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Privatdozent/in, Institut für Zellbiologie (Tumorforschung)
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WiSe 2024
- Neue Literatur (Zellbiologie, experimentelle Krebsforschung) (*)
- Laborpraktikum III für Masterstudenten der medizinischen Biologie (WP)
- Laborpraktikum II für Masterstudenten der medizinischen Biologie (WP)
- Mitarbeiterseminar zur Besprechung aktueller Arbeiten
- Anleitung zu selbständigen wissenschaftlichen Arbeiten (*)
- Seminar für Zellbiologie und experimentelle Krebsforschung (mit Gastsprechern) (*)
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SoSe 2024
- Neue Literatur der Zell- und Molekularbiologie für Med. Biologen
- Seminar Neue Literatur der Zell- und Molekularbiologie für med. Biologen (Bachelor) Gruppe II
- Seminar Neue Literatur der Zell- und Molekularbiologie für med. Biologen (Bachelor) Gruppe I
- Praktikum Zell- und Molekularbiologie für med. Biologen (Bachelor) (PV)
Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Effects of hyperthermia on cisplatin tissue penetration and gene expression in peritoneal metastases : Results from a randomized trial in ovarian cancerIn: British Journal of Surgery (BJS) , Jg. 111 2024, Nr. 4, znae078
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Establishment and Molecular Characterization of an In Vitro Model for PARPi-Resistant Ovarian CancerIn: Cancers , Jg. 15 2023, Nr. 15, 3774DOI (Open Access)
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Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapyIn: Blood , Jg. 142 2023, Nr. 25, S. 2175 – 2191DOI (Open Access)
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Adaptation to chronic-cycling hypoxia renders cancer cells resistant to mth1-inhibitor treatment which can be counteracted by glutathione depletionIn: Cells , Jg. 10 2021, Nr. 11, 3040DOI, Online Volltext (Open Access)
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HSP90 Inhibition Synergizes with Cisplatin to Eliminate Basal-like Pancreatic Ductal Adenocarcinoma CellsIn: Cancers , Jg. 13 2021, Nr. 24, 6163DOI (Open Access)
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RUNX3 transcript variants have distinct roles in ovarian carcinoma and differently influence platinum sensitivity and angiogenesisIn: Cancers , Jg. 13 2021, Nr. 3, S. 476DOI (Open Access)
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Detection of doxorubicin, cisplatin and therapeutic antibodies in formalin-fixed paraffin-embedded human cancer cellsIn: Histochemistry and Cell Biology , Jg. 153 2020, Nr. 5, S. 367 – 377DOI (Open Access)
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Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cellsIn: Molecular Oncology , Jg. 14 2020, Nr. 4, S. 686 – 703DOI (Open Access)
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Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repairIn: Oncogene , Jg. 38 2019, Nr. 19, S. 3616 – 3635DOI (Open Access)
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Metformin enhances the radiosensitizing effect of cisplatin in non-small cell lung cancer cell lines with different cisplatin sensitivitiesIn: Scientific Reports , Jg. 9 2019, S. 1282DOI (Open Access)
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Combined effects of metformin and cisplatin on radiation sensitivity in non-small cell lung cancer cellsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 194 2018, Nr. Suppl.1, S. 100DOI (Open Access)
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Multifaceted mechanisms of cisplatin resistance in long-term treated urothelial carcinoma cell linesIn: International Journal of Molecular Sciences (IJMS) , Jg. 19 2018, Nr. 2, S. 590DOI (Open Access)
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Cisplatin alters the function and expression of N-type voltage-gated calcium channels in the absence of morphological damage of sensory neurons.In: Molecular Pain , Jg. 13 2017, 1744806917746565DOI (Open Access)
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Cisplatin-induced neuropathic pain is mediated by upregulation of N-type voltage-gated calcium channels in dorsal root ganglion neuronsIn: Experimental Neurology , Jg. 288 2017, S. 62 – 74
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Comprehensive Molecular Characterization of a Cisplatin-Specific Monoclonal AntibodyIn: Molecular Pharmaceutics , Jg. 14 2017, Nr. 12, S. 4454 – 4461
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Differential effect of quercetin on cisplatin-induced toxicity in kidney and tumor tissuesIn: Food and Chemical Toxicology , Jg. 107 2017, S. 226 – 236
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Metformin potentiates radiosensitizing effect of cisplatin in NSCLC cellsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 193 2017, Nr. Suppl.1, S. 27
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Tribbles 2 mediates cisplatin sensitivity and DNA damage response in epithelial ovarian cancerIn: International Journal of Cancer , Jg. 141 2017, Nr. 8, S. 1600 – 1614
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DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progressionIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Jg. 113 2016, Nr. 30, S. E4311 – 9DOI (Open Access)
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Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific MannerIn: Molecular Cancer Research , Jg. 14 2016, Nr. 11, S. 1110 – 1123
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Lovastatin prevents cisplatin-induced activation of pro-apoptotic DNA damage response (DDR) of renal tubular epithelial cellsIn: Toxicology and Applied Pharmacology , Jg. 292 2016, S. 103 – 114
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ΔNp63 activates the Fanconi anemia DNA repair pathway and limits the efficacy of cisplatin treatment in squamous cell carcinomaIn: Nucleic Acids Research , Jg. 44 2016, Nr. 7, S. 3204 – 3218DOI (Open Access)
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DNA Ligases I and III Support Nucleotide Excision Repair in DT40 Cells with Similar EfficiencyIn: Photochemistry and Photobiology , Jg. 91 2015, Nr. 5, S. 1173 – 1180
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HIPEC ROC I : A phase i study of cisplatin administered as hyperthermic intraoperative intraperitoneal chemoperfusion followed by postoperative intravenous platinum-based chemotherapy in patients with platinum-sensitive recurrent epithelial ovarian cancerIn: International Journal of Cancer , Jg. 136 2015, Nr. 3, S. 699 – 708DOI (Open Access)
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Platinum-induced kidney damage : Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injuryIn: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research , Jg. 1853 2015, Nr. 3, S. 685 – 698DOI (Open Access)
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Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulationIn: OncoTarget , Jg. 5 2014, Nr. 23, S. 11778 – 11791DOI (Open Access)
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Inhibition of PARP activity by PJ34 sensitises NSCLC cells to cisplatinIn: Lung Cancer , Jg. 83 2014, Nr. Suppl. 1, S. 2
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Regulation of the functional interface between nucleotide excision repair and transcription by MITF modulates melanoma growthIn: Cancer Research , Jg. 74 2014, Nr. 19 Suppl., S. 2950
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Splenic macrophages induce chemotherapy resistance via DNA damage repairIn: Cancer Research , Jg. 74 2014, Nr. Suppl. 19, S. 3771
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Spongean alkaloids protect rat kidney cells against cisplatin-induced cytotoxicityIn: Anti-Cancer Drugs , Jg. 25 2014, Nr. 8, S. 917 – 929
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Comparative analysis of the sensitivity of normal rat kidney cells towards different types of platinum compoundsIn: Naunyn-Schmiedeberg's Archives of Pharmacology , Jg. 386 2013, Nr. Suppl. 1, S. 45
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ERCC1 isoform expression and DNA repair in non-small-cell lung cancerIn: The New England Journal of Medicine , Jg. 368 2013, Nr. 12, S. 1101 – 1110
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Effect of sorafenib combined with cytostatic agents on hepatoblastoma cell lines and xenograftsIn: British Journal of Cancer (BJC) , Jg. 108 2013, Nr. 2, S. 334 – 341DOI (Open Access)
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FTO levels affect RNA modification and the transcriptomeIn: European Journal of Human Genetics , Jg. 21 2013, Nr. 3, S. 317 – 323
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Formation and repair kinetics of Pt-(GpG) DNA adducts in extracted circulating tumour cells and response to platinum treatmentIn: British Journal of Cancer (BJC) , Jg. 109 2013, Nr. 5, S. 1223 – 1229DOI (Open Access)
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Generation and characterisation of cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signatureIn: PLoS ONE , Jg. 8 2013, Nr. 1, e54193DOI (Open Access)
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PARP1 impact on DNA repair of platinum adducts: Preclinical and clinical read-outsIn: Lung Cancer , Jg. 80 2013, Nr. 2, S. 216 – 222
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Parb inhibition increases sensitivity of NSCLC cells to cisplatinIn: Journal of Thoracic Oncology , Jg. 8 2013, Nr. Suppl. 2, S. 470
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Cisplatin resistance induced in germ cell tumour cells is due to reduced susceptibility towards cell death but not to altered DNA damage induction or repairIn: Cancer Letters , Jg. 324 2012, Nr. 2, S. 171 – 178
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Efficient pharmacological prevention of the major side effects of cisplatin without affecting the antineoplastic effiacy in vivoIn: Annals of Oncology , Jg. 23 2012, Nr. Suppl. 1, S. 25
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On the complexity and dynamics of in vivo Cisplatin-DNA adduct formation using HPLC/ICP-MSIn: Metallomics , Jg. 4 2012, Nr. 10, S. 1098 – 1104
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Prognostic Impact of Vitamin B6 Metabolism in Lung CancerIn: Cell Reports , Jg. 2 2012, Nr. 2, S. 257 – 269DOI (Open Access)
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Structures of oxaliplatin-oligonucleotide adducts from DNAIn: Journal of Mass Spectrometry , Jg. 47 2012, Nr. 10, S. 1282 – 1293
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Differential Melanoma-Chemoresistence to Temozolomide within varying Treatment Schemes : DNA-Damage-Accumulation as DeterminantsIn: Journal der Deutschen Dermatologischen Gesellschaft (JDDG) , Jg. 9 2011, Nr. 9, S. 791 – 791
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Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cellsIn: Molecular Cancer 2011, 24DOI, Online Volltext (Open Access)
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Temozolomide chemoresistance heterogeneity in melanoma with different treatment regimens : DNA damage accumulation contributionIn: Melanoma Research , Jg. 21 2011, Nr. 3, S. 206 – 216
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p53 Hypersensitivity Is the Predominant Mechanism of the Unique Responsiveness of Testicular Germ Cell Tumor (TGCT) Cells to CisplatinIn: PLoS ONE , Jg. 6 2011, Nr. 4DOI (Open Access)
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Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancerIn: Genes and Development , Jg. 24 2010, Nr. 8, S. 837 – 852
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Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expressionIn: Molecular Cancer , Jg. 9 2010, 248DOI (Open Access)
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Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer painIn: Neuroscience , Jg. 169 2010, Nr. 1, S. 463 – 474
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Recombinant human erythropoietin counteracts cisplatin-induced visceral hyperalgesiaIn: Neuroscience Bulletin , Jg. 26 2010, Nr. 4, S. 282 – 288
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Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicityIn: The Journal of Pharmacology and Experimental Therapeutics , Jg. 335 2010, Nr. 1, S. 2 – 12DOI (Open Access)
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Combined PER2 and CRY1 expression predicts outcome in chronic lymphocytic leukemiaIn: European Journal of Haematology , Jg. 83 2009, Nr. 4, S. 320 – 327
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Erythropoietin overrides the triggering effect of DNA platination products in a mouse model of Cisplatin-induced neuropathyIn: BMC Neuroscience , Jg. 10 2009, 77DOI (Open Access)
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Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression statusIn: Leukemia , Jg. 20 2006, Nr. 10, S. 1774 – 1782
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Cell cycle specific analysis of cisplatin-radiation interactions : Focus on DNA double strand break induction and processingIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 199 2023DOI (Open Access)
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Effect of combined Cisplatin treatment and Mre11 inhibition on radiation induced DSB Repair in NSCLC cell lines and human fibroblast cellsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 199 2023, Nr. Suppl. 1, S. S138DOI (Open Access)
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Diphenhydramin als potentieller Platinsensitizer für das Ovarialkarzinom
XXIX. Wissenschaftliche Tagung der Arbeitsgemeinschaft für gynäkologische Onkologie (AGO) der Österreichischen Gesellschaft für Gynäkologie und Geburtshilfe (OEGGG) und 18. Österreichischer Kongress „Krebs bei der Frau“, 15.-17.04.2021, Virtuell,In: Geburtshilfe und Frauenheilkunde , Jg. 81 2021, Nr. 6, S. E38 – E39 -
A single nucleotide polymorphism of the transcription factor Growth Factor Independence 1 (GFI1) accelerates AML evolution and sensitizes AML cells to treatment with DNA repair inhibitors
Virtuelle Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 09.–11. Oktober 2020,In: Oncology Research and Treatment , Jg. 43 2020, Nr. Suppl. 4, S. 36 – 37DOI (Open Access) -
Cisplatin-induced neuropathic pain is mediated by N-type voltage-gated calcium channelsIn: Acta Physiologica , Jg. 216 2016, Nr. Suppl. 707, Special Issue: Abstracts of the 95th Annual Meeting of the German Physiological Society, 3–5 March 2016, S. 87
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Characterization of the stress response of normal rat kidney cells to platinating anticancer drugs and modulation by lipid lowering drugs
Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V., 81th Annual Meeting, March 10 - 12, 2015, Kiel, Germany,In: Naunyn-Schmiedeberg's Archives of Pharmacology , Jg. 388 2015, Nr. Suppl.1, S. 66 -
Oxaliplatin modulates voltage-gated calcium channel currents in small DRG neurons
94th Annual Meeting of the German Physiological Society, 5‐7 March 2015, Magdeburg, Germany,In: Acta Physiologica , Jg. 213 2015, Nr. Suppl. 699, S. 68 -
Subtype-dependent modulation of voltage-gated calcium channels in small dorsal root ganglion neurons by cisplatin
94th Annual Meeting of the German Physiological Society, 5‐7 March 2015, Magdeburg, Germany,In: Acta Physiologica , Jg. 213 2015, Nr. Suppl. 699, S. 69 -
Prä-therapeutische ex-vivo Reparatur Kinetiken von Cisplatin-DNA-Addukten in Zirkulierenden Tumorzellen als Platin-Resistenz Test
119. Kongress der Deutschen Gesellschaft für Innere Medizin e.V., 06. - 09. April 2013, Wiesbaden,In: Der Internist , Jg. 54 2013, Nr. Suppl. 1, S. 95 – 96 -
Functional characterization of ERCC1 isoforms in NSCLCIn: Cancer Research , Jg. 71 2011, Nr. 8, Suppl., S. 3895
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Visualization and Quantitative Measurement of Drug-Induced Platinum Adducts in the Nuclear DNA of Individual Cells by an Immuno-Cytological AssayIn: Urothelial Carcinoma: Methods and Protocols / Schulz, Wolfgang A.; Hoffmann, Michèle J.; Niegisch, Günter (Hrsg.) 2018, S. 351 – 358
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MicroRNA profiling and cisplatin–DNA interactions in an isogenic model of cisplatin resistant NSCLC cell lines
11th Annual British Thoracic Oncology Group Conference, 23-25 January 2013, Dublin, Ireland,In: Lung Cancer , Jg. 79 2013, Nr. Suppl. 1, S. S1 -
Pre-therapeutic ex-vivo repair kinetics of cisplatin-DNA-adducts in circulating tumor cells (CTC) as platinum resistance test
11th Annual British Thoracic Oncology Group Conference, 23-25 January 2013, Dublin, Ireland,In: Lung Cancer , Jg. 79 2013, Nr. Suppl. 1, S. S2 -
Microrna profiling and CDDP-GPG dna adduct formation analysis in a panel of cisplatin resistant non-small cell lung cancer cell lines
37th ESMO Congress, 28 September - 2 October 2012, Vienna, Austria,In: Annals of Oncology , Jg. 23 2012, Nr. Suppl. 9, S. ix68