2024

Please see our editorial in EHJ https://doi.org/10.1093/eurheartj/ehae079 to the manuscript Vilahur et al. https://doi.org/10.1093/eurheartj/ehae107. Pre-clinical studies in clinically relevant animal models will close the translational gap in cardioprotection research.

Recently published in Med; 5:10-31

A brief summary of the state of the art in myocardial ischemia/reperfusion research with a view on both its coronary vascular and myocardial aspects

Recently published in Am J Physiol Heart Circ Physiol326: H408-H417

Animal models with a predisposition to metabolic syndrome and atherosclerosis are attracting growing interest for translational research, as they may better mimic the variability of patients with cardiovascular disease.

In Ossabaw minipigs, with a polygenic predisposition to metabolic syndrome, but without the diseased phenotype, we characterized that vasoconstriction is more and vasodilation less pronounced in mesenteric arteries than in Göttingen minipigs.

Thus, Ossabaw minipigs may be a more suitable model of human cardiovascular disease.

https://www.uni-due.de/med/meldung.php?id=1506

Award of the Doctor Honoris Causa for special services in cardiovascular research at Semmelweis University in Budapest

https://www.uni-due.de/med/meldung.php?id=1491

Reactive oxygen species are signals of cardioprotection and executors of injury

-> this review summarizes the beneficial and detrimental roles of reactive oxygen species in myocardial ischemia/reperfusion injury and cardioprotection.

Time-dependent—acute, subacute, chronic—and non-canonical vs. canonical effects of STAT3 activation on myocardial ischemia/reperfusion; created with BioRender.com

ATP adenosine triphosphate, MPTP mitochondrial permeability transition pore, ROS reactive oxygen species, STAT3 signal transducer and activator of transcription 3