Aktuelles
2024
März 2024 Cardioprotection research has left its comfort zone
Please see our editorial in EHJ https://doi.org/10.1093/eurheartj/ehae079 to the manuscript Vilahur et al. https://doi.org/10.1093/eurheartj/ehae107. Pre-clinical studies in clinically relevant animal models will close the translational gap in cardioprotection research.
Januar 2024 Myocardial ischemia/reperfusion: Translational pathophysiology of ischemic heart disease
Recently published in Med; 5:10-31
A brief summary of the state of the art in myocardial ischemia/reperfusion research with a view on both its coronary vascular and myocardial aspects
Januar 2024 Differences in vasomotor function of mesenteric arteries between Ossabaw minipigs with predisposition to metabolic syndrome and Göttingen minipigs
Recently published in Am J Physiol Heart Circ Physiol326: H408-H417
Animal models with a predisposition to metabolic syndrome and atherosclerosis are attracting growing interest for translational research, as they may better mimic the variability of patients with cardiovascular disease.
In Ossabaw minipigs, with a polygenic predisposition to metabolic syndrome, but without the diseased phenotype, we characterized that vasoconstriction is more and vasodilation less pronounced in mesenteric arteries than in Göttingen minipigs.
Thus, Ossabaw minipigs may be a more suitable model of human cardiovascular disease.
2023
17.11.2023 Bundesverdienstkreuz 1. Klasse: Pathophysiologe Prof. Dr. Dr. hc. Gerd Heusch erneut geehrt
16.11.2023
Verleihung des Doctor Honoris Causa für besondere Verdienste in der Herz-Kreislaufforschung an der Semmelweis Universität in Budapest
16.11.2023 Highly cited papers which rank in the top 1 % for field and publication year in the Web of Science
06.10.2023
November 2023 Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection
Reactive oxygen species are signals of cardioprotection and executors of injury
-> this review summarizes the beneficial and detrimental roles of reactive oxygen species in myocardial ischemia/reperfusion injury and cardioprotection.
August 2023 Perspective: mitochondrial STAT3 in cardioprotection
Time-dependent—acute, subacute, chronic—and non-canonical vs. canonical effects of STAT3 activation on myocardial ischemia/reperfusion; created with BioRender.com
ATP adenosine triphosphate, MPTP mitochondrial permeability transition pore, ROS reactive oxygen species, STAT3 signal transducer and activator of transcription 3
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