GRK 1739 - Research Projects

Research Project Principal Investigator

Molecular mechanisms linking repair of DNA double strand breaks by alternative end joining to growth factor signaling

Prof. Dr. phil. nat. George Iliakis

Mechanisms of the p97- and ubiquitin-governed radiation response

Prof. Dr. rer. physiol. Hemmo Meyer

Sensitization to radiotherapy and chemotherapy by inhibition of epigenetic modifiers in lung cancer cell lines with loss of function mutations in SWI/SNF chromatin remodeling genes, or overexpression of EZH2

Prof. Dr. med. Martin Stuschke
Dr. rer. nat. Ali Sak


Functions and regulations of the replication initiation regulator TopBP1 upon exposure to IR

Prof. Dr. rer. nat. Dominik Boos

An old passenger as a new driver: Defining Survivin’s role as a link between replication fork dynamics and radiation response

Prof. Dr. rer. nat. Shirley Knauer
(6) Role of the protein kinase B/AKT pathway for the cellular  radiation response Prof. Dr. rer. nat. Verena Jendrossek

Role of the tyrosine kinase TrkA and TrkB in checkpoint activation and DSB repair

Prof. Dr. rer. nat. Alexander Schramm

Identification of novel targets for rational chemoradiotherapy strategies in non-small-cell lung cancer

Prof. Dr. med. Martin Schuler

Elimination of the hypoxia-inducible factor-1α (HIF-1α) in murine tumor stroma: effects on tumor growth and sensitivity to ionizing radiation

Prof. Dr. med. Eric Metzen
(10) Role of stromal hyaluronan in radiation sensitivity

Prof. Dr. rer. nat. Jens W. Fischer

(11) Role of the acid sphingomyelinase in immune and endothelial cells for anti-tumor effects of irradiation

Prof. Dr. med. Erich Gulbins
Dr. Alexander Carpinteiro


Importance of Caveolin-1 for modulating the radiation response in the context of tumor-stroma interactions

PD Dr. rer. nat. Diana Klein
(13) Identifying and targeting resistance mechanisms to 177Lu-PSMA radioligand therapy of metastatic prostate cancer Prof. Dr. med. Ken Herrmann