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Prof. Dr. rer. nat. Alexander Schramm

Die folgenden Publikationen sind in der Online-Universitätsbibliographie der Universität Duisburg-Essen verzeichnet. Weitere Informationen finden Sie gegebenenfalls auch auf den persönlichen Webseiten der Person.

    Artikel in Zeitschriften

  • Simon, Mareike; Benary, Uwe; Baum, Katharina; Schramm, Alexander; Wolf, Jana
    A computational model elucidates the effects of oncogene-induced expression alterations on the energy metabolism of neuroblastoma
    In: Scientific Reports, Jg. 15, 2025, Nr. 1, 32708
    DOI (Open Access)
  • Wiegand, Felix; Lähnemann, David; Mölder, Felix; Uzuner, Hamdiye; Prinz, Adrian; Schramm, Alexander; Köster, Johannes
    Datavzrd : Rapid programming- and maintenance-free interactive visualization and communication of tabular data
    In: PLoS ONE, Jg. 20, 2025, Nr. 7, e0323079
    DOI (Open Access)
  • Roesch, Romina M; Schnorbach, Johannes; Klotz, Laura V; Griffo, Raffaella; Thomas, Michael; Stenzinger, Albrecht; Christopoulos, Petros; Allgaeuer, Michael; Schneider, Marc; Schuler, Martin; Wiesweg, Marcel; Schramm, Alexander; Bölükbas, Servet; Doerr, Fabian; Hegedüs, Balazs; Cvetkovic, Jelena; Kirchner, Marietta; Eichhorn, Martin E; Winter, Hauke; Bozorgmehr, Farastuk; Eichhorn, Florian
    NeoTRACK trial : Neo adjuvant TiRagolumab, A tezolizumab and Chemotherapy-dissection of IO-efficacy in NSCLC by longitudinal tracKing-protocol of a non-randomised, open-label, single-Arm, phase II study
    In: BMJ Open, Jg. 15, 2025, Nr. 3, e096617
    DOI (Open Access)
  • Malewicz-Oeck, Nathalie M.; Aulenkamp, Jana L.; Oeck, Sebastian; Scheffzük, Claudia; Zahn, Peter K.; Hansen, Wiebke; Schramm, Alexander; Meyer-Frießem, Christine H.
    The Relationship Between Chronic Postoperative Pain and Circulating Inflammatory Biomarkers (CC-Chemokine Ligand 5, Adiponectin, and Resistin) After Fracture-Related Surgery in Pain Chronification
    In: Anesthesia & Analgesia, 2025, in press
    DOI
  • Ryl, Tatsiana; Afanasyeva, Elena; Hartmann, Till; Schwermer, Melanie; Schneider, Markus; Schröder, Christopher; Wagemanns, Maren; Bister, Arthur; Kanber, Deniz; Steenpass, Laura; Schramm, Kathrin; Jones, Barbara; Jones, David T. W.; Biewald, Eva; Astrahantseff, Kathy; Hannenberg, Helmut; Rahmann, Sven; Lohmann, Dietmar R.; Schramm, Alexander; Ketteler, Petra
    A MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma
    In: Communications Biology, Jg. 7, 2024, Nr. 1, 919
    DOI, Online Volltext (Open Access)
  • Ryl, Tatsiana; Afanasyeva, Elena; Hartmann, Till; Schwermer, Melanie; Schneider, Markus; Schröder, Christopher; Wagemanns, Maren; Bister, Arthur; Kanber, Deniz; Steenpass, Laura; Schramm, Kathrin; Jones, Barbara; Jones, David T. W.; Biewald, Eva; Astrahantseff, Kathy; Hanenberg, Helmut; Rahmann, Sven; Lohmann, Dietmar; Schramm, Alexander; Ketteler, Petra
    Author Correction: A MYCN-driven de-differentiation profile identifies a subgroup of aggressive retinoblastoma
    In: Communications Biology, Jg. 7, 2024, Nr. 1, 1119
    DOI (Open Access)
  • Schuler, Martin; Cuppens, Kristof; Plönes, Till; Wiesweg, Marcel; Du Pont, Bert; Hegedus, Balazs; Köster, Johannes; Mairinger, Fabian; Darwiche, Kaid; Paschen, Annette; Maes, Brigitte; Vanbockrijck, Michel; Lähnemann, David; Zhao, Fang; Hautzel, Hubertus; Theegarten, Dirk; Hartemink, Koen; Reis, Henning; Baas, Paul; Schramm, Alexander; Aigner, Clemens
    Neoadjuvant nivolumab with or without relatlimab in resectable non-small-cell lung cancer : A randomized phase 2 trial
    In: Nature Medicine, Jg. 30, 2024, Nr. 6, S. 1602 – 1611
    DOI (Open Access)
  • Fiaschetti, G.; Castelletti, D.; Zoller, S.; Schramm, A.; Schroeder, C.; Nagaishi, M.; Stearns, D.; Mittelbronn, M.; Eggert, A.; Westermann, F.; Ohgaki, H.; Shalaby, T.; Pruschy, M.; Arcaro, A.; Grotzer, M.A.
    Correction: Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma
    In: Oncogene, Jg. 42, 2023, Nr. 2, S. 168
    DOI (Open Access)
  • Schwermer, Melanie; Hiber, Michaela; Dreesmann, Sabine; Rieb, Anja; Theißen, Jessica; Herold, Thomas; Schramm, Alexander; Temming, Petra; Steenpass, Laura
    Corrigendum to “Comprehensive characterization of RB1 mutant and MYCN amplified retinoblastoma cell lines”
    In: Experimental Cell Research, Jg. 426, 2023, Nr. 1, 113569
    DOI
  • Johny, Jacob; van Halteren, Charlotte; Cakir, Fatih-Can; Zwiehoff, Sandra; Behrends, Carina; Bäumer, Christian; Timmermann, Beate; Rauschenbach, Laurèl; Tippelt, Stephan; Scheffler, Björn; Schramm, Alexander; Rehbock, Christoph; Barcikowski, Stephan
    Surface Chemistry and Specific Surface Area Rule the Efficiency of Gold Nanoparticle Sensitizers in Proton Therapy
    In: Chemistry - A European Journal, Jg. 29, 2023, Nr. 50, e202301260
    DOI (Open Access)
  • Janetzko, Janina; Oeck, Sebastian; Schramm, Alexander
    The Multifaceted Roles of Lamins in Lung Cancer and DNA Damage Response
    In: Cancers, Jg. 15, 2023, Nr. 23, 5501
    DOI (Open Access)
  • Metzenmacher, Martin; Hegedüs, Balazs; Forster, Jan; Schramm, Alexander; Horn, Peter; Klein, Christoph A.; Bielefeld, Nicola; Ploenes, Till; Aigner, Clemens; Theegarten, Dirk; Schildhaus, Hans-Ulrich; Siveke, Jens T.; Schuler, Martin; Lueong, Smiths S.
    Combined multimodal ctDNA analysis and radiological imaging for tumor surveillance in Non-small cell lung cancer
    In: Translational Oncology, Jg. 15, 2022, Nr. 1, 101279
    DOI (Open Access)
  • Tüns, Alicia Isabell; Hartmann, Till; Magin, Simon; González, Rocío Chamorro; Henssen, Anton George; Rahmann, Sven; Schramm, Alexander; Köster, Johannes
    Detection and Validation of Circular DNA Fragments Using Nanopore Sequencing
    In: Frontiers in Genetics, Jg. 13, 2022, 867018
    DOI, Online Volltext (Open Access)
  • Voeltzke, Kai; Scharov, Katerina; Funk, Cornelius Maximilian; Kahler, Alisa; Picard, Daniel; Hauffe, Laura; Orth, Martin F.; Remke, Marc; Esposito, Irene; Kirchner, Thomas; Schramm, Alexander; Rotblat, Barak; Grünewald, Thomas G. P.; Reifenberger, Guido; Leprivier, Gabriel
    EIF4EBP1 is transcriptionally upregulated by MYCN and associates with poor prognosis in neuroblastoma
    In: Cell Death Discovery, Jg. 8, 2022, Nr. 1, 157
    DOI (Open Access)
  • Thumser-Henner, Clotilde; Oeck, Sebastian; Kalmbach, Sophie; Forster, Jan; Kindl, Franziska; Sak, Ali; Schramm, Alexander; Schuler, Martin
    Syntaxin 18 regulates the DNA damage response and epithelial-to-mesenchymal transition to promote radiation resistance of lung cancer
    In: Cell Death and Disease, Jg. 13, 2022, Nr. 6, 529
    DOI, Online Volltext (Open Access)
  • Metzenmacher, Martin; Hegedüs, Balazs; Forster, Jan; Schramm, Alexander; Horn, Peter; Klein, Christoph A.; Bielefeld, Nicola; Ploenes, Till; Aigner, Clemens; Siveke, Jens T.; Schuler, Martin; Lueong, Smiths S.
    The clinical utility of cfRNA for disease detection and surveillance : A proof of concept study in non-small cell lung cancer
    In: Thoracic Cancer, Jg. 13, 2022, Nr. 15, S. 2180 – 2191
    DOI, Online Volltext (Open Access)
  • Maricic, Nenad; Schwermer, Melanie; Schramm, Alexander; Morosan-Puopolo, Gabriela; Ketteler, Petra; Brand-Saberi, Beate
    Zebrafish as an Orthotopic Tumor Model for Retinoblastoma Mimicking Routes of Human Metastasis
    In: Cancers, Jg. 14, 2022, Nr. 23, 5814
    DOI (Open Access)
  • Menke, Katrin; Schwermer, Melanie; Eisenbraun, Jürgen; Schramm, Alexander; Zuzak, Tycho Jan
    Anticancer Effects of Viscum album Fraxini Extract on Medulloblastoma Cells in vitro
    In: Complementary Medicine Research, Jg. 28, 2021, Nr. 1, S. 15 – 22
    DOI
  • Korff, Johanna Maria; Menke, Katrin; Schwermer, Melanie; Falke, Katharina; Schramm, Alexander; Längler, Alfred; Zuzak, Tycho Jan
    Antitumoral Effects of Curcumin (Curcuma longa L.) and Thymoquinone (Nigella sativa L.) on Neuroblastoma Cell Lines
    In: Complementary Medicine Research, Jg. 28, 2021, Nr. 2, S. 164 – 168
    DOI
  • Seier, Johanna A.; Reinhardt, Julia; Saraf, Kritika; Ng, Susanna S.; Layer, Julian P.; Corvino, Dillon; Althoff, Kristina; Giordano, Frank A.; Schramm, Alexander; Fischer, Matthias; Hölzel, Michael
    Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma
    In: Journal for ImmunoTherapy of Cancer, Jg. 9, 2021, Nr. 5, e001335
    DOI (Open Access)
  • Ho, Cassandra S. L.; Tüns, Alicia I.; Schildhaus, Hans-Ulrich; Wiesweg, Marcel; Grüner, Barbara M.; Hegedus, Balazs; Schuler, Martin; Schramm, Alexander; Oeck, Sebastian
    HER2 mediates clinical resistance to the KRASG¹²C inhibitor sotorasib, which is overcome by co-targeting SHP2
    In: European Journal of Cancer (EJC), Jg. 159, 2021, S. 16 – 23
    DOI
  • Hassiepen, Christina; Soni, Aashish; Rudolf, Ines; Boron, Vivian; Oeck, Sebastian; Iliakis, George; Schramm, Alexander
    NTRK1/TrkA activation overrides the G₂ /M-checkpoint upon irradiation
    In: Cancers, Jg. 13, 2021, Nr. 23, 6023
    DOI, Online Volltext (Open Access)
  • Funke, Lukas; Bracht, Thilo; Oeck, Sebastian; Schork, Karin; Stepath, Markus; Dreesmann, Sabine; Eisenacher, Martin; Sitek, Barbara; Schramm, Alexander
    Ntrk1/trka signaling in neuroblastoma cells induces nuclear reorganization and intra‐nuclear aggregation of lamin a/c
    In: Cancers, Jg. 13, 2021, Nr. 21, 5293
    DOI, Online Volltext (Open Access)
  • Menke, Katrin; Schwermer, Melanie; Schramm, Alexander; Zuzak, Tycho Jan
    Präklinische Untersuchungen von Wechselwirkungen zwischen Mistel und Radio- oder Chemotherapie auf pädiatrische Tumorzellen
    In: Complementary Medicine Research, Jg. 28, 2021, Nr. 4, S. 308 – 316
    DOI
  • Dorsch, Madeleine; Kowalczyk, Manuela; Planque, Mélanie; Heilmann, Geronimo; Urban, Sebastian; Dujardin, Philip; Forster, Jan; Ueffing, Kristina; Nothdurft, Silke; Oeck, Sebastian; Paul, Annika; Liffers, Sven T.; Kaschani, Farnusch; Kaiser, Markus; Schramm, Alexander; Siveke, Jens T.; Winslow, Monte M.; Fendt, Sarah-Maria; Nalbant, Perihan; Grüner, Barbara M.
    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
    In: Cell Reports, Jg. 37, 2021, Nr. 8, 110056
    DOI, Online Volltext (Open Access)
  • Ahmadov, Ulvi; Picard, Daniel; Bartl, Jasmin; Silginer, Manuela; Trajkovic-Arsic, Marija; Qin, Nan; Blümel, Lena; Wolter, Marietta; Lim, Jonathan K. M.; Pauck, David; Winkelkotte, Alina Marie; Melcher, Marlen; Langini, Maike; Marquardt, Viktoria; Sander, Felix; Stefanski, Anja; Steltgens, Sascha; Hassiepen, Christina; Kaufhold, Anna; Meyer, Frauke-Dorothee; Seibt, Annette; Kleinesudeik, Lara; Hain, Anika; Münk, Carsten; Knobbe-Thomsen, Christiane Brigitte; Schramm, Alexander; Fischer, Ute; Leprivier, Gabriel; Stühler, Kai; Fulda, Simone; Siveke, Jens T.; Distelmaier, Felix; Borkhardt, Arndt; Weller, Michael; Roth, Patrick; Reifenberger, Guido; Remke, Marc
    The long non-coding RNA HOTAIRM1 promotes tumor aggressiveness and radiotherapy resistance in glioblastoma
    In: Cell Death and Disease, Jg. 12, 2021, Nr. 10, 885
    DOI (Open Access)
  • Nothdurft, Silke; Thumser-Henner, Clotilde; Breitenbücher, Frank; Okimoto, Ross A.; Dorsch, Madeleine; Opitz, Christiane A.; Sadik, Ahmed; Esser, Charlotte; Hölzel, Michael; Asthana, Saurabh; Forster, Jan; Beisser, Daniela; Kalmbach, Sophie; Grüner, Barbara M.; Bivona, Trever G.; Schramm, Alexander; Schuler, Martin
    Functional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis
    In: Oncogenesis, Jg. 9, 2020, Nr. 11, S. 102
    DOI, Online Volltext (Open Access)
  • Stockhammer, Paul; Ho, Cassandra Su Lyn; Hegedus, Luca; Lotz, Gabor; Molnár, Eszter; Bankfalvi, Agnes; Herold, Thomas; Kalbourtzis, Stavros; Ploenes, Till; Eberhardt, Wilfried; Schuler, Martin; Aigner, Clemens; Schramm, Alexander; Hegedus, Balazs
    HDAC inhibition synergizes with ALK inhibitors to overcome resistance in a novel ALK mutated lung adenocarcinoma model
    In: Lung Cancer, Jg. 144, 2020, S. 20 – 29
    DOI
  • Lu, Yuhong; Liu, Yanfeng; Oeck, Sebastian; Zhang, Gary J.; Schramm, Alexander; Glazer, Peter M.
    Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK Pathway
    In: Cancer Research, Jg. 80, 2020, Nr. 21, S. 4655 – 4667
    DOI (Open Access)
  • Pietzka, Sebastian; Kämmerer, Peer W.; Pietzka, Silke; Schramm, Alexander; Lampl, Lorenz; Lefering, Rolf; Bieler, Dan; Kulla, Martin
    Maxillofacial injuries in severely injured patients after road traffic accidents—a retrospective evaluation of the TraumaRegister DGU® 1993–2014
    In: Clinical Oral Investigations, Jg. 24, 2020, Nr. 1, S. 503 – 513
    DOI
  • Tjaden, Britta; Baum, Katharina; Marquardt, Viktoria; Simon, Mareike; Trajkovic-Arsic, Marija; Kouril, Theresa; Siebers, Bettina; Lisec, Jan; Siveke, Jens T.; Schulte, Johannes H.; Benary, Uwe; Remke, Marc; Wolf, Jana; Schramm, Alexander
    N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma
    In: Scientific Reports, Jg. 10, 2020, Nr. 1, 7157
    DOI, Online Volltext (Open Access)
  • Metzenmacher, Martin; Váraljai, Renáta; Hegedüs, Balazs; Cima, Igor; Forster, Jan; Schramm, Alexander; Scheffler, Björn; Horn, Peter; Klein, Christoph A.; Szarvas, Tibor; Reis, Henning; Bielefeld, Nicola; Rösch, Alexander; Aigner, Clemens; Kunzmann, Volker; Wiesweg, Marcel; Siveke, Jens T.; Schuler, Martin; Lueong, Smiths S.
    Plasma next generation sequencing and droplet digital-qpcr-based quantification of circulating cell-free rna for noninvasive early detection of cancer
    In: Cancers, Jg. 12, 2020, Nr. 2, 353
    DOI, Online Volltext (Open Access)
  • Oeck, Sebastian; Tüns, Alicia I.; Hurst, Sebastian; Schramm, Alexander
    Streamlining quantitative analysis of long RNA sequencing reads
    In: International Journal of Molecular Sciences (IJMS), Jg. 21, 2020, Nr. 19, S. 7259
    DOI, Online Volltext (Open Access)
  • Ali, Solin; Toews, Karin; Schwiebert, Silke; Klaus, Anika; Winkler, Annika; Grunewald, Laura; Oevermann, Lena; Deubzer, Hedwig E.; Tüns, Alicia; Jensen, Michael C.; Henssen, Anton G.; Eggert, Angelika; Schulte, Johannes H.; Schwich, Esther; Rebmann, Vera; Schramm, Alexander; Künkele, Annette
    Tumor-Derived Extracellular Vesicles Impair CD171-Specific CD4⁺ CAR T Cell Efficacy
    In: Frontiers in Immunology, Jg. 11, 2020, S. 531
    DOI (Open Access)
  • Schwermer, Melanie; Hiber, Michaela; Dreesmann, Sabine; Rieb, Anja; Theißen, Jessica; Herold, Thomas; Schramm, Alexander; Temming, Petra; Steenpass, Laura
    Comprehensive characterization of RB1 mutant and MYCN amplified retinoblastoma cell lines
    In: Experimental Cell Research, Jg. 375, 2019, Nr. 2, S. 92 – 99
    DOI (Open Access)
  • Wilde, F.; Krauß, O.; Sakkas, A.; Mascha, F.; Pietzka, S.; Schramm, Alexander
    Custom wave-shaped CAD/CAM orbital wall implants for the management of post-enucleation socket syndrome
    In: Journal of Cranio-Maxillofacial Surgery, Jg. 47, 2019, Nr. 9, S. 1398 – 1405
    DOI
  • Reßing, Nina; Marquardt, Viktoria; Gertzen, Christoph G.W.; Schöler, Andrea; Schramm, Alexander; Kurz, Thomas; Gohlke, Holger; Aigner, Achim; Remke, Marc; Hansen, Finn K.
    Design, synthesis and biological evaluation of β-peptoid-capped HDAC inhibitors with anti-neuroblastoma and anti-glioblastoma activity
    In: MedChemComm, Jg. 10, 2019, Nr. 7, S. 1109 – 1115
    DOI, Online Volltext (Open Access)
  • Sakkas, Andreas; Winter, Karsten; Rath, Maximilian; Mascha, Frank; Pietzka, Sebastian; Schramm, Alexander; Wilde, Frank
    Factors influencing the long-term prognosis of root tip resected teeth
    In: GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW, Jg. 8, 2019, 13
    DOI, Online Volltext (Open Access)
  • Brown, Peter; RELISH Consortium; Zhou, Yaoqi; Klump, Hannes; Rusch, Peter F.; Schramm, Alexander; Ranft, Andreas; Rassaf, Tienush
    Large expert-curated database for benchmarking document similarity detection in biomedical literature search
    In: Database: The Journal of Biological Databases and Curation, Jg. 2019, 2019, S. 1 – 67
    DOI (Open Access)
  • Menke, Katrin; Schwermer, Melanie; Schramm, Alexander; Zuzak, Tycho J.
    Preclinical Evaluation of Antitumoral and Cytotoxic Properties of Viscum album Fraxini Extract on Pediatric Tumor Cells
    In: Planta Medica, Jg. 85, 2019, Nr. 14-15, S. 1150 – 1159
    DOI
  • Han, Youjia; Lindner, Sven; Bei, Yi; Garcia, Heathcliff Dorado; Timme, Natalie; Althoff, Kristina; Odersky, Andrea; Schramm, Alexander; Lissat, Andrej; Künkele, Annette; Deubzer, Hedwig E.; Eggert, Angelika; Schulte, Johannes; Henssen, Anton G.
    Synergistic activity of BET inhibitor MK-8628 and PLK inhibitor Volasertib in preclinical models of medulloblastoma
    In: Cancer Letters, Jg. 455, 2019, S. 24 – 33
    DOI
  • Zuzak, Tycho Jan; Falke, Katharina; Felenda, Jessica; Beckmann, Christiane; Stintzing, Florian; Voigt, Anette; Menke, Katrin; Schramm, Alexander; Schwermer, Melanie
    Taraxacum officinale extract induces antitumorigenic effects in ovarian carcinoma cell lines
    In: European Journal of Gynaecological Oncology (EJGO), Jg. 40, 2019, Nr. 1, S. 106 – 112
    DOI
  • Telschow, T.; Wilde, F.; Pietzka, S.; Schramm, Alexander; Mascha, F.
    Unbreakable? : Frakturen patientenspezifischer Implantate nach alloplastischer Unterkieferrekonstruktion
    In: Der MKG-Chirurg, Jg. 12, 2019, Nr. 4, S. 263 – 267
    DOI
  • Ackermann, Sandra; Cartolano, Maria; Hero, Barbara; Welte, Anne; Kahlert, Yvonne; Roderwieser, Andrea; Bartenhagen, Christoph; Walter, Esther; Gecht, Judith; Kerschke, Laura; Volland, Ruth; Menon, Roopika; Heuckmann, Johannes M.; Gartlgruber, Moritz; Hartlieb, Sabine; Henrich, Kai-Oliver; Okonechnikov, Konstantin; Altmüller, Janine; Nürnberg, Peter; Lefever, Steve; De Wilde, Bram; Sand, Frederik; Ikram, Fakhera; Rosswog, Carolina; Fischer, Janina; Theissen, Jessica; Hertwig, Falk; Singhi, Aatur D.; Simon, Thorsten; Vogel, Wenzel; Perner, Sven; Krug, Barbara; Schmidt, Matthias; Rahmann, Sven; Achter, Viktor; Lang, Ulrich; Vokuhl, Christian; Ortmann, Monika; Büttner, Reinhard; Eggert, Angelika; Speleman, Frank; O’Sullivan, Roderick J.; Thomas, Roman K.; Berthold, Frank; Vandesompele, Jo; Schramm, Alexander; Westermann, Frank; Schulte, Johannes; Peifer, Martin; Fischer, Matthias
    A mechanistic classification of clinical phenotypes in neuroblastoma
    In: Science, Jg. 362, 2018, Nr. 6419, S. 1165 – 1170
    DOI, Online Volltext (Open Access)
  • Schulte, Marc; Köster, Johannes; Rahmann, Sven; Schramm, Alexander
    Cancer evolution, mutations, and clonal selection in relapse neuroblastoma
    In: Cell and Tissue Research, Jg. 372, 2018, Nr. 2, S. 263 – 268
    DOI
  • Zeka, Fjoralba; Decock, Anneleen; Van Goethem, Alan; Vanderheyden, Katrien; Demuynck, Fleur; Lammens, Tim; Helsmoortel, Hetty H.; Vermeulen, Joëlle; Noguera, Rosa; Berbegall, Ana P.; Combaret, Valérie; Schleiermacher, Gudrun; Laureys, Geneviève; Schramm, Alexander; Schulte, Johannes; Rahmann, Sven; Bienertová-Vašků, Julie; Mazánek, Pavel; Jeison, Marta; Ash, Shifra; Hogarty, Michael D.; Moreno-Smith, Mirthala; Barbieri, Eveline; Shohet, Jason; Berthold, Frank; Van Maerken, Tom; Speleman, Frank; Fischer, Matthias; De Preter, Katleen; Mestdagh, Pieter; Vandesompele, Jo
    Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients
    In: JCI Insight, Jg. 3, 2018, Nr. 23, e97021
    DOI (Open Access)
  • Pieper, Natalia; Zaremba, Anne; Leonardelli, Sonia; Harbers, Franziska Noelle; Schwamborn, Marion; Lübcke, Silke; Schrörs, Barbara; Baingo, Jolanthe; Schramm, Alexander; Haferkamp, Sebastian; Seifert, Ulrike; Sucker, Antje; Lennerz, Volker; Wölfel, Thomas; Schadendorf, Dirk; Schilling, Bastian; Paschen, Annette; Zhao, Fang
    Evolution of melanoma cross-resistance to CD8⁺ T cells and MAPK inhibition in the course of BRAFi treatment
    In: OncoImmunology, Jg. 7, 2018, Nr. 8, e1450127
    DOI, Online Volltext (Open Access)
  • Sakkas, Andreas; Schramm, Alexander; Winter, Karsten; Wilde, Frank
    Risk factors for post-operative complications after procedures for autologous bone augmentation from different donor sites
    In: Journal of Cranio-Maxillofacial Surgery, Jg. 46, 2018, Nr. 2, S. 312 – 322
    DOI
  • Menke, K.; Schwermer, M.; Felenda, J.; Beckmann, C.; Stintzing, F.; Schramm, Alexander; Zuzak, T.J.
    Taraxacum officinale extract shows antitumor effects on pediatric cancer cells and enhance mistletoe therapy
    In: Complementary Therapies in Medicine, Jg. 40, 2018
    DOI
  • De Wilde, Bram; Beckers, Anneleen; Lindner, Sven; Kristina, Althoff; De Preter, Katleen; Depuydt, Pauline; Mestdagh, Pieter; Sante, Tom; Lefever, Steve; Hertwig, Falk; Peng, Zhiyu; Shi, Le-Ming; Lee, Sangkyun; Vandermarliere, Elien; Martens, Lennart; Menten, Björn; Schramm, Alexander; Fischer, Matthias; Schulte, Johannes; Vandesompele, Jo; Speleman, Frank
    The mutational landscape of MYCN, Lin28b and ALKF1174L driven murine neuroblastoma mimics human disease
    In: OncoTarget, Jg. 9, 2018, Nr. 9, S. 8334 – 8349
    DOI (Open Access)
  • Batzke, Katharina; Büchel, Gabriele; Hansen, Wiebke; Schramm, Alexander
    TrkB-Target Galectin-1 Impairs Immune Activation and Radiation Responses in Neuroblastoma : Implications for Tumour Therapy
    In: International Journal of Molecular Sciences (IJMS), Jg. 19, 2018, Nr. 3, S. 718
    DOI, Online Volltext (Open Access)
  • Moreno, Lucas; Caron, Hubert; Geoerger, Birgit; Eggert, Angelika; Schleiermacher, Gudrun; Brock, Penelope; Valteau-Couanet, Dominique; Chesler, Louis; Schulte, Johannes H.; De Preter, Katleen; Molenaar, Jan; Schramm, Alexander; Eilers, Martin; Van Maerken, Tom; Johnsen, John Inge; Garrett, Michelle; George, Sally L.; Tweddle, Deborah A.; Kogner, Per; Berthold, Frank; Koster, Jan; Barone, Giuseppe; Tucker, Elizabeth R.; Marshall, Lynley; Herold, Ralf; Sterba, Jaroslav; Norga, Koen; Vassal, Gilles; Pearson, Andrew D.J.
    Accelerating drug development for neuroblastoma - New Drug Development Strategy : an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma project
    In: Expert Opinion on Drug Discovery, Jg. 12, 2017, Nr. 8, S. 801 – 811
    DOI, Online Volltext (Open Access)
  • Layer, Julian P.; Kronmüller, Marie T.; Quast, Thomas; Boorn-Konijnenberg, Debby van den; Effern, Maike; Hinze, Daniel; Althoff, Kristina; Schramm, Alexander; Westermann, Frank; Peifer, Martin; Hartmann, Gunther; Tüting, Thomas; Kolanus, Waldemar; Fischer, Matthias; Schulte, Johannes; Hölzel, Michael
    Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression
    In: OncoImmunology, Jg. 6, 2017, Nr. 6, e1320626
    DOI, Online Volltext (Open Access)
  • Shpacovitch, Victoria; Sidorenko, Irina; Lenssen, Jan Eric; Temchura, Vladimir; Weichert, Frank; Müller, Heinrich; Überla, Klaus; Zybin, Alexander; Schramm, Alexander; Hergenröder, Roland
    Application of the PAMONO-sensor for quantification of microvesicles and determination of nano-particle size distribution
    In: Sensors, Jg. 17, 2017, Nr. 2, S. 244
    DOI (Open Access)
  • Lelle, Marco; Freidel, Christoph; Kaloyanova, Stefka; Tabujew, Ilja; Schramm, Alexander; Musheev, Michael; Niehrs, Christof; Müllen, Klaus; Peneva, Kalina
    Overcoming drug resistance by cell-penetrating peptide-mediated delivery of a doxorubicin dimer with high DNA-binding affinity
    In: European Journal of Medicinal Chemistry, Jg. 130, 2017, S. 336 – 345
    DOI
  • Schwermer, Melanie; Dreesmann, Sabine; Eggert, Angelika; Althoff, Kristina; Steenpass, Laura; Schramm, Alexander; Schulte, Johannes; Temming, Petra
    Pharmaceutically inhibiting polo-like kinase 1 exerts a broad anti-tumour activity in retinoblastoma cell lines
    In: Clinical & Experimental Ophthalmology, Jg. 45, 2017, Nr. 3, S. 288 – 296
    DOI
  • Gottlieb, Aline; Althoff, Kristina; Grunewald, Laura; Thor, Theresa; Odersky, Andrea; Schulte, Marc; Deubzer, Hedwig E.; Heukamp, Lukas; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes; Künkele, Annette
    RITA displays anti-tumor activity in medulloblastomas independent of TP53 status
    In: OncoTarget, Jg. 8, 2017, Nr. 17, S. 27882 – 27891
    DOI (Open Access)
  • Henssen, Anton G; Odersky, Andrea; Szymansky, Annabell; Seiler, Marleen; Althoff, Kristina; Beckers, Anneleen; Speleman, Frank; Schäfers, Simon; De Preter, Katleen; Astrahanseff, Kathy; Struck, Joachim; Schramm, Alexander; Eggert, Angelika; Bergmann, Andreas; Schulte, Johannes
    Targeting tachykinin receptors in neuroblastoma
    In: OncoTarget, Jg. 8, 2017, Nr. 1, S. 430 – 443
    DOI (Open Access)
  • Pajtler, Kristian; Sadowski, Natalie; Ackermann, Sandra; Althoff, Kristina; Schönbeck, Kerstin; Batzke, Katharina; Schäfers, Simon; Odersky, Andrea; Heukamp, Lukas; Astrahantseff, Kathy; Künkele, Annette; Deubzer, Hedwig E; Schramm, Alexander; Sprüssel, Annika; Thor, Theresa; Lindner, Sven; Eggert, Angelika; Fischer, Matthias; Schulte, Johannes
    The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models
    In: OncoTarget, Jg. 8, 2017, Nr. 4, S. 6730 – 6741
    DOI (Open Access)
  • Fielitz, Kathrin; Althoff, Kristina; De Preter, Katleen; Nonnekens, Julie; Ohli, Jasmin; Elges, Sandra; Hartmann, Wolfgang; Klöppel, Günter; Knösel, Thomas; Schulte, Marc; Klein-Hitpaß, Ludger; Beisser, Daniela; Reis, Henning; Eyking, Annette; Cario, Elke; Schulte, Johannes; Schramm, Alexander; Schüller, Ulrich
    Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells
    In: OncoTarget, Jg. 7, 2016, Nr. 46, S. 74415 – 74426
    DOI (Open Access)
  • Müller, Jan; Reichel, Robin; Müller, Stefan; Sauerwein, Wolfgang; Brandau, Wolfgang; Eggert, Angelika; Schramm, Alexander
    Identification and Tumour-Binding Properties of a Peptide with High Affinity to the Disialoganglioside GD2
    In: PLoS ONE, Jg. 11, 2016, Nr. 10, S. e0163648
    DOI, Online Volltext (Open Access)
  • Büchel, Gabriele; Schulte, Johannes; Harrison, Luke; Batzke, Katharina; Schüller, Ulrich; Hansen, Wiebke; Schramm, Alexander
    Immune response modulation by Galectin-1 in a transgenic model of neuroblastoma
    In: OncoImmunology, Jg. 5, 2016, Nr. 5, e1131378
    DOI (Open Access)
  • Schramm, Alexander; Lode, Holger
    MYCN-targeting vaccines and immunotherapeutics
    In: Human Vaccines & Immunotherapeutics, Jg. 12, 2016, Nr. 9, S. 2257 – 2258
    DOI, Online Volltext (Open Access)
  • Henssen, Anton; Althoff, Kristina; Odersky, Andrea; Beckers, Anneleen; Koche, Richard; Speleman, Frank; Schäfers, Simon; Bell, Emma; Nortmeyer, Maike; Westermann, Frank; De Preter, Katleen; Florin, Alexandra; Heukamp, Lukas; Spruessel, Annika; Astrahanseff, Kathy; Lindner, Sven; Sadowski, Natalie; Schramm, Alexander; Astorgues-Xerri, Lucile; Riveiro, Maria E.; Eggert, Angelika; Cvitkovic, Esteban; Schulte, Johannes
    Targeting MYCN-driven transcription by BET-bromodomain inhibition
    In: Clinical Cancer Research, Jg. 22, 2016, Nr. 10, S. 2470 – 2781
    DOI (Open Access)
  • Riehl, Lara M; Schulte, Johannes; Mulaw, Medhanie A; Dahlhaus, Meike; Fischer, Matthias; Schramm, Alexander; Eggert, Angelika; Debatin, Klaus-Michael; Beltinger, Christian
    The mitochondrial genetic landscape in neuroblastoma from tumor initiation to relapse
    In: OncoTarget, Jg. 7, 2016, Nr. 6, S. 6620 – 6625
    DOI (Open Access)
  • Althoff, Kristina; Schulte, Johannes H.; Schramm, Alexander
    Towards diagnostic application of non-coding RNAs in neuroblastoma
    In: Expert Review of Molecular Diagnostics, Jg. 16, 2016, Nr. 12, S. 1307 – 1313
    DOI
  • Althoff, K; Beckers, A; Bell, E; Nortmeyer, M; Thor, T; Sprüssel, A; Lindner, S; De Preter, K; Florin, A; Heukamp, L C; Klein-Hitpaß, Ludger; Astrahantseff, K; Kumps, C; Speleman, F; Eggert, A; Westermann, F; Schramm, Alexander; Schulte, Johannes
    A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies
    In: Oncogene, Jg. 34, 2015, Nr. 26, S. 3357 – 3368
    DOI (Open Access)
  • Lindner, Sven; Bachmann, Hagen Sjard; Odersky, Andrea; Schaefers, Simon; Klein-Hitpaß, Ludger; Hero, Barbara; Fischer, Matthias; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes
    Absence of telomerase reverse transcriptase promoter mutations in neuroblastoma
    In: Biomedical Reports, Jg. 3, 2015, Nr. 4, S. 443 – 446
    DOI
  • Stephan, Harald; Menke, Katrin; Felenda, Jennifer; Zuzak, Tycho J.; Schramm, Alexander; Beckmann, Christiane; Stintzing, Florian
    Dandelion (Taraxacum officinale) extracts supply antitumour effects of mistletoe in pediatric cancer cells
    In: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, Jg. 22, 2015, Nr. Suppl.1, S. S25 – S26
    DOI
  • Thor, Theresa; Künkele, Annette; Pajtler, Kristian; Wefers, Annika K; Stephan, Harald; Mestdagh, Pieter; Heukamp, Lukas; Hartmann, Wolfgang; Vandesompele, Jo; Sadowski, Natalie; Becker, Lore; Garrett, Lillian; Hölter, Sabine M; Horsch, Marion; Calzada-Wack, Julia; Klein-Rodewald, Tanja; Racz, Ildiko; Zimmer, Andreas; Beckers, Johannes; Neff, Frauke; Klopstock, Thomas; De Antonellis, Pasqualino; Zollo, Massimo; Wurst, Wolfgang; Fuchs, Helmut; Gailus-Durner, Valérie; Schüller, Ulrich; de Angelis, Martin Hrab?; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes
    MiR-34a deficiency accelerates medulloblastoma formation in vivo
    In: International Journal of Cancer, Jg. 136, 2015, Nr. 10, S. 2293 – 2303
    DOI (Open Access)
  • Schramm, Alexander; Köster, Johannes; Assenov, Yassen; Althoff, Kristina; Peifer, Martin; Mahlow, Ellen; Odersky, Andrea; Beisser, Daniela; Ernst, Corinna; Henssen, Anton G; Stephan, Harald; Schröder, Christopher; Heukamp, Lukas; Engesser, Anne; Kahlert, Yvonne; Theissen, Jessica; Hero, Barbara; Roels, Frederik; Altmüller, Janine; Nürnberg, Peter; Astrahantseff, Kathy; Gloeckner, Christian; De Preter, Katleen; Plass, Christoph; Lee, Sangkyun; Lode, Holger N; Henrich, Kai-Oliver; Gartlgruber, Moritz; Speleman, Frank; Schmezer, Peter; Westermann, Frank; Rahmann, Sven; Fischer, Matthias; Eggert, Angelika; Schulte, Johannes
    Mutational dynamics between primary and relapse neuroblastomas
    In: Nature Genetics, Jg. 47, 2015, Nr. 8, S. 872 – 877
    DOI
  • Schwermer, Melanie; Lee, Sangkyun; Köster, Johannes; van Maerken, Tom; Stephan, Harald; Eggert, Angelika; Morik, Katharina; Schulte, Johannes; Schramm, Alexander
    Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors
    In: OncoTarget, Jg. 6, 2015, Nr. 17, S. 15425 – 15435
    DOI (Open Access)
  • Stermann, Alexander; Huebener, Nicole; Seidel, Diana; Fest, Stefan; Eschenburg, Georg; Stauder, Michael; Schramm, Alexander; Eggert, Angelika; Lode, Holger N
    Targeting of MYCN by means of DNA vaccination is effective against neuroblastoma in mice
    In: Cancer Immunology, Immunotherapy, Jg. 64, 2015, Nr. 10, S. 1215 – 1227
    DOI
  • Spruessel, Annika; Schäfers, Simon; De Preter, Katleen; Sadowski, Natalie; Eggert, Angelika; Florin, Alexandra; Schramm, Alexander; Astorgues-Xerri, Lucile; Beckers, Anneleen; Odersky, Andrea; Heukamp, Lukas; Althoff, Kristina; Riveiro, Eugenia; Astrahanseff, Kathy; Koche, Richard; Cvitkovic, Esteban; Speleman, Frank; Henssen, Anton; Schulte, Johannes
    Targeting super-enhancer induced gene expression with the novel BRD4 inhibitor OTX015 in preclinical models of MYCN-amplified neuroblastoma
    In: Cancer Research, Jg. 75, 2015, Nr. 15 Suppl., S. 4731
    DOI
  • Peifer, Martin; Hertwig, Falk; Roels, Frederik; Dreidax, Daniel; Gartlgruber, Moritz; Menon, Roopika; Krämer, Andrea; Roncaioli, Justin L; Sand, Frederik; Heuckmann, Johannes M; Ikram, Fakhera; Schmidt, Rene; Ackermann, Sandra; Engesser, Anne; Kahlert, Yvonne; Vogel, Wenzel; Altmüller, Janine; Nürnberg, Peter; Thierry-Mieg, Jean; Thierry-Mieg, Danielle; Mariappan, Aruljothi; Heynck, Stefanie; Mariotti, Erika; Henrich, Kai-Oliver; Gloeckner, Christian; Bosco, Graziella; Leuschner, Ivo; Schweiger, Michal R; Savelyeva, Larissa; Watkins, Simon C; Shao, Chunxuan; Bell, Emma; Höfer, Thomas; Achter, Viktor; Lang, Ulrich; Theissen, Jessica; Volland, Ruth; Saadati, Maral; Eggert, Angelika; de Wilde, Bram; Berthold, Frank; Peng, Zhiyu; Zhao, Chen; Shi, Leming; Ortmann, Monika; Büttner, Reinhard; Perner, Sven; Hero, Barbara; Schramm, Alexander; Schulte, Johannes; Herrmann, Carl; O'Sullivan, Roderick J; Westermann, Frank; Thomas, Roman K; Fischer, Matthias
    Telomerase activation by genomic rearrangements in high-risk neuroblastoma
    In: Nature, Jg. 526, 2015, Nr. 7575, S. 700 – 704
    DOI, Online Volltext (Open Access)
  • Kraemer, Andrea; Hertwig, Falk; Thomas, Roman K.; Buettner, Reinhard; Westermann, Frank; Perner, Sven; Fischer, Matthias; Schramm, Alexander; Menon, Roopika; Schulte, Johannes; Peifer, Martin; Roels, Frederik
    Telomerase activation by genomic rearrangements in high-risk neuroblastoma
    In: Cancer Research, Jg. 75, 2015, Nr. 15 Suppl., S. LB – 210
    DOI
  • Thiele, Oliver C.; Brom, Jörn; Dunsche, Anton; Ehrenfeld, Michael; Federspil, Philipp; Frerich, Bernhard; Hölzle, Frank; Klein, Martin; Kreppel, Matthias; Kübler, Alexander C.; Kübler, Norbert R.; Kunkel, Martin; Kuttenberger, Johannes; Lauer, Günter; Mayer, Boris; Mohr, Christopher; Neff, Andreas; Rasse, Michael; Reich, Rudolf H.; Reinert, Sigmar; Rothamel, Daniel; Sader, Robert; Schliephake, Henning; Schmelzeisen, Rainer; Schramm, Alexander; Sieg, Peter; Terheyden, Hendrik; Wiltfang, Jörg; Ziegler, Christoph M.; Mischkowski, Robert A.; Zöller, Joachim E.
    The current state of facial prosthetics : A multicenter analysis
    In: Journal of Oral and Maxillofacial Surgery, Jg. 43, 2015, Nr. 7, S. 1038 – 1041
    DOI
  • Althoff, Kristina; Lindner, Sven; Odersky, Andrea; Mestdagh, Pieter; Beckers, Anneleen; Karczewski, Sarah; Molenaar, Jan J; Bohrer, Anna; Knauer, Shirley; Speleman, Frank; Epple, Matthias; Kozlova, Diana; Yoon, Sena; Baek, Kwanghee; Vandesompele, Jo; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes
    miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin
    In: International Journal of Cancer, Jg. 136, 2015, Nr. 6, S. 1308 – 1320
    DOI (Open Access)
  • Pajtler, Kristian; Mahlow, Ellen; Odersky, Andrea; Lindner, Sven; Stephan, Harald; Bendix, Ivo; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes
    Neuroblastoma in dialog with its stroma : NTRK1 is a regulator of cellular cross-talk with Schwann cells
    In: OncoTarget, Jg. 5, 2014, Nr. 22, S. 11180 – 11192
    DOI (Open Access)
  • Lee, Sangkyun; Rahnenführer, Jörg; Lang, Michel; De Preter, Katleen; Mestdagh, Pieter; Koster, Jan; Versteeg, Rogier; Stallings, Raymond L; Varesio, Luigi; Asgharzadeh, Shahab; Schulte, Johannes; Fielitz, Kathrin; Schwermer, Melanie; Morik, Katharina; Schramm, Alexander
    Robust selection of cancer survival signatures from high-throughput genomic data using two-fold subsampling
    In: PLoS ONE, Jg. 9, 2014, Nr. 10, S. e108818
    DOI (Open Access)
  • Henssen, Anton; Thor, Theresa; Odersky, Andrea; Heukamp, Lukas; El-Hindy, Nicolai; Beckers, Anneleen; Speleman, Frank; Althoff, Kristina; Schäfers, Simon; Schramm, Alexander; Sure, Ulrich; Fleischhack, Gudrun; Eggert, Angelika; Schulte, Johannes
    BET bromodomain protein inhibition is a therapeutic option for medulloblastoma
    In: OncoTarget, Jg. 4, 2013, Nr. 11, S. 2080 – 2095
    DOI
  • Grum, Daniel; Franke, Stefan; Kraff, Oliver; Heider, Dominik; Schramm, Alexander; Hoffmann, Daniel; Bayer, Peter
    Design of a Modular Protein-Based MRI Contrast Agent for Targeted Application
    In: PLoS ONE, Jg. 8, 2013, Nr. 6, S. e65346
    DOI, Online Volltext (Open Access)
  • Leitão, Andrei; Schramm, Alexander; Eggert, Angelika
    Discovery of a new bioactive molecule for neuroblastoma
    In: Chemical Biology and Drug Design, Jg. 82, 2013, Nr. 2, S. 233 – 241
    DOI
  • Pajtler, Kristian; Rebmann, Vera; Lindemann, Monika; Schulte, Johannes; Schulte, Stefanie; Stauder, Michael; Leuschner, Ivo; Schmid, Kurt Werner; Köhl, Ulrike; Schramm, Alexander; Eggert, Angelika
    Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cells
    In: International Journal of Cancer, Jg. 133, 2013, Nr. 4, S. 908 – 919
    DOI
  • Kumps, Candy; Fieuw, Annelies; Mestdagh, Pieter; Menten, Björn; Lefever, Steve; Pattyn, Filip; De Brouwer, Sara; Sante, Tom; Schulte, Johannes; Schramm, Alexander; Van Roy, Nadine; Van Maerken, Tom; Noguera, Rosa; Combaret, Valérie; Devalck, Christine; Westermann, Frank; Laureys, Geneviève; Eggert, Angelika; Vandesompele, Jo; De Preter, Katleen; Speleman, Frank
    Focal DNA copy number changes in neuroblastoma target MYCN regulated genes
    In: PLoS ONE, Jg. 8, 2013, Nr. 1, S. e52321
    DOI (Open Access)
  • Rahmann, Sven; Martin, Marcel; Schulte, Johannes; Köster, Johannes; Marschall, Tobias; Schramm, Alexander
    Identifying transcriptional miRNA biomarkers by integrating high-throughput sequencing and real-time PCR data
    In: Methods: A Companion to Methods in Enzymology, Jg. 59, 2013, Nr. 1, S. 154 – 163
    DOI
  • Schulte, Johannes; Molenaar, J.; Lindner, S.; Schramm, Alexander; Mestdagh, P.; Speleman, F.; Versteeg, R.; Eggert, Angelika
    LIN28B drives neuroblastoma oncogenesis through let7-MYCN signaling
    In: Cancer Research, Jg. 73, 2013, Nr. 8 Suppl. 1, S. 4596
    DOI
  • Schulte, Johannes; Lindner, Sven; Bohrer, Anna Margarethe; Maurer, J.; De Preter, Katleen D.; Lefever, Steve; Heukamp, Lukas Carl; Schulte, Stefanie; Molenaar, Jan J.; Versteeg, Rogier; Thor, Theresa; Künkele, Annette; Vandesompele, Jo O.; Speleman, Frank P.; Schorle, Hubert; Eggert, Angelika; Schramm, Alexander
    MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells
    In: Oncogene, Jg. 32, 2013, Nr. 8, S. 1059 – 1065
    DOI
  • Althoff, Kristina; Beckers, Anneleen; Odersky, Andrea; Mestdagh, Pieter; Köster, Johannes; Bray, Isabella M; Bryan, Kenneth; Vandesompele, Jo; Speleman, Frank; Stallings, Raymond L; Schramm, Alexander; Eggert, Angelika; Sprüssel, Annika; Schulte, Johannes H.
    MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A
    In: International Journal of Cancer, Jg. 133, 2013, Nr. 5, S. 1064 – 1073
    DOI
  • Das, S.; Bryan, K.; Buckley, P. G.; Piskareva, O.; Bray, I. M.; Foley, N.; Ryan, J.; Lynch, J.; Creevey, L.; Fay, J.; Prenter, S.; Koster, J.; van Sluis, P.; Versteeg, R.; Eggert, Angelika; Schulte, Johannes; Schramm, Alexander; Mestdagh, P.; Vandesompele, J.; Speleman, F.; Stallings, R. L.
    Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs
    In: Oncogene, Jg. 32, 2013, Nr. 24, S. 2927 – 2936
    DOI
  • Carotenuto, Marianeve; Pedone, Emilia; Diana, Donatella; De Antonellis, Pasqualino; Džeroski, Sašo; Marino, Natascia; Navas, Luigi; Di Dato, Valeria; Scoppettuolo, Maria Nunzia; Cimmino, Flora; Correale, Stefania; Pirone, Luciano; Monti, Simona Maria; Bruder, Elisabeth; Ženko, Bernard; Slavkov, Ivica; Pastorino, Fabio; Ponzoni, Mirco; Schulte, Johannes; Schramm, Alexander; Eggert, Angelika; Westermann, Frank; Arrigoni, Gianluigi; Accordi, Benedetta; Basso, Giuseppe; Saviano, Michele; Fattorusso, Roberto; Zollo, Massimo
    Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction
    In: Scientific Reports, Jg. 3, 2013, S. 1351
    DOI (Open Access)
  • Schramm, Alexander; Köster, Johannes; Marschall, Tobias; Martin, Marcel; Schwermer, Melanie; Fielitz, Kathrin; Büchel, Gabriele; Barann, Matthias; Esser, Daniela; Rosenstiel, Philip; Rahmann, Sven; Eggert, Angelika; Schulte, Johannes
    Next-generation RNA sequencing reveals differential expression of MYCN target genes and suggests the mTOR pathway as a promising therapy target in MYCN-amplified neuroblastoma
    In: International Journal of Cancer, Jg. 132, 2013, Nr. 3, S. E106 – E115
    DOI
  • Schulte, Johannes; Schulte, S; Heukamp, L C; Astrahantseff, K; Stephan, H; Fischer, M; Schramm, Alexander; Eggert, Angelika
    Targeted Therapy for Neuroblastoma : ALK Inhibitors
    In: Klinische Pädiatrie, Jg. 225, 2013, Nr. 6, S. 303 – 308
    DOI
  • Muller, J.; Vogt, S.; Reichel, R.; Fielitz, K.; Muller, S.; Brandau, W.; Schramm, Alexander
    Targeting the disialoganglioside GD2 in neuroblastoma using a phage display derived oligopeptide
    In: European Journal of Nuclear Medicine and Molecular Imaging, Jg. 40, 2013, Nr. Suppl 2, S. S295
    DOI
  • Künkele, Annette; Grosse-Lordemann, Anja; Schramm, Alexander; Eggert, Angelika; Schulte, Johannes; Bachmann, Hagen Sjard
    The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia
    In: BMC Cancer, Jg. 13, 2013, S. 452
    DOI (Open Access)
  • Pajtler, Kristian W.; Weingarten, Christina; Thor, Theresa; Künkele, Annette; Heukamp, Lukas C.; Büttner, Reinhard; Suzuki, Takayoshi; Miyata, Naoki; Grotzer, Michael; Rieb, Anja; Sprüssel, Annika; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes
    The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma
    In: Acta Neuropathologica Communications, Jg. 1, 2013, Nr. 1, S. 19
    DOI (Open Access)
  • Cornero, Andrea; Acquaviva, Massimo; Fardin, Paolo; Versteeg, Rogier; Schramm, Alexander; Eva, Alessandra; Bosco, Maria Carla; Blengio, Fabiola; Barzaghi, Sara; Varesio, Luigi
    Design of a multi-signature ensemble classifier predicting neuroblastoma patients' outcome
    In: BMC Bioinformatics, Jg. 13, 2012, Nr. Suppl 4, S. 13
    DOI, Online Volltext (Open Access)
  • De Brouwer, Sara; Mestdagh, Pieter; Lambertz, Irina; Pattyn, Filip; De Paepe, Anne; Westermann, Frank; Schroeder, Christina; Schulte, Johannes; Schramm, Alexander; De Preter, Katleen; Vandesompele, Jo; Speleman, Frank
    Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma
    In: International Journal of Cancer, Jg. 130, 2012, Nr. 11, S. 2591 – 2598
    DOI
  • Schramm, Alexander; Schowe, Benjamin; Fielitz, Kathrin; Heilmann, Mareike N.; Martin, Marcel; Marschall, Tobias; Köster, Johannes; Vandesompele, Jo; Vermeulen, Joëlle; de Preter, Katleen D.; Koster, Jan; Versteeg, Rogier; Noguera, Rosa; Speleman, Frank P.; Rahmann, Sven; Eggert, Angelika; Morik, Katharina J.; Schulte, Johannes
    Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome
    In: British Journal of Cancer (BJC), Jg. 107, 2012, Nr. 8, S. 1409 – 1417
    DOI (Open Access)
  • Schramm, Alexander; Eggert, Angelika; Rahmann, Sven
    Genen auf der Spur : wie genomweite Analysen am Modell Neuroblastom zukünftige Therapiemöglichkeiten aufzeigen
    In: Unikate: Berichte aus Forschung und Lehre, 2012, Nr. 42: Translationale Krebsforschung: Auf dem Weg zu neuen Therapien, S. 22 – 31
    DOI, Online Volltext (Open Access)
  • Fieuw, Annelies; Kumps, Candy; Schramm, Alexander; Pattyn, Filip; Menten, Björn; Antonacci, Francesca; Sudmant, Peter; Schulte, Johannes; Van Roy, Nadine; Vergult, Sarah; Buckley, Patrick G.; De Paepe, Anne M.; Noguera, Rosa; Versteeg, Rogier; Stallings, Raymond; Eggert, Angelika; Vandesompele, Jo; De Preter, Katleen D.; Speleman, Frank
    Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas
    In: International Journal of Cancer, Jg. 130, 2012, Nr. 11, S. 2599 – 2606
    DOI
  • Lindner, S.; Molenaar, J.; Thor, T.; Spruessel, A.; Caron, H N; Versteeg, R.; Schramm, Alexander; Eggert, Angelika; Schulte, Johannes
    LIN28B drives neuroblastoma oncogenesis through let7-MYCN signaling
    In: Klinische Pädiatrie, Jg. 224, 2012, S. 222
    DOI
  • Molenaar, Jan J.; Domingo-Fernández, Raquel; Ebus, Marli E.; Lindner, Sven; Koster, Jan; Drabek, Ksenija; Mestdagh, Pieter; Van Sluis, Peter; Valentijn, Linda J.; Van Nes, Johan; Broekmans, Marloes; Haneveld, Franciska; Volckmann, Richard; Bray, Isabella; Heukamp, Lukas; Sprüssel, Annika; Thor, Theresa; Kieckbusch, Kristina; Klein-Hitpaß, Ludger; Fischer, Matthias; Vandesompele, Jo; Schramm, Alexander; Van Noesel, Max M.; Varesio, Luigi; Speleman, Frank; Eggert, Angelika; Stallings, Raymond L.; Caron, Huib N.; Versteeg, Rogier; Schulte, Johannes
    LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression
    In: Nature Genetics, Jg. 44, 2012, Nr. 11, S. 1199 – 1206
    DOI
  • Sprüssel, Annika; Schulte, Johannes; Weber, Stefanie; Necke, M.; Händschke, K.; Thor, Theresa; Pajtler, Kristian; Schramm, Alexander; König, Katharina; Diehl, Linda; Mestdagh, Pieter; Vandesompele, Jo; Speleman, Frank P.; Jastrow, Holger; Heukamp, Lukas Carl; Schüle, Roland; Dührsen, Ulrich; Buettner, Reinhard H.; Eggert, Angelika; Göthert, Joachim Rudolf
    Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation
    In: Leukemia, Jg. 26, 2012, Nr. 9, S. 2039 – 2051
    DOI
  • Künkele, Annette; De Preter, Katleen; Heukamp, Lukas; Thor, Theresa; Pajtler, Kristian; Hartmann, Wolfgang; Mittelbronn, Michel; Grotzer, Michael A.; Deubzer, Hedwig E.; Speleman, Frank; Schramm, Alexander; Eggert, Angelika; Schulte, Johannes
    Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas
    In: Neuro-Oncology, Jg. 14, 2012, Nr. 7, S. 859 – 869
    DOI (Open Access)
  • Gottlieb, A.; Kuenkele, A.; Schramm, Alexander; Eggert, Angelika; Schulte, Johannes
    RITA-p53 activation in medulloblastoma as a new approach for treatment?
    In: Klinische Pädiatrie, Jg. 224, 2012, S. 221
    DOI
  • Eschenburg, Georg; Eggert, Angelika; Schramm, Alexander; Lode, Holger N.; Hundsdoerfer, Patrick
    Smac mimetic LBW242 sensitizes XIAP-overexpressing neuroblastoma cells for TNF-α-independent apoptosis
    In: Cancer Research, Jg. 72, 2012, Nr. 10, S. 2645 – 2656
    DOI (Open Access)
  • Nittner, David; Lambertz, Irina; Clermont, Frederic; Mestdagh, Pieter; Köhler, Corinna; Nielsen, Soren Jensby; Jochemsen, Aart; Speleman, Frank; Vandesompele, Jo; Dyer, Michael A.; Schramm, Alexander; Schulte, Johannes; Marine, Jean-Christophe
    Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation
    In: Nature Cell Biology, Jg. 14, 2012, Nr. 9, S. 958 – 965
    DOI
  • Heukamp, Lukas C.; Thor, Theresa; Schramm, Alexander; De Preter, Katleen; Kumps, Candy; De Wilde, Bram; Odersky, Andrea; Peifer, Martin; Lindner, Sven; Spruessel, Annika; Pattyn, Filip; Mestdagh, Pieter; Menten, Bjoern; Kuhfittig-Kulle, Steffi; Künkele, Annette; König, Katharina; Meder, Lydia; Chatterjee, Sampurna; Ullrich, Roland T.; Schulte, Stefanie; Vandesompele, Jo; Speleman, Frank; Büttner, Reinhard; Eggert, Angelika; Schulte, Johannes
    Targeted expression of mutated ALK induces neuroblastoma in transgenic mice
    In: Science Translational Medicine, Jg. 4, 2012, Nr. 141, S. 141ra91
    DOI
  • Fielitz, K.; Schowe, B.; Schulte, Johannes; Vandesompele, J.; Mestdagh, P.; Eggert, Angelika; Morik, K.; Schramm, Alexander
    The JARID 1C histone demethylase is upregulated in aggressive neuroblastomas independent of MYCN amplification
    In: Klinische Pädiatrie, Jg. 224, 2012, S. 221 – 222
    DOI
  • Liguori, Lucia; Andolfo, Immacolata; De Antonellis, Pasqualino; Aglio, Veruska; Di Dato, Valeria; Marino, Natascia; Orlotti, Nicola Ivan; De Martino, Daniela; Capasso, Mario; Petrosino, Giuseppe; Schramm, Alexander; Navas, Luigi; Tonini, Gian Paolo; Eggert, Angelika; Iolascon, Achille; Zollo, Massimo
    The metallophosphodiesterase Mpped2 impairs tumorigenesis in neuroblastoma
    In: Cell Cycle, Jg. 11, 2012, Nr. 3, S. 569 – 581
    DOI
  • Fiaschetti, G.; Castelletti, D.; Zoller, S.; Schramm, Alexander; Schroeder, C.; Nagaishi, M.; Stearns, D.; Mittelbronn, M.; Eggert, Angelika; Westermann, F.; Ohgaki, H.; Shalaby, T.; Pruschy, M.; Arcaro, A.; Grotzer, M. A.
    Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma
    In: Oncogene, Jg. 30, 2011, Nr. 25, S. 2823 – 2835
    DOI
  • Esser, R.; Glienke, W.; Bochennek, K.; Erben, S.; Quaiser, A.; Pieper, C.; Eggert, Angelika; Schramm, Alexander; Astrahantseff, K.; Hansmann, M. L.; Schwabe, D.; Klingebiel, T.; Koehl, U.
    Detection of neuroblastoma cells during clinical follow up : advanced flow cytometry and rt-PCR for tyrosine hydroxylase using both conventional and real-time PCR
    In: Klinische Pädiatrie, Jg. 223, 2011, Nr. 6, S. 326 – 331
    DOI
  • Schulte, Johannes; Bachmann, Hagen Sjard; Brockmeyer, Bent; DePreter, Katleen; Oberthuer, Andre; Ackermann, Sandra; Kahlert, Yvonne; Pajtler, Kristian; Theissen, Jessica; Westermann, Frank; Vandesompele, J. o.; Speleman, Frank; Berthold, Frank; Eggert, Angelika; Brors, Benedikt; Hero, Barbara; Schramm, Alexander; Fischer, Matthias
    High ALK Receptor Tyrosine Kinase Expression Supersedes ALK Mutation as a Determining Factor of an Unfavorable Phenotype in Primary Neuroblastoma
    In: Clinical Cancer Research, Jg. 17, 2011, Nr. 15, S. 5082 – 5092
    DOI
  • Eggert, Angelika; Schulte, Johannes; Astrahantseff, K.; Pajtler, Kristian; Kunkele, A.; Schramm, Alexander
    Molecular Targets in Embryonal Tumors
    In: Klinische Pädiatrie, Jg. 223, 2011, Nr. 1, S. 48
    DOI
  • Kunkele, A.; de Preter, K.; Vandesompele, J.; Thor, T.; Pajtler, Kristian; Hartmann, W.; Heukamp, L.; Schramm, Alexander; Eggert, Angelika; Schulte, Johannes
    Pharmacological activation of the p53 pathway by nutlin-3 inhibits medulloblastoma cell proliferation in vitro and in vivo
    In: European Journal of Pediatrics, Jg. 170, 2011, Nr. 2, S. 267 – 268
    DOI
  • Ackermann, Sandra; Goeser, Felix; Schulte, Johannes; Schramm, Alexander; Ehemann, Felix; Hero, Barbara; Eggert, Angelika; Berthold, Frank; Fischer, Matthias
    Polo-like kinase 1 is a therapeutic target in high-risk neuroblastoma
    In: Clinical Cancer Research, Jg. 17, 2011, Nr. 4, S. 731 – 741
    DOI
  • Bachmann, Hagen Sjard; Heukamp, Lucas C.; Schmitz, Klaus Jürgen; Hilburn, Caroline F.; Kahl, Philip; Buettner, Reinhard; Nückel, Holger; Eisenhardt, Andreas; Rübben, Herbert; Schmid, Kurt Werner; Siffert, Winfried; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes
    Regulatory BCL2 promoter polymorphism (-938C>A) is associated with adverse outcome in patients with prostate carcinoma
    In: International Journal of Cancer, Jg. 129, 2011, Nr. 10, S. 2390 – 2399
    DOI
  • Zuzak, T. J.; Bornschein, M.; Stephan, H.; Pajtler, Kristian; Eisenbraun, J.; Schramm, Alexander; Eggert, Angelika
    Viscum Album (mistletoe) extract inhibits growth of pediatric tumor cells in vitro
    In: Klinische Pädiatrie, Jg. 223, 2011, Nr. 3, S. 198
    DOI
  • Zuzak, T. J.; Bornschein, M.; Menke, Katharina; Stephan, H.; Pajtler, Kristian; Eisenbraun, J.; Schramm, Alexander
    Viscum album inhibits cell growth, migration and invasion of pediatric tumor cell lines - But effects are limited at concentrations found in serum
    In: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, Jg. 18, 2011, Nr. Suppl. 8, S. 8 – S9
    DOI
  • De Preter, K.; Mestdagh, P.; Vermeulen, J.; Zeka, F.; Naranjo, A.; Bray, I.; Castel, V.; Chen, C.; Drozynska, E.; Eggert, Angelika; Hogarty, M. D.; Izycka-Swieszewska, E.; London, W. B.; Noguera, R.; Piqueras, M.; Bryan, K.; Schowe, B.; van Sluis, P.; Molenaar, J. J.; Schramm, Alexander; Schulte, Johannes; Stallings, R. L.; Versteeg, R.; Laureys, G.; Van Roy, N.; Speleman, F.; Vandesompele, J.
    miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples
    In: Clinical Cancer Research, Jg. 17, 2011, Nr. 24, S. 7684 – 7692
    DOI
  • Nittner, D.; Lambertz, I.; Schramm, Alexander; Mestdagh, P.; Vandesompele, J.; Dyer, M.A.; Schulte, J.; Marine, J.C.
    384 Dicer1 is a synthetic lethal partner of tumour suppressor p53
    In: European Journal of Cancer / EJC Supplements, Jg. 8, 2010, Nr. 5, S. 98
    DOI
  • De Preter, Katleen; Vermeulen, Joelle; Brors, Benedikt; Delattre, Olivier; Eggert, Angelika; Fischer, Matthias; Janoueix-Lerosey, Isabelle; Lavarino, Cinzia; Maris, John M.; Mora, Jaume; Nakagawara, Akira; Oberthuer, Andre; Ohira, Miki; Schleiermacher, Gudrun; Schramm, Alexander; Schulte, Johannes; Wang, Qun; Westermann, Frank; Speleman, Frank; Vandesompele, Jo
    Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature
    In: Clinical Cancer Research, Jg. 16, 2010, Nr. 5, S. 1532 – 1541
    DOI
  • Schulte, Johannes; Schowe, Benjamin; Mestdagh, Pieter; Kaderali, Lars; Kalaghatgi, Prabhav; Schlierf, Stefanie; Vermeulen, Joelle; Brockmeyer, Bent; Pajtler, Kristian; Thor, Theresa; de Preter, Katleen; Speleman, Frank; Morik, Katharina; Eggert, Angelika; Vandesompele, Jo; Schramm, Alexander
    Accurate prediction of neuroblastoma outcome based on miRNA expression profiles
    In: International Journal of Cancer, Jg. 127, 2010, Nr. 10, S. 2374 – 2385
    DOI
  • Mestdagh, P.; Fredlund, E.; Pattyn, F.; Rihani, A.; Van Maerken, T.; Vermeulen, J.; Kumps, C.; Menten, B.; De Preter, K.; Schramm, Alexander; Schulte, Johannes; Noguera, R.; Schleiermacher, G.; Janoueix-Lerosey, I.; Laureys, G.; Powel, R.; Nittner, D.; Marine, J. C.; Ringnér, M.; Speleman, F.; Vandesompele, J.
    An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours
    In: Oncogene, Jg. 29, 2010, Nr. 24, S. 3583 – 3592
    DOI
  • Buckley, Patrick G.; Alcock, Leah; Bryan, Kenneth; Bray, Isabella; Schulte, Johannes; Schramm, Alexander; Eggert, Angelika; Mestdagh, Pieter; De Preter, Katleen; Vandesompele, Jo; Speleman, Frank; Stallings, Raymond L.
    Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastoma
    In: Clinical Cancer Research, Jg. 16, 2010, Nr. 11, S. 2971 – 2978
    DOI
  • Schulte, Johannes; Marschall, Tobias; Martin, Marcel; Rosenstiel, Philipp; Mestdagh, Pieter; Schlierf, Stefanie; Thor, Theresa; Vandesompele, Jo; Eggert, Angelika; Schreiber, Stefan; Rahmann, Sven; Schramm, Alexander
    Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma
    In: Nucleic Acids Research, Jg. 38, 2010, Nr. 17, S. 5919 – 5928
    DOI
  • Huenecke, Sabine; Zimmermann, Stefanie Yvonne; Kloess, Stephan; Esser, Ruth; Brinkmann, Andrea; Tramsen, Lars; Koenig, Melanie; Erben, Stephanie; Seidl, Christian; Tonn, Torsten; Eggert, Angelika; Schramm, Alexander; Bader, Peter; Klingebiel, Thomas; Lehrnbecher, Thomas; Passweg, Jakob Robert; Soerensen, Jan; Schwabe, Dirk; Koehl, Ulrike
    IL-2-driven regulation of NK cell receptors with regard to the distribution of CD16+ and CD16- subpopulations and in vivo influence after haploidentical NK cell infusion
    In: Journal of Immunotherapy, Jg. 33, 2010, Nr. 2, S. 200 – 210
    DOI
  • Weingarten, C.; Thor, T.; Baumann, M.; Heukamp, L. C.; Buttner, R.; Schramm, Alexander; Eggert, Angelika; Schulte, Johannes; Pajtler, K.
    KDM 1A/LSD1 has a functional role in migration of medulloblastoma cells and their neuronal precursors
    In: Klinische Pädiatrie, Jg. 222, 2010, Nr. 3, S. 221
  • Pajtler, Kristian; Thor, T.; Baumann, M.; Heukamp, L.; Lim, S.; Kirfel, J.; Schramm, Alexander; Kuhfittig-Kulle, S.; Metzger, E.; Buttner, R.; Schuele, R.; Eggert, Angelika; Schulte, Johannes
    LSD1 is a novel therapeutic target in neuroblastoma (NB) and medulloblastoma (MB)
    In: European Journal of Pediatrics, Jg. 169, 2010, Nr. 3, S. 381
    DOI
  • Mestdagh, P.; Fredlund, E.; Pattyn, F.; Schulte, Johannes; Muth, D.; Vermeulen, J.; Kumps, C.; Schlierf, S.; De Preter, K.; Van Roy, N.; Noguera, R.; Laureys, G.; Schramm, Alexander; Eggert, Angelika; Westermann, F.; Speleman, F.; Vandesompele, J.
    MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors
    In: Oncogene, Jg. 29, 2010, Nr. 9, S. 1394 – 1404
    DOI
  • De Brouwer, Sara; De Preter, Katleen; Kumps, Candy; Zabrocki, Piotr; Porcu, Michael; Westerhout, Ellen M.; Lakeman, Arjan; Vandesompele, Jo; Hoebeeck, Jasmien; Van Maerken, Tom; De Paepe, Anne; Laureys, Genevieve; Schulte, Johannes; Schramm, Alexander; Van Den Broecke, Caroline; Vermeulen, Joelle; Van Roy, Nadine; Beiske, Klaus; Renard, Marleen; Noguera, Rosa; Delattre, Olivier; Janoueix-Lerosey, Isabelle; Kogner, Per; Martinsson, Tommy; Nakagawara, Akira; Ohira, Miki; Caron, Huib; Eggert, Angelika; Cools, Jan; Versteeg, Rogier; Speleman, Frank
    Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification
    In: Clinical Cancer Research, Jg. 16, 2010, Nr. 17, S. 4353 – 4362
    DOI
  • Pajtler, Kristian; Bohrer, Anna; Maurer, Jochen; Schorle, Hubert; Schramm, Alexander; Eggert, Angelika; Schulte, Johannes
    Production of chick embryo extract for the cultivation of murine neural crest stem cells
    In: JoVE, Jg. 2010, 2010, Nr. 45
    DOI, Online Volltext (Open Access)
  • Degen, S.; Kuhfittig-Kulle, Steffi; Schulte, Johannes; Westermann, F.; Schramm, Alexander; Eggert, Angelika; Astrahantseff, K.
    The DNA-binding protein YB-1 is a direct MYCN target and influences repair and resistance in neuroblastoma cell lines
    In: Klinische Pädiatrie, Jg. 222, 2010, Nr. 3, S. 219
    DOI
  • Mestdagh, Pieter; Boström, Anna-Karin; Impens, Francis; Fredlund, Erik; Van Peer, Gert; De Antonellis, Pasqualino; von Stedingk, Kristoffer; Ghesquière, Bart; Schulte, Stefanie; Dews, Michael; Thomas-Tikhonenko, Andrei; Schulte, Johannes; Zollo, Massimo; Schramm, Alexander; Gevaert, Kris; Axelson, Håkan; Speleman, Frank; Vandesompele, Jo
    The miR-17-92 MicroRNA Cluster Regulates Multiple Components of the TGF-β Pathway in Neuroblastoma
    In: Molecular Cell, Jg. 40, 2010, Nr. 5, S. 762 – 773
    DOI
  • Brockmeyer, B.; Schulte, Johannes; Oberthuer, A.; Mestdagh, P.; Pajtler, Kristian; Theissen, J.; Bachmann, Hagen Sjard; Hero, B.; Vandesompele, J.; Berthold, F.; Eggert, Angelika; Schramm, Alexander; Fischer, M.
    ALK Mutation Analysis in Patients of the German Neuroblastoma Study
    In: Klinische Pädiatrie, Jg. 221, 2009, Nr. 3, S. 195
    DOI
  • Kirchhoff, G.; Mahlow, E.; Eggert, Angelika; Schramm, Alexander
    Characterisation of stable cell clones derived from an unusual neuroblastoma stage 4S with MYCN amplification
    In: Klinische Pädiatrie, Jg. 221, 2009, Nr. 3, S. 200
    DOI
  • Cimmino, F.; Schulte, Johannes; Zollo, M.; Koster, J.; Versteeg, R.; Iolascon, A.; Eggert, Angelika; Schramm, Alexander
    Galectin-1 is a major effector of TrkB-mediated neuroblastoma aggressiveness
    In: Oncogene, Jg. 28, 2009, Nr. 19, S. 2015 – 2023
    DOI
  • Pajtler, Kristian; Thor, T.; Oles, L.; Baumann, M.; Heukamp, L. C.; Buttner, R.; Kirjel, J.; Schramm, Alexander; Eggert, Angelika; Schulte, Johannes
    LSD 1 is a Potential Therapeutic Target in Medulloblastoma
    In: Klinische Pädiatrie, Jg. 221, 2009, Nr. 3, S. 203 – 204
    DOI
  • Schulte, Johannes H.; Schramm, Alexander; Thor, T.; Lim, S.; Pajtler, Kristian; Kuhfittig-Kulle, Steffi; Metzger, E.; Schuele, R.; Buettner, R.; Kirfel, J.; Eggert, Angelika
    Lysine-Specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma : Implications for therapy
    In: Klinische Pädiatrie, Jg. 221, 2009, Nr. 3, S. A61
    DOI
  • Schulte, Johannes H.; Lim, Soyoung; Schramm, Alexander; Friedrichs, Nicolaus; Koster, Jan; Versteeg, Rogier; Ora, Ingrid; Pajtler, Kristian; Klein-Hitpaß, Ludger; Kuhfittig-Kulle, Steffi; Metzger, Eric; Schüle, Roland; Eggert, Angelika; Buettner, Reinhard; Kirfel, Jutta
    Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma : implications for therapy
    In: Cancer Research, Jg. 69, 2009, Nr. 5, S. 2065 – 2071
    DOI (Open Access)
  • De Preter, Katleen; De Brouwer, Sara; Van Maerken, Tom; Pattyn, Filip; Schramm, Alexander; Eggert, Angelika; Vandesompele, Jo; Speleman, Frank
    Meta-mining of neuroblastoma and neuroblast gene expression profiles reveals candidate therapeutic compounds
    In: Clinical Cancer Research, Jg. 15, 2009, Nr. 11, S. 3690 – 3696
    DOI
  • Thor, T.; Heukamp, L.; Hahn, H.; Kappler, R.; Buettner, R.; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes
    MicroRNAs 221 and 222 in the Pathogenesis of Solid Childhood Tumors
    In: Klinische Pädiatrie, Jg. 221, 2009, Nr. 3, S. 210
    DOI
  • Schulte, Johannes; Horn, Sebastian; Schlierf, Stefanie; Schramm, Alexander; Heukamp, Lukas C.; Christiansen, Holger; Buettner, Reinhard; Berwanger, Bernd; Eggert, Angelika
    MicroRNAs in the pathogenesis of neuroblastoma
    In: Cancer Letters, Jg. 274, 2009, Nr. 1, S. 10 – 15
    DOI
  • Bohrer, A. M.; Mahlow, E.; Maurer, J.; Schorle, H.; Schramm, Alexander; Eggert, Angelika; Schulte, Johannes
    N-myc induces transformation of neural crest stem cells in vitro and in vivo
    In: Klinische Pädiatrie, Jg. 221, 2009, Nr. 3, S. 195
    DOI
  • Kuenkele, A.; Baumann, M.; Odersky, Andrea; Deubzer, H.; Witt, O.; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes
    Pharmacologic activation of the p53 pathway using Nutlin-3 inhibits medulloblastoma cell proliferation in vitro
    In: Klinische Pädiatrie, Jg. 221, 2009, Nr. 3, S. 201
    DOI
  • Schlierf, S.; Mestdagh, P.; Thor, T.; DePreter, K.; Baumann, M.; Eggert, Angelika; Vandesompele, J.; Schramm, Alexander; Schulte, Johannes
    Prognostic role and functional analyses of miRNA expression in neuroblastoma
    In: Klinische Pädiatrie, Jg. 221, 2009, Nr. 3, S. 206
    DOI
  • Terjung, S.; Schulte, Johannes; Schlierf, S.; Schramm, Alexander; Eggert, Angelika; Meyer, H. E.; Stuhler, K.
    Proteomics of neuroblastoma master regulators
    In: Klinische Pädiatrie, Jg. 221, 2009, Nr. 3, S. 209
    DOI
  • Schramm, Alexander; Mierswa, Ingo; Kaderali, Lars; Morik, Katharina; Eggert, Angelika; Schulte, Johannes
    Reanalysis of neuroblastoma expression profiling data using improved methodology and extended follow-up increases validity of outcome prediction
    In: Cancer Letters, Jg. 282, 2009, Nr. 1, S. 55 – 62
    DOI
  • Schulte, Johannes; Pentek, Falk; Hartmann, Wolfgang; Schramm, Alexander; Friedrichs, Nicolaus; Øra, Ingrid; Koster, Jan; Versteeg, Rogier; Kirfel, Jutta; Buettner, Reinhard; Eggert, Angelika
    The low-affinity neurotrophin receptor, p75, is upregulated in ganglioneuroblastoma/ganglioneuroma and reduces tumorigenicity of neuroblastoma cells in vivo
    In: International Journal of Cancer, Jg. 124, 2009, Nr. 10, S. 2488 – 2494
    DOI
  • Biewald, E.; Mestdagh, P.; Stephan, H.; de Preter, K.; Thor, T.; Baumann, M.; Lohmann, Dietmar; Eggert, Angelika; Spelemann, F.; Schramm, Alexander; Vandesompele, J.; Schulte, Johannes
    The miR-17-92 gene cluster is amplified and overexpressed in retinoblastoma
    In: Klinische Pädiatrie, Jg. 221, 2009, Nr. 3, S. 195
    DOI
  • Huebener, Nicole; Fest, Stefan; Hilt, Kerstin; Schramm, Alexander; Eggert, Angelika; Durmus, Tahir; Woehler, Anja; Stermann, Alexander; Bleeke, Matthias; Baykan, Bianca; Weixler, Silke; Gaedicke, Gerhard; Lode, Holger N.
    Xenogeneic immunization with human tyrosine hydroxylase DNA vaccines suppresses growth of established neuroblastoma
    In: Molecular Cancer Therapeutics, Jg. 8, 2009, Nr. 8, S. 2392 – 2401
    DOI
  • Michels, Evi; Hoebeeck, Jasmien; De Preter, Katleen; Schramm, Alexander; Brichard, Benedicte; De Paepe, Anne; Eggert, Angelika; Laureys, Genevieve; Vandesompele, Jo; Speleman, Frank
    CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23
    In: BMC Cancer, Jg. 8, 2008, S. 173
    DOI
  • Schulte, Johannes; Kuhfittig-Kulle, Steffi; Klein-Hitpaß, Ludger; Schramm, Alexander; Biard, Denis S. F.; Pfeiffer, Petra; Eggert, Angelika
    Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells
    In: DNA Repair, Jg. 7, 2008, Nr. 10, S. 1757 – 1764
    DOI
  • Pentek, F.; Schramm, Alexander; Astrahantseff, K.; Hartmann, W.; Buttmer, R.; Eggert, Angelika; Schulte, Johannes
    Expression of the p75 neurotrophin receptor reduces tumorigenity of neuroblastoma cells in vivo and in vitro
    In: Klinische Pädiatrie, Jg. 220, 2008, Nr. 3, S. 206
  • Vandesompele, Jo; Michels, Evi; De Preter, Katleen; Menten, Bjoern; Schramm, Alexander; Eggert, Angelika; Ambros, Peter F.; Combaret, Valerie; Francotte, Nadine; Antonacci, Francesca; De Paepe, Anne; Laureys, Genevive; Speleman, Frank; Van Roy, Nadine
    Identification of 2 putative critical segments of 17q gain in neuroblastoma through integrative genomics
    In: International Journal of Cancer, Jg. 122, 2008, Nr. 5, S. 1177 – 1182
    DOI
  • Degen, S.; Zapatka, M.; Schramm, Alexander; Eggert, Angelika; Astrahantseff, K.
    Identification of potential new therapeutic and diagnostic targets for neuroblastoma using patient-derived autoantibodies
    In: Klinische Pädiatrie, Jg. 220, 2008, Nr. 3, S. 200
  • Becker, J.; Volland, S.; Noskova, I.; Schramm, Alexander; Schweigerer, L. L.; Wilting, J.
    Keratoepithelin reverts the suppression of tissue factor pathway inhibitor 2 by MYCN in human neuroblastoma : a mechanism to inhibit invasion
    In: International Journal of Oncology, Jg. 32, 2008, Nr. 1, S. 235 – 240
    DOI (Open Access)
  • Schulte, Johannes; Horn, Sebastian; Otto, Tobias; Samans, Birgit; Heukamp, Lukas C; Eilers, Ursula-Christa; Krause, Michael; Astrahantseff, Kathy; Klein-Hitpaß, Ludger; Buettner, Reinhard; Schramm, Alexander; Christiansen, Holger; Eilers, Martin; Eggert, Angelika; Berwanger, Bernd
    MYCN regulates oncogenic MicroRNAs in neuroblastoma
    In: International Journal of Cancer, Jg. 122, 2008, Nr. 3, S. 699 – 704
    DOI
  • Boller, Danielle; Schramm, Alexander; Doepfner, Kathrin T.; Shalaby, Tarek; von Bueren, Andre O.; Eggert, Angelika; Grotzer, Michael A.; Arcaro, Alexandre
    Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells
    In: Clinical Cancer Research, Jg. 14, 2008, Nr. 4, S. 1172 – 1181
    DOI
  • Schulte, Johannes; Lim, S.; Schramm, Alexander; Ora, I.; Kuhfittig-Kulle, Steffi; Metzger, E.; Schule, R.; Buttner, R.; Eggert, Angelika; Kirfel, J.
    The LSD 1 histone demethylase is highly expressed in poorly differentiated neuroblastoma and is a novel therpeutic target
    In: Klinische Pädiatrie, Jg. 220, 2008, Nr. 3, S. 208
  • Bitter, A.; Leise, M.; Schramm, Alexander; Eggert, Angelika; Astrahantseff, K.
    The role of heat-shock protein 90 in neuroblastoma tumor biology
    In: Klinische Pädiatrie, Jg. 220, 2008, Nr. 3, S. 199
  • Schulte, Johannes; Kirfel, Jutta; Lim, Soyoung; Schramm, Alexander; Friedrichs, Nicolaus; Deubzer, Hedwig E.; Witt, Olaf; Eggert, Angelika; Büttner, Reinhard
    Transcription factor AP2alpha (TFAP2a) regulates differentiation and proliferation of neuroblastoma cells
    In: Cancer Letters, Jg. 271, 2008, Nr. 1, S. 56 – 63
    DOI
  • De Brouwer, Sara; Michels, Evi; Vandesompele, Joe; De Preter, Katleen; Hoebeeck, Jasmien; Vermeulen, Joelle; Schramm, Alexander; Molenaar, Jan J.; Menten, Björn; Marques, Barbara; Stallings, Raymond L; Combaret, Valerie; Devalck, Christine; De Paepe, Anne; Versteeg, Rogier; Eggert, Angelika; Laureys, Geneveive; Van Roy, Nadine; Speleman, Frank
    ArrayCGH based classification of neuroblastoma into genomic subgroups
    In: Chromosome research, Jg. 15, 2007, Nr. Suppl. 2, S. 82 – 83
    DOI
  • Michels, Evi; Vandesompele, Jo; De Preter, Katleen; Hoebeeck, Jasmien; Vermeulen, Joelle; Schramm, Alexander; Molenaar, Jan J.; Menten, Bjorn; Marques, Barbara; Stallings, Raymond L.; Combaret, Valerie; Devalck, Christine; De Paepe, Anne; Versteeg, Rogier; Eggert, Angelika; Laureys, Genevieve; Van Roy, Nadine; Speleman, Frank
    ArrayCGH-based classification of neuroblastoma into genomic subgroups
    In: Genes, chromosomes & cancer, Jg. 46, 2007, Nr. 12, S. 1098 – 1108
    DOI
  • De Preter, K.; Vandesompele, J.; Heimann, P.; Yigit, N.; Beckman, S.; Schramm, Alexander; Eggert, Angelika; Stallings, R. L.; Benoit, Y.; Renard, M.; De Paepe, A.; Laureys, G.; Påhlman, S.; Speleman, F.
    Correction : Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes
    In: Genome biology, Jg. 8, 2007, Nr. 1, S. 401
    DOI
  • Zeng, Yan; Huebener, Nicole; Fest, Stefan; Weixler, Silke; Schroeder, Ulrike; Gaedicke, Gerhard; Xiang, Rong; Schramm, Alexander; Eggert, Angelika; Reisfeld, Ralph A.; Lode, Holger N.
    Fractalkine (CX3CL1)- and interleukin-2-enriched neuroblastoma microenvironment induces eradication of metastases mediated by T cells and natural killer cells
    In: Cancer Research, Jg. 67, 2007, Nr. 5, S. 2331 – 2338
    DOI
  • Hoebeeck, Jasmien; Michels, Evi; Menten, Bjoern; Van Roy, Nadine; Eggert, Angelika; Schramm, Alexander; De Preter, Katleen; Yigit, Nurten; De Smet, Els; De Paepe, Anne; Laureys, Genevieve; Vandesompele, Jo; Speleman, Frank
    High resolution tiling-path BAC array deletion mapping suggests commonly involved 3p21-p22 tumor suppressor genes in neuroblastoma and more frequent tumors
    In: International Journal of Cancer, Jg. 120, 2007, Nr. 3, S. 533 – 538
    DOI
  • Schulte, Johannes; Horn, Sebastian; Samans, Birgit; Heukamp, Lukas; Eilers, Ursula-Christa; Otto, Tobias; Krause, Michael; Astrahantseff, Kathy; Buttner, Reinhard; Schramm, Alexander; Christiansen, Holger; Eilers, Martin; Berwanger, Bernd; Eggert, Angelika
    N-MYC regulates oncogenic micrornas in neuroblastoma
    In: Pediatric Blood and Cancer, Jg. 49, 2007, Nr. 4, S. 429 – 429
    DOI
  • Schulte, J. H.; Horn, S.; Schlierf, S.; Samans, B.; Heukamp, L.; Eilers, U.; Otto, T.; Krause, M.; Astrahantseff, K.; Buettner, R.; Schramm, Alexander; Christiansen, H.; Eilers, M.; Eggert, Angelika; Berwanger, B.
    N-Myc regulates oncogenic microRNAs in neuroblastoma
    In: Klinische Pädiatrie, Jg. 219, 2007, Nr. 3, S. 192
  • Schulte, Johannes; Horn, S.; Samans, B.; Heukamp, L.; Eilers, U.; Otto, T.; Krause, M.; Astrahantseff, K.; Buettner, R.; Schramm, Alexander; Christiansen, H.; Eilers, M.; Eggert, Angelika; Berwanger, B.
    N-Myc regulates oncogenic micrortnas in neuroblastoma
    In: European Journal of Pediatrics, Jg. 166, 2007, Nr. 3, S. 278
    DOI
  • Kuhfittig-Kulle, Steffi; Schulte, J. H.; Mahlow, E.; Klein-Hitpaß, Ludger; Schramm, Alexander; Pfeiffer, P.; Eggert, Angelika
    Neurotrophin receptor status influences the capacity of nonhomologous DNA end joining INSY5Y neuroblastoma cells
    In: Klinische Pädiatrie, Jg. 219, 2007, Nr. 3, S. 187 – 187
  • Schramm, Alexander; Vandesompele, Jo; Schulte, Johannes; Dreesmann, Sabine; Kaderali, Lars; Brors, Benedikt; Eils, Roland; Speleman, Frank; Eggert, Angelika
    Translating expression profiling into a clinically feasible test to predict neuroblastoma outcome
    In: Clinical Cancer Research, Jg. 13, 2007, Nr. 5, S. 1459 – 1465
    DOI
  • Stauder, M. A.; Schmitz, Klaus Jürgen; Leuschner, I.; Schmid, Kurt Werner; Eggert, Angelika; Schramm, Alexander
    Development of a neuroblastoma-specific tissue-microarray as a tool for time- and cost-effective immunohistochemistry analyses
    In: Klinische Pädiatrie, Jg. 218, 2006, Nr. 3, S. 195
    DOI
  • Pajtler, Kristian; Schulte, Johannes; Dreesmann, S.; Mahlow, E.; Stauder, M.; Lindemann, Monika; Rebmann, Vera; Grosse-Wilde, H.; Schramm, Alexander; Eggert, Angelika
    Expression of TrkA is a potential regulator of immunogenicity in neuroblastoma cells
    In: Klinische Pädiatrie, Jg. 218, 2006, Nr. 3, S. 192 – 192
  • De Preter, Katleen; Vandesompele, Jo; Heimann, Pierre; Yigit, Nurten; Beckman, Siv; Schramm, Alexander; Eggert, Angelika; Stallings, Raymond L.; Benoit, Yves; Renard, Marleen; De Paepe, Anne; Laureys, Genevieve; Påhlman, Sven; Speleman, Frank
    Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes
    In: Genome biology, Jg. 7, 2006, Nr. 9, S. R84
    DOI
  • Steinbach, D.; Schramm, Alexander; Eggert, Angelika; Onda, M.; Dawczynski, K.; Rump, A.; Pastan, I.; Wittig, S.; Pfaffendorf, N.; Voigt, A.; Zintl, F.; Gruhn, B.
    Identification of a set of seven genes for the monitoring of minimal residual disease in pediatric acute myeloid leukemia
    In: Clinical Cancer Research, Jg. 12, 2006, Nr. 8, S. 2434 – 2441
    DOI
  • Schwanke, U.; Nabereit, A.; Koehl, U.; Brinkmann, A.; Eggert, Angelika; Schramm, Alexander; Moog, R.
    Isolation of CD3-/CD56+natural killer cells from whole blood derived buffy coats
    In: Bone Marrow Transplantation, Jg. 37, 2006, Nr. Suppl. 1, S. S303
    DOI
  • Becker, Jürgen; Erdlenbruch, B.; Noskova, I.; Schramm, Alexander; Aumailley, M.; Schorderet, D. F.; Schweigerer, L.
    Keratoepithelin suppresses the progression of experimental human neuroblastomas
    In: Cancer Research, Jg. 66, 2006, Nr. 10, S. 5314 – 5321
    DOI
  • Schulte, Johannes; Schramm, Alexander; Samans, B.; Krause, M.; Horn, S.; Fagin, A.; Astrahantseff, K.; Klein-Hitpaß, Ludger; Witt, O.; Westermann, F.; Christiansen, H.; Eilers, M.; Berwanger, B.; Eggert, Angelika
    MicroRNA expression analysis in neuroblastoma using pligonuclectide arrays
    In: Klinische Pädiatrie, Jg. 218, 2006, Nr. 3, S. 194
  • Pressel, T.; Schramm, Alexander; Schulte, Johannes; Klein-Hitpaß, Ludger; Eggert, Angelika
    Microarray analysis defines IPL/TSSC3 as a potential target mediating the synergistic effects of combined thermo-chemotherapy in neuroblastoma cells
    In: Klinische Pädiatrie, Jg. 218, 2006, Nr. 3, S. 192 – 193
    DOI
  • Scaruffi, P.; Valent, A.; Schramm, Alexander; Astrahantseff, K.; Eggert, Angelika; Tonini, G. P.
    Application of microarray-based technology to neuroblastoma
    In: Cancer letters, Jg. 228, 2005, Nr. 1-2, S. 13 – 20
    DOI
  • Schramm, Alexander; Schulte, Johannes; Astrahantseff, K.; Apostolov, O.; Limpt, V.; Sieverts, H.; Kuhfittig-Kulle, Steffi; Pfeiffer, Petra; Versteeg, R.; Eggert, Angelika
    Biological effects of TrkA and TrkB receptor signaling in neuroblastoma
    In: Cancer letters, Jg. 228, 2005, Nr. 1-2, S. 143 – 153
    DOI
  • Grasemann, Corinna; Gratias, S.; Stephan, H.; Schüler, A.; Schramm, Alexander; Klein-Hitpaß, Ludger; Rieder, H.; Schneider, S.; Kappes, F.; Eggert, Angelika; Lohmann, Dietmar
    Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma
    In: Oncogene, Jg. 24, 2005, Nr. 42, S. 6441 – 6449
    DOI
  • Schramm, Alexander; von Schuetz, V.; Christiansen, H.; Havers, Werner; Papoutsi, M.; Wilting, J.; Schweigerer, L.
    High activin A-expression in human neuroblastoma : suppression of malignant potential and correlation with favourable clinical outcome
    In: Oncogene, Jg. 24, 2005, Nr. 4, S. 680 – 687
    DOI
  • Steinbach, D.; Schramm, Alexander; Eggert, Angelika; Wittig, S.; Pfaffendorf, N.; Voigt, A.; Zintl, F.; Gruhn, B.
    Identification of a set of seven genes for the monitoring of minimal residual disease in pediatric acute myeloid leukemia
    In: Blood, Jg. 106, 2005, Nr. 11, S. 422A
  • Sitek, B.; Apostolov, O.; Stühler, K.; Pfeiffer, K.; Meyer, H. E.; Eggert, Angelika; Schramm, Alexander
    Identification of dynamic proteome changes upon ligand activation of Trk-receptors using two-dimensional fluorescence difference gel electrophoresis and mass spectrometry
    In: Molecular and Cellular Proteomics (MCP), Jg. 4, 2005, Nr. 3, S. 291 – 299
    DOI
  • Sitek, B.; Apostolov, O.; Stuhler, K.; Pfeiffer, K.; Meyer, H. E.; Eggert, Angelika; Schramm, Alexander
    Identification of dynamic proteome changes upon ligand activation of trk-receptors using two-dimensional fluorescence difference gel electrophoresis and mass spectrometry
    In: Molecular and Cellular Proteomics (MCP), Jg. 4, 2005, Nr. 8, S. 1210
  • Schulte, Johannes; Schramm, Alexander; Klein-Hitpaß, Ludger; Klenk, M.; Wessels, H.; Hauffa, Berthold; Eils, J.; Eils, R.; Brodeur, G. M.; Schweigerer, L.; Havers, Werner; Eggert, Angelika
    Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas
    In: Oncogene, Jg. 24, 2005, Nr. 1, S. 165 – 177
  • van Limpt, V.; Chan, A.; Schramm, Alexander; Eggert, Angelika; Versteeg, R.
    Phox2B mutations and the Delta-Notch pathway in neuroblastoma
    In: Cancer letters, Jg. 228, 2005, Nr. 1-2, S. 59 – 63
    DOI
  • Schramm, Alexander; Schulte, Johannes; Klein-Hitpaß, Ludger; Havers, Werner; Sieverts, H.; Berwanger, B.; Christiansen, H.; Warnat, P.; Brors, B.; Eils, J.; Eils, R.; Eggert, Angelika
    Prediction of clinical outcome and biological characterization of neuroblastoma by expression profiling
    In: Oncogene, Jg. 24, 2005, Nr. 53, S. 7902 – 7912
    DOI
  • Steinbach, D.; Schramm, Alexander; Eggert, Angelika; Wittig, S.; Pfaffendorf, N.; Voigt, A.; Zintl, F.; Gruhn, B.
    Quantitative phenotyping and discriminant analysis improve scoring classification in late B-lymphoproliferative disorders
    In: Blood, Jg. 106, 2005, Nr. 11, S. 422A
  • Steinbach, D.; Schramm, Alexander; Eggert, Angelika; Wittig, S.; Zintl, F.; Gruhn, B.
    Identification of new markers for the detection of minimal residual disease in AML by gene expression profiling and real time PCR
    In: Blood, Jg. 104, 2004, Nr. 11, S. 554A
  • Lang, D.; Patti, R.; Schulte, Johannes; Schramm, Alexander; Shalaby, T.; Phillips, P. C.; Eggert, Angelika; Grotzer, M. A.
    NT-3 mediated signaling pathways in DAOY medulloblastoma cells
    In: Neuro-Oncology, Jg. 6, 2004, Nr. 4, S. 409 – 409
    DOI
  • Walden, Helen; Taylor, Garry L.; Lorentzen, Esben; Pohl, Ehmke; Lilie, Hauke; Schramm, Alexander; Knura, Thomas; Stubbe, Kim; Tjaden, Britta; Hensel, Reinhard
    Structure and function of a regulated archaeal triosephosphate isomerase adapted to high temperature
    In: Journal of Molecular Biology (JMB), Jg. 342, 2004, Nr. 3, S. 861 – 875
    DOI
  • van Limpt, V.; Schramm, Alexander; van Lakeman, A.; Sluis, P.; Chan, A.; van Noesel, M.; Baas, F.; Caron, H.; Eggert, Angelika; Versteeg, R.
    The Phox2B homeobox gene is mutated in sporadic neuroblastomas
    In: Oncogene, Jg. 23, 2004, Nr. 57, S. 9280 – 9288
    DOI
  • Schulte, Johannes; Schramm, Alexander; Pressel, T.; Klein-Hitpaß, Ludger; Kremens, Bernhard; Eils, J.; Havers, Werner; Eggert, Angelika
    Microarray-analysis : a new approach to study the molecular mechanisms of thermo-chemotherapy
    In: Klinische Pädiatrie, Jg. 215, 2003, Nr. 6, S. 298 – 302
    DOI
  • Schramm, Alexander; Apostolov, O.; Sitek, B.; Pfeiffer, K.; Stühler, K.; Meyer, H. E.; Havers, Werner; Eggert, Angelika
    Proteomics : techniques and applications in cancer research
    In: Klinische Pädiatrie, Jg. 215, 2003, Nr. 6, S. 293 – 297
    DOI
  • Wai, D. H.; Schaefer, K. L.; Schramm, Alexander; Korsching, E.; Van Valen, F.; Ozaki, T.; Boecker, W.; Schweigerer, L.; Dockhorn-Dworniczak, B.; Poremba, C.
    Expression analysis of pediatric solid tumor cell lines using oligonucleotide microarrays
    In: International journal of oncology, Jg. 20, 2002, Nr. 3, S. 441 – 451
  • Schramm, Alexander; Siebers, Bettina; Tjaden, Britta; Brinkmann, Henner; Hensel, Reinhard
    Pyruvate kinase of the hyperthermophilic crenarchaeote Thermoproteus tenax : Physiological role and phylogenetic aspects
    In: Journal of Bacteriology, Jg. 182, 2000, Nr. 7, S. 2001 – 2009
    DOI (Open Access)

    • Vorworte / Nachworte

  • Althoff, Kristina; Schramm, Alexander
    Editorial: MYCN-mediated murine cancer models
    In: Aging. Orchard Park: Impact Journals LLC, Jg. 9, 2017, Nr. 4, S. 1084 – 1085
    DOI

    • Abstracts

  • Bernardo, Teresa; Behrends, Carina; Oeck, Sebastian; Ludemann, Lutz; Kuntze, Anna; Möllers, Christian; Schramm, Alexander; Timmermann, Beate; von Neubeck, Cläre
    Bestrahlungsefekt von Photonen oder Protonen auf Weichgewebssarkome und ihre Gefäße im ChorionAllantois-Membran Assay
    In: Strahlentherapie und Onkologie: Journal of Radiation Oncology, Biology, Physics. Heidelberg: Springer, Jg. 199, 2023, Nr. Suppl. 1, S. S126
    DOI (Open Access)
  • Schuler, Martin H. H.; Cuppens, K.; Ploenes, T.; Vanbockrijck, M.; Wiesweg, Marcel; Darwiche, Kaid; Schramm, Alexander; Maes, B.; Hegedus, B.; Schildhaus, Hans-Ulrich; Hautzel, H.; Theegarten, Dirk; Baas, P.; Hartemink, K.; Du Pont, B.; Aigner, Clemens
    A randomized, multicentric phase II study of preoperative nivolumab plus relatlimab or nivolumab in patients with resectable non-small cell lung cancer (NEOpredict-Lung)
    ESMO Congress 2022, 9 - 13 September 2022, Paris, France,
    In: Annals of Oncology. Amsterdam: Elsevier, Jg. 33, 2022, Nr. Supplement 7: Abstract Book of the ESMO Congress 2022, 9 - 13 September 2022, S. S1404
    DOI (Open Access)
  • Petzold, A.; Dujardin, P.; Oeck, S.; Wiesweg, Marcel; Hegedüs, B.; Schuler, Martin; Grüner, Barbara M.; Schramm, Alexander
    Combining Patient-Derived Xenografts and Barcoding Technology to Evaluate Response to Targeted Therapies in ALK+NSCLC
    In: Journal of Thoracic Oncology. Amsterdam: Elsevier, Jg. 17, 2022, Nr. 9, S. 611
    DOI
  • Tüns, A.I.; Ho, C.S.L.; Schildhaus, Hans-Ulrich; Wiesweg, Marcel; Grüner, Barbara M.; Hegedüs, B.; Schuler, Martin; Schramm, Alexander; Oeck, S.
    Targeting SHP2 Reverts Oncogenic Mediated Resistance to KRAS-G12C Inhibition
    In: Journal of Thoracic Oncology. Amsterdam: Elsevier, Jg. 17, 2022, Nr. 9, S. S586 – S587
    DOI
  • Stockhammer, P.; Ho, C.S.L.; Bankfalvi, Agnes; Plönes, T.; Hegedus, L.; Schuler, Martin; Aigner, Clemens; Schramm, Alexander; Hegedus, B.
    A Novel Patient Derived Synchronous Cell Pair with Different Mutations in an ALK-Rearranged Lung Adenocarcinoma Underlines Tumor Heterogeneity
    In: Journal of Thoracic Oncology. Amsterdam: Elsevier, Jg. 14, 2019, Nr. 10, Supplement, S. S571 – S572
    DOI (Open Access)
  • Nothdurft, S.; Breitenbücher, Frank; Okimoto, R.; Bivona, T.; Grüner, Barbara M.; Hoelzel, M.; Forster, J.; Kalmbach, S.; Schramm, Alexander; Schuler, Martin
    MA17.07 Identification of AHR as a Novel Regulator of Lung Cancer Metastasis
    In: Journal of Thoracic Oncology. Amsterdam: Elsevier, Jg. 14, 2019, Nr. 10, Supplement, S. S319
    DOI (Open Access)
  • Menke, Katrin; Schwermer, Melanie; Falke, Katharina; Eisenbraun, Jürgen; Schramm, Alexander; Zuzak, Zuzak, Tycho Jan
    Preclinical investigation of interaction of mistletoe extract (Viscum album L.) with radio- and chemotherapy in pediatric tumor cell lines
    7th Mistletoe Symposium: Mistletoe in Tumour Therapy Basic Research and Clinical Practice, 7 - 9 November 2019, Nonnweiler-Otzenhausen, Germany,
    In: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology. Amsterdam: Elsevier, Jg. 61, 2019, Nr. Supplement 1, S. 4
    DOI
  • Eggert, Angelika; Schramm, Alexander; Koester, J.; Assenov, Y.; Kristina, A.; Engesser, A.; Kahlert, Y.; Theissen, J.; Hero, B.; Roels, F.; Peifer, M.; Astrahantseff, K.; Depreter, K.; Lode, H.; Speleman, F.; Schmezer, P.; Westermann, F.; Rahmann, Sven; Fischer, Markus; Schulte, Johannes
    Integrated Genomic Analysis Identifies Specific Alterations and Activation of Yap in Relapsed Neuroblastoma
    47th Congress of the International Society of Paediatric Oncology (SIOP), October 8–11, 2015, Cape Town, South Africa,
    In: Pediatric Blood and Cancer. Hoboken: Wiley-Blackwell - STM, Jg. 62, 2015, Nr. S4, S. S145 – S145
    DOI
  • Rebmann, Vera; Manvailer, Luis Felipe Santos; Wagner, Bettina; Rieb, Anja; Collenburg, Monika; Horn, Peter; Pajtler, Kristian; Schramm, Alexander
    Soluble NKG2DL are released by Tumor Cell Lines in a Mutually exclusive fashion as free Molecules or via extracellular vesicles
    28th EFI European Immunogenetics and Histocompatibility Conference Stockholm, Sweden, June 25th–28th, 2014,
    In: Tissue Antigens. Oxford: Wiley-Blackwell, Jg. 84, 2014, Nr. 1, S. 17 – 18
    DOI
  • Hilhorst, Riet; Hovestad, Liesbeth; de Wijn, Rik; Pijnenburg, Dirk; Ruijtenbeek, Rob; Schramm, Alexander; Eggert, Angelika; Schulte, Johannes H.
    ALK F1174L kinase activity as driver of cell proliferation in neuroblastoma cell line models and neuroblastoma tumors
    In: Cancer Research. Philadelphia: American Association for Cancer Research (AACR), Jg. 72, 2012, Nr. 8, Suppl., S. 1683
    DOI
  • Pajtler, Kristian; Weingarten, Christina; Thor, Theresa; Kuenkele, Annette; Fleischhack, Gudrun; Heukamp, Lukas C; Buettner, Reinhard; Kirfel, Jutta; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes
    Lysin-Specific Histone Dementhylase 1(LSD1) is a promising new Epigenetic Theapy target Crucially involved in the migration of Medulloblastoma Cells
    15th International Symposium on Pediatric Neuro-Oncology, June 24-27 2012 Toronto, Ontario, Canada,
    In: Neuro-Oncology. Oxford: Oxford University Press, Jg. 14, 2012, Nr. Suppl. 1, S. i92
    DOI
  • Thor, Theresa; Mestdagh, Pieter; Vandesomple, J. o.; Fuchs, Helmut; Durner, Valerie G; de Angelis, Martin Hr; Heukamp, Lukas; Kuenkele, Annette; Pajtler, Kristian; Eggert, Angelika; Schramm, Alexander; Schulte, Johannes
    miR-34a is dispensable for normal development but its loss Accelerates medulloblastoma formation
    15th International Symposium on Pediatric Neuro-Oncology, June 24-27 2012 Toronto, Ontario, Canada,
    In: Neuro-Oncology. Oxford: Oxford University Press, Jg. 14, 2012, Nr. Suppl. 1, S. 89
    DOI
  • Schulte, Johannes; Schowe, Benjamin; Mestdagh, Pieter; Kaderali, Lars; Kalaghatgi, Prabhav; Schlierf, Stefanie; Vermeulen, Joelle; Brockmeyer, Bent; Pajtler, Kristian; Thor, Theresa; de Preter, Katleen; Speleman, Frank; Marik, Katharina; Eggert, Angelika; Vandesompele, Jo; Schramm, Alexander
    Accurate prediction of neuroblastoma outcome based on miRNA expression profiles
    42nd Congress of the International Society of Pediatric Oncology (SIOP), October 21-24, 2010, Boston, USA,
    In: Pediatric Blood and Cancer. Hoboken: Wiley-Blackwell - STM, Jg. 55, 2010, Nr. 5, S. 812
    DOI
  • Schulte, Johannes; Marshall, Tobias; Martin, Marcel; Rosenstiel, Philipp; Mestdagh, Pieter; Schlierf, Stefanie; Thor, Theresa; Vandesompele, Jo; Eggert, Angelika; Schreiber, Stefan; Rahmann, Sven; Schramm, Alexander
    Deep Sequencing Revals Differential Expression of Micrornas in Favourable Versus Unfavourable Neuroblastoma
    42nd Congress of the International Society of Pediatric Oncology (SIOP) in Boston,
    In: Pediatric Blood and Cancer. Hoboken: Wiley-Blackwell - STM, Jg. 55, 2010, Nr. 5, S. 826 – 827
    DOI
  • Schulte, Johannes; Bachmann, Hagen Sjard; Brockmeyer, Bent; Nowacki, Sandra; Kahlert, Yvonne; Oberthur, Andre; de Preter, Katleen; Pajtler, Kristian; Theissen, Jessica; Westermann, Frank; Speleman, Frank; Vandesompele, Jo; Berthold, Frank; Eggert, Angelika; Hero, Barbara; Schramm, Alexander; Fischer, Matthias
    High Expression of the alk Receptor Tyrosine Kinase Precedes Mutation as a Determining Factor of Unfavourable Phenotype in Primary Neuroblastoma
    42nd Congress of the International Society of Pediatric Oncology (SIOP), October 21-24, 2010, Boston, USA,
    In: Pediatric Blood and Cancer. Hoboken: Wiley-Blackwell - STM, Jg. 55, 2010, Nr. 5, S. 827
    DOI
  • Kuenkele, Annette; de Preter, Katleen; Vandesompele, Jo; Pajtler, Kristian; Heukamp, Lukas; Grotzer, Michael; Schramm, Alexander; Eggert, Angelika; Schulte, Johannes
    Pharmacologic Activation of the P53 Pathway by Nutlin-3 Inhibits Medulloblastoma Cell Proliferation in Vitro
    42nd Congress of the International Society of Pediatric Oncology (SIOP), October 21-24, 2010, Boston, USA,
    In: Pediatric Blood and Cancer. Hoboken: Wiley-Blackwell - STM, Jg. 55, 2010, Nr. 5, S. 918
    DOI
  • Schulte, Johannes; Schowe, Benjamin; Martin, Marcel; Rahmann, Sven; Theissen, Jessica; Hero, Barbara; Morik, Katharina; Schramm, Alexander; Eggert, Angelika
    Exon-Level gene expression analysis of primary neuroblastomas improves risk prediction and identifies jaridic as a novel Therapeutic target
    41st Annual conference of International Society of Paediatric Oncology SIOP 2009, Sao Paulo, Brazil, October 5–9, 2009,
    In: Pediatric Blood and Cancer. Hoboken: Wiley-Blackwell - STM, Jg. 53, 2009, Nr. 5, S. 742 – 743
    DOI
  • Schulte, Johannes; Pajtler, Kristian; Buettner, Reinhard; Kirfel, Jutta; Thor, Theresa; Schramm, Alexander; Eggert, Angelika
    LSD1 is a Potential Therapeutic Target in Medulloblastoma
    41st Annual conference of International Society of Paediatric Oncology SIOP 2009, October 5–9, 2009, Sao Paulo, Brazil,
    In: Pediatric Blood and Cancer. Hoboken: Wiley-Blackwell - STM, Jg. 53, 2009, Nr. 5, S. 826
    DOI
  • Schulte, Johannes; Bohrer, Anna; Mahlow, Ellen; Maurer, Jochen; Schorle, Hubert; DePreter, Katleen; Vandesompele, Jo; Speleman, Frank; Schlierf, Stefanie; Pajtler, Kristian; Schramm, Alexander; Eggert, Angelika
    Modeling Neuroblastomagenesis from neural crest Stem Cells in Vitro and in Vivo
    41st Annual conference of International Society of Paediatric Oncology SIOP 2009, Sao Paulo, Brazil, October 5–9, 2009,
    In: Pediatric Blood and Cancer. Hoboken: Wiley-Blackwell - STM, Jg. 53, 2009, Nr. 5, S. 703 – 704
    DOI
  • Schulte, Johannes; Biewald, Eva; Mestdagh, Pieter; Stephan, Harald; Katleen, DePreter; Lohmann, Dietmar; Spelemann, Frank; Schramm, Alexander; Vandesompele, Jo; Eggert, Angelika
    The MIR-17-92 Gene Cluster is Amplified an overexpressed in Rettinoblastoma
    41st Annual conference of International Society of Paediatric Oncology SIOP 2009, Sao Paulo, Brazil, October 5–9, 2009,
    In: Pediatric Blood and Cancer. Hoboken: Wiley-Blackwell - STM, Jg. 53, 2009, Nr. 5, S. 735
    DOI

    • Beiträge in Sammelwerken und Tagungsbänden

  • Oeck, Sebastian; Tüns, Alicia I.; Schramm, Alexander
    Nanopore Sequencing Techniques : A Comparison of the MinKNOW and the Alignator Sequencers
    In: Metagenomic Data Analysis / Mitra, Suparna (Hrsg.). Totowa, NJ: NLM (Medline), 2023, S. 209 – 221
    DOI
  • Schramm, Alexander
    Proteomics and Cancer Risk Assessment
    In: Cancer Risk Evaluation: Methods and Trends / Obe, Günter; Jandrig, Burkhard; Marchant, Gary E.; Schütz, Holger; Wiedermann, Peter M. (Hrsg.). Weinheim: Wiley-VCH, 2011, S. 207 – 217
    DOI

    • Bücher/Sammelwerke/Tagungsbände

  • Schramm, Alexander
    Identifizierung und Charakterisierung von Kandidatengenen in embryonalen Tumoren durch die Anwendung molekularer Hochdurchsatzverfahren
    Duisburg, Essen, 2008