapy in former injecting drug users with HIV-1 receiving opiate treatment : Results of a 48-week open-label studyIn: European Journal of Medical Research Jg. 16 (2011) Nr. 10, S. 427 - 436Online Volltext: dx.doi.org/ (Open Access)
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Pericardial effusion of HIV-infected patients : Results of a prospective multicenter cohort study in the era of antiretroviral therapyIn: European Journal of Medical Research Jg. 16 (2011) Nr. 11, S. 480 - 483Online Volltext: dx.doi.org/ (Open Access)
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HIV prevalence and route of transmission in Turkish immigrants living in North-Rhine Westphalia, GermanyIn: Medical Microbiology and Immunology Jg. 200 (2011) Nr. 4, S. 219 - 223Online Volltext: dx.doi.org/
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Improved outcome with rituximab in patients with HIV-associated multicentric Castleman diseaseIn: Blood Jg. 118 (2011) Nr. 13, S. 3499 - 3503Online Volltext: dx.doi.org/
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An epidemiologic study to determine the prevalence of the HLA-B*5701 allele among HIV-positive patients in EuropeIn: Pharmacogenetics and Genomics Jg. 20 (2010) Nr. 5, S. 307 - 314Online Volltext: dx.doi.org/
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Prevalence of Cardiac Diastolic Dysfunction in HIV-Infected Patients : Results of the HIV-HEART StudyIn: HIV Clinical Trials Jg. 11 (2010) Nr. 3, S. 156 - 162Online Volltext: dx.doi.org/
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Lipodystrophy – a sign for metabolic syndrome in patients of the HIV-HEART studyIn: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) Jg. 8 (2010) Nr. 2, S. 92 - 97Online Volltext: dx.doi.org/