GRK 1739 - Research Projects

Research Project Principal Investigator
   
(1)

Molecular mechanisms linking repair of DNA double strand breaks by alternative end joining to growth factor signaling

Prof. Dr. phil. nat. George Iliakis
(2)

Mechanisms of the p97- and ubiquitin-governed radiation response

Prof. Dr. rer. physiol. Hemmo Meyer
(3)

Sensitization to radiotherapy and chemotherapy by inhibition of epigenetic modifiers in lung cancer cell lines with loss of function mutations in SWI/SNF chromatin remodeling genes, or overexpression of EZH2

Prof. Dr. med. Martin Stuschke
Dr. rer. nat. Ali Sak

(4)

Functions and regulations of the replication initiation regulator TopBP1 upon exposure to IR

Prof. Dr. rer. nat. Dominik Boos
(5)

An old passenger as a new driver: Defining Survivin’s role as a link between replication fork dynamics and radiation response

Prof. Dr. rer. nat. Shirley Knauer
(6) Role of the protein kinase B/AKT pathway for the cellular  radiation response Prof. Dr. rer. nat. Verena Jendrossek
(7)

Role of the tyrosine kinase TrkA and TrkB in checkpoint activation and DSB repair

Prof. Dr. rer. nat. Alexander Schramm
(8)

Identification of novel targets for rational chemoradiotherapy strategies in non-small-cell lung cancer

Prof. Dr. med. Martin Schuler
 
(9)

Elimination of the hypoxia-inducible factor-1α (HIF-1α) in murine tumor stroma: effects on tumor growth and sensitivity to ionizing radiation

Prof. Dr. med. Eric Metzen
(10) Role of stromal hyaluronan in radiation sensitivity

Prof. Dr. rer. nat. Jens W. Fischer
Dr. rer. nat. Katharina Röck

(11) Role of the acid sphingomyelinase in immune and endothelial cells for anti-tumor effects of irradiation

Prof. Dr. med. Erich Gulbins
Dr. Alexander Carpinteiro

(12)

Importance of Caveolin-1 for modulating the radiation response in the context of tumor-stroma interactions

PD Dr. rer. nat. Diana Klein