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Universitätsprofessor/in, Zentrum für Kinder- und Jugendmedizin
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Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.
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Efficacy of Brincidofovir in Pediatric Stem Cell Transplant Recipients With Adenovirus InfectionsIn: Journal of the Pediatric Infectious Diseases Society , Jg. 10 2021, Nr. 11, S. 987 – 993
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Eye tumors in childhood as first sign of tumor predisposition syndromes : Insights from an observational study conducted in Germany and AustriaIn: Cancers , Jg. 13 2021, Nr. 8, S. 1876DOI, Online Volltext (Open Access)
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Hematopoietic stem cell transplantation in children and adolescents with GATA2-related myelodysplastic syndromeIn: Bone Marrow Transplantation , Jg. 56 2021, Nr. 11, S. 2732 – 2741DOI (Open Access)
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N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastomaIn: Scientific Reports , Jg. 10 2020, Nr. 1, S. 7157DOI, Online Volltext (Open Access)
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The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressivenessIn: Scientific Reports , Jg. 10 2020, Nr. 1, S. 218DOI (Open Access)
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Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4⁺ CAR T Cell EfficacyIn: Frontiers in Immunology , Jg. 11 2020, S. 531DOI (Open Access)
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ALK positively regulates MYCN activity through repression of HBP1 expressionIn: Oncogene , Jg. 38 2019, Nr. 15, S. 2690 – 2705
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Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in MiceIn: Thyroid , Jg. 29 2019, Nr. 10, S. 1438 – 1446DOI (Open Access)
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Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastomaIn: Cancer Letters , Jg. 455 2019, S. 24 – 33
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The small molecule Bcl-2/Mcl-1 inhibitor TW-37 shows single-agent cytotoxicity in neuroblastoma cell linesIn: BMC Cancer , Jg. 19 2019, S. 243DOI (Open Access)
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A mechanistic classification of clinical phenotypes in neuroblastomaIn: Science , Jg. 362 2018, Nr. 6419, S. 1165 – 1170DOI (Open Access)
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Circulating microRNA biomarkers for metastatic disease in neuroblastoma patientsIn: JCI Insight , Jg. 3 2018, Nr. 23, e97021DOI (Open Access)
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The landscape of genomic alterations across childhood cancersIn: Nature , Jg. 555 2018, Nr. 7696, S. 321 – 327DOI (Open Access)
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The mutational landscape of MYCN, Lin28b and ALKF1174L driven murine neuroblastoma mimics human diseaseIn: OncoTarget , Jg. 9 2018, Nr. 9, S. 8334 – 8349DOI (Open Access)
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2017 GPOH Guidelines for Diagnosis and Treatment of Patients with Neuroblastic TumorsIn: Klinische Pädiatrie , Jg. 229 2017, Nr. 3, S. 147 – 167
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Accelerating drug development for neuroblastoma - New Drug Development Strategy : an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma projectIn: Expert Opinion on Drug Discovery , Jg. 12 2017, Nr. 8, S. 801 – 811DOI (Open Access)
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Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expressionIn: OncoImmunology , Jg. 6 2017, Nr. 6, e1320626DOI (Open Access)
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Overexpression of Lin28b in neural stem cells is insufficient for brain tumor formation, but induces pathological lobulation of the developing cerebellumIn: The Cerebellum , Jg. 16 2017, Nr. 1, S. 122 – 131
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Pharmaceutically inhibiting polo-like kinase 1 exerts a broad anti-tumour activity in retinoblastoma cell linesIn: Clinical & Experimental Ophthalmology , Jg. 45 2017, Nr. 3, S. 288 – 296
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RITA displays anti-tumor activity in medulloblastomas independent of TP53 statusIn: OncoTarget , Jg. 8 2017, Nr. 17, S. 27882 – 27891DOI (Open Access)
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Targeting tachykinin receptors in neuroblastomaIn: OncoTarget , Jg. 8 2017, Nr. 1, S. 430 – 443DOI (Open Access)
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The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma modelsIn: OncoTarget , Jg. 8 2017, Nr. 4, S. 6730 – 6741DOI (Open Access)
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Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cellsIn: OncoTarget , Jg. 7 2016, Nr. 46, S. 74415 – 74426DOI (Open Access)
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Development of Port-Site Metastases Following Thoracoscopic Resection of a NeuroblastomaIn: Pediatric Blood and Cancer , Jg. 63 2016, Nr. 1, S. 149 – 151
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Immune response modulation by Galectin-1 in a transgenic model of neuroblastomaIn: OncoImmunology , Jg. 5 2016, Nr. 5, e1131378DOI (Open Access)
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LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19In: Haematologica / The Hematology Journal , Jg. 101 2016, Nr. 6, S. e240 – e244DOI (Open Access)
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MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastomaIn: OncoTarget , Jg. 7 2016, S. 66344 – 66359DOI (Open Access)
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Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastomaIn: OncoTarget , Jg. 7 2016, Nr. 2, S. 1960 – 1972
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Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot studyIn: European Journal of Cancer (EJC) , Jg. 65 2016, S. 91 – 101
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Targeting MYCN-driven transcription by BET-bromodomain inhibitionIn: Clinical Cancer Research , Jg. 22 2016, Nr. 10, S. 2470 – 2781DOI (Open Access)
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The mitochondrial genetic landscape in neuroblastoma from tumor initiation to relapseIn: OncoTarget , Jg. 7 2016, Nr. 6, S. 6620 – 6625DOI (Open Access)
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Towards diagnostic application of non-coding RNAs in neuroblastomaIn: Expert Review of Molecular Diagnostics , Jg. 16 2016, Nr. 12, S. 1307 – 1313
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A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studiesIn: Oncogene , Jg. 34 2015, Nr. 26, S. 3357 – 3368DOI (Open Access)
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Absence of telomerase reverse transcriptase promoter mutations in neuroblastomaIn: Biomedical Reports , Jg. 3 2015, Nr. 4, S. 443 – 446
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IGF2BP1 Harbors Prognostic Significance by Gene Gain and Diverse Expression in NeuroblastomaIn: Journal of Clinical Oncology (JCO) , Jg. 33 2015, Nr. 11, S. 1285 – 1293
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MIBG scans in patients with stage 4 neuroblastoma reveal two metastatic patterns, one is associated with MYCN amplification and in MYCN-amplified tumours correlates with a better prognosisIn: European Journal of Nuclear Medicine and Molecular Imaging , Jg. 42 2015, Nr. 2, S. 222 – 230DOI (Open Access)
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MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastomaIn: Cancer Letters , Jg. 366 2015, Nr. 1, S. 123 – 132DOI (Open Access)
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MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formationIn: OncoTarget , Jg. 6 2015, Nr. 7, S. 5204 – 5216DOI (Open Access)
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MiR-34a deficiency accelerates medulloblastoma formation in vivoIn: International Journal of Cancer , Jg. 136 2015, Nr. 10, S. 2293 – 2303DOI (Open Access)
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Mutational dynamics between primary and relapse neuroblastomasIn: Nature Genetics , Jg. 47 2015, Nr. 8, S. 872 – 877
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Neoadjuvant/adjuvant treatment of high-risk retinoblastoma : a report from the German Retinoblastoma Referral CentreIn: British Journal of Ophthalmology (BJO) , Jg. 99 2015, Nr. 7, S. 949 – 953
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Relapsed neuroblastomas show frequent RAS-MAPK pathway mutationsIn: Nature Genetics , Jg. 47 2015, Nr. 8, S. 864 – 871DOI (Open Access)
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Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumorsIn: OncoTarget , Jg. 6 2015, Nr. 17, S. 15425 – 15435DOI (Open Access)
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Targeting super-enhancer induced gene expression with the novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastomaIn: Cancer Research , Jg. 75 2015, Nr. 15 Suppl., S. 4731
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Telomerase activation by genomic rearrangements in high-risk neuroblastomaIn: Cancer Research , Jg. 75 2015, Nr. 15 Suppl., S. LB – 210
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Telomerase activation by genomic rearrangements in high-risk neuroblastomaIn: Nature , Jg. 526 2015, Nr. 7575, S. 700 – 704DOI (Open Access)
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Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiationIn: Science Signaling , Jg. 8 2015, Nr. 374
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Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : Implications for targeted treatmentIn: Clinical Cancer Research , Jg. 21 2015, Nr. 14, S. 3327 – 3339DOI (Open Access)
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miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating SurvivinIn: International Journal of Cancer , Jg. 136 2015, Nr. 6, S. 1308 – 1320DOI (Open Access)
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BET protein inhibitor OTX015 has selective anti-tumoral activity in preclinical models of MYCN- amplified neuroblastomaIn: Cancer Research , Jg. 74 2014, Nr. 19 Suppl., S. 3967
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CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patientsIn: PLoS ONE , Jg. 9 2014, Nr. 12, S. e114696DOI (Open Access)
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Early Targets of miR-34a in NeuroblastomaIn: Molecular and Cellular Proteomics (MCP) , Jg. 13 2014, Nr. 8, S. 2114 – 2131
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Lack of association between MDM2 promoter SNP309 and clinical outcome in patients with neuroblastomaIn: Pediatric Blood and Cancer , Jg. 61 2014, Nr. 10, S. 1867 – 1870
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Neuroblastoma in dialog with its stroma : NTRK1 is a regulator of cellular cross-talk with Schwann cellsIn: OncoTarget , Jg. 5 2014, Nr. 22, S. 11180 – 11192DOI (Open Access)
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Robust selection of cancer survival signatures from high-throughput genomic data using two-fold subsamplingIn: PLoS ONE , Jg. 9 2014, Nr. 10, S. e108818DOI (Open Access)
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p19-INK4d inhibits neuroblastoma cell growth, induces differentiation and is hypermethylated and downregulated in MYCN-amplified neuroblastomasIn: Human Molecular Genetics , Jg. 23 2014, Nr. 25, S. 6826 – 6837
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BET bromodomain protein inhibition is a therapeutic option for medulloblastomaIn: OncoTarget , Jg. 4 2013, Nr. 11, S. 2080 – 2095
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Chemoreduction improves eye retention in patients with retinoblastoma : a report from the German Retinoblastoma Reference CentreIn: British Journal of Ophthalmology (BJO) , Jg. 97 2013, Nr. 10, S. 1277 – 1283
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Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cellsIn: International Journal of Cancer , Jg. 133 2013, Nr. 4, S. 908 – 919
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Focal DNA copy number changes in neuroblastoma target MYCN regulated genesIn: PLoS ONE , Jg. 8 2013, Nr. 1, S. e52321DOI (Open Access)
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Histone deacetylase 10 promotes autophagy-mediated cell survivalIn: Proceedings of the National Academy of Sciences of the United States of America (PNAS) , Jg. 110 2013, Nr. 28
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Identifying transcriptional miRNA biomarkers by integrating high-throughput sequencing and real-time PCR dataIn: Methods: A Companion to Methods in Enzymology , Jg. 59 2013, Nr. 1, S. 154 – 163
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Knock-down of lysine specific demethylase-1 drives hematopoietic stem cells into a CD41+myeloid biased phenotypeIn: Onkologie , Jg. 36 2013, Nr. Suppl. 7, S. 228 – 228
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LIN28B drives neuroblastoma oncogenesis through let7-MYCN signalingIn: Cancer Research , Jg. 73 2013, Nr. 8 Suppl. 1, S. 4596
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Long-term follow-up of pediatric patients receiving total body irradiation before hematopoietic stem cell transplantation and post-transplant survival of >2 yearsIn: Pediatric Blood and Cancer , Jg. 60 2013, Nr. 11, S. 1792 – 1797
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MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cellsIn: Oncogene , Jg. 32 2013, Nr. 8, S. 1059 – 1065
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MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastomaIn: Nucleic Acids Research , Jg. 41 2013, Nr. 12, S. 6018 – 6033DOI (Open Access)
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MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1AIn: International Journal of Cancer , Jg. 133 2013, Nr. 5, S. 1064 – 1073
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Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAsIn: Oncogene , Jg. 32 2013, Nr. 24, S. 2927 – 2936
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Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interactionIn: Scientific Reports , Jg. 3 2013, S. 1351DOI (Open Access)
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Next-generation RNA sequencing reveals differential expression of MYCN target genes and suggests the mTOR pathway as a promising therapy target in MYCN-amplified neuroblastomaIn: International Journal of Cancer , Jg. 132 2013, Nr. 3, S. E106 – E115
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Targeted Therapy for Neuroblastoma : ALK InhibitorsIn: Klinische Pädiatrie , Jg. 225 2013, Nr. 6, S. 303 – 308
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The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemiaIn: BMC Cancer , Jg. 13 2013, S. 452DOI (Open Access)
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The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastomaIn: Acta Neuropathologica Communications , Jg. 1 2013, Nr. 1, S. 19DOI (Open Access)
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CD57(high) neuroblastoma cells have aggressive attributes ex situ and an undifferentiated phenotype in patientsIn: PLoS ONE , Jg. 7 2012, Nr. 8, S. e42025DOI (Open Access)
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Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastomaIn: International Journal of Cancer , Jg. 130 2012, Nr. 11, S. 2591 – 2598
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Die Vision der personalisierten Medizin : Neue Wege in der Diagnostik und Behandlung von Tumoren des zentralen Nervensystems im Kindes- und JugendalterIn: Unikate: Berichte aus Forschung und Lehre 2012, Nr. 42: Translationale Krebsforschung: Auf dem Weg zu neuen Therapien, S. 124 – 135DOI, Online Volltext (Open Access)
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Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcomeIn: British Journal of Cancer (BJC) , Jg. 107 2012, Nr. 8, S. 1409 – 1417DOI (Open Access)
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Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkersIn: Genome Biology , Jg. 13 2012, Nr. 10 , R 95DOI, Online Volltext (Open Access)
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Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomasIn: International Journal of Cancer , Jg. 130 2012, Nr. 11, S. 2599 – 2606
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LIN28B drives neuroblastoma oncogenesis through let7-MYCN signalingIn: Klinische Pädiatrie , Jg. 224 2012, S. 222
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LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppressionIn: Nature Genetics , Jg. 44 2012, Nr. 11, S. 1199 – 1206
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Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiationIn: Leukemia , Jg. 26 2012, Nr. 9, S. 2039 – 2051
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Maßgeschneiderte Nager : Genetisch veränderte Mäuse helfen bei der Entwicklung zielgerichteter TherapienIn: Unikate: Berichte aus Forschung und Lehre 2012, Nr. 42: Translationale Krebsforschung: Auf dem Weg zu neuen Therapien, S. 42 – 50DOI, Online Volltext (Open Access)
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Oncogenic activation of FOXR1 by 11q23 intrachromosomal deletion-fusions in neuroblastomaIn: Oncogene , Jg. 31 2012, Nr. 12, S. 1571 – 1581
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Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomasIn: Neuro-Oncology , Jg. 14 2012, Nr. 7, S. 859 – 869DOI (Open Access)
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RITA-p53 activation in medulloblastoma as a new approach for treatment?In: Klinische Pädiatrie , Jg. 224 2012, S. 221
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Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formationIn: Nature Cell Biology , Jg. 14 2012, Nr. 9, S. 958 – 965
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Targeted expression of mutated ALK induces neuroblastoma in transgenic miceIn: Science Translational Medicine , Jg. 4 2012, Nr. 141, S. 141ra91
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The JARID 1C histone demethylase is upregulated in aggressive neuroblastomas independent of MYCN amplificationIn: Klinische Pädiatrie , Jg. 224 2012, S. 221 – 222
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Total body irradiation (TBI) in the conditioning regimens prior to hematopoietic stem cell transplantation (HSCT) : Long-term follow-up of 98 pediatric patientsIn: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics , Jg. 188 2012, Nr. Suppl. 1, S. 108
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CAMTA1, a 1p36 Tumor Suppressor Candidate, Inhibits Growth and Activates Differentiation Programs in Neuroblastoma CellsIn: Cancer Research , Jg. 71 2011, Nr. 8, S. 3142 – 3151
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High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary NeuroblastomaIn: Clinical Cancer Research , Jg. 17 2011, Nr. 15, S. 5082 – 5092
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MiR-34a targeting of Notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastomaIn: PLoS ONE , Jg. 6 2011, Nr. 9, S. e24584DOI (Open Access)
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Neuroblastoma develops from neural crest stem cellsIn: Klinische Pädiatrie , Jg. 223 2011, Nr. 3, S. 198 – 198
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Pharmacological activation of the p53 pathway by nutlin-3 inhibits medulloblastoma cell proliferation in vitro and in vivoIn: European Journal of Pediatrics , Jg. 170 2011, Nr. 2, S. 267 – 268
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Polo-like kinase 1 is a therapeutic target in high-risk neuroblastomaIn: Clinical Cancer Research , Jg. 17 2011, Nr. 4, S. 731 – 741
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Regulatory BCL2 promoter polymorphism (-938C>A) is associated with adverse outcome in patients with prostate carcinomaIn: International Journal of Cancer , Jg. 129 2011, Nr. 10, S. 2390 – 2399
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miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samplesIn: Clinical Cancer Research , Jg. 17 2011, Nr. 24, S. 7684 – 7692
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Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signatureIn: Clinical Cancer Research , Jg. 16 2010, Nr. 5, S. 1532 – 1541
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Accurate prediction of neuroblastoma outcome based on miRNA expression profilesIn: International Journal of Cancer , Jg. 127 2010, Nr. 10, S. 2374 – 2385
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An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumoursIn: Oncogene , Jg. 29 2010, Nr. 24, S. 3583 – 3592
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Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastomaIn: Clinical Cancer Research , Jg. 16 2010, Nr. 11, S. 2971 – 2978
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Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastomaIn: Nucleic Acids Research , Jg. 38 2010, Nr. 17, S. 5919 – 5928
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KDM 1A/LSD1 has a functional role in migration of medulloblastoma cells and their neuronal precursorsIn: Klinische Pädiatrie , Jg. 222 2010, Nr. 3, S. 221
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LSD1 is a novel therapeutic target in neuroblastoma (NB) and medulloblastoma (MB)In: European Journal of Pediatrics , Jg. 169 2010, Nr. 3, S. 381
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MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumorsIn: Oncogene , Jg. 29 2010, Nr. 9, S. 1394 – 1404
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Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplificationIn: Clinical Cancer Research , Jg. 16 2010, Nr. 17, S. 4353 – 4362
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Plk1 is a novel target for high-risk neuroblastoma therapyIn: Klinische Pädiatrie , Jg. 222 2010, Nr. 3, S. 222 – A21
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Production of chick embryo extract for the cultivation of murine neural crest stem cellsIn: JoVE , Jg. 2010 2010, Nr. 45DOI (Open Access)
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The DNA-binding protein YB-1 is a direct MYCN target and influences repair and resistance in neuroblastoma cell linesIn: Klinische Pädiatrie , Jg. 222 2010, Nr. 3, S. 219
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The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in NeuroblastomaIn: Molecular Cell , Jg. 40 2010, Nr. 5, S. 762 – 773
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ALK Mutation Analysis in Patients of the German Neuroblastoma StudyIn: Klinische Pädiatrie , Jg. 221 2009, Nr. 3, S. 195
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Galectin-1 is a major effector of TrkB-mediated neuroblastoma aggressivenessIn: Oncogene , Jg. 28 2009, Nr. 19, S. 2015 – 2023
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LSD 1 is a Potential Therapeutic Target in MedulloblastomaIn: Klinische Pädiatrie , Jg. 221 2009, Nr. 3, S. 203 – 204
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Lysine-Specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma : Implications for therapyIn: Klinische Pädiatrie , Jg. 221 2009, Nr. 3, S. A61
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Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma : implications for therapyIn: Cancer Research , Jg. 69 2009, Nr. 5, S. 2065 – 2071DOI (Open Access)
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MicroRNAs 221 and 222 in the Pathogenesis of Solid Childhood TumorsIn: Klinische Pädiatrie , Jg. 221 2009, Nr. 3, S. 210
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MicroRNAs in the pathogenesis of neuroblastomaIn: Cancer Letters , Jg. 274 2009, Nr. 1, S. 10 – 15
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N-myc induces transformation of neural crest stem cells in vitro and in vivoIn: Klinische Pädiatrie , Jg. 221 2009, Nr. 3, S. 195
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Pharmacologic activation of the p53 pathway using Nutlin-3 inhibits medulloblastoma cell proliferation in vitroIn: Klinische Pädiatrie , Jg. 221 2009, Nr. 3, S. 201
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Prognostic role and functional analyses of miRNA expression in neuroblastomaIn: Klinische Pädiatrie , Jg. 221 2009, Nr. 3, S. 206
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Proteomics of neuroblastoma master regulatorsIn: Klinische Pädiatrie , Jg. 221 2009, Nr. 3, S. 209
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Reanalysis of neuroblastoma expression profiling data using improved methodology and extended follow-up increases validity of outcome predictionIn: Cancer Letters , Jg. 282 2009, Nr. 1, S. 55 – 62
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Stabilization of N-Myc is a critical function of Aurora A in human neuroblastomaIn: Cancer Cell , Jg. 15 2009, Nr. 1, S. 67 – 78
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The low-affinity neurotrophin receptor, p75, is upregulated in ganglioneuroblastoma/ganglioneuroma and reduces tumorigenicity of neuroblastoma cells in vivoIn: International Journal of Cancer , Jg. 124 2009, Nr. 10, S. 2488 – 2494
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The miR-17-92 gene cluster is amplified and overexpressed in retinoblastomaIn: Klinische Pädiatrie , Jg. 221 2009, Nr. 3, S. 195
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Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cellsIn: DNA Repair , Jg. 7 2008, Nr. 10, S. 1757 – 1764
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Expression of the p75 neurotrophin receptor reduces tumorigenity of neuroblastoma cells in vivo and in vitroIn: Klinische Pädiatrie , Jg. 220 2008, Nr. 3, S. 206
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Insulin-like growth factor-1 receptor acts as a growth regulator in synovial sarcomaIn: The Journal of Pathology , Jg. 216 2008, Nr. 4, S. 428 – 439
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MYCN regulates oncogenic MicroRNAs in neuroblastomaIn: International Journal of Cancer , Jg. 122 2008, Nr. 3, S. 699 – 704
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The LSD 1 histone demethylase is highly expressed in poorly differentiated neuroblastoma and is a novel therpeutic targetIn: Klinische Pädiatrie , Jg. 220 2008, Nr. 3, S. 208
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Transcription factor AP2alpha (TFAP2a) regulates differentiation and proliferation of neuroblastoma cellsIn: Cancer Letters , Jg. 271 2008, Nr. 1, S. 56 – 63
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N-MYC regulates oncogenic micrornas in neuroblastomaIn: Pediatric Blood and Cancer , Jg. 49 2007, Nr. 4, S. 429 – 429
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N-Myc regulates oncogenic micrortnas in neuroblastomaIn: European Journal of Pediatrics , Jg. 166 2007, Nr. 3, S. 278
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Translating expression profiling into a clinically feasible test to predict neuroblastoma outcomeIn: Clinical Cancer Research , Jg. 13 2007, Nr. 5, S. 1459 – 1465
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Expression of TrkA is a potential regulator of immunogenicity in neuroblastoma cellsIn: Klinische Pädiatrie , Jg. 218 2006, Nr. 3, S. 192 – 192
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MicroRNA expression analysis in neuroblastoma using pligonuclectide arraysIn: Klinische Pädiatrie , Jg. 218 2006, Nr. 3, S. 194
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Microarray analysis defines IPL/TSSC3 as a potential target mediating the synergistic effects of combined thermo-chemotherapy in neuroblastoma cellsIn: Klinische Pädiatrie , Jg. 218 2006, Nr. 3, S. 192 – 193
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Biological effects of TrkA and TrkB receptor signaling in neuroblastomaIn: Cancer letters , Jg. 228 2005, Nr. 1-2, S. 143 – 153
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Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomasIn: Oncogene , Jg. 24 2005, Nr. 1, S. 165 – 177
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Prediction of clinical outcome and biological characterization of neuroblastoma by expression profilingIn: Oncogene , Jg. 24 2005, Nr. 53, S. 7902 – 7912
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The neurotrophin receptor TrkB cooperates with c-Met in enhancing neuroblastoma invasivenessIn: Carcinogenesis , Jg. 26 2005, Nr. 12, S. 2105 – 2115
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NT-3 mediated signaling pathways in DAOY medulloblastoma cellsIn: Neuro-Oncology , Jg. 6 2004, Nr. 4, S. 409 – 409
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Microarray-analysis : a new approach to study the molecular mechanisms of thermo-chemotherapyIn: Klinische Pädiatrie , Jg. 215 2003, Nr. 6, S. 298 – 302
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Author Correction : The landscape of genomic alterations across childhood cancersIn: Nature , Jg. 559 2018, Nr. 7714, S. E10
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Integrated Genomic Analysis Identifies Specific Alterations and Activation of Yap in Relapsed Neuroblastoma
47th Congress of the International Society of Paediatric Oncology (SIOP), October 8–11, 2015, Cape Town, South Africa,In: Pediatric Blood and Cancer , Jg. 62 2015, Nr. S4, S. S145 – S145 -
ALK F1174L kinase activity as driver of cell proliferation in neuroblastoma cell line models and neuroblastoma tumorsIn: Cancer Research , Jg. 72 2012, Nr. 8, Suppl., S. 1683
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Lysin-Specific Histone Dementhylase 1(LSD1) is a promising new Epigenetic Theapy target Crucially involved in the migration of Medulloblastoma Cells
15th International Symposium on Pediatric Neuro-Oncology, June 24-27 2012 Toronto, Ontario, Canada,In: Neuro-Oncology , Jg. 14 2012, Nr. Suppl. 1, S. i92 -
miR-34a is dispensable for normal development but its loss Accelerates medulloblastoma formation
15th International Symposium on Pediatric Neuro-Oncology, June 24-27 2012 Toronto, Ontario, Canada,In: Neuro-Oncology , Jg. 14 2012, Nr. Suppl. 1, S. 89 -
Long-term follow-up of patients receiving chemoreduction for intraocular rettinoblatoma in the German RB Center (1995-2004)
43rd Congress of the International Society of Paediatric Oncology (SIOP) 2011 ; 28th–30th October, 2011, Auckland, New Zealand,In: Pediatric Blood and Cancer , Jg. 57 2011, Nr. 5, S. 785 -
Long-term follow-up of pediatric patients receiving total body irradiation before bone marrow transplantation
43rd Congress of the International Society of Paediatric Oncology (SIOP) 2011 ; 28th–30th October, 2011, Auckland, New Zealand,In: Pediatric Blood and Cancer , Jg. 57 2011, Nr. 5, S. 827 -
Lysine-Specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma : Implications for therapyIn: Klinische Pädiatrie , Jg. 223 2011, Nr. 1, S. A15
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Accurate prediction of neuroblastoma outcome based on miRNA expression profiles
42nd Congress of the International Society of Pediatric Oncology (SIOP), October 21-24, 2010, Boston, USA,In: Pediatric Blood and Cancer , Jg. 55 2010, Nr. 5, S. 812 -
Deep Sequencing Revals Differential Expression of Micrornas in Favourable Versus Unfavourable Neuroblastoma
42nd Congress of the International Society of Pediatric Oncology (SIOP) in Boston,In: Pediatric Blood and Cancer , Jg. 55 2010, Nr. 5, S. 826 – 827 -
High Expression of the alk Receptor Tyrosine Kinase Precedes Mutation as a Determining Factor of Unfavourable Phenotype in Primary Neuroblastoma
42nd Congress of the International Society of Pediatric Oncology (SIOP), October 21-24, 2010, Boston, USA,In: Pediatric Blood and Cancer , Jg. 55 2010, Nr. 5, S. 827 -
Pharmacologic Activation of the P53 Pathway by Nutlin-3 Inhibits Medulloblastoma Cell Proliferation in Vitro
42nd Congress of the International Society of Pediatric Oncology (SIOP), October 21-24, 2010, Boston, USA,In: Pediatric Blood and Cancer , Jg. 55 2010, Nr. 5, S. 918 -
Development of Guidelines for Parents with Children Neuwly Diagnosed with Cancer : Nutrition, Personal and Oral Hygiene
41st Annual conference of International Society of Paediatric Oncology SIOP 2009, Sao Paulo, Brazil, October 5–9, 2009,In: Pediatric Blood and Cancer , Jg. 53 2009, Nr. 5, S. 757 -
Exon-Level gene expression analysis of primary neuroblastomas improves risk prediction and identifies jaridic as a novel Therapeutic target
41st Annual conference of International Society of Paediatric Oncology SIOP 2009, Sao Paulo, Brazil, October 5–9, 2009,In: Pediatric Blood and Cancer , Jg. 53 2009, Nr. 5, S. 742 – 743 -
LSD1 is a Potential Therapeutic Target in Medulloblastoma
41st Annual conference of International Society of Paediatric Oncology SIOP 2009, October 5–9, 2009, Sao Paulo, Brazil,In: Pediatric Blood and Cancer , Jg. 53 2009, Nr. 5, S. 826 -
Modeling Neuroblastomagenesis from neural crest Stem Cells in Vitro and in Vivo
41st Annual conference of International Society of Paediatric Oncology SIOP 2009, Sao Paulo, Brazil, October 5–9, 2009,In: Pediatric Blood and Cancer , Jg. 53 2009, Nr. 5, S. 703 – 704 -
The MIR-17-92 Gene Cluster is Amplified an overexpressed in Rettinoblastoma
41st Annual conference of International Society of Paediatric Oncology SIOP 2009, Sao Paulo, Brazil, October 5–9, 2009,In: Pediatric Blood and Cancer , Jg. 53 2009, Nr. 5, S. 735 -
Analysen molekularer und epigenetischer Veränderungen in neuroblastischen TumorenDuisburg, Essen 2011
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Analyse neurotrophinrezeptor-vermittelter Genregulationsmuster in neuroblastischen TumorenDuisburg, Essen 2007