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Prof. Dr.rer.nat. Barbara M. Grüner

Innere Klinik (Tumorforschung)

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Zhao, Ben; Fang, Rui; Schürmann, Hendrik; Hemmer, Erik Jan; Mayer, Gina Lauren; Trajkovic-Arsic, Marija; Althoff, Kristina; Yang, Jiajin; Godfrey, Laura; Liffers, Sven T.; Savvatakis, Konstantinos; Dorsch, Madeleine; Grüner, Barbara M.; Hahn, Stephan; Remke, Marc; Lueong, Smiths S.; Siveke, Jens T.
    PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma
    In: Cell Reports, Jg. 44, 2025, Nr. 4, 115541
    DOI (Open Access)
  • Cai, Ling; Wu, Fangjiang; Zhou, Qinbo; Gao, Ying; Yao, Bo; DeBerardinis, Ralph J.; Acquaah-Mensah, George K.; Aidinis, Vassilis; Beane, Jennifer E.; Biswal, Shyam; Chen, Ting; Concepcion-Crisol, Carla P.; Grüner, Barbara M.; Jia, Deshui; Jones, Robert A.; Kurie, Jonathan M.; Lee, Min Gyu; Lindahl, Per; Lissanu, Yonathan; Lorz, Corina; MacPherson, David; Martinelli, Rosanna; Mazur, Pawel K.; Mazzilli, Sarah A.; Mii, Shinji; Moll, Herwig P.; Moorehead, Roger A.; Morrisey, Edward E.; Ng, Sheng Rong; Oser, Matthew G.; Pandiri, Arun R.; Powell, Charles A.; Ramadori, Giorgio; Santos, Mirentxu; Snyder, Eric L.; Sotillo, Rocio; Su, Kang-Yi; Taki, Tetsuro; Taparra, Kekoa; Tran, Phuoc T.; Xia, Yifeng; van Veen, J. Edward; Winslow, Monte M.; Xiao, Guanghua; Rudin, Charles M.; Oliver, Trudy G.; Xie, Yang; Minna, John D.
    The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
    In: Cancer Research, Jg. 85, 2025, Nr. 10, S. 1769 – 1783
    DOI
  • Ullrich, Vivien; Ertmer, Sarah; Baginska, Anna; Dorsch, Madeleine; Gull, Hanah H.; Cima, Igor; Berger, Pia; Dobersalske, Celia; Langer, Sarah; Meyer, Loona; Dujardin, Philip; Kebir, Sied; Glas, Martin; Blau, Tobias; Keyvani, Kathy; Rauschenbach, Laurèl; Sure, Ulrich; Roesch, Alexander; Grüner, Barbara M.; Scheffler, Björn
    KDM5B predicts temozolomide-resistant subclones in glioblastoma
    In: iScience, Jg. 27, 2024, Nr. 1, 108596
    DOI (Open Access)
  • Kebir, Sied; Ullrich, Vivien; Berger, Pia; Dobersalske, Celia; Langer, Sarah; Rauschenbach, Laurèl; Trageser, Daniel; Till, Andreas; Lorbeer, Franziska K.; Wieland, Anja; Wilhelm-Buchstab, Timo; Ahmad, Ashar; Fröhlich, Holger; Cima, Igor; Prasad, Shruthi; Matschke, Johann; Jendrossek, Verena; Remke, Marc; Grüner, Barbara M.; Rösch, Alexander; Siveke, Jens T.; Herold-Mende, Christel; Blau, Tobias; Keyvani, Kathy; van Landeghem, Frank K H; Pietsch, Torsten; Felsberg, Jörg; Reifenberger, Guido; Weller, Michael; Sure, Ulrich; Brüstle, Oliver; Simon, Matthias; Glas, Martin; Scheffler, Björn
    A Sequential Targeting Strategy Interrupts AKT-Driven Subclone-Mediated Progression in Glioblastoma
    In: Clinical Cancer Research, Jg. 29, 2023, Nr. 2, S. 488 – 500
    DOI (Open Access)
  • Zecha, Jana; Bayer, Florian P.; Wiechmann, Svenja; Woortman, Julia; Berner, Nicola; Müller, Julian; Schneider, Annika; Kramer, Karl; Abril-Gil, Mar; Hopf, Thomas; Reichart, Leonie; Chen, Lin; Hansen, Fynn M.; Lechner, Severin; Samaras, Patroklos; Eckert, Stephan; Lautenbacher, Ludwig; Reinecke, Maria; Hamood, Firas; Prokofeva, Polina; Vornholz, Larsen; Falcomatà, Chiara; Dorsch, Madeleine; Schröder, Ayla; Venhuizen, Anton; Wilhelm, Stephanie; Médard, Guillaume; Stoehr, Gabriele; Ruland, Jürgen; Grüner, Barbara M.; Saur, Dieter; Buchner, Maike; Ruprecht, Benjamin; Hahne, Hannes; The, Matthew; Wilhelm, Mathias; Kuster, Bernhard
    Decrypting drug actions and protein modifications by dose- and time-resolved proteomics
    In: Science, Jg. 380, 2023, Nr. 6640, S. 93 – 101
    DOI, Online Volltext (Open Access)
  • Chuang, Chen-Hua; Dorsch, Madeleine; Dujardin, Philip; Silas, Sukrit; Ueffing, Kristina; Hölken, Johanna M; Yang, Dian; Winslow, Monte M.; Grüner, Barbara M.
    Altered mitochondria functionality defines a metastatic cell state in lung cancer and creates an exploitable vulnerability
    In: Cancer Research, Jg. 81, 2021, Nr. 3, S. 567 – 579
    DOI, Online Volltext (Open Access)
  • Ho, Cassandra S. L.; Tüns, Alicia I.; Schildhaus, Hans-Ulrich; Wiesweg, Marcel; Grüner, Barbara M.; Hegedus, Balazs; Schuler, Martin; Schramm, Alexander; Oeck, Sebastian
    HER2 mediates clinical resistance to the KRASG¹²C inhibitor sotorasib, which is overcome by co-targeting SHP2
    In: European Journal of Cancer (EJC), Jg. 159, 2021, S. 16 – 23
    DOI
  • Dorsch, Madeleine; Kowalczyk, Manuela; Planque, Mélanie; Heilmann, Geronimo; Urban, Sebastian; Dujardin, Philip; Forster, Jan; Ueffing, Kristina; Nothdurft, Silke; Oeck, Sebastian; Paul, Annika; Liffers, Sven T.; Kaschani, Farnusch; Kaiser, Markus; Schramm, Alexander; Siveke, Jens T.; Winslow, Monte M.; Fendt, Sarah-Maria; Nalbant, Perihan; Grüner, Barbara M.
    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
    In: Cell Reports, Jg. 37, 2021, Nr. 8, 110056
    DOI, Online Volltext (Open Access)
  • Dujardin, Philip; Baginska, Anna K.; Urban, Sebastian; Grüner, Barbara M.
    Unraveling tumor heterogeneity by using DNA barcoding technologies to develop personalized treatment strategies in advanced-stage pdac
    In: Cancers, Jg. 13, 2021, Nr. 16, 4187
    DOI, Online Volltext (Open Access)
  • Dujardin, Philip; Grüner, Barbara M.
    „Yes, we (s)can“ : Molekulare Barcodes in der Tumorforschung für neue in vivo-Screening Verfahren
    In: Unikate: Berichte aus Forschung und Lehre, 2021, Nr. 56 : "Junge Wilde" - Die nächste Generation, S. 22 – 29
    DOI, Online Volltext (Open Access)
  • Grüner, Barbara M.; Fendt, Sarah-Maria
    Cancer cells stock up in lymph vessels to survive
    In: Nature, Jg. 585, 2020, Nr. 7823, S. 36 – 37
    DOI, Online Volltext (Open Access)
  • Nothdurft, Silke; Thumser-Henner, Clotilde; Breitenbücher, Frank; Okimoto, Ross A.; Dorsch, Madeleine; Opitz, Christiane A.; Sadik, Ahmed; Esser, Charlotte; Hölzel, Michael; Asthana, Saurabh; Forster, Jan; Beisser, Daniela; Kalmbach, Sophie; Grüner, Barbara M.; Bivona, Trever G.; Schramm, Alexander; Schuler, Martin
    Functional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis
    In: Oncogenesis, Jg. 9, 2020, Nr. 11, S. 102
    DOI, Online Volltext (Open Access)
  • Yang, Dian; Qu, Fangfei; Cai, Hongchen; Chuang, Chen-Hua; Lim, Jing Shan; Jahchan, Nadine; Grüner, Barbara M.; Kuo, Christin S.; Kong, Christina; Oudin, Madeleine J.; Winslow, Monte M.; Sage, Julien; S. Kuo, Christin
    Axon-like protrusions promote small cell lung cancer migration and metastasis
    In: eLife, Jg. 8, 2019, S. e50616
    DOI (Open Access)
  • Chiou, Shin-Heng; Dorsch, Madeleine; Kusch, Eva; Naranjo, Santiago; Kozak, Margaret M.; Koong, Albert C.; Winslow, Monte M.; Grüner, Barbara M.
    Hmga2 is dispensable for pancreatic cancer development, metastasis, and therapy resistance
    In: Scientific Reports, Jg. 8, 2018, Nr. 1, S. 14008
    DOI (Open Access)
  • Chiou, Shin-Heng; Risca, Viviana I.; Wang, Gordon X.; Yang, Dian; Grüner, Barbara M.; Kathiria, Arwa S.; Ma, Rosanna K.; Vaka, Dedeepya; Chu, Pauline; Kozak, Margaret; Castellini, Laura; Graves, Edward E.; Kim, Grace E.; Mourrain, Philippe; Koong, Albert C.; Giaccia, Amato J.; Winslow, Monte M.
    BLIMP1 induces transient metastatic heterogeneity in pancreatic cancer
    In: Cancer Discovery, Jg. 7, 2017, Nr. 10, S. 1184 – 1199
    DOI
  • Chuang, Chen-Hua; Greenside, Peyton G.; Rogers, Zoë N.; Brady, Jennifer J.; Yang, Dian; Ma, Rosanna K.; Caswell, Deborah R.; Chiou, Shin-Heng; Winters, Aidan F.; Grüner, Barbara M.; Ramaswami, Gokul; Spencley, Andrew L.; Kopecky, Kimberly E.; Sayles, Leanne C.; Sweet-Cordero, E Alejandro; Li, Jin Billy; Kundaje, Anshul; Winslow, Monte M.
    Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis
    In: Nature Medicine, Jg. 23, 2017, Nr. 3, S. 291 – 300
    DOI, Online Volltext (Open Access)
  • Grüner, Barbara M.; Schulze, Christopher J.; Yang, Dian; Ogasawara, Daisuke; Dix, Melissa M.; Rogers, Zoë N.; Chuang, Chen-Hua; McFarland, Christopher D.; Chiou, Shin-Heng; Brown, J. Mark; Cravatt, Benjamin F.; Bogyo, Matthew; Winslow, Monte M.
    An in vivo multiplexed small-molecule screening platform
    In: Nature Methods, Jg. 13, 2016, Nr. 10, S. 883 – 889
    DOI, Online Volltext (Open Access)
  • Grüner, Barbara M.; Winkelmann, Isabel; Feuchtinger, Annette; Sun, Na; Balluff, Benjamin; Teichmann, Nicole; Herner, Alexander; Kalideris, Evdokia; Steiger, Katja; Braren, Rickmer; Aichler, Michaela; Esposito, Irene; Schmid, Roland M.; Walch, Axel; Siveke, Jens T.
    Modeling therapy response and spatial tissue distribution of erlotinib in pancreatic cancer
    In: Molecular Cancer Therapeutics, Jg. 15, 2016, Nr. 5, S. 1145 – 1152
    DOI (Open Access)
  • Denny, Sarah K.; Yang, Dian; Chuang, Chen-Hua; Brady, Jennifer J.; Lim, Jing Shan; Grüner, Barbara M.; Chiou, Shin-Heng; Schep, Alicia N.; Baral, Jessika; Hamard, Cécile; Antoine, Martine; Wislez, Marie; Kong, Christina S.; Connolly, Andrew J.; Park, Kwon-Sik; Sage, Julien; Greenleaf, William J.; Winslow, Monte M.
    Nfib Promotes Metastasis through a Widespread Increase in Chromatin Accessibility
    In: Cell, Jg. 166, 2016, Nr. 2, S. 328 – 342
    DOI (Open Access)
  • Chiou, Shin-Heng; Winters, Ian P.; Wang, Jing; Naranjo, Santiago; Dudgeon, Crissy; Tamburini, Fiona B.; Brady, Jennifer J.; Yang, Dian; Grüner, Barbara M.; Chuang, Chen-Hua; Caswell, Deborah R.; Zeng, Hong; Chu, Pauline; Kim, Grace E.; Carpizo, Darren R.; Kim, Seung K.; Winslow, Monte M.
    Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing
    In: Genes and Development, Jg. 29, 2015, Nr. 14, S. 1576 – 1585
    DOI (Open Access)
  • Grosch, Melanie; Grüner, Barbara M.; Spranger, Stephanie; Stütz, Adrian M.; Rausch, Tobias; Korbel, Jan O.; Seelow, Dominik; Nürnberg, Peter; Sticht, Heinrich; Lausch, Ekkehart; Zabel, Bernhard; Winterpacht, Andreas; Tagariello, Andreas
    Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype
    In: Matrix Biology, Jg. 32, 2013, Nr. 7-8, S. 387 – 392
    DOI
  • Ardito, Christine M.; Grüner, Barbara M.; Takeuchi, Kenneth K.; Lubeseder-Martellato, Clara; Teichmann, Nicole; Mazur, Pawel K.; DelGiorno, Kathleen E.; Carpenter, Eileen S.; Halbrook, Christopher J.; Hall, Jason C.; Pal, Debjani; Briel, Thomas; Herner, Alexander; Trajkovic-Arsic, Marija; Sipos, Bence; Liou, Geou-Yarh; Storz, Peter; Murray, Nicole R.; Threadgill, David W.; Sibilia, Maria; Washington, M. Kay; Wilson, Carole L.; Schmid, Roland M.; Raines, Elaine W.; Crawford, Howard C.; Siveke, Jens T.
    EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis
    In: Cancer Cell, Jg. 22, 2012, Nr. 3, S. 304 – 317
    DOI (Open Access)
  • Grüner, Barbara M.; Hahne, Hannes; Mazur, Pawel K.; Trajkovic-Arsic, Marija; Maier, Stefan; Esposito, Irene; Kalideris, Evdokia; Michalski, Christoph W.; Kleeff, Jörg; Rauser, Sandra; Schmid, Roland M.; Küster, Bernhard; Walch, Axel; Siveke, Jens T.
    MALDI imaging mass spectrometry for in situ proteomic analysis of preneoplastic lesions in pancreatic cancer
    In: PLoS ONE, Jg. 7, 2012, Nr. 6, e39424
    DOI (Open Access)
  • Falkowska-Hansen, Berit; Kollar, Jasmin; Grüner, Barbara M.; Schanz, Merle; Boukamp, Petra; Siveke, Jens; Rethwilm, Axel; Kirschner, Marc
    An inducible Tet-Off-H2B-GFP lentiviral reporter vector for detection and in vivo isolation of label-retaining cells
    In: Experimental Cell Research, Jg. 316, 2010, Nr. 11, S. 1885 – 1895
    DOI
  • Mazur, Pawel K.; Grüner, Barbara M.; Nakhai, Hassan; Sipos, Bence; Zimber-Strobl, Ursula; Strobl, Lothar J.; Radtke, Freddy; Schmid, Roland M.; Siveke, Jens T.
    Identification of epidermal pdx1 expression discloses different roles of notch1 and notch2 in murine krasG¹²D-induced skin carcinogenesis in vivo
    In: PLoS ONE, Jg. 5, 2010, Nr. 10, e13578
    DOI (Open Access)

    • Abstracts

  • Ullrich, Vivien; Ertmer, Sarah; Berger, Pia; Langer, Sarah; Baginska, Anna; Gull, Hanah; Dorsch, Madeleine; Cima, Igor; Dobersalske, Celia; Kebir, Sied; Glas, Martin; Rauschenbach, Laurèl; Sure, Ulrich; Rösch, Alexander; Grüner, Barbara M.; Scheffler, Björn
    Predicting and targeting clonally expanding, tmz-resistant tumor cells in glioblastoma
    28th Annual Scientific Meeting of the Society-for-Neuro-Oncology (SNO); NOV 15-19, 2023; Vancouver, Canada,
    In: Neuro-Oncology. Oxford: Oxford University Press, Jg. 25, 2023, Nr. Suppl. 5, S. v110 – v110
    DOI
  • Petzold, A.; Dujardin, P.; Oeck, S.; Wiesweg, Marcel; Hegedüs, B.; Schuler, Martin; Grüner, Barbara M.; Schramm, Alexander
    Combining Patient-Derived Xenografts and Barcoding Technology to Evaluate Response to Targeted Therapies in ALK+NSCLC
    In: Journal of Thoracic Oncology. Amsterdam: Elsevier, Jg. 17, 2022, Nr. 9, S. 611
    DOI
  • Tüns, A.I.; Ho, C.S.L.; Schildhaus, Hans-Ulrich; Wiesweg, Marcel; Grüner, Barbara M.; Hegedüs, B.; Schuler, Martin; Schramm, Alexander; Oeck, S.
    Targeting SHP2 Reverts Oncogenic Mediated Resistance to KRAS-G12C Inhibition
    In: Journal of Thoracic Oncology. Amsterdam: Elsevier, Jg. 17, 2022, Nr. 9, S. S586 – S587
    DOI
  • Nothdurft, S.; Breitenbücher, Frank; Okimoto, R.; Bivona, T.; Grüner, Barbara M.; Hoelzel, M.; Forster, J.; Kalmbach, S.; Schramm, Alexander; Schuler, Martin
    MA17.07 Identification of AHR as a Novel Regulator of Lung Cancer Metastasis
    In: Journal of Thoracic Oncology. Amsterdam: Elsevier, Jg. 14, 2019, Nr. 10, Supplement, S. S319
    DOI (Open Access)
  • Dorsch, Madeleine; Schulze, Christopher James; Yang, Dian; Bogyo, Matthew; Winslow, Monte Meier; Grüner, Barbara M.
    Multiplexed in vivo small molecule screening for immediate drug repositioning reveals novel therapeutic targets in metastatic pancreatic cancer
    AACR Special Conference: Advances in Modeling Cancer in Mice: Technology, Biology, and Beyond; September 24-27, 2017; Orlando, Florida,
    In: Cancer Research. Philadelphia: American Association for Cancer Research (AACR), Jg. 78, 2018, Nr. 10, S. 34 – 35

    • Preprints

  • Klink, Nikolas; Urban, Sebastian; Seier, Johanna A.; Adhikari, Bikash; Schwalm, Martin P.; Müller, Juliane; Dorsch, Madeleine; Kaschani, Farnusch; Koch, Johannes; Führer, Siska; Kaiser, Markus; Schulze, Nina; Knapp, Stefan; Wolf, Elmar; Paschen, Annette; Grüner, Barbara M.; Gersch, Malte
    Targeted degradation of USP7 in solid cancer cells reveals disparate effects of deubiquitinase inhibition vs. acute protein depletion
    2025
    DOI, Online Volltext (Open Access)
  • Kitanovski, Simo; Conroy, Shannon; Sonneck, Justin; Dorsch, Madeleine; Urban, Sebastian; Chen, Jianxu; Grüner, Barbara M.; Hoffmann, Daniel
    Uncertainty-aware quantitative analysis of high-throughput live cell migration data
    2025
    DOI (Open Access)

    • Beiträge in Sammelwerken und Tagungsbänden

  • Dujardin, Philip; Grüner, Barbara M.
    Barcoding Technology for Multiplexed Analysis of Metastatic Ability In Vivo
    In: Metastasis: Methods and Protocols / Stein, Ulrike S. (Hrsg.). Berlin: Springer, 2021, S. 239 – 251
    DOI